Gene Details:

• Gene ID: AT3G49660
• Gene Symbol: AtWDR5a, WDR5a
• Gene Name: human WDR5 (WD40 repeat) homolog a
• Description: Transducin/WD40 repeat-like superfamily protein;(source:Araport11)
• TAIR Accession: locus:2097435
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G49660.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Gene Ontology:

• GO:0042393  — enables — histone binding
• GO:0010228  — acts upstream of or within — vegetative to reproductive phase transition of meristem
• GO:0005634  — located in — nucleus
• GO:0051568  — involved in — histone H3-K4 methylation
• GO:0048188  — part of — Set1C/COMPASS complex
• GO:0005515  — enables — protein binding

Germplasm Phenotype:

• Wdr5a  — great reduction of H3K4me3 level at MAF4 and impaired cold-induced MAF4 expression

Function-related keywords:

• shoot axis apex ,  plant embryo ,  flower ,  collective leaf structure

Literature:

• and phyA-mediated responses of germination in Arabidopsis.   DOI:  10.1046/j.1365-313x.2003.01848.x ;  PMID:  12969431
• Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.   DOI:  10.1074/jbc.M308435200 ;  PMID:  14576160
• ABA activates ADPR cyclase and cADPR induces a subset of ABA-responsive genes in Arabidopsis.   DOI:  10.1111/j.1365-313X.2004.02055.x ;  PMID:  15086800
• A chloroplast-localized vesicular transport system: a bio-informatics approach.   DOI:  10.1186/1471-2164-5-40 ;  PMID:  15236667
• Combinatorial microarray analysis revealing arabidopsis genes implicated in cytokinin responses through the His->Asp Phosphorelay circuitry.   DOI:  10.1093/pcp/pci033 ;  PMID:  15695462
• Non conservation of the meiotic function of the Ski8/Rec103 homolog in Arabidopsis.   DOI:  10.1111/j.1365-2443.2006.00972.x ;  PMID:  16716192
• Arabidopsis COMPASS-like complexes mediate histone H3 lysine-4 trimethylation to control floral transition and plant development.   DOI:  10.1371/journal.pgen.1001330 ;  PMID:  21423667
• Analysis of essential Arabidopsis nuclear genes encoding plastid-targeted proteins.   DOI:  10.1371/journal.pone.0073291 ;  PMID:  24023856
• Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants.   DOI:  10.1073/pnas.1419703112 ;  PMID:  25730865
• WD40-REPEAT 5a represses root meristem growth by suppressing auxin synthesis through changes of nitric oxide accumulation in Arabidopsis.   DOI:  10.1111/tpj.13816 ;  PMID:  29315929
• WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis.   DOI:  10.1007/s00425-020-03486-z ;  PMID:  33033954
• COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis.   DOI:  10.1093/plcell/koab187 ;  PMID:  34270751
• The Arabidopsis DREAM complex antagonizes WDR5A to modulate histone H3K4me2/3 deposition for a subset of genome repression.   DOI:  10.1073/pnas.2206075119 ;  PMID:  35759663

Sequences: