Gene Details:
- Gene ID: AT4G25470
- Gene Symbol: ATCBF2, CBF2, DREB1C, FTQ4
- Gene Name: C-repeat/DRE binding factor 2, DRE/CRT-BINDING PROTEIN 1C, FREEZING TOLERANCE QTL 4
- Description: C-repeat/DRE binding factor 2;(source:Araport11)
- TAIR Accession: locus:2131834
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0000013 — cauline leaf — hoja caulinar (Spanish, exact), 茎生葉、茎葉 (Japanese, exact)
- PO:0009001 — fruit — frucht (exact, German), fruto (exact, Spanish), 果実 (exact, Japanese), coenocarp (narrow), syncarp (narrow), aggregate fruit (broad), compound fruit (broad), dehiscent fruit (broad), diaspore (broad), indehiscent fruit (broad), multiple fruit (broad), propagule (broad)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009010 — seed — semilla (Spanish, exact), 種子 (Japanese, exact), pyrene (narrow), diaspore (broad)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009032 — petal — pétalo (Spanish, exact), 花弁 (Japanese, exact)
- PO:0009047 — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)
- PO:0009062 — gynoecium — ginoecio (Spanish, exact), gynaecium (exact), gynoecia (exact, plural), 雌蕊群 (Japanese, exact), Poaceae gynoecium (narrow), Zea gynoecium (narrow), apocarpous gynoecium (narrow), gynoecium of ear floret (narrow), gynoecium of lower floret of pedicellate spikelet of ear (narrow), gynoecium of lower floret of pedicellate spikelet of tassel (narrow), gynoecium of lower floret of sessile spikelet of ear (narrow), gynoecium of lower floret of sessile spikelet of tassel (narrow), gynoecium of tassel floret (narrow), gynoecium of upper floret of pedicellate spikelet of ear (narrow), gynoecium of upper floret of pedicellate spikelet of tassel (narrow), gynoecium of upper floret of sessile spikelet of ear (narrow), gynoecium of upper floret of sessile spikelet of tassel (narrow), syncarpous gynoecium (narrow), pistil (broad)
Gene Ontology:
- GO:0000976 — enables — transcription cis-regulatory region binding
- GO:0009409 — acts upstream of or within — response to cold
- GO:0009631 — acts upstream of or within — cold acclimation
- GO:0006355 — involved in — regulation of DNA-templated transcription
- GO:0003700 — enables — DNA-binding transcription factor activity
- GO:0005634 — located in — nucleus
- GO:0005515 — enables — protein binding
Germplasm Phenotype:
- CS73345 — enhanced arsenite resistance; slight cadmium sensitivity
- CS73346 — enhanced arsenite resistance; slight cadmium sensitivity
- cbf2 — Plants have higher capacity to tolerate freezing than WT plants before and after cold acclimation and are more tolerant to dehydration and salt stress.
Function-related keywords:
- shoot axis apex , vascular leaf , stamen , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , cauline leaf , fruit , root , seed , stamen , sepal , petal , stem , gynoecium , cotyledon , hypocotyl
Literature:
- The sfr6 mutation in Arabidopsis suppresses low-temperature induction of genes dependent on the CRT/DRE sequence motif. DOI: 10.1105/tpc.11.5.875 ; PMID: 10330472
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures. DOI: 10.1073/pnas.112040099 ; PMID: 12032361
- Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway. DOI: 10.1105/tpc.003483 ; PMID: 12172015
- Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis. DOI: 10.1104/pp.006478 ; PMID: 12376631
- OsDREB genes in rice, Oryza sativa L., encode transcription activators that and cold-responsive gene expression. DOI: 10.1046/j.1365-313x.2003.01661.x ; PMID: 12609047
- ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis. DOI: 10.1101/gad.1077503 ; PMID: 12672693
- The sfr6 mutant of Arabidopsis is defective in transcriptional activation via CBF/DREB1 and DREB2 and shows sensitivity to osmotic stress. DOI: 10.1046/j.1365-313x.2003.01734.x ; PMID: 12753580
- Heterosis in the freezing tolerance of crosses between two Arabidopsis thaliana accessions (Columbia-0 and C24) that show differences in non-acclimated and acclimated freezing tolerance. DOI: 10.1111/j.1365-313X.2004.02080.x ; PMID: 15144380
- Arabidopsis transcriptional activators CBF1, CBF2, and CBF3 have matching functional activities. DOI: 10.1023/B:PLAN.0000040902.06881.d4 ; PMID: 15356394
- Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis. DOI: 10.1111/j.1365-313X.2004.02288.x ; PMID: 15634197
- Low temperature induction of Arabidopsis CBF1, 2, and 3 is gated by the circadian clock. DOI: 10.1104/pp.104.058354 ; PMID: 15728337
- The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. DOI: 10.1104/pp.105.068171 ; PMID: 16258011
- Involvement of GIGANTEA gene in the regulation of the cold stress response in Arabidopsis. DOI: 10.1007/s00299-005-0061-x ; PMID: 16231185
- Light-quality regulation of freezing tolerance in Arabidopsis thaliana. DOI: 10.1038/ng.2007.3 ; PMID: 17965713
- Arabidopsis CBF1 and CBF3 have a different function than CBF2 in cold acclimation and define different gene classes in the CBF regulon. DOI: 10.1073/pnas.0705639105 ; PMID: 18093929
- Combinatorial interactions of multiple cis-elements regulating the induction of the Arabidopsis XERO2 dehydrin gene by abscisic acid and cold. DOI: 10.1111/j.1365-313X.2007.03399.x ; PMID: 18088305
- Roles for Arabidopsis CAMTA transcription factors in cold-regulated gene expression and freezing tolerance. DOI: 10.1105/tpc.108.063958 ; PMID: 19270186
- The phytochrome-interacting factor PIF7 negatively regulates DREB1 expression under circadian control in Arabidopsis. DOI: 10.1104/pp.109.147033 ; PMID: 19837816
- Heterologous expression of wheat VERNALIZATION 2 (TaVRN2) gene in Arabidopsis delays flowering and enhances freezing tolerance. DOI: 10.1371/journal.pone.0008690 ; PMID: 20084169
- Nitric oxide participates in cold-responsive phosphosphingolipid formation and gene expression in Arabidopsis thaliana. DOI: 10.1111/j.1469-8137.2010.03500.x ; PMID: 21039566
- Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis. DOI: 10.1073/pnas.1103741108 ; PMID: 21471455
- Photoperiodic regulation of the C-repeat binding factor (CBF) cold acclimation pathway and freezing tolerance in Arabidopsis thaliana. DOI: 10.1073/pnas.1211295109 ; PMID: 22927419
- Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. DOI: 10.1186/1471-2229-13-229 ; PMID: 24377444
- The Cysteine2/Histidine2-Type Transcription Factor ZINC FINGER OF ARABIDOPSIS THALIANA6 Modulates Biotic and Abiotic Stress Responses by Activating Salicylic Acid-Related Genes and C-REPEAT-BINDING FACTOR Genes in Arabidopsis. DOI: 10.1104/pp.114.242404 ; PMID: 24834923
- Promoter-based integration in plant defense regulation. DOI: 10.1104/pp.114.248716 ; PMID: 25352272
- An Arabidopsis gene regulatory network for secondary cell wall synthesis. DOI: 10.1038/nature14099 ; PMID: 25533953
- Overexpression of LOV KELCH protein 2 confers dehydration tolerance and is associated with enhanced expression of dehydration-inducible genes in Arabidopsis thaliana. DOI: 10.1007/s00299-015-1746-4 ; PMID: 25627253
- A study on the regulatory network with promoter analysis for Arabidopsis DREB-genes. DOI: 10.6026/97320630011101 ; PMID: 25848171
- Melatonin induces the transcripts of CBF/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis. DOI: 10.1111/jpi.12262 ; PMID: 26182834
- The unified ICE-CBF pathway provides a transcriptional feedback control of freezing tolerance during cold acclimation in Arabidopsis. DOI: 10.1007/s11103-015-0365-3 ; PMID: 26311645
- Delayed germination of Arabidopsis seeds under chilling stress by overexpressing an abiotic stress inducible GhTPS11. DOI: 10.1016/j.gene.2015.08.056 ; PMID: 26325072
- Burkholderia phytofirmans PsJN reduces impact of freezing temperatures on photosynthesis in Arabidopsis thaliana. DOI: 10.3389/fpls.2015.00810 ; PMID: 26483823
- RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway. DOI: 10.1111/nph.13727 ; PMID: 26522658
- A cotton miRNA is involved in regulation of plant response to salt stress. DOI: 10.1038/srep19736 ; PMID: 26813144
- Melatonin-induced CBF/DREB1s are essential for diurnal change of disease resistance and CCA1 expression in Arabidopsis. DOI: 10.1016/j.plaphy.2016.01.018 ; PMID: 26828406
- Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors. DOI: 10.1016/j.devcel.2016.09.031 ; PMID: 27923776
- BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis. DOI: 10.1016/j.molp.2017.01.004 ; PMID: 28089951
- Different Cold-Signaling Pathways Function in the Responses to Rapid and Gradual Decreases in Temperature. DOI: 10.1105/tpc.16.00669 ; PMID: 28351986
- Plant Temperature Acclimation and Growth Rely on Cytosolic Ribosome Biogenesis Factor Homologs. DOI: 10.1104/pp.17.01448 ; PMID: 29382692
- Variation in ICE1 Methylation Primarily Determines Phenotypic Variation in Freezing Tolerance in Arabidopsis thaliana. DOI: 10.1093/pcp/pcy197 ; PMID: 30295898
- BYPASS1-LIKE, A DUF793 Family Protein, Participates in Freezing Tolerance via the CBF Pathway in Arabidopsis. DOI: 10.3389/fpls.2019.00807 ; PMID: 31297122
- Transcriptional regulation of nitrogen-associated metabolism and growth. DOI: 10.1038/s41586-018-0656-3 ; PMID: 30356219
- SPL9 mediates freezing tolerance by directly regulating the expression of CBF2 in Arabidopsis thaliana. DOI: 10.1186/s12870-022-03445-8 ; PMID: 35109794
- Specific CBF transcription factors and cold-responsive genes fine-tune the early triggering response after acquisition of cold priming and memory. DOI: 10.1111/ppl.13740 ; PMID: 35776365
- Temperature modulation of CAMTA3 gene induction activity is mediated through the DNA binding domain. DOI: 10.1111/tpj.15944 ; PMID: 35960653
- An amiRNA screen uncovers redundant CBF and ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses. DOI: 10.1111/pce.14023 ; PMID: 33554343
- The salt-activated CBF1/CBF2/CBF3-GALS1 module fine-tunes galactan-induced salt hypersensitivity in Arabidopsis. DOI: 10.1111/jipb.13501 ; PMID: 37149782
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- An annotation update via cDNA sequence analysis and comprehensive profiling of developmental, hormonal or environmental responsiveness of the Arabidopsis AP2/EREBP transcription factor gene family. DOI: 10.1007/s11103-005-1511-0 ; PMID: 16307362
- Genome-wide analysis of the ERF gene family in Arabidopsis and rice. DOI: 10.1104/pp.105.073783 ; PMID: 16407444
Sequences:
cDNA Sequence
- >AT4G25470.1
AACTTCAAACACTTACCTGAATTAGAAAAGAAAGATAGATAGAGAAATAAATATTTTATCATACCATACAAAAAAAGACAGAGATCTTCTACTTACTCTACTCTCATAAACCTTATCCAGTTTCTTGAAACAGAGTACTCTTCTGATCAATGAACTCATTTTCTGCCTTTTCTGAAATGTTTGGCTCCGATTACGAGTCTCCGGTTTCCTCAGGCGGTGATTACAGTCCGAAGCTTGCCACGAGCTGCCCCAAGAAACCAGCGGGAAGGAAGAAGTTTCGTGAGACTCGTCACCCAATTTACAGAGGAGTTCGTCAAAGAAACTCCGGTAAGTGGGTGTGTGAGTTGAGAGAGCCAAACAAGAAAACGAGGATTTGGCTCGGGACTTTCCAAACCGCTGAGATGGCAGCTCGTGCTCACGACGTCGCCGCCATAGCTCTCCGTGGCAGATCTGCCTGTCTCAATTTCGCTGACTCGGCTTGGCGGCTACGAATCCCGGAATCAACCTGTGCCAAGGAAATCCAAAAGGCGGCGGCTGAAGCCGCGTTGAATTTTCAAGATGAGATGTGTCATATGACGACGGATGCTCATGGTCTTGACATGGAGGAGACCTTGGTGGAGGCTATTTATACGCCGGAACAGAGCCAAGATGCGTTTTATATGGATGAAGAGGCGATGTTGGGGATGTCTAGTTTGTTGGATAACATGGCCGAAGGGATGCTTTTACCGTCGCCGTCGGTTCAATGGAACTATAATTTTGATGTCGAGGGAGATGATGACGTGTCCTTATGGAGCTATTAAAATTCGATTTTTATTTCCATTTTTGGTATTATAGCTTTTTATACATTTGATCCTTTTTTAGAATGGATCTTCTTCTTTTTTTGGTTGTGAGAAACGAATGTAAATGGTAAAAGTTGTTGTCAAATGCAAATGTTTTTGAGTGCAGAATATATAATCTTTGGTCTCCCCATAAGCAACAAATCAAAA
CDS Sequence
Protein Sequence