Gene Details:

• Gene ID: AT4G24210
• Gene Symbol: GAR2, GAR2, SLY1
• Gene Name: GAI AN REVERTANT 2, SLEEPY1
• Description: F-box family protein;(source:Araport11)
• TAIR Accession: locus:2135917
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G24210.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0009938  — acts upstream of or within — negative regulation of gibberellic acid mediated signaling pathway
• GO:0005634  — located in — nucleus
• GO:0010162  — acts upstream of or within — seed dormancy process
• GO:0009937  — involved in — regulation of gibberellic acid mediated signaling pathway
• GO:0005737  — is active in — cytoplasm
• GO:0009740  — involved in — gibberellic acid mediated signaling pathway
• GO:0019005  — part of — SCF ubiquitin ligase complex
• GO:0009939  — acts upstream of or within — positive regulation of gibberellic acid mediated signaling pathway
• GO:0009739  — acts upstream of or within — response to gibberellin
• GO:0031146  — involved in — SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
• GO:0009845  — acts upstream of or within — seed germination

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen

Literature:

• Extragenic suppressors of the Arabidopsis gai mutation alter the dose-response relationship of diverse gibberellin responses.   DOI:  10.1104/pp.119.4.1199 ;  PMID:  10198078
• Isolation of the GA-response mutant sly1 as a suppressor of ABI1-1 in Arabidopsis thaliana.   DOI:  10.1093/genetics/149.2.509 ;  PMID:  9611170
• The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses.   DOI:  10.1101/gad.11.23.3194 ;  PMID:  9389651
• A role for brassinosteroids in germination in Arabidopsis.   DOI:  10.1104/pp.125.2.763 ;  PMID:  11161033
• Phenotypic Suppression of the Gibberellin-Insensitive Mutant (gai) of Arabidopsis.   DOI:  10.1104/pp.108.2.495 ;  PMID:  12228487
• The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase.   DOI:  10.1105/tpc.010827 ;  PMID:  12724538
• The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation.   DOI:  10.1105/tpc.020958 ;  PMID:  15155881
• Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis.   DOI:  10.1104/pp.104.039578 ;  PMID:  15173565
• Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY.   DOI:  10.1073/pnas.0404287101 ;  PMID:  15308775
• Molecular analysis of Arabidopsis endosperm and embryo promoter trap lines: reporter-gene expression can result from T-DNA insertions in antisense orientation, in introns and in intergenic regions, in addition to sense insertion at the 5' end of genes.   DOI:  10.1093/jxb/eri242 ;  PMID:  16014362
• Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis.   DOI:  10.1105/tpc.106.047415 ;  PMID:  17194763
• Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis.   DOI:  10.1105/tpc.106.048009 ;  PMID:  17384169
• The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity.   DOI:  10.1105/tpc.108.061515 ;  PMID:  18941053
• Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1.   DOI:  10.1105/tpc.108.058487 ;  PMID:  18827182
• Karrikins discovered in smoke trigger Arabidopsis seed germination by a mechanism requiring gibberellic acid synthesis and light.   DOI:  10.1104/pp.108.131516 ;  PMID:  19074625
• DELLA proteins restrain germination and elongation growth in Arabidopsis thaliana COP9 signalosome mutants.   DOI:  10.1016/j.ejcb.2009.12.001 ;  PMID:  20083325
• The role of two f-box proteins, SLEEPY1 and SNEEZY, in Arabidopsis gibberellin signaling.   DOI:  10.1104/pp.110.166272 ;  PMID:  21163960
• and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1.   DOI:  10.1042/BJ20101941 ;  PMID:  21323638
• Geminiviruses subvert ubiquitination by altering CSN-mediated derubylation of SCF E3 ligase complexes and inhibit jasmonate signaling in Arabidopsis thaliana.   DOI:  10.1105/tpc.110.080267 ;  PMID:  21441437
• Mutations in the F-box gene SNEEZY result in decreased Arabidopsis GA signaling.   DOI:  10.4161/psb.6.6.15164 ;  PMID:  21455025
• Nitric oxide regulates DELLA content and PIF expression to promote photomorphogenesis in Arabidopsis.   DOI:  10.1104/pp.111.177741 ;  PMID:  21562334
• A survey of dominant mutations in Arabidopsis thaliana.   DOI:  10.1016/j.tplants.2012.08.006 ;  PMID:  22995285
• A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins.   DOI:  10.1371/journal.pone.0050009 ;  PMID:  23166809
• The SKP1-like gene family of Arabidopsis exhibits a high degree of differential gene expression and gene product interaction during development.   DOI:  10.1371/journal.pone.0050984 ;  PMID:  23226441
• Lifting della repression of Arabidopsis seed germination by nonproteolytic gibberellin signaling.   DOI:  10.1104/pp.113.219451 ;  PMID:  23818171
• E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signalling and plant development.   DOI:  10.1042/BJ20141302 ;  PMID:  26008766
• Biology in the Dry Seed: Transcriptome Changes Associated with Dry Seed Dormancy and Dormancy Loss in the Arabidopsis GA-Insensitive sleepy1-2 Mutant.   DOI:  10.3389/fpls.2017.02158 ;  PMID:  29312402
• Interplay between REVEILLE1 and RGA-LIKE2 regulates seed dormancy and germination in Arabidopsis.   DOI:  10.1111/nph.16236 ;  PMID:  31580487
• HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis.   DOI:  10.1016/j.xplc.2023.100517 ;  PMID:  36597357
• Extragenic suppressors of the Arabidopsis gai mutation alter the dose-response relationship of diverse gibberellin responses.   DOI:  10.1104/pp.119.4.1199 ;  PMID:  10198078
• The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses.   DOI:  10.1101/gad.11.23.3194 ;  PMID:  9389651
• Phenotypic Suppression of the Gibberellin-Insensitive Mutant (gai) of Arabidopsis.   DOI:  10.1104/pp.108.2.495 ;  PMID:  12228487
• The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase.   DOI:  10.1105/tpc.010827 ;  PMID:  12724538

Sequences: