Information report for AT5G06310
Gene Details
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Functional Descriptions
- GO:0051974 — involved in — negative regulation of telomerase activity
- GO:0032210 — involved in — regulation of telomere maintenance via telomerase
- GO:0005515 — enables — protein binding
- GO:0000723 — involved in — telomere maintenance
- GO:0098505 — enables — G-rich strand telomeric DNA binding
- GO:0016233 — involved in — telomere capping
- GO:0000783 — part of — nuclear telomere cap complex
- GO:0043047 — enables — single-stranded telomeric DNA binding
- GO:0005634 — located in — nucleus
- GO:0003723 — enables — RNA binding
- GO:0010521 — enables — telomerase inhibitor activity
Functional Keywords
Literature and News
- The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection. DOI: 10.1128/MCB.25.17.7725-7733.2005 ; PMID: 16107718
- Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. DOI: 10.1038/sj.emboj.7601792 ; PMID: 17627276
- Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase. DOI: 10.1242/jcs.004119 ; PMID: 17911168
- POT1-independent single-strand telomeric DNA binding activities in Brassicaceae. DOI: 10.1111/j.1365-313X.2009.03837.x ; PMID: 19228335
- Alternative splicing of Pot1 (Protection of telomere)-like genes in Arabidopsis thaliana. DOI: 10.1266/ggs.80.41 ; PMID: 15824455
- Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics. DOI: 10.1042/BJ20082195 ; PMID: 19102728
- POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA. DOI: 10.1093/nar/gkp785 ; PMID: 19783822
- Two RNA subunits and POT1a are components of Arabidopsis telomerase. DOI: 10.1073/pnas.1013021107 ; PMID: 21164032
- Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction. DOI: 10.1093/molbev/msv025 ; PMID: 25697340
- Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulation. DOI: 10.1093/nar/gkw807 ; PMID: 27651456
- Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants. DOI: 10.1016/j.febslet.2004.11.021 ; PMID: 15589838
- Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. DOI: 10.1038/sj.emboj.7601792 ; PMID: 17627276
- Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana. DOI: 10.1016/j.febslet.2008.03.034 ; PMID: 18387366
Gene Resources
- UniProt: A0A178UKU3
- EMBL: CACSHJ010000096, LR881470, LUHQ01000005
- AlphaFoldDB: A0A178UKU3
- EnsemblPlants: AT5G06310.1
- Gramene: AT5G06310.1
- KEGG: ath:AT5G06310
- Orthologous matrix: WNPIARC
- ExpressionAtlas: AT5G06310
- InterPro: IPR011564, IPR012340, IPR028389
- PANTHER: PTHR14513, PTHR14513:SF6
- SUPFAM: SSF50249
- Gene3D: 2.40.50.140
- OrthoDB: A0A178UKU3
- SWISS-MODEL: A0A178UKU3
- Conserved Domain Database: cd04497
Sequences
cDNA Sequence
- >AT5G06310.1
ATTTGAGTTACGAGAGCTCCTAAACGACTCAGCAAGATTCACCGGAGTGGCACCGGCCGAGTCATCGCATCCATCGCCGTTGTCGATTTCCTTCAAACCCTTGCAAAACCCCAACGATCAGAGACATGGAGGAGGAGAGAAGAGATGACTACAAATTCCTGAGAATTCAAGACGCTTTCAAAGCATTGCATCTTCATGTTAACCTCATTGGAGTCATCGTTGAGCTAGGATTCTCCAATGGCTCTGATTGTTCATGTACGCTCAAAATCGTTGATCCATGGTATTCGGGATCTGGCCTTCCCGTTAAGTTCGTCGCTCGTACCATTCGAGACCTTCCTCGTGTTGAATCGATCGGAGATATCATCTTACTTTCACGTGTAAAGATTGTGCTGATTAACCGGAAAATCACAGCTCTCTGCAATGAAACAACCTCTTCGTCTTTTGCTTTATTCAATGGGAAACATAGCGTGGATTCTATACCTTACCAGTCCTCACCTAAATTCCTGATGAGAGAACAGGATAAGAACTTCTTATCGAATCTGAGAGAATGGATGATCACGTACAAGTTTGAAGATGGGTCATGCTGTTTCACATCCCTGAAAGATATCAAAGAAGGCGAATGTTCAAACCTATCTTGCCAGATTGTTCACATTTCCAAGGTCTATAAAGATAGATGGTACCTCTTTGTTTGGGATGGAACTGAGATGCCACCCTGCAACATCTTGGTTAAGTCAGAAAGGCTTCCTTTATGTGTAGAACCCGAGATGTTGCCTACATACATGTTACGTAAGTTTCCTACTTTTGGTTCCGTTTTGAGGATCATAGTAGATAGAGTTAGTGAGAAGCAGGCCATTCACTGTCTTCAACCTGGTCAACACGTGAAGCTTCTGAACCTTTTCTTTCAAGTAAATATGGGATTATGGAACGCCACTTTTACTCCCTCTACAAAGATGCAGTACACAATGAGCAGAGAGATGGAAGCCTTTAGTCCTCAAAGAATGTGTGGGGAGAAGTTTTCACCGAGATGGAACCCAATCGCGCGTTGCATTAGTCGTTCACATTCTGAAATCACAGGGGTTGCCCATGACGATGCTCCATTTGTTTCTCTGATGGACATCCTGACCTATCACAATGTGACTGCTAAATTCAGGTGTGTTGTTCGGTTCATACAAGTGTATCCCCGAGACGTCAGAAAACTCCGTGATATCAACGGAAATATCAAATTGGTAGCTATACTAGAAGATGCAACCGCCAGAATCCATGCTTCTCTATATGCTGATGAAGGGGAAAAGTTTTTCGGGTGTGACGAATCTGATGAAGAGGCTCTAGTCAAGAAGCTGAATAGATTGTTGGGAGGTGAAGAGATGGAGAAAGTGCCAAGAAATCCTCCATGGGTACAATGTTGCTTGTTCTCATTCTACAAACACAAAATGGATCAGTGGGAAAGCAGAAGATTCCGCATTTTTGATACTTGGATCAATGCTTCATGAGACAATCATAATGCTAATTGTATAGTTATTAGCATTAAACAAAATGTGATTATTTATTTACATGGAACCATACAATAAAACATTACATAAGAAAAATATCTCTCTCCAACGATATGTATGGAAGATAATAAAGCAAAACAATCTAAAATAAGAATC
CDS Sequence
Protein Sequence