Gene Details:

• Gene ID: AT4G30110
• Gene Symbol: ATHMA2, HMA2
• Gene Name: ARABIDOPSIS HEAVY METAL ATPASE 2, heavy metal atpase 2
• Description: heavy metal atpase 2;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G30110.1     AT4G30110.2

Plant Ontology Annotations:

• PO:0000056  — flower bud — floral bud (exact), yema floral (Spanish, exact), 花芽 (Japanese, exact)
• PO:0005020  — vascular bundle — haz vascular (Spanish, exact), vein (exact), 維管束 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009066  — anther — antera (Spanish, exact), 半葯,花粉のう (Japanese, exact), Poaceae anther (narrow), Zea anther (narrow)
• PO:0009071  — anther wall tapetum — pollen sac tapetum (exact), portion of anther wall tapetal tissue (exact), tapete (Spanish, exact), 葯壁タペート組織 (Japanese, exact), Poaceae tapetum (narrow), Zea tapetum (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Germplasm Phenotype:

• CS68120  — No visible phenotype.
• CS68121  — No visible phenotype.
• CS68123  — No visible phenotype.
• CS68126  — Extreme zinc-deficient phenotype. Chlorotic, stunted, and male-sterile phenotype results in the absence of a zinc supplement.
• CS68127  — Extreme zinc-deficient phenotype. Chlorotic, stunted, and male-sterile phenotype results in the absence of a zinc supplement.

Function-related keywords:

• flower bud ,  vascular bundle ,  root ,  vascular leaf ,  anther ,  anther wall tapetum ,  vascular leaf ,  sepal ,  flower ,  cotyledon ,  leaf apex ,  collective leaf structure

Literature:

• Inventory of the superfamily of P-type ion pumps in Arabidopsis.   DOI:  10.1104/pp.126.2.696 ;  PMID:  11402198
• P(1B)-ATPases–an ancient family of transition metal pumps with diverse functions in plants.   DOI:  10.1016/j.tplants.2005.08.008 ;  PMID:  16154798
• A novel major facilitator superfamily protein at the tonoplast influences zinc tolerance and accumulation in Arabidopsis.   DOI:  10.1104/pp.106.092015 ;  PMID:  17277087
• The use of the zinc-fluorophore, Zinpyr-1, in the study of zinc homeostasis in Arabidopsis roots.   DOI:  10.1111/j.1469-8137.2007.02030.x ;  PMID:  17335495
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Functional analysis of the heavy metal binding domains of the Zn/Cd-transporting ATPase, HMA2, in Arabidopsis thaliana.   DOI:  10.1111/j.1469-8137.2008.02637.x ;  PMID:  19076719
• HMA P-type ATPases are the major mechanism for root-to-shoot Cd translocation in Arabidopsis thaliana.   DOI:  10.1111/j.1469-8137.2008.02638.x ;  PMID:  19076718
• Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains.   DOI:  10.1021/bi901573b ;  PMID:  19883117
• Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes.   DOI:  10.1016/j.cub.2010.01.051 ;  PMID:  20226671
• Arabidopsis PCR2 is a zinc exporter involved in both zinc extrusion and long-distance zinc transport.   DOI:  10.1105/tpc.109.070185 ;  PMID:  20647347
• Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.   DOI:  10.1093/molbev/msq204 ;  PMID:  20736450
• Functional significance of AtHMA4 C-terminal domain in planta.   DOI:  10.1371/journal.pone.0013388 ;  PMID:  20975991
• The phylogenetic tree gathering the plant Zn/Cd/Pb/Co P1B-ATPases appears to be structured according to the botanical families.   DOI:  10.1016/j.crvi.2011.09.004 ;  PMID:  22123088
• Effects of deficiency and excess of zinc on morphophysiological traits and spatiotemporal regulation of zinc-responsive genes reveal incidence of cross talk and macronutrients.   DOI:  10.1021/es400113y ;  PMID:  23590825
• Arabidopsis HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.   DOI:  10.1093/mp/sst122 ;  PMID:  23974911
• Inactivation of two newly identified tobacco heavy metal ATPases leads to reduced Zn and Cd accumulation in shoots and reduced pollen germination.   DOI:  10.1039/c4mt00071d ;  PMID:  24760325
• Effects of Ca addition on the uptake, translocation, and distribution of Cd in Arabidopsis thaliana.   DOI:  10.1016/j.ecoenv.2017.01.023 ;  PMID:  28152404
• and HMA2-Mediated Zn Partitioning to the Shoot Supplements Local Zn Deficiency Responses.   DOI:  10.1105/tpc.18.00207 ;  PMID:  30150315
• Jasmonic acid alleviates cadmium toxicity in Arabidopsis via suppression of cadmium uptake and translocation.   DOI:  10.1111/jipb.12801 ;  PMID:  30912267
• Arabidopsis thaliana Zn2+-efflux ATPases HMA2 and HMA4 are required for resistance to the necrotrophic fungus Plectosphaerella cucumerina BMM.   DOI:  10.1093/jxb/erab400 ;  PMID:  34463334
• MYB43 as a novel substrate for CRL4(PRL1) E3 ligases negatively regulates cadmium tolerance through transcriptional inhibition of HMAs in Arabidopsis.   DOI:  10.1111/nph.18020 ;  PMID:  35129221
• Transcription factor ANAC004 enhances Cd tolerance in Arabidopsis thaliana by regulating cell wall fixation, translocation and vacuolar detoxification of Cd, ABA accumulation and antioxidant capacity.   DOI:  10.1016/j.jhazmat.2022.129121 ;  PMID:  35580499
• Exogenous abscisic acid alleviates Cd toxicity in Arabidopsis thaliana by inhibiting Cd uptake, translocation and accumulation, and promoting Cd chelation and efflux.   DOI:  10.1016/j.plantsci.2022.111464 ;  PMID:  36130666
• Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis.   DOI:  10.1104/pp.104.046292 ;  PMID:  15475410

Sequences: