Gene Details:

• Gene ID: AT5G12080
• Gene Symbol: ATMSL10, MscS-LIKE 10, MSL10
• Gene Name: mechanosensitive channel of small conductance-like 10
• Description: mechanosensitive channel of small conductance-like 10;(source:Araport11)
• TAIR Accession: locus:2143069
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G12080.1     AT5G12080.2     AT5G12080.3

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0000025  — root tip — punta de la raíz (Spanish, exact), 根端 (Japanese, exact)
• PO:0000036  — leaf vascular system — sistema vascular de la hoja (Spanish, exact), 葉維管系 (Japanese, exact), leaf venation (related)
• PO:0003011  — root vascular system — sistema vascular de la raíz (Spanish, exact), 根維管系 (Japanese, exact), root vein (related)

Gene Ontology:

• GO:0005886  — located in — plasma membrane
• GO:0097468  — acts upstream of or within — programmed cell death in response to reactive oxygen species
• GO:0005886  — is active in — plasma membrane
• GO:0010150  — acts upstream of or within — leaf senescence
• GO:0005634  — located in — nucleus
• GO:0006820  — acts upstream of or within — monoatomic anion transport
• GO:0008381  — enables — mechanosensitive monoatomic ion channel activity
• GO:0006820  — involved in — monoatomic anion transport
• GO:0050982  — acts upstream of or within — detection of mechanical stimulus
• GO:0050982  — involved in — detection of mechanical stimulus

Germplasm Phenotype:

• CS69760  — No visible phenotype
• CS72414  — Accumulation of anthocyanin in young and developing leaves. Adult plants exhibit several morphological abnormalities including stunted growth, shorter petioles and loss of apical dominance resulting in a bushy phenotype. Plants also display spontaneous cell death and hyperaccumulation of jasmonic acid (JA) in response to wounding.
• CS73273  — dwarfed; leaves exhibit visible lesions of dead cells
• CS73274  — dwarfed; leaves exhibit visible lesions of dead cells
• CS73277  — dwarfed; leaves exhibit visible lesions of dead cells
• CS73278  — dwarfed; leaves exhibit visible lesions of dead cells
• CS73289  — dwarfed
• CS73290  — dwarfed
• CS73291  — moderate height and reduced ectopic cell death compared to parental msl10-3G mutant plants (suppression of msl10-3G phenotypes)
• CS73292  — moderate height and reduced ectopic cell death compared to parental msl10-3G mutant plants (suppression of msl10-3G phenotypes)
• CS73296  — dwarfed
• CS73298  — moderate height
• CS73300  — moderate height
• CS73303  — dwarfed
• CS73306  — dwarfed
• CS73309  — dwarfed
• CS73312  — dwarfed
• CS73317  — dwarfed
• CS73319  — dwarfed
• CS73321  — dwarfed
• CS73327  — dwarfed
• CS73328  — dwarfed
• CS73329  — dwarfed
• CS73330  — dwarfed
• CS73331  — dwarfed
• CS73332  — dwarfed
• CS73333  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• CS73334  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• CS73335  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• CS73336  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• CS73337  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• CS73338  — moderate height (taller than untransformed msl10-3G plants); amount of ectopic cell death suppressed compared to the msl10-3G mutant
• SALK_076254  — Shifts single-channel amplitude peak from 10pa (WT) to 7.3pa
• msl4-1; msl5-2; msl6-1; msl9-1; msl10-1  — Abolished stretch-activate mechanosensitive channel activity
• msl9-1; msl10-1  — Reduced stretch-activated mechanosensitive channel activity.

Function-related keywords:

• root ,  root tip ,  leaf vascular system ,  root vascular system

Literature:

• Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana.   DOI:  10.1093/pcp/pch099 ;  PMID:  15215502
• Transcriptional profile of the Arabidopsis root quiescent center.   DOI:  10.1105/tpc.105.031724 ;  PMID:  15937229
• Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root.   DOI:  10.1016/j.cub.2008.04.039 ;  PMID:  18485707
• Genome-wide identification and evolutionary analysis of Arabidopsis sm genes family.   DOI:  10.1080/07391102.2011.10508593 ;  PMID:  21142222
• A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.   DOI:  10.1111/jipb.12427 ;  PMID:  26356550
• Sensing and transducing forces in plants with MSL10 and DEK1 mechanosensors.   DOI:  10.1002/1873-3468.13102 ;  PMID:  29782638
• Nonpolar residues in the presumptive pore-lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function.   DOI:  10.1002/pld3.59 ;  PMID:  30506019
• Mechanisms of cytosolic calcium elevation in plants: the role of ion channels, calcium extrusion systems and NADPH oxidase-mediated 'ROS-Ca(2+) Hub'.   DOI:  10.1071/FP16420 ;  PMID:  32291018
• The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana.   DOI:  10.1094/MPMI-08-21-0207-FI ;  PMID:  34775835
• Integration of long-range signals in plants: A model for wound-induced Ca(2+), electrical, ROS, and glutamate waves.   DOI:  10.1016/j.pbi.2022.102270 ;  PMID:  35926395
• Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.   DOI:  10.1074/mcp.T300006-MCP200 ;  PMID:  14506206
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.   DOI:  10.1074/mcp.T300006-MCP200 ;  PMID:  14506206
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660

Sequences: