Gene Details:

• Gene ID: AT5G14750
• Gene Symbol: ATMYB66, MYB66, WER, WER1
• Gene Name: myb domain protein 66, myb domain protein 66, WEREWOLF, WEREWOLF 1
• Description: myb domain protein 66;(source:Araport11)
• TAIR Accession: locus:2185470
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G14750.1     AT5G14750.3     AT5G14750.2     AT5G14750.4

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0000026  — primary root tip — punta de la raíz primaria (Spanish, exact), 一次根端 (Japanese, exact)
• PO:0000263  — non-hair root epidermal cell — atrichoblast (exact), atricoblasto (Spanish, exact), 非毛根形成細胞、アトリコブラスト (Japanese, exact), non-hair cell (broad)
• PO:0003021  — central root cap of primary root — caliptra de la raíz central de la raíz primaria (Spanish, exact), 一次根の中心根冠 (Japanese, exact)
• PO:0000061  — lateral root cap epidermal initial cell — célula inicial del caliptra de la raíz lateral (Spanish, exact), lateral root-cap epidermal initial (exact), lateral root-cap-epidermal stem cell (exact), 側根冠表皮始原細胞 (Japanese, exact)
• PO:0003018  — root cap of lateral root — caliptra de la raíz lateral (Spanish, exact), 側根の根冠 (Japanese, exact)
• PO:0006036  — root epidermis — epidermis de la raíz (Spanish, exact), 根表皮 (Japanese, exact), epiblem (related), rhizodermis (related)
• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)

Gene Ontology:

• GO:0045893  — acts upstream of or within — positive regulation of DNA-templated transcription
• GO:0005634  — located in — nucleus
• GO:0000976  — enables — transcription cis-regulatory region binding
• GO:0005515  — enables — protein binding
• GO:0045165  — acts upstream of or within — cell fate commitment
• GO:0048765  — acts upstream of or within — root hair cell differentiation
• GO:0030154  — involved in — cell differentiation
• GO:0005634  — is active in — nucleus
• GO:0006355  — involved in — regulation of DNA-templated transcription
• GO:0003700  — enables — DNA-binding transcription factor activity
• GO:0003677  — enables — DNA binding

Function-related keywords:

• root ,  primary root tip ,  non-hair root epidermal cell ,  central root cap of primary root ,  lateral root cap epidermal initial cell ,  root cap of lateral root ,  root epidermis ,  plant sperm cell

Literature:

• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The R2R3-MYB gene family in Arabidopsis thaliana.   DOI:  10.1016/s1369-5266(00)00199-0 ;  PMID:  11597504
• Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.   DOI:  10.1073/pnas.0510607103 ;  PMID:  16581911
• A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis.   DOI:  10.1371/journal.pbio.0060235 ;  PMID:  18816165
• A feedback mechanism controlling SCRAMBLED receptor accumulation and cell-type pattern in Arabidopsis.   DOI:  10.1016/j.cub.2008.10.064 ;  PMID:  19097902
• Steroids are required for epidermal cell fate establishment in Arabidopsis roots.   DOI:  10.1073/pnas.0811633106 ;  PMID:  19416891
• The GLABRA2 homeodomain protein directly regulates CESA5 and XTH17 gene expression in Arabidopsis roots.   DOI:  10.1111/j.1365-313X.2009.03976.x ;  PMID:  19619157
• Cellular pattern formation by SCRAMBLED, a leucine-rich repeat receptor-like kinase in Arabidopsis.   DOI:  10.4161/psb.3.2.4969 ;  PMID:  19704725
• JACKDAW controls epidermal patterning in the Arabidopsis root meristem through a non-cell-autonomous mechanism.   DOI:  10.1242/dev.048777 ;  PMID:  20356954
• Auxin modulates the enhanced development of root hairs in Arabidopsis thaliana (L.) Heynh. under elevated CO(2).   DOI:  10.1111/j.1365-3040.2011.02330.x ;  PMID:  21477123
• WEREWOLF, a regulator of root hair pattern formation, controls flowering time through the regulation of FT mRNA stability.   DOI:  10.1104/pp.111.176685 ;  PMID:  21653190
• Cell fate in the Arabidopsis root epidermis is determined by competition between WEREWOLF and CAPRICE.   DOI:  10.1104/pp.111.185785 ;  PMID:  21914815
• Amino acid substitution converts WEREWOLF function from an activator to a repressor of Arabidopsis non-hair cell development.   DOI:  10.1016/j.plantsci.2011.11.001 ;  PMID:  22195575
• A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.   DOI:  10.1074/jbc.M111.280735 ;  PMID:  22334670
• Nuclear ribosome biogenesis mediated by the DIM1A rRNA dimethylase is required for organized root growth and epidermal patterning in Arabidopsis.   DOI:  10.1105/tpc.112.101022 ;  PMID:  22829145
• Transcriptional programs related to phytochrome A function in Arabidopsis seed germination.   DOI:  10.1093/mp/sst001 ;  PMID:  23292879
• Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana.   DOI:  10.1371/journal.pone.0075452 ;  PMID:  24130712
• Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases.   DOI:  10.7554/eLife.02525 ;  PMID:  24771765
• SABRE is required for stabilization of root hair patterning in Arabidopsis thaliana.   DOI:  10.1111/ppl.12257 ;  PMID:  25124848
• WEREWOLF and ENHANCER of GLABRA3 are interdependent regulators of the spatial expression pattern of GLABRA2 in Arabidopsis.   DOI:  10.1016/j.bbrc.2015.09.115 ;  PMID:  26408906
• TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana.   DOI:  10.1080/15592324.2015.1103407 ;  PMID:  26451798
• The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development.   DOI:  10.1105/tpc.16.00719 ;  PMID:  28138017
• Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana.   DOI:  10.1111/tpj.13656 ;  PMID:  28771873
• Expression of Arabidopsis class 1 phytoglobin (AtPgb1) delays death and degradation of the root apical meristem during severe PEG-induced water deficit.   DOI:  10.1093/jxb/erx371 ;  PMID:  29059380
• Root hair abundance impacts cadmium accumulation in Arabidopsis thaliana shoots.   DOI:  10.1093/aob/mcx220 ;  PMID:  29394308
• Contribution of Root Hair Development to Sulfate Uptake in Arabidopsis.   DOI:  10.3390/plants8040106 ;  PMID:  31010206
• Root Epidermal Cell Patterning Is Modulated by a Critical Residue in the WEREWOLF Transcription Factor.   DOI:  10.1104/pp.19.00458 ;  PMID:  31492737
• Arabidopsis ZINC FINGER PROTEIN1 Acts Downstream of GL2 to Repress Root Hair Initiation and Elongation by Directly Suppressing bHLH Genes.   DOI:  10.1105/tpc.19.00226 ;  PMID:  31732703
• Molecular Basis for a Cell Fate Switch in Response to Impaired Ribosome Biogenesis in the Arabidopsis Root Epidermis.   DOI:  10.1105/tpc.19.00773 ;  PMID:  32371546
• The Arabidopsis O-fucosyltransferase SPINDLY regulates root hair patterning independently of gibberellin signaling.   DOI:  10.1242/dev.192039 ;  PMID:  32928908
• Tyrosylprotein sulfotransferase-dependent and -independent regulation of root development and signaling by PSK LRR receptor kinases in Arabidopsis.   DOI:  10.1093/jxb/erab233 ;  PMID:  34028532
• Structural insights into partner selection for MYB and bHLH transcription factor complexes.   DOI:  10.1038/s41477-022-01223-w ;  PMID:  35995835
• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• Positional information and mobile transcriptional regulators determine cell pattern in the Arabidopsis root epidermis.   DOI:  10.1093/jxb/erj037 ;  PMID:  16317033
• Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.   DOI:  10.1371/journal.pbio.0040143 ;  PMID:  16640459
• Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.   DOI:  10.1073/pnas.0510607103 ;  PMID:  16581911
• [The mechanism of root hair development and molecular regulation in plants].   DOI:  10.1360/yc-007-0413 ;  PMID:  17548302
• Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis.   DOI:  10.1105/tpc.106.045732 ;  PMID:  17644729
• Arabidopsis TRANSPARENT TESTA GLABRA2 is directly regulated by R2R3 MYB transcription factors and is involved in regulation of GLABRA2 transcription in epidermal differentiation.   DOI:  10.1105/tpc.107.052274 ;  PMID:  17766401
• Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana.   DOI:  10.1007/s10265-007-0123-y ;  PMID:  18060349
• Cell identity mediates the response of Arabidopsis roots to abiotic stress.   DOI:  10.1126/science.1153795 ;  PMID:  18436742
• Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis.   DOI:  10.1186/1471-2229-8-81 ;  PMID:  18644155

Sequences: