Gene Details:

• Gene ID: AT5G10540
• Gene Symbol: TOP2
• Gene Name: thimet metalloendopeptidase 2
• Description: Zincin-like metalloproteases family protein;(source:Araport11)
• TAIR Accession: locus:2142484
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G10540.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Gene Ontology:

• GO:0004222  — enables — metalloendopeptidase activity
• GO:0005886  — located in — plasma membrane
• GO:0009507  — located in — chloroplast
• GO:0006508  — involved in — proteolysis
• GO:0048046  — located in — apoplast
• GO:0006518  — involved in — peptide metabolic process
• GO:0005829  — located in — cytosol

Function-related keywords:

• root ,  guard cell

Literature:

• The gene complement for proteolysis in the cyanobacterium Synechocystis sp. PCC 6803 and Arabidopsis thaliana chloroplasts.   DOI:  10.1007/s00294-002-0309-8 ;  PMID:  12185496
• A proteomic approach to apoplastic proteins involved in cell wall regeneration in protoplasts of Arabidopsis suspension-cultured cells.   DOI:  10.1093/pcp/pci089 ;  PMID:  15769804
• The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses.   DOI:  10.1002/pmic.200500543 ;  PMID:  16502469
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Divergent evolution of the M3A family of metallopeptidases in plants.   DOI:  10.1111/ppl.12457 ;  PMID:  27100569
• Nitrogen remobilization during leaf senescence: lessons from Arabidopsis to crops.   DOI:  10.1093/jxb/erw365 ;  PMID:  27707774
• Arabidopsis thimet oligopeptidases are redox-sensitive enzymes active in the local and systemic plant immune response.   DOI:  10.1016/j.jbc.2021.100695 ;  PMID:  33894200
• The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions.   DOI:  10.1016/j.cub.2004.02.039 ;  PMID:  15028209
• The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses.   DOI:  10.1002/pmic.200500543 ;  PMID:  16502469
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study.   DOI:  10.1016/j.phytochem.2008.04.007 ;  PMID:  18538804
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: