Gene Details:

• Gene ID: AT3G50630
• Gene Symbol: ICK2, KRP2
• Gene Name: KIP-related protein 2
• Description: KIP-related protein 2;(source:Araport11)
• TAIR Accession: locus:2101679
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G50630.1     AT3G50630.2

Plant Ontology Annotations:

• PO:0000017  — vascular leaf primordium — leaf primordium (exact), portion of vascular leaf primordium tissue (exact), primordio de hoja (Spanish, exact), vascular leaf primordia (exact, plural), 葉原基 (Japanese, exact)
• PO:0006109  — pith — médula (Spanish, exact), medulla (exact), 髄 (Japanese, exact)
• PO:0006205  — spongy mesophyll cell — célula del mesófilo esponjoso (Spanish, exact), 海綿状葉肉細胞 (Japanese, exact), spongy parenchyma cell (related)
• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0042023  — acts upstream of or within — DNA endoreduplication
• GO:0004861  — enables — cyclin-dependent protein serine/threonine kinase inhibitor activity
• GO:0045736  — involved in — negative regulation of cyclin-dependent protein serine/threonine kinase activity
• GO:0005634  — located in — nucleus
• GO:0019210  — enables — kinase inhibitor activity

Function-related keywords:

• vascular leaf primordium ,  pith ,  spongy mesophyll cell ,  shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen

Literature:

• Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.   DOI:  10.1016/j.febslet.2005.12.018 ;  PMID:  16376885
• RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle.   DOI:  10.1111/j.1365-313X.2008.03737.x ;  PMID:  19000158
• Gibberellin signaling controls cell proliferation rate in Arabidopsis.   DOI:  10.1016/j.cub.2009.05.059 ;  PMID:  19576768
• Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.   DOI:  10.1038/msb.2010.53 ;  PMID:  20706207
• UV-B-induced DNA damage mediates expression changes of cell cycle regulatory genes in Arabidopsis root tips.   DOI:  10.1007/s00425-010-1340-5 ;  PMID:  21221633
• Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots.   DOI:  10.1242/dev.057331 ;  PMID:  21270057
• The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation.   DOI:  10.1105/tpc.110.080002 ;  PMID:  21357490
• Ectopic expression of Kip-related proteins restrains root-knot nematode-feeding site expansion.   DOI:  10.1111/nph.12255 ;  PMID:  23574394
• Downregulation of multiple CDK inhibitor ICK/KRP genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis.   DOI:  10.1111/tpj.12228 ;  PMID:  23647236
• Arabidopsis JAGGED links floral organ patterning to tissue growth by repressing Kip-related cell cycle inhibitors.   DOI:  10.1073/pnas.1320457111 ;  PMID:  24497510
• Down-regulation of multiple CDK inhibitor ICK/KRP genes promotes cell proliferation, callus induction and plant regeneration in Arabidopsis.   DOI:  10.3389/fpls.2015.00825 ;  PMID:  26528298
• AtPRMT5 Regulates Shoot Regeneration through Mediating Histone H4R3 Dimethylation on KRPs and Pre-mRNA Splicing of RKP in Arabidopsis.   DOI:  10.1016/j.molp.2016.10.010 ;  PMID:  27780782
• Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.   DOI:  10.1111/pce.12912 ;  PMID:  28103637
• A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana.   DOI:  10.1016/j.devcel.2020.04.004 ;  PMID:  32386600
• The Arabidopsis Cdc2a-interacting protein ICK2 is structurally related to ICK1 and is a potent inhibitor of cyclin-dependent kinase activity in vitro.   DOI:  10.1046/j.1365-313x.2000.00688.x ;  PMID:  10758489
• Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis.   DOI:  10.1105/tpc.010087 ;  PMID:  11449057
• Synchronous Arabidopsis suspension cultures for analysis of cell-cycle gene activity.   DOI:  10.1046/j.1365-313x.2002.01274.x ;  PMID:  12000456
• Auxin-mediated cell cycle activation during early lateral root initiation.   DOI:  10.1105/tpc.004960 ;  PMID:  12368490
• Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana.   DOI:  10.1093/aob/mch077 ;  PMID:  15037450
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519
• Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.   DOI:  10.1016/j.febslet.2005.12.018 ;  PMID:  16376885
• Arabidopsis cyclin-dependent kinase inhibitors are nuclear-localized and show different localization patterns within the nucleoplasm.   DOI:  10.1007/s00299-006-0294-3 ;  PMID:  17253089

Sequences: