Gene Details:

• Gene ID: AT5G24270
• Gene Symbol: ATSOS3, CBL4, SOS3
• Gene Name: SALT OVERLY SENSITIVE 3, CALCINEURIN B-LIKE PROTEIN 4, SALT OVERLY SENSITIVE 3
• Description: Calcium-binding EF-hand family protein;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G24270.1     AT5G24270.2     AT5G24270.4     AT5G24270.5     AT5G24270.3

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Germplasm Phenotype:

• CS3864  — hypersensitive to sodium and lithium stresses; plants accumulate more sodium and retain less potassium than wild type under salt stress; incapable of growing under low-potassium conditions; increased calcium in the culture medium can partially suppress the sodium hypersensitivity of plants and completely suppress the defect in potassium nutrition; trichomes absent on leaves and stems, some trichomes in leaf margins
• CS6529  — Suppressor of sos3-1 NaCl sensitivity and growth deficiency under low potassium conditions; NaCl sensitivity of sos3-1 seedlings is strongly suppressed by hkt1-1; seedlings exhibit greater root growth and shoot development with less leaf anthocyanin accumulation when grown in medium supplemented with NaCl; trichomes absent on leaves and stems, some trichomes in leaf margins.
• CS6530  — Suppressor of sos3-1 NaCl sensitivity and growth deficiency under low potassium conditions; NaCl sensitivity of sos3-1 seedlings is strongly suppressed by hkt1-4, which restores Na+ homeostasis of sos3-1 plants to near that of wild type; seedlings exhibit greater root growth and shoot development with less leaf anthocyanin accumulation when grown in medium supplemented with NaCl; trichomes absent on leaves and stems, some trichomes in leaf margins.
• CS6558  — Plants are hyper-responsive to phosphate (Pi) deficiency in root architecture development; reduced primary root elongation; enhanced lateral root development; enhanced root hair number and development; increased root/shoot mass ratio; greater anthocyanin accumulation in leaves; reduced plant size compared to wild type; resistant to Finale (100ppm).
• sos3-1 siz1-1  — Decrease of macronutrients concentration in the MS salt formulation to 1/20X results in a substantial reduction in primary root growth.
• sos3-1 siz1-1  — Mutant grown in greenhouse or growth chamber exhibits reduced shoot and root biomass relative to the wild-type.
• sos3-1 siz1-1  — Mutant grown on Pi-deficient medium for 25 days accumulate more anthocyanins than wild-type.
• sos3-1 siz1-1  — Substantially more pronounced prototypical Pi starvation root architecture responses than sos3-1 or wild-type seedlings. On Pi-limited medium, mutant seedlings exhibit an inhibition of primary root growth, an increase of lateral root development and length, and higher root/shoot fresh weight ratio than wild-type. Enhanced resistance to Pseudomonas syringae DC3000. Smaller in stature. Impaired drought tolerance.
• sos3-1 siz1-1  — Suppression of NaCl sensitivity of sos3-1 seedlings.

Function-related keywords:

• root ,  root

Literature:

