Gene Details:
- Gene ID: AT5G13570
- Gene Symbol: ATDCP2, DCP2, ITS1, TDT
- Gene Name: decapping 2, INCREASED TRANSGENE SILENCING 1, TRIDENT
- Description: decapping 2;(source:Araport11)
- TAIR Accession: locus:2173174
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0000025 — root tip — punta de la raíz (Spanish, exact), 根端 (Japanese, exact)
- PO:0000034 — vascular system — sistema vascular (Spanish, exact), vasculature (exact), 維管束系 (Japanese, exact)
- PO:0000256 — root hair cell — célula del pelo de la raíz (Spanish, exact), 根毛細胞 (Japanese, exact)
Gene Ontology:
- GO:0042803 — enables — protein homodimerization activity
- GO:0000184 — involved in — nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- GO:0031087 — acts upstream of or within — deadenylation-independent decapping of nuclear-transcribed mRNA
- GO:0009791 — involved in — post-embryonic development
- GO:0000932 — located in — P-body
- GO:0006402 — acts upstream of or within — mRNA catabolic process
- GO:0000290 — involved in — deadenylation-dependent decapping of nuclear-transcribed mRNA
- GO:0005515 — enables — protein binding
- GO:0003729 — enables — mRNA binding
- GO:0010072 — involved in — primary shoot apical meristem specification
- GO:0005634 — located in — nucleus
- GO:0016441 — acts upstream of or within — post-transcriptional gene silencing
- GO:0005737 — is active in — cytoplasm
- GO:0030145 — enables — manganese ion binding
- GO:0005737 — located in — cytoplasm
- GO:0000287 — enables — magnesium ion binding
Germplasm Phenotype:
- TDT:tdt-1 — Among the embryos derived from a tdt-1 heterozygote, 25% were clearly distinguishable by their misshapen cells (5 of 23). These embryos contained small dense cells in the SAM region; however, they were not organized into distinct layers and they did not appear as a dome.
- dcp2-1 — Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. The homozygous progeny of these mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology.
- dcp2-1 — The homozygous progeny does not form flower buds.
- dcp2-1 — The homozygous progeny is seedling lethal, showed arrested postembryonic development including cotyledon expansion, development of vascular networks, root elongation, and shoot development.
- dcp2-1 — The mutant produced no leaves, short roots with short and swollen root hairs, chlorotic cotyledons that accumulated anthocyanins around their margins, and a short and swollen hypocotyl. In addition, the cotyledon-hypocotyl junction was extremely fragile, which caused cotyledons to frequently fall off, even with gentle handling.
- dcp2-1 — Vascular defects in tdt mutants were also similar to those of vcs-7 in that cotyledon secondary veins mostly failed to form closed loops.
- tdt MC4 — Much greater leaf development in both vcs-1 and tdt MC4 when grown at 16°C, whereas growth at 22 and 29°C resulted in progressively more severe defects in leaf development. However, tdt MC4 showed less extensive leaf development than that shown by vcs-1. Although some details of the vcs and tdt phenotypes differed, the major phenotypic defects were similar.
- tdt MC4 — Produced leaf primordia.
- tdt-1 — 3-day-old seedlings still showed disorganized cell layers and no leaf primordia.
- tdt-1 — The mutant produced no leaves, short roots with short and swollen root hairs, chlorotic cotyledons that accumulated anthocyanins around their margins, and a short and swollen hypocotyl. In addition, the cotyledon-hypocotyl junction was extremely fragile, which caused cotyledons to frequently fall off, even with gentle handling.
- tdt-1 — The vascular transition is a region where the root-like vascular organization of the lower hypocotyl shifts to a shoot-like vascular organization. In tdt-1 mutants, this region ranged from being devoid of detectable xylem to containing xylem but with poorly aligned veins. This defect showed incomplete penetrance, but it was most prevalent when seedlings were germinated at higher temperatures.
- tdt-1 — Vascular defects in tdt mutants were also similar to those of vcs-7 in that cotyledon secondary veins mostly failed to form closed loops.
- vcs-7 tdt-1 — Appears similar to the single mutants.
Function-related keywords:
Literature:
- Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. DOI: 10.1101/gad.1495506 ; PMID: 17158744
- Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development. DOI: 10.1105/tpc.106.047605 ; PMID: 17158604
- Components of the Arabidopsis mRNA decapping complex are required for early seedling development. DOI: 10.1105/tpc.106.047621 ; PMID: 17513503
- Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development. DOI: 10.1016/j.febslet.2007.04.051 ; PMID: 17485080
- Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis. DOI: 10.1104/pp.108.128413 ; PMID: 18815383
- Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development. DOI: 10.1105/tpc.109.070078 ; PMID: 19855049
- AtTZF gene family localizes to cytoplasmic foci. DOI: 10.4161/psb.5.2.10988 ; PMID: 20173417
- The Arabidopsis DCP2 gene is required for proper mRNA turnover and prevents transgene silencing in Arabidopsis. DOI: 10.1111/j.1365-313X.2012.05066.x ; PMID: 22639932
- The role of decapping proteins in the miRNA accumulation in Arabidopsis thaliana. DOI: 10.4161/rna.19877 ; PMID: 22614834
- Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation. DOI: 10.1093/nar/gkt296 ; PMID: 23620288
- Diffuse decapping enzyme DCP2 accumulates in DCP1 foci under heat stress in Arabidopsis thaliana. DOI: 10.1093/pcp/pcu151 ; PMID: 25339350
- Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants. DOI: 10.1093/jxb/eru447 ; PMID: 25385769
- AtCCR4a and AtCCR4b are Involved in Determining the Poly(A) Length of Granule-bound starch synthase 1 Transcript and Modulating Sucrose and Starch Metabolism in Arabidopsis thaliana. DOI: 10.1093/pcp/pcv012 ; PMID: 25630334
- Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. DOI: 10.1371/journal.ppat.1005196 ; PMID: 26431425
- Functional and molecular characterization of the conserved Arabidopsis PUMILIO protein, APUM9. DOI: 10.1007/s11103-019-00853-7 ; PMID: 30868544
- Alterations in cellular RNA decapping dynamics affect tomato spotted wilt virus cap snatching and infection in Arabidopsis. DOI: 10.1111/nph.16049 ; PMID: 31292958
- A NYN domain protein directly interacts with DECAPPING1 and is required for phyllotactic pattern. DOI: 10.1093/plphys/kiab529 ; PMID: 34791434
- Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development. DOI: 10.1016/j.febslet.2007.04.051 ; PMID: 17485080
Sequences:
cDNA Sequence
- >AT5G13570.2
GCCCACCTTTTAGATACACACAATCGTCGCACTCTCAGATTCTTCTCCGGAGCGATCAGATTTCACCGACGACGGTTGTTTTTGCCTCCTCTTTCAATCAGAGGAAGCCAAAGCTTAGAGCAACAGTTGTAAATCTATATATAGAGAGGGAGAGAGAGAGAGAGAGCTCCTCTCGTCCAGTATTAGGGTTTTAAAGGCAAGAACTACTAGAACAAGAGAAGGTACAAAAAAAAATGTCGGGCCTCCATCGATCATCAAGTTCATCGAAGAACATCGGAAATTGCCTTCCCTCCAAAGAACTCCTTGATGATCTTTGCAGTCGATTTGTTTTGAATGTCCCTGAAGAAGATCAACAGTCATTCGAGAGAATTTTGTTTCTGGTGGAGTATGCTTATTGGTACTATGAAGATAATGCTGTAGAGAATGATCCAAAGCTTAAGTCCCTGTCTTTGAAAGAGTTTACTTCGCTCTTATTCAACAGCTGTGATGTGTTGAGACCTTATGTTACTCACATTGATGATATCTTTAAAGACTTCACTTCTTACAAGTGTCGAGTTCCAGTCACTGGGGCAATTATCCTGGATGAGACATATGAAAGGTGCCTGTTGGTGAAGGGATGGAAAGGATCGAGCTGGAGCTTTCCCCGCGGAAAAAAGAGCAAGGATGAAGAAGACCATGCTTGTGCCATACGTGAGCTCTCTAGTGCTATTCTCCTGGTGAATGTAGCATTTCAGGTCTTAGAGGAAACTGGATTTGATGTCTCAAAGCTACTCAAGAGAGAAGAATATATAGAGTTTGTTTTCAGGCAGCAAAGAGTACGACTTTACATTGTTGCTGGGGTGACAGAAGATACAGTTTTTGCACCACTTACAAAGAAGGAAATCAGTGAAATCACATGGCATCGGCTTGATCATCTTCAGCCAGCAAGTAATGAGGTGATAACTCATGGAGTTTCTGGTCTCAAATTGTACATGGTGGCACCTTTCCTTTCGTCATTGAAGTCGTGGATATTAAAGCATCCTTCACCTGTAGCACGGAGACCTAACAAGCCCCTTAAAGCACTCTGCGTGTGGAATGCAAGGACTAGTGTTGGAGGGAACGGGACAGCAACAGTGGAAAGCCAAAATAGAAAGTCTGAACTCAGGACAACAACAATGGAAAGCAACAGTAGAAAGCCTGAACTCAAGAGAACAACAATGGAAAGCCACAGTACAAAGCCTGAACTCAGGAAAGGAACAATGGAAAGCCACAATACAACAGCAACAGTAGAAAGCCACAATACAAAGCCTGTAGTCGACCATTCTCAGGACATAAAACCTGGTGGCAGTTTCATAAACTTCAAGTTCAACCAGTCAGTTATCTTACAGGCGTTGGAATCTGGTAATTCAGCTTGACTGGTCAGTTTGTCACATATCGGTTGGATTGGTGTTGGGAGTAATGATGCGGTTGGATTGGTGGGTTTGTCTATAGCAAAACCGTTGGATATGTTCATACACGCTGGTAGCTTTCTATTTCTTTGCCATTTGGTTTATATACCTCTCGTTTCTTCTAGAATGAAAGGGTTGTTGTAAATGATGTTAGTAGGGAAGTGGTGAATCCTTTGGATCATGGCTTTAGATGACAATGTTACGACCAGCTATAAAGGTTAAAAGAGTTTCTTATCCGAG - >AT5G13570.1
GCCCACCTTTTAGATACACACAATCGTCGCACTCTCAGATTCTTCTCCGGAGCGATCAGATTTCACCGACGACGGTTGTTTTTGCCTCCTCTTTCAATCAGAGGAAGCCAAAGCTTAGAGCAACAGTTGTAAATCTATATATAGAGAGGGAGAGAGAGAGAGAGAGCTCCTCTCGTCCAGTATTAGGGTTTTAAAGGCAAGAACTACTAGAACAAGAGAAGGTACAAAAAAAAATGTCGGGCCTCCATCGATCATCAAGTTCATCGAAGAACATCGGAAATTGCCTTCCCTCCAAAGAACTCCTTGATGATCTTTGCAGTCGATTTGTTTTGAATGTCCCTGAAGAAGATCAACAGTCATTCGAGAGAATTTTGTTTCTGGTGGAGTATGCTTATTGGTACTATGAAGATAATGCTGTAGAGAATGATCCAAAGCTTAAGTCCCTGTCTTTGAAAGAGTTTACTTCGCTCTTATTCAACAGCTGTGATGTGTTGAGACCTTATGTTACTCACATTGATGATATCTTTAAAGACTTCACTTCTTACAAGTGTCGAGTTCCAGTCACTGGGGCAATTATCCTGGATGAGACATATGAAAGGTGCCTGTTGGTGAAGGGATGGAAAGGATCGAGCTGGAGCTTTCCCCGCGGAAAAAAGAGCAAGGATGAAGAAGACCATGCTTGTGCCATACGTGAGCTCTCTAGTGCTATTCTCCTGGTGAATGTAGCATTTCAGGTCTTAGAGGAAACTGGATTTGATGTCTCAAAGCTACTCAAGAGAGAAGAATATATAGAGTTTGTTTTCAGGCAGCAAAGAGTACGACTTTACATTGTTGCTGGGGTGACAGAAGATACAGTTTTTGCACCACTTACAAAGAAGGAAATCAGTGAAATCACATGGCATCGGCTTGATCATCTTCAGCCAGCAAGTAATGAGGTGATAACTCATGGAGTTTCTGGTCTCAAATTGTACATGGTGGCACCTTTCCTTTCGTCATTGAAGTCGTGGATATTAAAGCATCCTTCACCTGTAGCACGGAGACCTAACAAGCCCCTTAAAGCACTCTGCGTGTGGAATGCAAGGACTAGTGTTGGAGGGAACGGGACAGCAACAGTGGAAAGCCAAAATAGAAAGTCTGAACTCAGGACAACAACAATGGAAAGCAACAGTAGAAAGCCTGAACTCAAGAGAACAACAATGGAAAGCCACAGTACAAAGCCTGAACTCAGGAAAGGAACAATGGAAAGCCACAATACAACAGCAACAGTAGAAAGCCACAATACAAAGCCTGTAGTCGACCATTCTCAGGACATAAAACCTGGTGGCAGTTTCATAAACTTCAAGTTCAACCAGTCAGTTATCTTACAGGCGTTGGAATCTGGTAATTCAGCTTGACTGGTCAGTTTGTCACATATCGGTTGGATTGGTGTTGGGAGTAATGATGCGGTTGGATTGGTGGGTTTGTCTATAGCAAAACCGTTGGATATGTTCATACACGCTGGTAGCTTTCTATTTCTTTGCCATTTGGTTTATATACCTCTCGTTTCTTCTAGAATGAAAGGGTTGTTGTAAATGATGTTAGTAGGGAAGTGGTGAATCCTTTGGATCATGGCTTTAGATGACAATGTTACGACCAGCTATAAAGGTTAAAAGAGTTTCTTATCCGAG
CDS Sequence
Protein Sequence