Gene Details:

• Gene ID: AT4G21980
• Gene Symbol: APG8A, ATG8A
• Gene Name: AUTOPHAGY 8A, AUTOPHAGY-RELATED 8A
• Description: Ubiquitin-like superfamily protein;(source:Araport11)
• TAIR Accession: locus:2120618
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G21980.1     AT4G21980.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0050832  — acts upstream of or within — defense response to fungus
• GO:0019776  — enables — Atg8-family ligase activity
• GO:0006914  — acts upstream of or within — autophagy
• GO:0005776  — located in — autophagosome
• GO:0019786  — enables — protein-phosphatidylethanolamide deconjugating activity
• GO:0009507  — located in — chloroplast
• GO:0006995  — involved in — cellular response to nitrogen starvation
• GO:0005515  — enables — protein binding
• GO:0005775  — located in — vacuolar lumen
• GO:0005737  — located in — cytoplasm
• GO:0061908  — located in — phagophore
• GO:0019779  — enables — Atg8 activating enzyme activity

Function-related keywords:

• root ,  flower ,  pollen tube cell ,  pollen

Literature:

• The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana.   DOI:  10.1074/jbc.M204630200 ;  PMID:  12070171
• Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene.   DOI:  10.1104/pp.011024 ;  PMID:  12114572
• Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins.   DOI:  10.1016/j.febslet.2004.04.088 ;  PMID:  15178341
• Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy.   DOI:  10.1105/tpc.104.025395 ;  PMID:  15494556
• Post-translational regulation in plants employing a diverse set of polypeptide tags.   DOI:  10.1042/BST0330393 ;  PMID:  15787614
• Autophagic nutrient recycling in Arabidopsis directed by the ATG8 and ATG12 conjugation pathways.   DOI:  10.1104/pp.105.060673 ;  PMID:  16040659
• Starvation-induced expression of autophagy-related genes in Arabidopsis.   DOI:  10.1042/BC20040516 ;  PMID:  16354162
• Genome-wide analysis of Arabidopsis responsive transcriptome to nitrogen limitation and its regulation by the ubiquitin ligase gene NLA.   DOI:  10.1007/s11103-007-9241-0 ;  PMID:  17885809
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• An autophagy-associated Atg8 protein is involved in the responses of Arabidopsis seedlings to hormonal controls and abiotic stresses.   DOI:  10.1093/jxb/ern244 ;  PMID:  18836138
• Homologs of genes associated with programmed cell death in animal cells are differentially expressed during senescence of Ipomoea nil petals.   DOI:  10.1093/pcp/pcp019 ;  PMID:  19182226
• A critical role of autophagy in plant resistance to necrotrophic fungal pathogens.   DOI:  10.1111/j.1365-313X.2011.04553.x ;  PMID:  21395886
• Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway.   DOI:  10.1073/pnas.1209487109 ;  PMID:  23019378
• The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis.   DOI:  10.1105/tpc.113.113399 ;  PMID:  23800962
• Perception of Arabidopsis AtPep peptides, but not bacterial elicitors, accelerates starvation-induced senescence.   DOI:  10.3389/fpls.2015.00014 ;  PMID:  25667591
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis.   DOI:  10.1105/tpc.17.00056 ;  PMID:  28351989
• Dicot-specific ATG8-interacting ATI3 proteins interact with conserved UBAC2 proteins and play critical roles in plant stress responses.   DOI:  10.1080/15548627.2017.1422856 ;  PMID:  29313416
• Overexpression of ATG8 in Arabidopsis Stimulates Autophagic Activity and Increases Nitrogen Remobilization Efficiency and Grain Filling.   DOI:  10.1093/pcp/pcy214 ;  PMID:  30407574
• The Local Phosphate Deficiency Response Activates Endoplasmic Reticulum Stress-Dependent Autophagy.   DOI:  10.1104/pp.18.01379 ;  PMID:  30510038
• ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors.   DOI:  10.1016/j.cell.2019.02.009 ;  PMID:  30955882
• Cadmium induces reactive oxygen species-dependent pexophagy in Arabidopsis leaves.   DOI:  10.1111/pce.13597 ;  PMID:  31152467
• Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins.   DOI:  10.1093/jxb/erz404 ;  PMID:  31494674
• Arabidopsis SINAT Proteins Control Autophagy by Mediating Ubiquitylation and Degradation of ATG13.   DOI:  10.1105/tpc.19.00413 ;  PMID:  31732704
• Phytopathogen Effectors Use Multiple Mechanisms to Manipulate Plant Autophagy.   DOI:  10.1016/j.chom.2020.07.010 ;  PMID:  32810441
• C53 is a cross-kingdom conserved reticulophagy receptor that bridges the gap betweenselective autophagy and ribosome stalling at the endoplasmic reticulum.   DOI:  10.1080/15548627.2020.1846304 ;  PMID:  33164651
• Salicylic acid is a key player of Arabidopsis autophagy mutant susceptibility to the necrotrophic bacterium Dickeya dadantii.   DOI:  10.1038/s41598-021-83067-6 ;  PMID:  33574453
• Subcellular Localization of Acyl-CoA: Lysophosphatidylethanolamine Acyltransferases (LPEATs) and the Effects of Knocking-Out and Overexpression of Their Genes on Autophagy Markers Level and Life Span of A. thaliana.   DOI:  10.3390/ijms22063006 ;  PMID:  33809440
• Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis.   DOI:  10.1016/j.molcel.2021.03.026 ;  PMID:  33961777
• A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies.   DOI:  10.15252/embj.2021108050 ;  PMID:  34155657
• Thermopriming-Induced Autophagy in Shoot Apical Meristem of Arabidopsis.   DOI:  10.30498/ijb.2021.253616.2901 ;  PMID:  35350643
• An Arabidopsis nonhost resistance gene, IMPORTIN ALPHA 2 provides immunity against rice sheath blight pathogen, Rhizoctonia solani.   DOI:  10.1016/j.crmicr.2022.100109 ;  PMID:  35243446
• Type one protein phosphatase regulates fixed-carbon starvation-induced autophagy in Arabidopsis.   DOI:  10.1093/plcell/koac251 ;  PMID:  35961047
• TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy.   DOI:  10.1038/s41467-022-33402-w ;  PMID:  36163196
• The phosphatidylinositol 3-phosphate effector FYVE3 regulates FYVE2-dependent autophagy in Arabidopsis thaliana.   DOI:  10.3389/fpls.2023.1160162 ;  PMID:  37008475
• An emerging role of non-canonical conjugation of ATG8 proteins in plant response to heat stress.   DOI:  10.1080/15548627.2023.2219161 ;  PMID:  37246814
• The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana.   DOI:  10.1074/jbc.M204630200 ;  PMID:  12070171

Sequences: