Gene Details:
- Gene ID: AT5G25350
- Gene Symbol: EBF2
- Gene Name: EIN3-binding F box protein 2
- Description: EIN3-binding F box protein 2;(source:Araport11)
- TAIR Accession: locus:2145512
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000013 — cauline leaf — hoja caulinar (Spanish, exact), 茎生葉、茎葉 (Japanese, exact)
- PO:0000014 — rosette leaf — hoja en roseta (Spanish, exact), ロゼット葉 (Japanese, exact)
- PO:0009001 — fruit — frucht (exact, German), fruto (exact, Spanish), 果実 (exact, Japanese), coenocarp (narrow), syncarp (narrow), aggregate fruit (broad), compound fruit (broad), dehiscent fruit (broad), diaspore (broad), indehiscent fruit (broad), multiple fruit (broad), propagule (broad)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009047 — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)
- PO:0000084 — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)
Gene Ontology:
- GO:0006511 — acts upstream of or within — ubiquitin-dependent protein catabolic process
- GO:0010105 — acts upstream of or within — negative regulation of ethylene-activated signaling pathway
- GO:0009723 — acts upstream of or within — response to ethylene
- GO:0005515 — enables — protein binding
- GO:0031146 — involved in — SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- GO:0009507 — located in — chloroplast
- GO:0005634 — located in — nucleus
- GO:0019005 — part of — SCF ubiquitin ligase complex
Germplasm Phenotype:
- ebf1-1 ebf2-1 — Double mutants exhibits a clearly detectable delay in bolting time: plants had still not bolted by ~25 days after the mean bolting time of WT in LDs.
- ebf1-1 ebf2-1 — GA treatment did not restore a normal growth phenotype or floral transition to double mutant plants grown in SDs.
- ebf1-1 ebf2-1 — The double mutant is still responsive to ethylene. Moreover, inhibitors of ethylene perception or biosynthesis including AgNO3 and aminoethoxyvinyl glycine (AVG) could not suppress the constitutive triple response (ctr1).
- ebf1-1 ebf2-1 — The mutant shows dwarfed growth, supernumerary epinastically curled leaves, early senescence, and abnormal flowers with the gynoecium protruding from the unopened floral buds. However, the phenotypes seen in double mutant plants are more severe than those seen in ctr1. This becomes apparent at about two weeks after germination, except for the reduced root growth, which is already obvious at three days after germination. Moreover, unlike the ctr1 mutation that has a reduced transmission of the ctr1 allele relative to wild-type and infertile early flowers, the double mutants have a greatly reduced fertility but can readily be pollinated with wild-type pollen.
- ebf1-1 ebf2-1 — When germinated in the dark, the mutant display a ctr1-like phenotype (short hypocotyls, short roots, and exaggerated apical hooks).
- ebf1-1 ebf2-1 — When grown in the light, the double mutants display slightly longer hypocotyls, curled unexpanded cotyledons, and short and thicker roots with ectopic root hairs, similar to the ctr1 mutant. Moreover, the average area of the leaf epidermal cells was reduced 5-fold compared to wild type.
- ebf1-2 ebf2-1 — ctr1-like phenotype (short hypocotyls, short roots, and exaggerated apical hooks).
- ebf1-3 ebf2-3 — Strong growth arrest following germination even in the absence of ethylene. Plants fail to develop true leaves.
- ebf1-3 ebf2-3 eil1-3 — Modest rescue of the ebf1-3 ebf2-3 phenotype. Seedlings continue grow and develop at a slow pace after germination. Cotyledons partially expanded and turned pale green. Stunted root densely covered with root hair. Plants never flowered or set seeds.
- ebf1-3 ebf2-3 ein3-1 — More dramatic rescue of the ebf1-3 ebf2-3 phenotype. Seedlings grow rapidly after germination and eventually developed large rosette of true leaves. However the leaves are epinastic with elongated petioles and small leaf blades. Produced fertile but shorter flowers and viable seeds.
- ebf1-3 ebf2-3 ein3-1 eil1-3 — Almost complete rescue of the ebf1-3 ebf2-3 phenotype. Plants are phenotypically indistinguishable from the wild type.
- ebf2-1 — Flowering of the mutant is not significantly delayed.
- ebf2-1 — The mutants were indistinguishable from wild-type under normal growth conditions. However, when germinated in the dark, all three mutant alleles showed a slightly exaggerated response to ACC. Nevertheless, striking developmental alterations resembling those of the ctr1 mutants were observed.
Function-related keywords:
- cauline leaf , rosette leaf , fruit , root , flower , stem , root , plant sperm cell
Literature:
- EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. DOI: 10.1016/s0092-8674(03)00968-1 ; PMID: 14675533
- Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. DOI: 10.1016/s0092-8674(03)00969-3 ; PMID: 14675532
- Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation. DOI: 10.1073/pnas.0401698101 ; PMID: 15090654
- Arabidopsis ethylene signaling pathway. DOI: 10.1126/stke.2762005cm4 ; PMID: 15784880
- ETHYLENE-INSENSITIVE5 encodes a 5'–>3' exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2. DOI: 10.1073/pnas.0605528103 ; PMID: 16920797
- The exoribonuclease XRN4 is a component of the ethylene response pathway in Arabidopsis. DOI: 10.1105/tpc.106.046508 ; PMID: 17085683
- The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling. DOI: 10.1105/tpc.106.048140 ; PMID: 17307926
- The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes. DOI: 10.1073/pnas.0610717104 ; PMID: 17389366
- Ethylene signaling in Arabidopsis involves feedback regulation via the elaborate control of EBF2 expression by EIN3. DOI: 10.1111/j.1365-313X.2008.03551.x ; PMID: 18466304
- Genetic basis of ethylene perception and signal transduction in Arabidopsis. DOI: 10.1111/j.1744-7909.2008.00710.x ; PMID: 18713391
- Ethylene-induced stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 is mediated by proteasomal degradation of EIN3 binding F-box 1 and 2 that requires EIN2 in Arabidopsis. DOI: 10.1105/tpc.110.076588 ; PMID: 20647342
- A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins. DOI: 10.1371/journal.pone.0050009 ; PMID: 23166809
- Salt-induced stabilization of EIN3/EIL1 confers salinity tolerance by deterring ROS accumulation in Arabidopsis. DOI: 10.1371/journal.pgen.1004664 ; PMID: 25330213
- EIN2-directed translational regulation of ethylene signaling in Arabidopsis. DOI: 10.1016/j.cell.2015.09.037 ; PMID: 26496607
- Activation of HLS1 by Mechanical Stress via Ethylene-Stabilized EIN3 Is Crucial for Seedling Soil Emergence. DOI: 10.3389/fpls.2016.01571 ; PMID: 27822221
- PIF3 is a negative regulator of the CBF pathway and freezing tolerance in Arabidopsis. DOI: 10.1073/pnas.1706226114 ; PMID: 28739888
- Light-Dependent Degradation of PIF3 by SCF(EBF1/2) Promotes a Photomorphogenic Response in Arabidopsis. DOI: 10.1016/j.cub.2017.06.062 ; PMID: 28736168
- The plant hormone ethylene restricts Arabidopsis growth via the epidermis. DOI: 10.1073/pnas.1717649115 ; PMID: 29643073
- The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis. DOI: 10.1073/pnas.2024592118 ; PMID: 33526703
- Tuning self-renewal in the Arabidopsis stomatal lineage by hormone and nutrient regulation of asymmetric cell division. DOI: 10.7554/eLife.63335 ; PMID: 33739283
- Metabolic control of arginine and ornithine levels paces the progression of leaf senescence. DOI: 10.1093/plphys/kiac244 ; PMID: 35604104
- Brassinosteroids promote etiolated apical structures in darkness by amplifying the ethylene response via the EBF-EIN3/PIF3 circuit. DOI: 10.1093/plcell/koac316 ; PMID: 36321994
- Ethylene signaling in Arabidopsis involves feedback regulation via the elaborate control of EBF2 expression by EIN3. DOI: 10.1111/j.1365-313X.2008.03551.x ; PMID: 18466304
Sequences:
cDNA Sequence
- >AT5G25350.1
CTAGTGGATCATCCTTTTTAAAAATCGACATCTCTCAAATGTTTTTGTCAACAATGCATGTATTCTCTTCCTTCAATGTATTCAGTCTTTTTCGTCAAACCACATTTCAAAACTTTACGAATTTATTTTTATAATAATGTTTTTGATATGTTTCATTATAAATTAAAAATATGATGACAATTGGGTTCGGTGTGGGAACAAAGAAGGTGGAGAAGAAATCCGACTTTTTCGCGTGTATACATTGAACTTAAGAGTTTTTATCCTCTACATCAACTTCCACCGTACACCTCTCTCACCATTAAAGACGTTTCTCATTTTCTTCCTTGTTCTTCTCAATATCACAAACATTTCTTCTGTAAAAATCTTCTCTTTTTGCCCTAATCTTCTAGGGTTCTTCTTCTTTTCATGAATCTTAGTCTTCGATCTCTTCAAATCTTCGTCTTTCTTCTTCAAATCTTCTTCGAATTATGTCTGGAATCTTCAGATTTAGTGGTGATGAAGATTGTTTACTTGGGGGATCGATGTATCTATCACCAGGGAGCTGTCCCGGTGTATATTACCCAGCGCGTAAGAGGTTACGTGTTGCTGCGACGTCGTTTTACAGCGGTTTTGAGGAGAAGCAAACTTCAATCGATGTATTGCCTGAAGAGTGTTTATTTGAGATTCTAAGACGTTTACCTTCTGGACAAGAGAGGAGTGCTTGCGCTTGTGTTTCCAAGCATTGGCTTAATCTTTTGAGTAGTATCAGTAGGAGTGAAGTGAATGAGTCATCAGTTCAAGATGTGGAGGAGGGTGAAGGGTTTTTGTCTAGGAGTTTGGAGGGGAAGAAGGCGACGGATTTGAGGTTGGCGGCGATTGCGGTTGGGACGTCGAGTCGTGGTGGGTTGGGGAAGCTTCAGATTCGTGGGAGTGGGTTTGAGAGTAAGGTGACTGATGTTGGTCTTGGTGCTGTTGCTCATGGTTGTCCATCTCTTAGGATTGTTTCTTTATGGAACTTGCCTGCTGTTAGTGATTTGGGTTTGTCTGAGATCGCACGGTCATGCCCGATGATTGAAAAACTTGACCTTTCACGGTGTCCTGGAATAACTGACAGTGGATTGGTTGCTATTGCTGAGAACTGTGTGAATCTGAGTGATCTGACGATTGATTCTTGCTCTGGTGTTGGGAATGAGGGTTTAAGGGCTATTGCAAGACGTTGTGTCAATCTGAGATCTATCTCTATCAGGAGCTGCCCACGTATTGGTGATCAAGGTGTTGCCTTCCTCTTGGCTCAAGCTGGTTCTTACTTGACGAAAGTGAAACTCCAGATGCTGAACGTATCTGGTTTGTCTCTTGCTGTTATTGGTCACTACGGAGCAGCTGTTACTGATCTTGTGCTTCATGGACTTCAAGGTGTGAATGAGAAAGGCTTCTGGGTTATGGGAAATGCAAAAGGGTTGAAGAAACTGAAGTCCCTCTCAGTAATGTCGTGCAGAGGTATGACCGATGTTGGGCTCGAAGCTGTTGGAAATGGTTGCCCTGATCTGAAGCATGTCTCTCTGAACAAATGCTTGCTTGTTTCTGGTAAAGGACTTGTCGCTTTGGCCAAATCTGCATTGTCACTTGAAAGTTTGAAACTTGAAGAATGCCACAGGATCAACCAGTTTGGTCTTATGGGTTTTCTCATGAACTGTGGCTCAAAGTTGAAAGCTTTCTCTTTGGCAAACTGTCTGGGCATCAGTGACTTCAACTCAGAATCCTCTCTGCCATCACCCAGTTGCAGCTCTTTACGTTCTCTGTCAATCCGATGCTGCCCTGGGTTTGGGGATGCAAGTCTCGCTTTCTTGGGAAAGTTCTGTCATCAGCTTCAGGATGTTGAACTCTGTGGACTAAACGGAGTGACAGATGCAGGTGTGCGCGAGTTGCTACAGAGCAACAATGTTGGTCTAGTGAAGGTGAACCTGAGCGAATGTATCAATGTTTCAGACAACACAGTCTCTGCAATTTCTGTTTGCCACGGACGCACATTGGAGTCTCTTAACCTTGACGGCTGCAAGAACATCACAAACGCAAGCCTTGTCGCAGTAGCCAAGAACTGCTACTCAGTCAATGACCTTGACATCTCAAATACTTTGGTCTCAGATCACGGAATCAAGGCCTTGGCATCTTCTCCTAACCATCTGAATCTTCAGGTTCTTTCCATTGGCGGCTGCTCCTCAATTACAGACAAAAGCAAGGCATGCATACAAAAACTCGGCCGCACGCTTTTGGGATTAAACATCCAACGTTGTGGCAGAATCAGCAGCAGCACTGTGGATACTCTTCTCGAAAATCTATGGAGGTGCGATATACTCTACTAAATTCCCACTTTTTCTACAAAACCTTAGTATCATCATCATCAGTCCAAGTCTTTTTCCTAGGTTTTGGTCGCTAAAACCCATAGATTCCACCTAGAACTTAGTTTCTTTCTCAGGACACTGCAGTTGTTTTTTAAAATTTTTGGCAGGTTCCTTCTAAACAAAGGAGCCTGTTTCTACAACTGTTAGTGTTTTTGTGAAGCCTGTCACTGAGTTCTGGTAATCTAGTTTAGGGTTTAGTCTTGACCGTCTTTTTGGAGTTGTTGTCTCTCTATGTTCAGTAAAGTTCTTGTAGAAGTCATTTGTTCTTTGGTTTAGGTTCGTGATAGTGCCTTTTATCTTCTTCCACTGTAGAGCTTTTGGCAATGGCGGTGTAACTTCTTAATCCGCCATTACAACTCTTCGGAGTTGTTTTTTTGTGTGTTATGTATCTGCCAAAAGCTCTGTTTTTTCCCACTTTTTTGTTTAAGGCACTATCTTGTACTTATGAATCATTGTAACTTTGTACTCTCTATTATAAAGCTTTCACTGAACATAATTACTACCCTTTGTAATAGAACTTGATCCTTACATAATTGGATCATTTTGTTGTG
CDS Sequence
Protein Sequence