Gene Details:

• Gene ID: AT5G23880
• Gene Symbol: ATCPSF100, CPSF100, EMB1265, ESP5
• Gene Name: CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 100, cleavage and polyadenylation specificity factor 100, EMBRYO DEFECTIVE 1265, ENHANCED SILENCING PHENOTYPE 5
• Description: cleavage and polyadenylation specificity factor 100;(source:Araport11)
• TAIR Accession: locus:2172843
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G23880.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)

Gene Ontology:

• GO:0006378  — involved in — mRNA polyadenylation
• GO:0005515  — enables — protein binding
• GO:0035194  — acts upstream of or within — regulatory ncRNA-mediated post-transcriptional gene silencing
• NONE  — involved in — mRNA 3-end processing by stem-loop binding and cleavage GO:0006398 6009 P other metabolic processes IBA none PANTHER:PTN000128675|UniProtKB:Q9P2I0|FB:FBgn0027873 Communication:501741973 2023-06-07 AT5G23880 locus:2172843 AT5G23880 acts upstream of or within mRNA polyadenylation GO:0006378 6229 P nucleobase-containing compound metabolic process ISS Sequence similarity (homologue of/most closely related to) mammalian CPSF100 Publication:501683342|PMID:12602868 TAIR 2003-08-12 AT5G23880 gene:2172842 AT5G23880.1 located in nucleus GO:0005634 537 C nucleus ISM predicted protein features AnalysisReference:501780126 rkaundal 2018-08-31 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI none UniProtKB:Q6NLV4 Publication:501719845|PMID:17008405 2023-05-23 AT5G23880 locus:2172843 AT5G23880 involved in mRNA polyadenylation GO:0006378 6229 P other metabolic processes IBA none PANTHER:PTN000128675|SGD:S000004105|FB:FBgn0027873 Communication:501741973 2023-01-14 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI none UniProtKB:Q6NLV4 Publication:501724763|PMID:18479511 2023-05-23 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI none UniProtKB:Q6NLV4 Publication:501730401|PMID:19439664 2023-05-23 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI yeast two-hybrid assay Tair:gene:2043559 Publication:501719773|PMID:16897494 quinnli 2007-08-02 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI none UniProtKB:O82312 Publication:501683342|PMID:12602868 2023-05-23 AT5G23880 locus:2172843 AT5G23880 located in cytoplasm GO:0005737 231 C cytoplasm IDA none Publication:501733590|PMID:19573236 2016-08-01 AT5G23880 locus:2172843 AT5G23880 part of mRNA cleavage and polyadenylation specificity factor complex GO:0005847 445 C nucleus NAS inferred by author from multiple lines of evidence NONE Publication:501719845|PMID:17008405 TAIR 2006-12-19 AT5G23880 locus:2172843 AT5G23880 part of mRNA cleavage and polyadenylation specificity factor complex GO:0005847 445 C nucleus ISS Sequence similarity (homologue of/most closely related to) mammalian CPSF100 Publication:501683342|PMID:12602868 TAIR 2003-08-12 AT5G23880 locus:2172843 AT5G23880 enables RNA binding GO:0003723 1217 F RNA binding IBA none PANTHER:PTN000128675|SGD:S000004105 Communication:501741973 2021-04-02 AT5G23880 locus:2172843 AT5G23880 enables protein binding GO:0005515 3877 F protein binding IPI none UniProtKB:Q8GUU3 Publication:501719773|PMID:16897494 2023-05-23 AT5G23880 locus:2172843 AT5G23880 acts upstream of or within embryo development ending in seed dormancy GO:0009793 11994 P reproduction NAS Database entries that dont cite a paper (e.g. SwissProt records)
• GO:0009793  — acts upstream of or within — embryo development ending in seed dormancy
• GO:0003677  — enables — DNA binding
• GO:0005847  — part of — mRNA cleavage and polyadenylation specificity factor complex
• GO:0006378  — acts upstream of or within — mRNA polyadenylation

Germplasm Phenotype:

• esp5-1  — Early flowering, normal stature and leaf morphology.
• esp5-1  — Two- to three-fold fewer of the endogenous PDS mRNA than in the wild-type plants and 10- to 50-fold higher levels of PDS siRNA.

Function-related keywords:

• root ,  plant sperm cell

Literature:

• AtCPSF73-II gene encoding an Arabidopsis homolog of CPSF 73 kDa subunit is critical for early embryo development.   DOI:  10.1016/j.gene.2003.09.025 ;  PMID:  14693369
• Identification of genes required for embryo development in Arabidopsis.   DOI:  10.1104/pp.104.045179 ;  PMID:  15266054
• An Arabidopsis Fip1 homolog interacts with RNA and provides conceptual links with a number of other polyadenylation factor subunits.   DOI:  10.1074/jbc.M510964200 ;  PMID:  16282318
• Defective RNA processing enhances RNA silencing and influences flowering of Arabidopsis.   DOI:  10.1073/pnas.0606536103 ;  PMID:  17008405
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunits.   DOI:  10.1186/1471-2121-10-51 ;  PMID:  19573236
• Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies.   DOI:  10.1104/pp.109.142729 ;  PMID:  19748916
• Systematic identification of functional plant modules through the integration of complementary data sources.   DOI:  10.1104/pp.112.196725 ;  PMID:  22589469
• Role of cleavage and polyadenylation specificity factor 100: anchoring poly(A) sites and modulating transcription termination.   DOI:  10.1111/tpj.13611 ;  PMID:  28621907
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• The 73 kD subunit of the cleavage and polyadenylation specificity factor (CPSF) complex affects reproductive development in Arabidopsis.   DOI:  10.1007/s11103-006-0051-6 ;  PMID:  16897494
• Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies.   DOI:  10.1104/pp.109.142729 ;  PMID:  19748916

Sequences: