Gene Details:

• Gene ID: AT5G04560
• Gene Symbol: DME, EMB1649
• Gene Name: DEMETER,
• Description: HhH-GPD base excision DNA repair family protein;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G04560.1     AT5G04560.2     AT5G04560.3

Plant Ontology Annotations:

• PO:0020090  — embryo sac central cell — célula central (Spanish, exact), 中央細胞 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Function-related keywords:

• embryo sac central cell ,  root ,  pollen

Literature:

• DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis.   DOI:  10.1016/s0092-8674(02)00807-3 ;  PMID:  12150995
• DEMETER, Goddess of the harvest, activates maternal MEDEA to produce the perfect seed.   DOI:  10.1016/s1097-2765(02)00582-8 ;  PMID:  12150899
• Imprinting of the MEA Polycomb gene is controlled by antagonism between MET1 methyltransferase and DME glycosylase.   DOI:  10.1016/s1534-5807(03)00361-7 ;  PMID:  14667411
• An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene.   DOI:  10.1073/pnas.0402328101 ;  PMID:  15128940
• Identification of genes required for embryo development in Arabidopsis.   DOI:  10.1104/pp.104.045179 ;  PMID:  15266054
• Genomic imprinting in plants: the epigenetic version of an Oedipus complex.   DOI:  10.1016/j.pbi.2004.11.011 ;  PMID:  15653395
• DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.   DOI:  10.1016/j.cell.2005.12.034 ;  PMID:  16469697
• MEDEA takes control of its own imprinting.   DOI:  10.1016/j.cell.2006.01.020 ;  PMID:  16469694
• DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.   DOI:  10.1073/pnas.0601109103 ;  PMID:  16624880
• AGL80 is required for central cell and endosperm development in Arabidopsis.   DOI:  10.1105/tpc.106.040824 ;  PMID:  16798889
• DNA demethylation in the Arabidopsis genome.   DOI:  10.1073/pnas.0701861104 ;  PMID:  17409185
• Identification of putative Arabidopsis DEMETER target genes by GeneChip analysis.   DOI:  10.1016/j.bbrc.2007.10.092 ;  PMID:  17964287
• Genetic interactions between DNA demethylation and methylation in Arabidopsis.   DOI:  10.1104/pp.107.107730 ;  PMID:  17951456
• Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks.   DOI:  10.1007/s11103-008-9346-0 ;  PMID:  18493721
• Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis.   DOI:  10.1371/journal.pbio.0060194 ;  PMID:  18700816
• MATERNALLY EXPRESSED PAB C-TERMINAL, a novel imprinted gene in Arabidopsis, encodes the conserved C-terminal domain of polyadenylate binding proteins.   DOI:  10.1105/tpc.108.061929 ;  PMID:  18796636
• DNA demethylation: a lesson from the garden.   DOI:  10.1007/s00412-008-0183-3 ;  PMID:  18839198
• DNA LIGASE I exerts a maternal effect on seed development in Arabidopsis thaliana.   DOI:  10.1242/dev.041020 ;  PMID:  20023162
• Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes.   DOI:  10.1016/j.cub.2010.01.051 ;  PMID:  20226671
• Regulation of imprinted gene expression in Arabidopsis endosperm.   DOI:  10.1073/pnas.1019273108 ;  PMID:  21257907
• Function of the DEMETER DNA glycosylase in the Arabidopsis thaliana male gametophyte.   DOI:  10.1073/pnas.1105117108 ;  PMID:  21518889
• Histone H1 affects gene imprinting and DNA methylation in Arabidopsis.   DOI:  10.1111/j.1365-313X.2012.05028.x ;  PMID:  22519754
• The Armadillo repeat gene ZAK IXIK promotes Arabidopsis early embryo and endosperm development through a distinctive gametophytic maternal effect.   DOI:  10.1105/tpc.112.102384 ;  PMID:  23064319
• Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA.   DOI:  10.1016/j.cell.2012.09.001 ;  PMID:  23000270
• The study of a barley epigenetic regulator, HvDME, in seed development and under drought.   DOI:  10.1186/1471-2229-13-172 ;  PMID:  24175960
• Identification of Arabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions.   DOI:  10.1073/pnas.1319985110 ;  PMID:  24255109
• Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases.   DOI:  10.1016/j.bbrc.2014.03.060 ;  PMID:  24661881
• AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.   DOI:  10.1093/nar/gku834 ;  PMID:  25228464
• An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected].   DOI:  10.1371/journal.pgen.1004905 ;  PMID:  25569774
• Control of Paternally Expressed Imprinted UPWARD CURLY LEAF1, a Gene Encoding an F-Box Protein That Regulates CURLY LEAF Polycomb Protein, in the Arabidopsis Endosperm.   DOI:  10.1371/journal.pone.0117431 ;  PMID:  25689861
• Correction: An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis.   DOI:  10.1371/journal.pgen.1005198 ;  PMID:  25915657
• The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation.   DOI:  10.1038/srep26443 ;  PMID:  27193999
• DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape.   DOI:  10.1105/tpc.16.00474 ;  PMID:  27531226
• The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications.   DOI:  10.1038/nplants.2016.169 ;  PMID:  27797352
• DNA demethylase ROS1 negatively regulates the imprinting of DOGL4 and seed dormancy in Arabidopsis thaliana.   DOI:  10.1073/pnas.1812847115 ;  PMID:  30266793
• Rare earth elements regulate the endocytosis and DNA methylation in root cells of Arabidopsis thaliana.   DOI:  10.1016/j.chemosphere.2019.04.076 ;  PMID:  31004819
• DEMETER plays a role in DNA demethylation and disease response in somatic tissues of Arabidopsis.   DOI:  10.1080/15592294.2019.1631113 ;  PMID:  31189415
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes.   DOI:  10.3389/fgene.2020.00460 ;  PMID:  32528522
• Single-cell RNA-seq analysis reveals ploidy-dependent and cell-specific transcriptome changes in Arabidopsis female gametophytes.   DOI:  10.1186/s13059-020-02094-0 ;  PMID:  32698836
• Roles of DEMETER in regulating DNA methylation in vegetative tissues and pathogen resistance.   DOI:  10.1111/jipb.13037 ;  PMID:  33236824
• Male fertility in Arabidopsis requires active DNA demethylation of genes that control pollen tube function.   DOI:  10.1038/s41467-020-20606-1 ;  PMID:  33462227
• DEMETHYLATION REGULATOR 1 regulates DNA demethylation of the nuclear and mitochondrial genomes.   DOI:  10.1111/jipb.13386 ;  PMID:  36223079
• Molecular basis of the plant ROS1-mediated active DNA demethylation.   DOI:  10.1038/s41477-022-01322-8 ;  PMID:  36624257
• Loss of linker histone H1 in the maternal genome influences DEMETER-mediated demethylation and affects the endosperm DNA methylation landscape.   DOI:  10.3389/fpls.2022.1070397 ;  PMID:  36618671

Sequences: