Gene Details:

• Gene ID: AT3G51160
• Gene Symbol: GMD2, MUR1, MUR_1, SFR8
• Gene Name: GDP-D-MANNOSE-4,6-DEHYDRATASE 2, MURUS 1, MURUS 1, SENSITIVE TO FREEZING8
• Description: NAD(P)-binding Rossmann-fold superfamily protein;(source:Araport11)
• TAIR Accession: locus:2080933
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G51160.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Gene Ontology:

• GO:0042351  — acts upstream of or within — de novo GDP-L-fucose biosynthetic process
• GO:0042351  — involved in — de novo GDP-L-fucose biosynthetic process
• GO:0009826  — acts upstream of or within — unidimensional cell growth
• GO:0005829  — located in — cytosol
• GO:0019673  — involved in — GDP-mannose metabolic process
• GO:0005737  — is active in — cytoplasm
• GO:0008446  — enables — GDP-mannose 4,6-dehydratase activity
• GO:0005634  — located in — nucleus

Germplasm Phenotype:

• CS6243  — Contains less than 2% of wild-type amount of fucose in aerial parts of the plant body. Fucose content in total root polysaccharides is only reduced by about 40%.
• CS6243  — Elongating parts of inflorescences are fragile.
• CS6243  — Mutant grown axenically in the presence of 10 mM L-fucose contain WT amounts of fucose in both root- and leaf-derived cell wall material.
• CS6243  — Reduced freezing tolerance. After cold treatment plants fail to regrow and remain chlorotic. Reduced fucosylation levels.
• CS6243  — deficient in L-fucose, constituent of pectic and hemicellulosic cell wall polysaccharides; root growth rate reduced, decreased length of petioles, rounded leaves, decreased internode length, reduced height, reduced apical dominance, slight decrease in flower size; decreased strength of primary cell wall; same as fucose synthesis.
• CS6244  — Contains less than 2% of wild-type amount of fucose in aerial parts of the plant body. Fucose content in total root polysaccharides is only reduced by about 40%.
• CS6244  — Elongating parts of inflorescences are fragile.
• CS6244  — Mutant grown axenically in the presence of 10 mM L-fucose contain WT amounts of fucose in both root- and leaf-derived cell wall material.
• CS6244  — deficient in L-fucose, constituent of pectic and hemicellulosic cell wall polysaccharides; plants similar to mur1-1 but more dwarfed; same as fucose synthesis.
• CS71676  — Left-handed helically twisted petals and hyponastic cotyledons.
• CS71677  — Left-handed helically twisted petals and hyponastic cotyledons.
• CS8559  — leaky; fucose content in leaf polysaccharides reduced to approximately one-third of wild type; no visible phenotypic effect; same as fucose synthesis.
• CS8560  — Reduced freezing tolerance. After cold treatment plants fail to regrow and remain chlorotic. Reduced fucosylation levels.
• CS8560  — fucose content in leaf polysaccharides reduced to approximately 1 percent of wild type; slightly dwarfed; decreased tensile strength in elongating inflorescence stems; same as fucose synthesis.
• CS8561  — fucose content in leaf polysaccharides reduced to approximately 1 percent of wild type; slightly dwarfed; decreased tensile strength in elongating inflorescence stems; same as fucose synthesis.
• CS8562  — fucose content in leaf polysaccharides reduced to approximately 1 percent of wild type; slightly dwarfed; decreased tensile strength in elongating inflorescence stems; same as fucose synthesis.
• CS8563  — leaky; fucose content in leaf polysaccharides reduced to approximately 10 percent of wild type; no visible phenotypic effect; same as fucose synthesis.
• CS8564  — fucose content in leaf polysaccharides reduced to approximately 1 percent of wild type; slightly dwarfed; decreased tensile strength in elongating inflorescence stems; same as fucose synthesis.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  pollen tube cell ,  pollen ,  guard cell

Literature:

• A bifunctional epimerase-reductase acts downstream of the MUR1 gene product and completes the de novo synthesis of GDP-L-fucose in Arabidopsis.   DOI:  10.1046/j.1365-313x.2000.00698.x ;  PMID:  10758496
• Mutants of Arabidopsis thaliana with altered cell wall polysaccharide composition.   DOI:  10.1046/j.1365-313x.1997.12020335.x ;  PMID:  9301086
• The mur2 mutant of Arabidopsis thaliana lacks fucosylated xyloglucan because of a lesion in fucosyltransferase AtFUT1.   DOI:  10.1073/pnas.052450699 ;  PMID:  11854459
• Rapid structural phenotyping of plant cell wall mutants by enzymatic oligosaccharide fingerprinting.   DOI:  10.1104/pp.011965 ;  PMID:  12481058
• Tensile properties of Arabidopsis cell walls depend on both a xyloglucan cross-linked microfibrillar network and rhamnogalacturonan II-borate complexes.   DOI:  10.1104/pp.103.021873 ;  PMID:  12805631
• High-throughput mapping of cell-wall polymers within and between plants using novel microarrays.   DOI:  10.1111/j.1365-313X.2007.03114.x ;  PMID:  17565618
• Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana.   DOI:  10.1105/tpc.106.049965 ;  PMID:  17693536
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Structural characterisation of the pectic polysaccharide rhamnogalacturonan II using an acidic fingerprinting methodology.   DOI:  10.1007/s00425-009-0996-1 ;  PMID:  19672621
• Pectin may hinder the unfolding of xyloglucan chains during cell deformation: implications of the mechanical performance of Arabidopsis hypocotyls with pectin alterations.   DOI:  10.1093/mp/ssp065 ;  PMID:  19825674
• Species specific amino acid sequence-protein local structure relationships: An analysis in the light of a structural alphabet.   DOI:  10.1016/j.jtbi.2011.01.047 ;  PMID:  21333657
• Suppression of Arabidopsis GGLT1 affects growth by reducing the L-galactose content and borate cross-linking of rhamnogalacturonan-II.   DOI:  10.1111/tpj.14088 ;  PMID:  30203879
• Arabidopsis thaliana α1,2-l-fucosyltransferase catalyzes the transfer of l-galactose to xyloglucan oligosaccharides.   DOI:  10.1002/1873-3468.13303 ;  PMID:  30478825
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: