Gene Details:
- Gene ID: AT4G25530
- Gene Symbol: FWA, HDG6
- Gene Name: FLOWERING WAGENINGEN, HOMEODOMAIN GLABROUS 6
- Description: FLOWERING WAGENINGEN;(source:Araport11)
- TAIR Accession: locus:2131814
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009089 — endosperm — albumen (exact), endosperma (Spanish, exact), 内胚乳、胚乳 (Japanese, exact)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
Gene Ontology:
- GO:0009911 — acts upstream of or within — positive regulation of flower development
- GO:0005515 — enables — protein binding
- GO:0006349 — acts upstream of or within — regulation of gene expression by genomic imprinting
- GO:0008289 — enables — lipid binding
- GO:0003700 — enables — DNA-binding transcription factor activity
- GO:0031047 — acts upstream of or within — regulatory ncRNA-mediated gene silencing
- GO:0042803 — enables — protein homodimerization activity
- GO:0005634 — located in — nucleus
Germplasm Phenotype:
- CS106
— Complete absence of cytosine methylation in two direct repeated sequences located in FWA 5 promoter and coding regions. This is opposite to the strong methylation observed in wild-type FWA. Hypomethylation activates expression of the gene and leads to late flowering. 11090618
AT4G25530 CS106 like fd, but more extreme. AT4G25530 CS188 Complete absence of cytosine methylation in two direct repeated sequences located in FWA 5 promoter and coding regions. This is opposite to the strong methylation observed in wild-type FWA. Hypomethylation activates expression of the gene and leads to late flowering. - CS188 — late flowering; vernalization affects flowering time under both long days and short days; increased number of cauline leaves; dominant mutation; flowering occurs about 10 days later than wild type.
- CS6520 — late flowering phenotype (delay in the transition to flowering is relatively stronger under long day than under short day light conditions), dark-green rosettes with increased number of leaves; very bright green stems and siliques, complete absence of lobed plates and tube-shaped structures on the epicuticular wax layer; dwarf (12-17 cm height), responsive to gibberellin, gibberellin not required for germination; abscisic acid resistant, reduced sensitivity to ABA inhibition of germination.
- fwa-d — late flowering
Function-related keywords:
Literature:
- Mutagenesis of plants overexpressing CONSTANS demonstrates novel interactions among Arabidopsis flowering-time genes. DOI: 10.1105/tpc.12.6.885 ; PMID: 10852935
- Sucrose availability on the aerial part of the plant promotes morphogenesis and flowering of Arabidopsis in the dark. DOI: 10.1046/j.1365-313x.1999.00632.x ; PMID: 10652130
- The early-flowering mutant efs is involved in the autonomous promotion pathway of Arabidopsis thaliana. DOI: 10.1242/dev.126.21.4763 ; PMID: 10518493
- Late-flowering genes interact with early-flowering genes to regulate flowering time in Arabidopsis thaliana. DOI: 10.1093/oxfordjournals.pcp.a029596 ; PMID: 10501030
- EMF genes interact with late-flowering genes to regulate Arabidopsis shoot development. DOI: 10.1093/oxfordjournals.pcp.a029381 ; PMID: 9615462
- Different roles of flowering-time genes in the activation of floral initiation genes in Arabidopsis. DOI: 10.1105/tpc.9.11.1921 ; PMID: 9401118
- Interaction of FLC and late-flowering mutations in Arabidopsis thaliana. DOI: 10.1007/BF02174346 ; PMID: 8628249
- A genetic and physiological analysis of late flowering mutants in Arabidopsis thaliana. DOI: 10.1007/BF00264213 ; PMID: 1896021
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. DOI: 10.1016/s0960-9822(02)00925-9 ; PMID: 12121623
- Phytochrome B and at Least One Other Phytochrome Mediate the Accelerated Flowering Response of Arabidopsis thaliana L. to Low Red/Far-Red Ratio. DOI: 10.1104/pp.104.4.1311 ; PMID: 12232170
- EMF genes interact with late-flowering genes in regulating floral initiation genes during shoot development in Arabidopsis thaliana. DOI: 10.1093/pcp/pce062 ; PMID: 11382816
- Revisiting phase transition during flowering in Arabidopsis. DOI: 10.1093/pcp/pcg109 ; PMID: 12941876
- Ectopic expression of an orchid (Oncidium Gower Ramsey) AGL6-like gene promotes flowering by activating flowering time genes in Arabidopsis thaliana. DOI: 10.1093/pcp/pcg099 ; PMID: 12941870
- Two lily SEPALLATA-like genes cause different effects on floral formation and floral transition in Arabidopsis. DOI: 10.1104/pp.103.026997 ; PMID: 14526112
- [Genomic imprinting and seed development]. DOI: 0253-9772(2005)04-0665-06 ; PMID: 16120596
- A transcriptome-based characterization of habituation in plant tissue culture. DOI: 10.1104/pp.105.076059 ; PMID: 16489130
- Polycomb group complexes self-regulate imprinting of the Polycomb group gene MEDEA in Arabidopsis. DOI: 10.1016/j.cub.2006.01.020 ; PMID: 16527743
- Maintenance of DNA methylation during the Arabidopsis life cycle is essential for parental imprinting. DOI: 10.1105/tpc.106.041178 ; PMID: 16648367
- Characterization of the class IV homeodomain-Leucine Zipper gene family in Arabidopsis. DOI: 10.1104/pp.106.077388 ; PMID: 16778018
- Two-step recruitment of RNA-directed DNA methylation to tandem repeats. DOI: 10.1371/journal.pbio.0040363 ; PMID: 17105345
- Molecular basis of late-flowering phenotype caused by dominant epi-alleles of the FWA locus in Arabidopsis. DOI: 10.1093/pcp/pcl061 ; PMID: 17189287
- Identification of putative Arabidopsis DEMETER target genes by GeneChip analysis. DOI: 10.1016/j.bbrc.2007.10.092 ; PMID: 17964287
- Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition. DOI: 10.1105/tpc.107.052373 ; PMID: 17921315
- ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases. DOI: 10.1111/j.1365-313X.2008.03631.x ; PMID: 18643997
- Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis. DOI: 10.1371/journal.pbio.0060194 ; PMID: 18700816
- Parental genome dosage imbalance deregulates imprinting in Arabidopsis. DOI: 10.1371/journal.pgen.1000885 ; PMID: 20333248
- Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. DOI: 10.1016/j.cub.2010.01.051 ; PMID: 20226671
- Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. DOI: 10.1093/molbev/msq204 ; PMID: 20736450
- Identification of genes required for de novo DNA methylation in Arabidopsis. DOI: 10.4161/epi.6.3.14242 ; PMID: 21150311
- Determination of DNA methylation of imprinted genes in Arabidopsis endosperm. DOI: 10.3791/2327 ; PMID: 21307831
- Function of the DEMETER DNA glycosylase in the Arabidopsis thaliana male gametophyte. DOI: 10.1073/pnas.1105117108 ; PMID: 21518889
- Inflorescence abnormalities occur with overexpression of Arabidopsis lyrata FT in the fwa mutant of Arabidopsis thaliana. DOI: 10.1016/j.plantsci.2011.07.017 ; PMID: 21889057
- Histone H1 affects gene imprinting and DNA methylation in Arabidopsis. DOI: 10.1111/j.1365-313X.2012.05028.x ; PMID: 22519754
- A survey of dominant mutations in Arabidopsis thaliana. DOI: 10.1016/j.tplants.2012.08.006 ; PMID: 22995285
- Flowering and genome integrity control by a nuclear matrix protein in Arabidopsis. DOI: 10.4161/nucl.25612 ; PMID: 23836195
- An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]. DOI: 10.1371/journal.pgen.1004905 ; PMID: 25569774
- Correction: An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis. DOI: 10.1371/journal.pgen.1005198 ; PMID: 25915657
- Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. DOI: 10.1038/s41477-019-0378-z ; PMID: 30833711
- Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. DOI: 10.1038/s41467-021-24553-3 ; PMID: 34257299
- Cytosine methylation of the FWA promoter promotes direct in vitro shoot regeneration in Arabidopsis thaliana. DOI: 10.1111/jipb.13156 ; PMID: 34292662
- BPM1 regulates RdDM-mediated DNA methylation via a cullin 3 independent mechanism. DOI: 10.1007/s00299-022-02911-9 ; PMID: 36066603
- Elongation of Siliques Without Pollination 3 Regulates Nutrient Flow Necessary for Embryogenesis. DOI: 10.1093/pcp/pcac151 ; PMID: 36264192
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. DOI: 10.1093/molbev/msj051 ; PMID: 16280546
Sequences:
cDNA Sequence
- >AT4G25530.1
CGCCGCTCTAGGGTTTTTGCTTTTCGCCATTGGTCCAAGTGCTATTTGGTTGTTTAAGCCAAATATCAGATCTTGCGCCGCTCTTTATCCCATTCAACATTCATACGAGCACCGCTTTACGGTTTTTGCTTTTCGACATTGGTCGAAGTGCTATTTGGTTGTTTAAGGTTATTGCATTGAGGGAAAATGAATGGACAAGGTGATTTGGATGCGGTTGGAAACATTCCAAAACCAGGTGAAGCTGAAGGCGATGAGATTGATATGATTAATGATATGTCTGGTGTTAATGATCAAGATGGTGGAAGGATGAGAAGAACCCATAGGCGCACTGCTTATCAAACTCAAGAACTTGAAAATTTCTACATGGAAAATCCTCATCCCACTGAAGAACAGAGGTACGAGCTTGGACAAAGGCTTAATATGGGTGTCAATCAAGTCAAGAATTGGTTCCAGAATAAAAGAAATCTCGAGAAGATCAATAATGACCACCTTGAGAATGTAACTCTTAGAGAAGAGCATGACAGATTGCTAGCAACTCAGGATCAGCTTAGAAGCGCAATGCTACGTAGTTTATGCAACATTTGTGGTAAGGCAACTAATTGTGGAGACACTGAATATGAGGTGCAAAAACTTATGGCTGAGAATGCTAACTTGGAGCGGGAGATAGACCAGTTCAATTCCAGATACCTTTCTCATCCCAAACAAAGGATGGTCAGTACATCCGAACAGGCGCCTTCTTCTTCCTCTAATCCAGGAATAAATGCAACACCAGTACTTGATTTTAGTGGTGGAACTAGGACGTCTGAGAAGGAGACATCAATTTTTCTGAATCTTGCCATTACGGCTTTGAGAGAGTTGATTACATTGGGAGAAGTGGACTGTCCATTTTGGATGATAGATCCAATCGTTAGATCCAAAGGAGTATCAAAGATCTATGAGAAGTATAGAAGTTCTTTCAACAATGTCACAAAACCTCCCGGGCAAATTGTGGAGGCTTCAAGAGCTAAAGGTTTAGTTCCCATGACTTGCGTGACTCTGGTCAAGACTCTTATGGACACAGGCAAATGGGTCAACGTGTTTGCACCTATAGTCCCTGTGGCATCAACCCATAAAGTGCTATCTACCGGTTCTGGTGGAACCAAAAGTGGCTCACTCCAACAGATTCAAGCAGAATTTCAAGTAATTTCTCCGCTGGTACCAAAGAGAAAAGTAACGTTTATTAGATACTGCAAAGAGATCAGACAGGGCTTATGGGTGGTCGTCGACGTTACTCCTACTCAAAATCCGACTTTGCTGCCCTATGGTTGTTCTAAGAGGCTACCCTCAGGCCTTATCATAGACGACCTGTCCAATGGGTACTCCCAGGTTACATGGATTGAACAAGCGGAATATAATGAGAGTCACATCCACCAACTCTACCAGCCTTTGATTGGCTATGGGATCGGGCTAGGTGCAAAGAGATGGCTCGCGACGCTGCAGAGACACTGCGAAAGCCTCTCGACCCTTTCATCTACCAACTTGACTGAAATTAGTCCAGGATTGTCTGCAAAAGGTGCAACTGAAATAGTGAAGCTAGCACAGCGAATGACTCTCAACTACTACAGAGGTATTACGAGTCCTTCGGTGGACAAGTGGCAGAAAATTCAGGTGGAGAATGTGGCACAAAACATGAGTTTCATGATCCGAAAGAACGTGAATGAGCCTGGTGAGCTAACTGGGATTGTGCTGAGTGCATCCACTTCTGTTTGGCTCCCAGTGAACCAGCATACACTCTTTGCTTTCATTAGCCACCTGAGTTTCAGACACGAGTGGGATATCTTGACCAATGATACTACCATGGAAGAAACAATCCGGATTCAAAAAGCAAAACGCCATGGAAACATCATCTCTCTTCTGAAAATCGTTAATAATGGTATGCTGGTTCTGCAAGAGATTTGGAATGATGCATCAGGTGCAATGGTGGTGTATGCACCAGTGGAAACCAATTCTATTGAGCTGGTCAAGAGAGGTGAAAATTCAGATTCTGTGAAGTTTCTTCCTTCGGGATTTTCGATAGTGCCAGATGGAGTAAATGGGTCATATCATAGAGGCAATACTGGTGGAGGATGTCTACTGACATTTGGACTTCAGATCTTGGTGGGCATCAATCCAACTGCTGCACTCATTCAAGGTACTGTCAAAAGTGTCGAGACACTCATGGCTCATACTATTGTCAAGATCAAATCCGCGTTAGATTTACAGACGTAACCATCAGCAGCTCCAGTTTCCGTTGTTCCGCAAGAAATTCGACATTGGCTTGTGCCCTAGTTTGCTTTTCCAACCAAGACTCTTCTGGATTAACTTTTTTATGCGTTTGTTGATCTGTTTGCTGGATATTTCTTGCTTCCTTTCTTCTTTCCTTTTCTGAAACTCTCAAATTGTTACAAACCAGAATTAATAGAGAGTTAGAACAATATATTTCGTATTCAA
CDS Sequence
Protein Sequence