• The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter.   DOI:  10.1073/pnas.120170197 ;  PMID:  10823923
• The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3.   DOI:  10.1073/pnas.97.7.3735 ;  PMID:  10725350
• Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition.   DOI:  10.1105/tpc.10.7.1181 ;  PMID:  9668136
• An Arabidopsis mutant that requires increased calcium for potassium nutrition and salt tolerance.   DOI:  10.1073/pnas.94.26.14960 ;  PMID:  9405721
• The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases.   DOI:  10.1093/emboj/20.5.1051 ;  PMID:  11230129
• Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases.   DOI:  10.1104/pp.124.4.1844 ;  PMID:  11115898
• Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants.   DOI:  10.1104/pp.126.1.363 ;  PMID:  11351099
• Ion homeostasis during salt stress in plants.   DOI:  10.1016/s0955-0674(00)00227-1 ;  PMID:  11454443
• Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis.   DOI:  10.1073/pnas.132092099 ;  PMID:  12070350
• Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response.   DOI:  10.1046/j.1365-313x.2002.01309.x ;  PMID:  12047628
• Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3.   DOI:  10.1073/pnas.122224699 ;  PMID:  12034882
• Regulation of expression of the vacuolar Na+/H+ antiporter gene AtNHX1 by salt stress and abscisic acid.   DOI:  10.1023/a:1019859319617 ;  PMID:  12369629
• Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote.   DOI:  10.1074/jbc.M307321200 ;  PMID:  12912986
• Regulation of vacuolar Na+/H+ exchange in Arabidopsis thaliana by the salt-overly-sensitive (SOS) pathway.   DOI:  10.1074/jbc.M307982200 ;  PMID:  14570921
• The protein kinase SOS2 activates the Arabidopsis H(+)/Ca(2+) antiporter CAX1 to integrate calcium transport and salt tolerance.   DOI:  10.1074/jbc.M309084200 ;  PMID:  14583601
• Transgenic evaluation of activated mutant alleles of SOS2 reveals a critical requirement for its kinase activity and C-terminal regulatory domain for salt tolerance in Arabidopsis thaliana.   DOI:  10.1105/tpc.019174 ;  PMID:  14742879
• Salinity-induced ion flux patterns from the excised roots of Arabidopsis sos mutants.   DOI:  10.1007/s00425-005-0074-2 ;  PMID:  16079998
• Identification of plant stress-responsive determinants in Arabidopsis by large-scale forward genetic screens.   DOI:  10.1093/jxb/erj093 ;  PMID:  16513815
• Conservation of the salt overly sensitive pathway in rice.   DOI:  10.1104/pp.106.092635 ;  PMID:  17142477
• SCABP8/CBL10, a putative calcium sensor, interacts with the protein kinase SOS2 to protect Arabidopsis shoots from salt stress.   DOI:  10.1105/tpc.106.042291 ;  PMID:  17449811
• Overexpression of a putative maize calcineurin B-like protein in Arabidopsis confers salt tolerance.   DOI:  10.1007/s11103-007-9238-8 ;  PMID:  17882512
• The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.   DOI:  10.1016/j.molcel.2007.04.013 ;  PMID:  17499048
• and salt-stress signaling in plants: shedding light on SOS pathway.   DOI:  10.1016/j.abb.2008.01.010 ;  PMID:  18241665
• Overexpression of SOS (Salt Overly Sensitive) genes increases salt tolerance in transgenic Arabidopsis.   DOI:  10.1093/mp/ssn058 ;  PMID:  19529826
• A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes.   DOI:  10.1111/j.1744-7909.2009.00847.x ;  PMID:  19686372
• Na(+)/H(+) antiporter activity of the SOS1 gene: lifetime imaging analysis and electrophysiological studies on Arabidopsis seedlings.   DOI:  10.1111/j.1399-3054.2009.01274.x ;  PMID:  19758408
• Regulation by salt of vacuolar H+-ATPase and H+-pyrophosphatase activities and Na+/H+ exchange.   DOI:  10.4161/psb.4.8.9236 ;  PMID:  19820346
• The woody plant poplar has a functionally conserved salt overly sensitive pathway in response to salinity stress.   DOI:  10.1007/s11103-010-9680-x ;  PMID:  20803312
• and K(+)-sensitive 1, regulates ion homeostasis in an SOS-independent pathway in Arabidopsis.   DOI:  10.1016/j.phytochem.2010.12.005 ;  PMID:  21227472
• Species specific amino acid sequence-protein local structure relationships: An analysis in the light of a structural alphabet.   DOI:  10.1016/j.jtbi.2011.01.047 ;  PMID:  21333657
• Transcriptome analyses of a salt-tolerant cytokinin-deficient mutant reveal differential regulation of salt stress response by cytokinin deficiency.   DOI:  10.1371/journal.pone.0032124 ;  PMID:  22355415
• Molecular cloning and functional characterization of a novel apple MdCIPK6L gene reveals its involvement in multiple abiotic stress tolerance in transgenic plants.   DOI:  10.1007/s11103-012-9899-9 ;  PMID:  22382993
• Arabidopsis SOS3 plays an important role in salt tolerance by mediating calcium-dependent microfilament reorganization.   DOI:  10.1007/s00299-012-1348-3 ;  PMID:  23052592
• Structural insights on the plant salt-overly-sensitive 1 (SOS1) Na(+)/H(+) antiporter.   DOI:  10.1016/j.jmb.2012.09.015 ;  PMID:  23022605
• A role for GIGANTEA: keeping the balance between flowering and salinity stress tolerance.   DOI:  10.4161/psb.24820 ;  PMID:  23656866
• Loss of the R2R3 MYB, AtMyb73, causes hyper-induction of the SOS1 and SOS3 genes in response to high salinity in Arabidopsis.   DOI:  10.1016/j.jplph.2013.05.011 ;  PMID:  23809151
• The Arabidopsis thaliana mutant air1 implicates SOS3 in the regulation of anthocyanins under salt stress.   DOI:  10.1007/s11103-013-0099-z ;  PMID:  23925404
• Co-expression of the Arabidopsis SOS genes enhances salt tolerance in transgenic tall fescue (Festuca arundinacea Schreb.).   DOI:  10.1007/s00709-013-0540-9 ;  PMID:  24022678
• Heterologous expression of the wheat aquaporin gene TaTIP2;2 compromises the abiotic stress tolerance of Arabidopsis thaliana.   DOI:  10.1371/journal.pone.0079618 ;  PMID:  24223981
• Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses.   DOI:  10.1007/s00299-014-1717-1 ;  PMID:  25447637
• Chrysanthemum WRKY gene CmWRKY17 negatively regulates salt stress tolerance in transgenic chrysanthemum and Arabidopsis plants.   DOI:  10.1007/s00299-015-1793-x ;  PMID:  25893877
• CYCLIN-DEPENDENT KINASE G2 regulates salinity stress response and salt mediated flowering in Arabidopsis thaliana.   DOI:  10.1007/s11103-015-0324-z ;  PMID:  25948280
• Overexpression of a NF-YB3 transcription factor from Picea wilsonii confers tolerance to salinity and drought stress in transformed Arabidopsis thaliana.   DOI:  10.1016/j.plaphy.2015.05.001 ;  PMID:  26093308
• Joint genetic and network analyses identify loci associated with root growth under NaCl stress in Arabidopsis thaliana.   DOI:  10.1111/pce.12691 ;  PMID:  26667381
• Overexpression of NaKR3 enhances salt tolerance in Arabidopsis.   DOI:  10.4238/gmr.15016378 ;  PMID:  26909945
• Arabidopsis CALCINEURIN B-LIKE10 Functions Independently of the SOS Pathway during Reproductive Development in Saline Conditions.   DOI:  10.1104/pp.16.00334 ;  PMID:  26979332
• EIN3 and SOS2 synergistically modulate plant salt tolerance.   DOI:  10.1038/srep44637 ;  PMID:  28300216
• The AtrbohF-dependent regulation of ROS signaling is required for melatonin-induced salinity tolerance in Arabidopsis.   DOI:  10.1016/j.freeradbiomed.2017.04.009 ;  PMID:  28412199
• Glutamate Receptor Homolog3.4 is Involved in Regulation of Seed Germination Under Salt Stress in Arabidopsis.   DOI:  10.1093/pcp/pcy034 ;  PMID:  29432559
• AtDIV2, an R-R-type MYB transcription factor of Arabidopsis, negatively regulates salt stress by modulating ABA signaling.   DOI:  10.1007/s00299-018-2321-6 ;  PMID:  30014159
• Pseudomonas knackmussii MLR6, a rhizospheric strain isolated from halophyte, enhances salt tolerance in Arabidopsis thaliana.   DOI:  10.1111/jam.14082 ;  PMID:  30142236
• CBL-interacting protein kinase 25 contributes to root meristem development.   DOI:  10.1093/jxb/ery334 ;  PMID:  30239807
• SENSITIVE TO SALT1, An Endoplasmic Reticulum-Localized Chaperone, Positively Regulates Salt Resistance.   DOI:  10.1104/pp.18.00840 ;  PMID:  30287478
• Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.   DOI:  10.1038/s41467-019-09181-2 ;  PMID:  30867421
• Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.   DOI:  10.3390/ijms20102421 ;  PMID:  31100786
• The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.   DOI:  10.1093/jxb/erz549 ;  PMID:  31858132
• Salinity Stress-Mediated Suppression of Expression of Salt Overly Sensitive Signaling Pathway Genes Suggests Negative Regulation by AtbZIP62 Transcription Factor in Arabidopsis thaliana.   DOI:  10.3390/ijms21051726 ;  PMID:  32138325
• ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis.   DOI:  10.1016/j.molp.2020.05.010 ;  PMID:  32439321
• PLATZ2 negatively regulates salt tolerance in Arabidopsis seedlings by directly suppressing the expression of the CBL4/SOS3 and CBL10/SCaBP8 genes.   DOI:  10.1093/jxb/eraa259 ;  PMID:  32453821
• The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana.   DOI:  10.1016/j.devcel.2020.08.005 ;  PMID:  32891194
• Identification and Functional Analysis of Two Purple Acid Phosphatases AtPAP17 and AtPAP26 Involved in Salt Tolerance in Arabidopsis thaliana Plant.   DOI:  10.3389/fpls.2020.618716 ;  PMID:  33679819
• Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 A dissection of molecular mechanisms involved in acclimation.   DOI:  10.1016/j.plaphy.2021.09.029 ;  PMID:  34592706
• Distinct Roles of N-Terminal Fatty Acid Acylation of the Salinity-Sensor Protein SOS3.   DOI:  10.3389/fpls.2021.691124 ;  PMID:  34630451
• Linker histone variant HIS1-3 and WRKY1 oppositely regulate salt stress tolerance in Arabidopsis.   DOI:  10.1093/plphys/kiac174 ;  PMID:  35474141
• A Ca(2+)-sensor switch for tolerance to elevated salt stress in Arabidopsis.   DOI:  10.1016/j.devcel.2022.08.001 ;  PMID:  36007523
• Raf-like kinases and receptor-like (pseudo)kinase GHR1 are required for stomatal vapor pressure difference response.   DOI:  10.1073/pnas.2107280118 ;  PMID:  34799443
• S-acylated and nucleus-localized SALT OVERLY SENSITIVE3/CALCINEURIN B-LIKE4 stabilizes GIGANTEA to regulate Arabidopsis flowering time under salt stress.   DOI:  10.1093/plcell/koac289 ;  PMID:  36135824
• RAP2.6 enhanced salt stress tolerance by reducing Na(+) accumulation and stabilizing the electron transport in Arabidopsis thaliana.   DOI:  10.1016/j.plaphy.2023.01.003 ;  PMID:  36634508
• A salt stress-activated GSO1-SOS2-SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion.   DOI:  10.15252/embj.2022113004 ;  PMID:  37211994
• Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote.   DOI:  10.1074/jbc.M307321200 ;  PMID:  12912986

Sequences: