AT5G16850

Gene Details

Gene ID: AT5G16850
Gene Symbol: ATTERT, TERT
Gene Name: telomerase reverse transcriptase, telomerase reverse transcriptase
Description: telomerase reverse transcriptase;(source:Araport11)
TAIR Accession:
Genome: Araport11_genome_release
Species: Arabidopsis thaliana

Functional Descriptions

PO:0000003 — whole plant — planta entera (Spanish, exact), 植物体全体 (Japanese, exact), clonal colony (related), colony (related), bush (narrow), frutex (narrow), frutices (narrow), gametophyte (narrow), herb (narrow), liana (narrow), prothalli (narrow), prothallium (narrow), prothallus (narrow), seedling (narrow), shrub (narrow), sporophyte (narrow), suffrutex (narrow), suffrutices (narrow), tree (narrow), vine (narrow), woody clump (narrow), genet (broad), ramet (broad)

SALK_041265C — AtTERT deficiency leads to telomere shortening and absence of telomerase activity.
SALK_050921 — AtTERT deficiency leads to telomere shortening and absence of telomerase activity.
atm / tert — During five generations of growth, both tert and atm/tert lose about 500 bp of chromosome length per generation. But, whereas tert mutants show no visible growth defects through the G6 generation, atm/tert mutants in G5 show severe growth defects, such as aberrant leaf shape, delayed flowering, a loss of apical dominance, and reduced fertility. atm/tert mutants in G5 have a much higher rate of bridged chromosomes than G5 tert mutants.
atm / tert — atm tert mutants undergo Telomere Rapid Deletion (TRD) events, that can lead to the production of a chromosome with a very short telomere. Just one of these structures can prompt end-to-end chromosomal fusion events in the G5 generation. The anaphase bridges apparent in these atm/tert mutants seem to involve only a single chromosome in each distinct mutant line, and seem to occur between sister chromatids. These plants exhibit the same overall level of aneuploidy in the G5 generation as tert mutants do in the G6 generation (~52% of cells showing abnormal centromeric signals in interphase). atm/tert mutants are not as likely to undergo ALT (alternative lengthening of telomeres, a telomerase-independent process) as tert mutants, implicating ATM in this process.
atr / tert — atr/tert mutants show a more rapid loss of telomeric length than tert and atm/tert mutants, and show a more rapid degeneration in growth habit, becoming small, with aberrant leaf shape, and very low fertility by the third generation whereas tert mutants and tert/atm mutants show normal growth features until later generations. These mutants also have marked defects in chromosomal organization by G3 as evidenced by the presence of anaphase bridges, sometimes involving multiple chromosomes, a phenotype not seen in tert or atm/tert mutants.
ku70 tert — In contrast to the ku70 mutant, which undergo telomerase-dependent expansion to more than twice the normal length in a single generation, the ku70 tert double mutant displays accelerated telomere shortening and a precocious onset of genome stability.
pot1-1 ku70 tert — Same degree of telomere shortening as in the pot1 ku70 and ku70 tert double mutants.
pot1-1 tert — Telomeres in the double mutants shortened at the same rate as in either single mutant.
pot1-1 tert — Telomeres of the same length and sharp banding profile were found in the double mutant, as in their tert and pot1-1 siblings.
tert — 50% of the mitotic nuclei in anaphase from tert mutants with severe growth defects (in the G8 generation) have anaphase bridges, while none are found in comparable wild type controls. These anaphase bridges occur disproportionately often between rDNA regions. A number of chromosomal defects can also be visualized during metaphase in these mutants. About 30% of the leaf mesophyll cells examined in tert G8 mutants have elevated numbers of nucleoli.
tert — Late generation, starting around G3, tert mutants have decreased root meristem size and overall root length. This is correlated with decreased telomere length in successive generations suggesting maintenance of meristem activity is coupled to telomere length.
tert — No obvious phenotypic changes in the first (G1) or second (G2) generation. However, starting in G1, the telomeric smear in AtTERT-deficient plants was replaced by several sharp bands. By G2 at least 11 discrete telomeric fragments were visible.
tert-2 — tert-2 mutants in the G4 generation exhibit shorter chromosomes, but also form more massive calluses, indicative of an accelerated cell cycle. These calluses also die more quickly than calluses from wild type plants.

Functional Keywords

Literature and News

Gene Resources

Sequences

cDNA Sequence

>AT5G16850.1
CGAGAACCCAGAAGACCTTTAATCTCCCGCCTCTTTCACACCATCAGACTCCATTATCGAAGCTCGTTCACTCTTCTCTCTCTCCAAATTCGAGAGAAAGGAGGAGGAAGGTGTAATGCCGCGTAAACCTAGACATCGTGTACCGGAGATTCTATGGAGGTTATTCGGAAACAGAGCCAGGAATTTAAACGACGCAATAGTAGATCTGATTCCTAACCGGAATATCCAGCCGGAGCAATGCCGATGCCGGGGTCAAGGTTGTCTCGGTTGCAGCAGCGATAAACCGGCGTTTCTGCTGCGTTCCGATGATCCCATTCACTACCGTAAACTTCTTCACCGTTGCTTCGTTGTACTTCACGAACAAACCCCTCCGCTTCTGGATTTCTCTCCAACATCTTGGTGGTCACAGAGAGAGATTGTTGAAAGGATTATTGAAATGATGCAATCTGGATGTGATTGCCAAAATGTGATATGTGCCAGATATGATAAGTATGATCAGTCGAGCCCTATTTTGGAGCTATTGACAAGTTCATCTTGGGAGTTTCTTCTCAAGCGGGTCGGTCATGACGTCATGGTTTATCTTCTACAGCAAACATCAATATTCTTACCATTACTAGGGAAAAAACACCAGCAAGTGTCTGGACCTCCTCTATGTATCAAGCATAAGCGGACATTGTCAGTCCATGAAAACAAAAGAAAGAGGGATGACAACGTTCAGCCACCAACGAAAAGGCAGTGGCTTTCTTCAGCTGTCGATGACTGTCCTAAGGATGACTCTGCAACTATTACGCCCATAGTTGGCGAGGATGTAGACCAACATAGAGAGAAAAAAACTACTAAGCGTTCAAGAATATATCTTAAGCGTCGGCGAAAGCAGAGAAAGGTCAATTTCAAAAAAGTTGACTGTAATGCTCCTTGTATAACTCCCAGTACAAATGGTAAAGTCTCAACTGGTAATGACGAAATGAATCTGCACATTGGTATAAATGGAAGTCTCACTGATTTTGTAAAGCAGGCTAAACAGGTTAAAAGAAACAAGAATTTCAAGTTTGGCCTCTCAGAAACGTATTCAGTTATACCACCAAACCACATTTTAAAAACCTTGAGGCCCAACTGCTCTGATTCAAAGCTCCTAATGAACCATATATTTGGTGAAGTAAATGTTTGGTCAACGACGCCATCTCATGGCAAAGGCAATTGCCCCAGTGGATCTATTTGCTTATACCATTCATTGCTCAAGTCTCTTAAAAATCTAATAGGAAAAACAAAGTCTTCACATTTAAAAATGCTACTAGACAAACACTGTCCTGTTCTCTTGCTGCAAGAGGATGCATTGAAGTCCGGAACGACTTCTCAGAGTTCAAGGAGGCAAAAAGCAGATAAGCTGCCTCATGGATCAAGTTCATCACAAACGGGAAAACCCAAATGTCCCAGTGTTGAAGAAAGGAAGCTGTATTGCACGAACGACCAAGTAGTTTCCTTTATTTGGGCCATCTGTAGGTACATTGTTCCAGAAAGTTTGCTTGGGACCACTCATCAGATGAGGGTGCTTAGGAAAAATATAGCGTGGTTTGTTTCAAGGCGACGAAATGAGAAATGCACAGTGAATCAGTTTTTGCATAAAGTGAAACCATCAGATTTCCCATTCTTTGCTAGAAAAGAGTTATGCTGTATGGTCAACGGACATGAACTCCAAAGTGAATCCATCAGAAGTACACAGCAGATGTTGTGCACGAAATGGATTTCTTGGCTTTTTTTAGAGATTGTCAAGAAATTGGTGCACTTCAACTTCTATGCCACTGAAAGCCAAGGAGGACGGCTAAATATTTATTATTACCGGAAAAGGAGCTGGGAAAGATTAATAAGCAAAGAAATTAGCAAAGCCCTTGATGGATATGTCCTAGTAGACGATGCTGAAGCTGAAAGTAGCAGGAAGAAGCTATCAAAGTTTAGATTTTTACCAAAGGCCAATGGTGTGAGGATGGTGTTAGACTTTAGTTCTTCGTCAAGGTCGCAATCTCTTCGTGATACACATGCTGTTTTGAAGGACATCCAGCTCAAAGAACCAGATGTTCTTGGGTCTTCTGTCTTTGACCATGATGATTTCTACAGAAACCTATGCCCATATCTGATCCATTTAAGAAGTCAATCTGGAGAACTTCCTCCTTTGTACTTTGTGGTTGCGGATGTATTCAAAGCATTTGATTCAGTCGACCAGGGTAAGCTGCTTCATGTCATTCAAAGTTTTCTGAAAGATGAATACATCTTAAACAGATGTAGGCTGGTCTGCTGTGGGAAGAGATCCAATTGGGTAAACAAAATACTAGTCTCGAGTGACAAAAATTCTAACTTTTCAAGATTCACATCAACTGTTCCATATAATGCACTGCAAAGTATCGTGGTTGATAAGGGAGAAAACCATCGAGTGAGGAAAAAGGATCTAATGGTTTGGATAGGAAATATGCTAAAGAACAACATGCTGCAGTTGGATAAAAGCTTCTATGTACAAATAGCTGGAATACCTCAGGGACACAGATTATCATCCTTGTTATGTTGTTTTTACTACGGGCATCTCGAGAGGACTTTGATCTACCCATTCCTCGAAGAAGCCTCTAAAGATGTGTCTTCTAAAGAATGCAGTAGAGAGGAAGAGCTTATAATTCCCACGAGCTATAAGTTACTGAGATTTATTGATGACTACCTTTTTGTGTCTACCTCAAGAGATCAGGCGAGTAGCTTCTATCACAGGTTGAAGCATGGATTTAAAGATTACAACTGCTTCATGAACGAAACAAAATTCTGCATAAATTTTGAAGATAAAGAAGAACATAGGTGTTCTTCTAATAGAATGTTTGTGGGAGATAATGGAGTTCCTTTTGTCAGATGGACGGGTTTGCTTATTAATTCCCGCACATTTGAAGTTCAAGTTGACTACACAAGGTACTTGAGTGGCCATATAAGCTCAACTTTTTCTGTAGCTTGGCAGAACAAACCAGTTAGAAATCTTCGGCAAAAATTGTGTTACTTCTTGGTTCCGAAATGTCATCCAATTCTATTTGACTCGAACATCAACTCGGGAGAAATCGTCAGGTTAAACATCTATCAGATCTTTCTGTTGGCTGCAATGAAGTTTCACTGTTATGTCTACGAGGTGTCCCGGTTTTGGAAGCTTCATCCTCAAACTTTGTTCAAATTCATCACAATATCTGTCAGGTACATGTTCAGACTCATAAATAGAAGGGTGCGCAGAATCAACACTGGTTCTAGTTTCAGACCAGTTCTTAAACTATACAAAGAAGAAGTGATATGGCTTGGCTTAGACGCTTATATTCAAGTTCTGAAGAAGAAAAACTCGAGATATCGAATGCTCTTGATCTATTTAAAATCTGCACTTTCTAAACACTCTCTTTCTCAGCAGCTATCGTCGGAATTGAGGTATGCAACAGACCGGTCAAACTCTTCTTCGCTGTGGAAGTTGAATTATTGAAACTGATCTTAACTAGATTTTATCATCGAAACTTAGGTAGATCCTTTAAATTTCTATTTCAGTCATTTTGATAATCTAGGAACAAAATGGATTTGTAACATTTAGGGTAAAGAAAGATTTAAATGTCAACTTATTAAATATGT
>AT5G16850.2
CGAGAACCCAGAAGACCTTTAATCTCCCGCCTCTTTCACACCATCAGACTCCATTATCGAAGCTCGTTCACTCTTCTCTCTCTCCAAATTCGAGAGAAAGGAGGAGGAAGGTGTAATGCCGCGTAAACCTAGACATCGTGTACCGGAGATTCTATGGAGGTTATTCGGAAACAGAGCCAGGAATTTAAACGACGCAATAGTAGATCTGATTCCTAACCGGAATATCCAGCCGGAGCAATGCCGATGCCGGGGTCAAGGTTGTCTCGGTTGCAGCAGCGATAAACCGGCGTTTCTGCTGCGTTCCGATGATCCCATTCACTACCGTAAACTTCTTCACCGTTGCTTCGTTGTACTTCACGAACAAACCCCTCCGCTTCTGGATTTCTCTCCAACATCTTGGTGGTCACAGAGAGAGATTGTTGAAAGGATTATTGAAATGATGCAATCTGGATGTGATTGCCAAAATGTGATATGTGCCAGATATGATAAGTATGATCAGTCGAGCCCTATTTTGGAGCTATTGACAAGTTCATCTTGGGAGTTTCTTCTCAAGCGGGTCGGTCATGACGTCATGGTTTATCTTCTACAGCAAACATCAATATTCTTACCATTACTAGGGAAAAAACACCAGCAAGTGTCTGGACCTCCTCTATGTATCAAGCATAAGCGGACATTGTCAGTCCATGAAAACAAAAGAAAGAGGGATGACAACGTTCAGCCACCAACGAAAAGGCAGTGGCTTTCTTCAGCTGTCGATGACTGTCCTAAGGATGACTCTGCAACTATTACGCCCATAGTTGGCGAGGATGTAGACCAACATAGAGAGAAAAAAACTACTAAGCGTTCAAGAATATATCTTAAGCGTCGGCGAAAGCAGAGAAAGGTCAATTTCAAAAAAGTTGACTGTAATGCTCCTTGTATAACTCCCAGTACAAATGGTAAAGTCTCAACTGGTAATGACGAAATGAATCTGCACATTGGTATAAATGGAAGTCTCACTGATTTTGTAAAGCAGGCTAAACAGGTTAAAAGAAACAAGAATTTCAAGTTTGGCCTCTCAGAAACGTATTCAGTTATACCACCAAACCACATTTTAAAAACCTTGAGGCCCAACTGCTCTGATTCAAAGCTCCTAATGAACCATATATTTGGTGAAGTAAATGTTTGGTCAACGACGCCATCTCATGGCAAAGGCAATTGCCCCAGTGGATCTATTTGCTTATACCATTCATTGCTCAAGTCTCTTAAAAATCTAATAGGAAAAACAAAGTCTTCACATTTAAAAATGCTACTAGACAAACACTGTCCTGTTCTCTTGCTGCAAGAGGATGCATTGAAGTCCGGAACGACTTCTCAGAGTTCAAGGAGGCAAAAAGCAGATAAGCTGCCTCATGGATCAAGTTCATCACAAACGGGAAAACCCAAATGTCCCAGTGTTGAAGAAAGGAAGCTGTATTGCACGAACGACCAAGTAGTTTCCTTTATTTGGGCCATCTGTAGGTACATTGTTCCAGAAAGTTTGCTTGGGACCACTCATCAGATGAGGGTGCTTAGGAAAAATATAGCGTGGTTTGTTTCAAGGCGACGAAATGAGAAATGCACAGTGAATCAGTTTTTGCATAAAGTGAAACCATCAGATTTCCCATTCTTTGCTAGAAAAGAGTTATGCTGTATGGTCAACGGACATGAACTCCAAAGTGAATCCATCAGAAGTACACAGCAGATGTTGTGCACGAAATGGATTTCTTGGCTTTTTTTAGAGATTGTCAAGAAATTGGTGCACTTCAACTTCTATGCCACTGAAAGCCAAGGAGGACGGCTAAATATTTATTATTACCGGAAAAGGAGCTGGGAAAGATTAATAAGCAAAGAAATTAGCAAAGCCCTTGATGGATATGTCCTAGTAGACGATGCTGAAGCTGAAAGTAGCAGGAAGAAGCTATCAAAGTTTAGATTTTTACCAAAGGCCAATGGTGTGAGGATGGTGTTAGACTTTAGTTCTTCGTCAAGGTCGCAATCTCTTCGTGATACACATGCTGTTTTGAAGGACATCCAGCTCAAAGAACCAGATGTTCTTGGGTCTTCTGTCTTTGACCATGATGATTTCTACAGAAACCTATGCCCATATCTGATCCATTTAAGAAGTCAATCTGGAGAACTTCCTCCTTTGTACTTTGTGGTTGCGGATGTATTCAAAGCATTTGATTCAGTCGACCAGGGTAAGCTGCTTCATGTCATTCAAAGTTTTCTGAAAGATGAATACATCTTAAACAGATGTAGGCTGGTCTGCTGTGGGAAGAGATCCAATTGGGTAAACAAAATACTAGTCTCGAGTGACAAAAATTCTAACTTTTCAAGATTCACATCAACTGTTCCATATAATGCACTGCAAAGTATCGTGGTTGATAAGGGAGAAAACCATCGAGTGAGGAAAAAGGATCTAATGGTTTGGATAGGAAATATGCTAAAGAACAACATGCTGCAGTTGGATAAAAGCTTCTATGTACAAATAGCTGGAATACCTCAGGGACACAGATTATCATCCTTGTTATGTTGTTTTTACTACGGGCATCTCGAGAGGACTTTGATCTACCCATTCCTCGAAGAAGCCTCTAAAGATGTGTCTTCTAAAGAATGCAGTAGAGAGGAAGAGCTTATAATTCCCACGAGCTATAAGTTACTGAGATTTATTGATGACTACCTTTTTGTGTCTACCTCAAGAGATCAGGCGAGTAGCTTCTATCACAGGTTGAAGCATGGATTTAAAGATTACAACTGCTTCATGAACGAAACAAAATTCTGCATAAATTTTGAAGATAAAGAAGAACATAGGTGTTCTTCTAATAGAATGTTTGTGGGAGATAATGGAGTTCCTTTTGTCAGATGGACGGGTTTGCTTATTAATTCCCGCACATTTGAAGTTCAAGTTGACTACACAAGGTACTTGAGTGGCCATATAAGCTCAACTTTTTCTGTAGCTTGGCAGAACAAACCAGTTAGAAATCTTCGGCAAAAATTGTGTTACTTCTTGGTTCCGAAATGTCATCCAATTCTATTTGACTCGAACATCAACTCGGGAGAAATCGTCAGGTTAAACATCTATCAGATCTTTCTGTTGGCTGCAATGAAGTTTCACTGTTATGTCTACGAGGTGTCCCGGTTTTGGAAGCTTCATCCTCAAACTTTGTTCAAATTCATCACAATATCTGTCAGGTACATGTTCAGACTCATAAATAGAAGGGTGCGCAGAATCAACACTGGTTCTAGTTTCAGACCAGTTCTTAAACTATACAAAGAAGAAGTGATATGGCTTGGCTTAGACGCTTATATTCAAGTTCTGAAGAAGAAAAACTCGAGATATCGAATGCTCTTGATCTATTTAAAATCTGCACTTTCTAAACACTCTCTTTCTCAGCAGCTATCGTCGGAATTGAGGTATGCAACAGACCGGTCAAACTCTTCTTCGCTGTGGAAGTTGAATTATTGAAACTGATCTTAACTAGATTTTATCATCGAAACTTAGGTAGATCCTTTAAATTTCTATTTCAGTCATTTTGATAATCTAGGAACAAAATGGATTTGTAACATTTAGGGTAAAGAAAGATTTAAATGTCAACTTATTAAATATGT

CDS Sequence

Protein Sequence