Gene Details:

• Gene ID: AT4G29810
• Gene Symbol: ATMKK2, MK1, MKK2
• Gene Name: MAP kinase kinase 2, MAP KINASE KINASE 1, MAP kinase kinase 2
• Description: MAP kinase kinase 2;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G29810.1     AT4G29810.2     AT4G29810.3

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Germplasm Phenotype:

• CS66015  — Mutants have significantly less complex venation architecture compared to wild-type.
• CS66015  — No visible phenotype; average height = 37 cm.
• mkk1/mkk2  — Phenotype resembles MPK4 mutant.Leaves are dark green and curled.Constitutively overproduces SA and exhibits enhanced resistance to biotrophic pathogens. Insensitive to jasmonic acid.Enhanced basal expression of PR1 other SA dependent genes.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  guard cell

Literature:

• Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis.   DOI:  10.1006/bbrc.1998.9796 ;  PMID:  9878570
• MAP kinase signalling cascade in Arabidopsis innate immunity.   DOI:  10.1038/415977a ;  PMID:  11875555
• Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6.   DOI:  10.1104/pp.126.4.1579 ;  PMID:  11500556
• Mitogen-activated protein kinase cascades in plants: a new nomenclature.   DOI:  10.1016/s1360-1385(02)02302-6 ;  PMID:  12119167
• The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis.   DOI:  10.1016/j.molcel.2004.06.023 ;  PMID:  15225555
• High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions.   DOI:  10.1111/j.1365-313X.2004.02281.x ;  PMID:  15610358
• The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis.   DOI:  10.1094/MPMI-20-5-0589 ;  PMID:  17506336
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• A broad-spectrum, efficient and nontransgenic approach to control plant viruses by application of salicylic acid and jasmonic acid.   DOI:  10.1007/s00425-010-1308-5 ;  PMID:  21046144
• Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system.   DOI:  10.1016/j.phytochem.2011.02.029 ;  PMID:  21477822
• The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis.   DOI:  10.1105/tpc.112.097253 ;  PMID:  22643122
• Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2.   DOI:  10.1016/j.chom.2012.01.015 ;  PMID:  22423965
• A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.   DOI:  10.1105/tpc.112.104695 ;  PMID:  23263767
• Structural and functional characteristics of cGMP-dependent methionine oxidation in Arabidopsis thaliana proteins.   DOI:  10.1186/1478-811X-11-1 ;  PMID:  23289948
• Membrane rigidification functions upstream of the MEKK1-MKK2-MPK4 cascade during cold acclimation in Arabidopsis thaliana.   DOI:  10.1016/j.febslet.2014.04.032 ;  PMID:  24801600
• Timing is everything: highly specific and transient expression of a MAP kinase determines auxin-induced leaf venation patterns in Arabidopsis.   DOI:  10.1093/mp/ssu080 ;  PMID:  25064848
• A double-mutant collection targeting MAP kinase related genes in Arabidopsis for studying genetic interactions.   DOI:  10.1111/tpj.13292 ;  PMID:  27490954
• BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.   DOI:  10.1104/pp.17.01757 ;  PMID:  29440595
• MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling.   DOI:  10.1104/pp.18.00592 ;  PMID:  30185442
• Disruption of the MAMP-Induced MEKK1-MKK1/MKK2-MPK4 Pathway Activates the TNL Immune Receptor SMN1/RPS6.   DOI:  10.1093/pcp/pcy243 ;  PMID:  30590768
• Stigma Receptivity Is Controlled by Functionally Redundant MAPK Pathway Components in Arabidopsis.   DOI:  10.1016/j.molp.2020.08.015 ;  PMID:  32890733
• The MEKK1-MKK1/2-MPK4 cascade phosphorylates and stabilizes STOP1 to confer aluminum resistance in Arabidopsis.   DOI:  10.1016/j.molp.2022.11.010 ;  PMID:  36419357
• Mitogen-activated protein kinase cascades in plants: a new nomenclature.   DOI:  10.1016/s1360-1385(02)02302-6 ;  PMID:  12119167
• Ancient signals: comparative genomics of plant MAPK and MAPKK gene families.   DOI:  10.1016/j.tplants.2006.02.007 ;  PMID:  16537113
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• MASCP Gator: an aggregation portal for the visualization of Arabidopsis proteomics data.   DOI:  10.1104/pp.110.168195 ;  PMID:  21075962
• Structural and functional characteristics of cGMP-dependent methionine oxidation in Arabidopsis thaliana proteins.   DOI:  10.1186/1478-811X-11-1 ;  PMID:  23289948
• Ancient signals: comparative genomics of plant MAPK and MAPKK gene families.   DOI:  10.1016/j.tplants.2006.02.007 ;  PMID:  16537113
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660

Sequences: