Gene Details:
- Gene ID: AT4G26070
- Gene Symbol: ATMEK1, MEK1, MKK1, NMAPKK
- Gene Name: MAP kinase/ ERK kinase 1, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1
- Description: MAP kinase/ ERK kinase 1;(source:Araport11)
- TAIR Accession: locus:2120855
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
Gene Ontology:
- GO:0004674 — enables — protein serine/threonine kinase activity
- GO:0005515 — enables — protein binding
- GO:0042742 — acts upstream of or within — defense response to bacterium
- GO:0006468 — involved in — protein phosphorylation
- GO:0002237 — acts upstream of or within — response to molecule of bacterial origin
- GO:0042542 — acts upstream of or within — response to hydrogen peroxide
- GO:0004708 — enables — MAP kinase kinase activity
- GO:0009875 — acts upstream of or within — pollen-pistil interaction
- GO:0009414 — acts upstream of or within — response to water deprivation
- GO:0009611 — acts upstream of or within — response to wounding
- GO:0009507 — located in — chloroplast
- GO:0098542 — acts upstream of or within — defense response to other organism
- GO:0005737 — is active in — cytoplasm
- GO:0005634 — located in — nucleus
- GO:0000165 — acts upstream of or within — MAPK cascade
Germplasm Phenotype:
- CS66014 — No visible phenotype; average height = 38 cm.
- mkk1 — Enhanced susceptibility to Pseudomonas syringae pv. tomato.
- mkk1/mkk2 — Phenotype resembles MPK4 mutant.Leaves are dark green and curled.Constitutively overproduces SA and exhibits enhanced resistance to biotrophic pathogens. Insensitive to jasmonic acid.Enhanced basal expression of PR1 other SA dependent genes.
Function-related keywords:
- shoot axis apex , leaf lamina base , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen
Literature:
- ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation. DOI: 10.1104/pp.122.4.1301 ; PMID: 10759527
- Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis. DOI: 10.1006/bbrc.1998.9796 ; PMID: 9878570
- MAP kinase signalling cascade in Arabidopsis innate immunity. DOI: 10.1038/415977a ; PMID: 11875555
- Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6. DOI: 10.1104/pp.126.4.1579 ; PMID: 11500556
- Mitogen-activated protein kinase cascades in plants: a new nomenclature. DOI: 10.1016/s1360-1385(02)02302-6 ; PMID: 12119167
- The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. DOI: 10.1016/j.molcel.2004.06.023 ; PMID: 15225555
- The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. DOI: 10.1111/j.1365-313X.2006.02888.x ; PMID: 17059410
- AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis. DOI: 10.1093/jxb/erm144 ; PMID: 17728292
- AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis. DOI: 10.1111/j.1365-313X.2008.03433.x ; PMID: 18248592
- Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. DOI: 10.1104/pp.108.121038 ; PMID: 18650403
- AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination. DOI: 10.1007/s11103-009-9503-0 ; PMID: 19484493
- A broad-spectrum, efficient and nontransgenic approach to control plant viruses by application of salicylic acid and jasmonic acid. DOI: 10.1007/s00425-010-1308-5 ; PMID: 21046144
- Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. DOI: 10.1016/j.phytochem.2011.02.029 ; PMID: 21477822
- The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. DOI: 10.1105/tpc.112.097253 ; PMID: 22643122
- Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. DOI: 10.1016/j.chom.2012.01.015 ; PMID: 22423965
- A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation. DOI: 10.1105/tpc.112.104695 ; PMID: 23263767
- A double-mutant collection targeting MAP kinase related genes in Arabidopsis for studying genetic interactions. DOI: 10.1111/tpj.13292 ; PMID: 27490954
- Role and interrelationship of MEK1-MPK6 cascade, hydrogen peroxide and nitric oxide in darkness-induced stomatal closure. DOI: 10.1016/j.plantsci.2017.06.010 ; PMID: 28716416
- BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis. DOI: 10.1104/pp.17.01757 ; PMID: 29440595
- MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling. DOI: 10.1104/pp.18.00592 ; PMID: 30185442
- Disruption of the MAMP-Induced MEKK1-MKK1/MKK2-MPK4 Pathway Activates the TNL Immune Receptor SMN1/RPS6. DOI: 10.1093/pcp/pcy243 ; PMID: 30590768
- Jasmonic acid-induced hydrogen sulfide activates MEK1/2 in regulating the redox state of ascorbate in Arabidopsis thaliana leaves. DOI: 10.1080/15592324.2019.1629265 ; PMID: 31187685
- Arabidopsis MAPKKK δ-1 is required for full immunity against bacterial and fungal infection. DOI: 10.1093/jxb/erz556 ; PMID: 31844896
- RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation. DOI: 10.1104/pp.19.01555 ; PMID: 32165446
- Stigma Receptivity Is Controlled by Functionally Redundant MAPK Pathway Components in Arabidopsis. DOI: 10.1016/j.molp.2020.08.015 ; PMID: 32890733
- Ethylene-induced stomatal closure is mediated via MKK1/3-MPK3/6 cascade to EIN2 and EIN3. DOI: 10.1111/jipb.13083 ; PMID: 33605510
- The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses. DOI: 10.1007/s11103-022-01308-2 ; PMID: 36109466
- The MEKK1-MKK1/2-MPK4 cascade phosphorylates and stabilizes STOP1 to confer aluminum resistance in Arabidopsis. DOI: 10.1016/j.molp.2022.11.010 ; PMID: 36419357
- Mitogen-activated protein kinase cascades in plants: a new nomenclature. DOI: 10.1016/s1360-1385(02)02302-6 ; PMID: 12119167
- Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. DOI: 10.1016/j.tplants.2006.02.007 ; PMID: 16537113
- Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. DOI: 10.1016/j.tplants.2006.02.007 ; PMID: 16537113
- Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. DOI: 10.1016/j.tplants.2006.02.007 ; PMID: 16537113
Sequences:
cDNA Sequence
- >AT4G26070.5
CTTTTACTGTGTAATCATTGTTAGGAATTGAAATTGTTTGAATGGAGTTTTCTGACATTGAAAATTGGATTAGAACACAGAGTGGAACGTTTAAAGATGGAGATCTTCGAGTGAACAAAGATGGAATCCAGACCGTGTCTCTGTCCGAACCAGGAGCTCCACCTCCTATTGAGCCATTGGACAACCAATTGAGTTTGGCAGATTTAGAAGTGATCAAAGTCATTGGCAAAGGAAGTAGTGGTAATGTCCAGTTGGTCAAACACAAACTCACTCAACAGTTTTTCGCTCTTAAGGTCATTCAATTGAACACAGAAGAATCAACATGTCGGGCGATTTCTCAGGAGCTGAGAATAAACTTGAGCTCGCAATGTCCATATCTTGTCTCATGTTATCAATCTTTCTACCACAACGGTCTTGTTTCAATCATATTGGAATTCATGGATGGTGGATCCCTTGCAGACTTGTTAAAGAAAGTCGGAAAAGTTCCTGAAAACATGCTATCTGCCATCTGCAAGCGAGTTCTTCGAGGTCTTTGTTATATTCATCATGAGAGGCGAATCATTCATCGGGACTTAAAGCCTTCAAACTTGCTAATCAATCATAGAGGTGAAGTCAAGATCACAGACTTTGGTGTCAGCAAGATCTTGACAAGCACAAGTAGTCTTGCTAATTCTTTCGTGGGCACATACCCTTATATGTCTCCAGAGAGAATCAGCGGGAGTTTGTACAGTAACAAGAGCGATATTTGGAGCTTGGGACTGGTTTTGCTCGAATGTGCAACGGGTAAATTCCCGTATACTCCTCCAGAACACAAGAAAGGATGGAGTAGCGTGTACGAGCTTGTGGACGCCATTGTTGAAAACCCGCCTCCTTGTGCACCTTCCAATCTCTTTTCTCCAGAGTTTTGCTCCTTCATCTCGCAATGTGTACAAAAAGATCCAAGGGACAGAAAATCAGCAAAGGAGCTTCTGGAACACAAGTTCGTAAAGATGTTTGAAGATTCGGATACAAATCTCTCGGCTTACTTCACCGACGCAGGATCTTTGATTCCCCCACTTGCTAACTAGAACCGAGTTTGAACAATCTTTTAACCTCCAAGTTATTATTTCATATCCACTAGAAGAGATTTTATGAAAGATAAATTTACGAGATGTTATGACTTAAGAGACTTGTCTACAAAATTTGATTTAATGTGTGTACTTTTCACATCACTATTATAAACACAACTATCATCAGTTATGTTTCTCTGCTAGTGGTGGATATACTTATATAGTAGTTCATATCATTATACACATTTTGTTTTGT - >AT4G26070.3
CTTTTACTGTGTAATCATTGTTAGGAATTGAAATTGTTTGAATGGAGTTTTCTGACATTGAAAATTGGATTAGAACACAGAGTGGAACGTTTAAAGATGGAGATCTTCGAGTGAACAAAGATGGAATCCAGACCGTGTCTCTGTCCGAACCAGGAGCTCCACCTCCTATTGAGCCATTGGACAACCAATTGAGTTTGGCAGATTTAGAAGTGATCAAAGTCATTGGCAAAGGAAGTAGTGGTAATGTCCAGTTGGTCAAACACAAACTCACTCAACAGTTTTTCGCTCTTAAGGTCATTCAATTGAACACAGAAGAATCAACATGTCGGGCGATTTCTCAGGAGCTGAGAATAAACTTGAGCTCGCAATGTCCATATCTTGTCTCATGTTATCAATCTTTCTACCACAACGGTCTTGTTTCAATCATATTGGAATTCATGGATGGTGGATCCCTTGCAGACTTGTTAAAGAAAGTCGGAAAAGTTCCTGAAAACATGCTATCTGCCATCTGCAAGCGAGTTCTTCGAGGTCTTTGTTATATTCATCATGAGAGGCGAATCATTCATCGGGACTTAAAGCCTTCAAACTTGCTAATCAATCATAGAGGTGAAGTCAAGATCACAGACTTTGGTGTCAGCAAGATCTTGACAAGCACAAGTAGTCTTGCTAATTCTTTCGTGGGCACATACCCTTATATGTCTCCAGAGAGAATCAGCGGGAGTTTGTACAGTAACAAGAGCGATATTTGGAGCTTGGGACTGGTTTTGCTCGAATGTGCAACGGGTAAATTCCCGTATACTCCTCCAGAACACAAGAAAGGATGGAGTAGCGTGTACGAGCTTGTGGACGCCATTGTTGAAAACCCGCCTCCTTGTGCACCTTCCAATCTCTTTTCTCCAGAGTTTTGCTCCTTCATCTCGCAATGTGTACAAAAAGATCCAAGGGACAGAAAATCAGCAAAGGAGCTTCTGGAACACAAGTTCGTAAAGATGTTTGAAGATTCGGATACAAATCTCTCGGCTTACTTCACCGACGCAGGATCTTTGATTCCCCCACTTGCTAACTAGAACCGAGTTTGAACAATCTTTTAACCTCCAAGTTATTATTTCATATCCACTAGAAGAGATTTTATGAAAGATAAATTTACGAGATGTTATGACTTAAGAGACTTGTCTACAAAATTTGATTTAATGTGTGTACTTTTCACATCACTATTATAAACACAACTATCATCAGTTATGTTTCTCTGCTAGTGGTGGATATACTTATATAGTAGTTCATATCATTATACACATTTTGTTTTGT - >AT4G26070.1
CTTTTACTGTGTAATCATTGTTAGGAATTGAAATTGTTTGAATGGAGTTTTCTGACATTGAAAATTGGATTAGAACACAGAGTGGAACGTTTAAAGATGGAGATCTTCGAGTGAACAAAGATGGAATCCAGACCGTGTCTCTGTCCGAACCAGGAGCTCCACCTCCTATTGAGCCATTGGACAACCAATTGAGTTTGGCAGATTTAGAAGTGATCAAAGTCATTGGCAAAGGAAGTAGTGGTAATGTCCAGTTGGTCAAACACAAACTCACTCAACAGTTTTTCGCTCTTAAGGTCATTCAATTGAACACAGAAGAATCAACATGTCGGGCGATTTCTCAGGAGCTGAGAATAAACTTGAGCTCGCAATGTCCATATCTTGTCTCATGTTATCAATCTTTCTACCACAACGGTCTTGTTTCAATCATATTGGAATTCATGGATGGTGGATCCCTTGCAGACTTGTTAAAGAAAGTCGGAAAAGTTCCTGAAAACATGCTATCTGCCATCTGCAAGCGAGTTCTTCGAGGTCTTTGTTATATTCATCATGAGAGGCGAATCATTCATCGGGACTTAAAGCCTTCAAACTTGCTAATCAATCATAGAGGTGAAGTCAAGATCACAGACTTTGGTGTCAGCAAGATCTTGACAAGCACAAGTAGTCTTGCTAATTCTTTCGTGGGCACATACCCTTATATGTCTCCAGAGAGAATCAGCGGGAGTTTGTACAGTAACAAGAGCGATATTTGGAGCTTGGGACTGGTTTTGCTCGAATGTGCAACGGGTAAATTCCCGTATACTCCTCCAGAACACAAGAAAGGATGGAGTAGCGTGTACGAGCTTGTGGACGCCATTGTTGAAAACCCGCCTCCTTGTGCACCTTCCAATCTCTTTTCTCCAGAGTTTTGCTCCTTCATCTCGCAATGTGTACAAAAAGATCCAAGGGACAGAAAATCAGCAAAGGAGCTTCTGGAACACAAGTTCGTAAAGATGTTTGAAGATTCGGATACAAATCTCTCGGCTTACTTCACCGACGCAGGATCTTTGATTCCCCCACTTGCTAACTAGAACCGAGTTTGAACAATCTTTTAACCTCCAAGTTATTATTTCATATCCACTAGAAGAGATTTTATGAAAGATAAATTTACGAGATGTTATGACTTAAGAGACTTGTCTACAAAATTTGATTTAATGTGTGTACTTTTCACATCACTATTATAAACACAACTATCATCAGTTATGTTTCTCTGCTAGTGGTGGATATACTTATATAGTAGTTCATATCATTATACACATTTTGTTTTGT - >AT4G26070.4
CTTTTACTGTGTAATCATTGTTAGGAATTGAAATTGTTTGAATGGAGTTTTCTGACATTGAAAATTGGATTAGAACACAGAGTGGAACGTTTAAAGATGGAGATCTTCGAGTGAACAAAGATGGAATCCAGACCGTGTCTCTGTCCGAACCAGGAGCTCCACCTCCTATTGAGCCATTGGACAACCAATTGAGTTTGGCAGATTTAGAAGTGATCAAAGTCATTGGCAAAGGAAGTAGTGGTAATGTCCAGTTGGTCAAACACAAACTCACTCAACAGTTTTTCGCTCTTAAGGTCATTCAATTGAACACAGAAGAATCAACATGTCGGGCGATTTCTCAGGAGCTGAGAATAAACTTGAGCTCGCAATGTCCATATCTTGTCTCATGTTATCAATCTTTCTACCACAACGGTCTTGTTTCAATCATATTGGAATTCATGGATGGTGGATCCCTTGCAGACTTGTTAAAGAAAGTCGGAAAAGTTCCTGAAAACATGCTATCTGCCATCTGCAAGCGAGTTCTTCGAGGTCTTTGTTATATTCATCATGAGAGGCGAATCATTCATCGGGACTTAAAGCCTTCAAACTTGCTAATCAATCATAGAGGTGAAGTCAAGATCACAGACTTTGGTGTCAGCAAGATCTTGACAAGCACAAGTAGTCTTGCTAATTCTTTCGTGGGCACATACCCTTATATGTCTCCAGAGAGAATCAGCGGGAGTTTGTACAGTAACAAGAGCGATATTTGGAGCTTGGGACTGGTTTTGCTCGAATGTGCAACGGGTAAATTCCCGTATACTCCTCCAGAACACAAGAAAGGATGGAGTAGCGTGTACGAGCTTGTGGACGCCATTGTTGAAAACCCGCCTCCTTGTGCACCTTCCAATCTCTTTTCTCCAGAGTTTTGCTCCTTCATCTCGCAATGTGTACAAAAAGATCCAAGGGACAGAAAATCAGCAAAGGAGCTTCTGGAACACAAGTTCGTAAAGATGTTTGAAGATTCGGATACAAATCTCTCGGCTTACTTCACCGACGCAGGATCTTTGATTCCCCCACTTGCTAACTAGAACCGAGTTTGAACAATCTTTTAACCTCCAAGTTATTATTTCATATCCACTAGAAGAGATTTTATGAAAGATAAATTTACGAGATGTTATGACTTAAGAGACTTGTCTACAAAATTTGATTTAATGTGTGTACTTTTCACATCACTATTATAAACACAACTATCATCAGTTATGTTTCTCTGCTAGTGGTGGATATACTTATATAGTAGTTCATATCATTATACACATTTTGTTTTGT - >AT4G26070.2
CTTTTACTGTGTAATCATTGTTAGGAATTGAAATTGTTTGAATGGAGTTTTCTGACATTGAAAATTGGATTAGAACACAGAGTGGAACGTTTAAAGATGGAGATCTTCGAGTGAACAAAGATGGAATCCAGACCGTGTCTCTGTCCGAACCAGGAGCTCCACCTCCTATTGAGCCATTGGACAACCAATTGAGTTTGGCAGATTTAGAAGTGATCAAAGTCATTGGCAAAGGAAGTAGTGGTAATGTCCAGTTGGTCAAACACAAACTCACTCAACAGTTTTTCGCTCTTAAGGTCATTCAATTGAACACAGAAGAATCAACATGTCGGGCGATTTCTCAGGAGCTGAGAATAAACTTGAGCTCGCAATGTCCATATCTTGTCTCATGTTATCAATCTTTCTACCACAACGGTCTTGTTTCAATCATATTGGAATTCATGGATGGTGGATCCCTTGCAGACTTGTTAAAGAAAGTCGGAAAAGTTCCTGAAAACATGCTATCTGCCATCTGCAAGCGAGTTCTTCGAGGTCTTTGTTATATTCATCATGAGAGGCGAATCATTCATCGGGACTTAAAGCCTTCAAACTTGCTAATCAATCATAGAGGTGAAGTCAAGATCACAGACTTTGGTGTCAGCAAGATCTTGACAAGCACAAGTAGTCTTGCTAATTCTTTCGTGGGCACATACCCTTATATGTCTCCAGAGAGAATCAGCGGGAGTTTGTACAGTAACAAGAGCGATATTTGGAGCTTGGGACTGGTTTTGCTCGAATGTGCAACGGGTAAATTCCCGTATACTCCTCCAGAACACAAGAAAGGATGGAGTAGCGTGTACGAGCTTGTGGACGCCATTGTTGAAAACCCGCCTCCTTGTGCACCTTCCAATCTCTTTTCTCCAGAGTTTTGCTCCTTCATCTCGCAATGTGTACAAAAAGATCCAAGGGACAGAAAATCAGCAAAGGAGCTTCTGGAACACAAGTTCGTAAAGATGTTTGAAGATTCGGATACAAATCTCTCGGCTTACTTCACCGACGCAGGATCTTTGATTCCCCCACTTGCTAACTAGAACCGAGTTTGAACAATCTTTTAACCTCCAAGTTATTATTTCATATCCACTAGAAGAGATTTTATGAAAGATAAATTTACGAGATGTTATGACTTAAGAGACTTGTCTACAAAATTTGATTTAATGTGTGTACTTTTCACATCACTATTATAAACACAACTATCATCAGTTATGTTTCTCTGCTAGTGGTGGATATACTTATATAGTAGTTCATATCATTATACACATTTTGTTTTGT
CDS Sequence
Protein Sequence