Gene Details:

• Gene ID: AT4G30190
• Gene Symbol: AHA2, AtHA2, HA2, PMA2
• Gene Name: H(+)-ATPase 2, H(+)-ATPase 2, PLASMA MEMBRANE PROTON ATPASE 2
• Description: H[+]-ATPase 2;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G30190.1     AT4G30190.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)
• PO:0004006  — mesophyll cell — célula del mesófilo (Spanish, exact), 葉肉細胞 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Germplasm Phenotype:

• CS2109768  — shorter root length; longer and denser root hairs
• CS2109769  — shorter root length; longer and denser root hairs
• CS67807  — No visible phenotype.
• CS67808  — No visible phenotype.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  guard cell ,  mesophyll cell ,  root ,  vascular leaf ,  guard cell

Literature:

• Expression analysis of two gene subfamilies encoding the plasma membrane H+-ATPase in Nicotiana plumbaginifolia reveals the major transport functions of this enzyme.   DOI:  10.1046/j.1365-313x.1999.00495.x ;  PMID:  10417724
• The 14-3-3 protein interacts directly with the C-terminal region of the plant plasma membrane H(+)-ATPase.   DOI:  10.1105/tpc.9.10.1805 ;  PMID:  9368417
• Localization of plasma membrane H+-ATPase in nodules of Phaseolus vulgaris L.   DOI:  10.1007/BF00041388 ;  PMID:  9002603
• Sugar regulates mRNA abundance of H(+)-ATPase gene family members in tomato.   DOI:  10.1104/pp.112.3.1229 ;  PMID:  8938420
• Functional comparisons between plant plasma membrane H(+)-ATPase isoforms expressed in yeast.   DOI:  S0021-9258(17)42042-4 ;  PMID:  8300635
• The Arabidopsis thaliana plasma membrane H(+)-ATPase multigene family. Genomic sequence and expression of a third isoform.   DOI:  S0021-9258(18)77391-2 ;  PMID:  2143186
• Biochemical characterization of plasma membrane H+-ATPase activation in guard cell protoplasts of Arabidopsis thaliana in response to blue light.   DOI:  10.1093/pcp/pci104 ;  PMID:  15821287
• Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane.   DOI:  10.1105/tpc.105.038950 ;  PMID:  16531497
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• Divalent cation effects on interactions between multiple Arabidopsis 14-3-3 isoforms and phosphopeptide targets.   DOI:  10.1021/bi061366c ;  PMID:  17240989
• Arabidopsis protein kinase PKS5 inhibits the plasma membrane H+ -ATPase by preventing interaction with 14-3-3 protein.   DOI:  10.1105/tpc.105.035626 ;  PMID:  17483306
• Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis.   DOI:  10.1074/mcp.M700164-MCP200 ;  PMID:  17586839
• Dissecting iron deficiency-induced proton extrusion in Arabidopsis roots.   DOI:  10.1111/j.1469-8137.2009.02908.x ;  PMID:  19549134
• RIN4 functions with plasma membrane H+-ATPases to regulate stomatal apertures during pathogen attack.   DOI:  10.1371/journal.pbio.1000139 ;  PMID:  19564897
• Molecular characterization of mutant Arabidopsis plants with reduced plasma membrane proton pump activity.   DOI:  10.1074/jbc.M110.101733 ;  PMID:  20348108
• Species specific amino acid sequence-protein local structure relationships: An analysis in the light of a structural alphabet.   DOI:  10.1016/j.jtbi.2011.01.047 ;  PMID:  21333657
• Fitting into the harsh reality: regulation of iron-deficiency responses in dicotyledonous plants.   DOI:  10.1093/mp/ssr065 ;  PMID:  21873619
• Phosphosite mapping of P-type plasma membrane H+-ATPase in homologous and heterologous environments.   DOI:  10.1074/jbc.M111.307264 ;  PMID:  22174420
• The effect of a genetically reduced plasma membrane protonmotive force on vegetative growth of Arabidopsis.   DOI:  10.1104/pp.111.189167 ;  PMID:  22214817
• Expression of a translationally fused TAP-tagged plasma membrane proton pump in Arabidopsis thaliana.   DOI:  10.1021/bi401096m ;  PMID:  24397334
• Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.   DOI:  10.1039/c4mt00005f ;  PMID:  24549117
• Receptor kinase-mediated control of primary active proton pumping at the plasma membrane.   DOI:  10.1111/tpj.12680 ;  PMID:  25267325
• Correlation analysis of proteins responsive to Zn, Mn, or Fe deficiency in Arabidopsis roots based on iTRAQ analysis.   DOI:  10.1007/s00299-014-1696-2 ;  PMID:  25366567
• Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1.   DOI:  10.1105/tpc.15.00306 ;  PMID:  26071421
• The Plasma Membrane H+-ATPase AHA1 Plays a Major Role in Stomatal Opening in Response to Blue Light.   DOI:  10.1104/pp.16.01581 ;  PMID:  27261063
• Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency.   DOI:  10.1016/j.bbrc.2017.04.014 ;  PMID:  28390898
• A bioassay-guided fractionation system to identify endogenous small molecules that activate plasma membrane H+-ATPase activity in Arabidopsis.   DOI:  10.1093/jxb/erx156 ;  PMID:  28582540
• Genome-wide analysis of gene expression profiling revealed that COP9 signalosome is essential for correct expression of Fe homeostasis genes in Arabidopsis.   DOI:  10.1007/s10534-017-0036-8 ;  PMID:  28744713
• The ethylene response factor AtERF4 negatively regulates the iron deficiency response in Arabidopsis thaliana.   DOI:  10.1371/journal.pone.0186580 ;  PMID:  29045490
• Comparative Analysis of Arabidopsis Ecotypes Reveals a Role for Brassinosteroids in Root Hydrotropism.   DOI:  10.1104/pp.17.01563 ;  PMID:  29439211
• Copper excess reduces nitrate uptake by Arabidopsis roots with specific effects on gene expression.   DOI:  10.1016/j.jplph.2018.06.005 ;  PMID:  29933138
• Acidic cell elongation drives cell differentiation in the Arabidopsis root.   DOI:  10.15252/embj.201899134 ;  PMID:  30012836
• Red Light-Induced Phosphorylation of Plasma Membrane H(+)-ATPase in Stomatal Guard Cells.   DOI:  10.1104/pp.18.00544 ;  PMID:  30104254
• VAMP711 Is Required for Abscisic Acid-Mediated Inhibition of Plasma Membrane H(+)-ATPase Activity.   DOI:  10.1104/pp.18.00499 ;  PMID:  30217827
• Roles of plasma membrane proton ATPases AHA2 and AHA7 in normal growth of roots and root hairs in Arabidopsis thaliana.   DOI:  10.1111/ppl.12842 ;  PMID:  30238999
• EBP1 nuclear accumulation negatively feeds back on FERONIA-mediated RALF1 signaling.   DOI:  10.1371/journal.pbio.2006340 ;  PMID:  30339663
• Regulation of plasma membrane H(+)-ATPase activity by the members of the V-SNARE VAMP7C family in arabidopsis thaliana.   DOI:  10.1080/15592324.2019.1573097 ;  PMID:  30720384
• The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and Promotes Alkali Tolerance in Arabidopsis.   DOI:  10.1105/tpc.18.00568 ;  PMID:  30962395
• Mutation of a Conserved Motif of PP2C.D Phosphatases Confers SAUR Immunity and Constitutive Activity.   DOI:  10.1104/pp.19.00496 ;  PMID:  31311832
• Calcium-Regulated Phosphorylation Systems Controlling Uptake and Balance of Plant Nutrients.   DOI:  10.3389/fpls.2020.00044 ;  PMID:  32117382
• Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses.   DOI:  10.1186/s12870-020-02392-6 ;  PMID:  32460700
• Arabidopsis V-ATPase d2 Subunit Plays a Role in Plant Responses to Oxidative Stress.   DOI:  10.3390/genes11060701 ;  PMID:  32630497
• Dynamic Control of the High-Affinity Iron Uptake Complex in Root Epidermal Cells.   DOI:  10.1104/pp.20.00234 ;  PMID:  32873629
• Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.   DOI:  10.3390/ijms21217963 ;  PMID:  33120933
• Physiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency.   DOI:  10.1038/s41598-021-94908-9 ;  PMID:  34330973
• Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.   DOI:  10.1016/j.molp.2021.07.020 ;  PMID:  34339895
• Enhanced Iron Uptake in Plants by Volatile Emissions of Rahnella aquatilis JZ-GX1.   DOI:  10.3389/fpls.2021.704000 ;  PMID:  34394158
• Loss-of-function mutations in the ERF96 gene enhance iron-deficient tolerance in Arabidopsis.   DOI:  10.1016/j.plaphy.2022.02.002 ;  PMID:  35158317
• ABP1-TMK auxin perception for global phosphorylation and auxin canalization.   DOI:  10.1038/s41586-022-05187-x ;  PMID:  36071161
• An LRR receptor kinase controls ABC transporter substrate preferences during plant growth-defense decisions.   DOI:  10.1016/j.cub.2023.04.029 ;  PMID:  37146609
• Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.   DOI:  10.1074/mcp.T300006-MCP200 ;  PMID:  14506206
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture.   DOI:  10.1074/mcp.M600250-MCP200 ;  PMID:  17151019
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• Membrane proteomic analysis of Arabidopsis thaliana using alternative solubilization techniques.   DOI:  10.1021/pr060525b ;  PMID:  17432890
• A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome.   DOI:  10.1074/mcp.M700099-MCP200 ;  PMID:  17644812
• Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism.   DOI:  10.1021/pr1009433 ;  PMID:  21166475

Sequences: