Gene Details:

• Gene ID: AT3G49500
• Gene Symbol: AtRDR6, RDR6, SDE1, SGS2
• Gene Name: RNA-dependent RNA polymerase 6, SILENCING DEFECTIVE 1, SUPPRESSOR OF GENE SILENCING 2
• Description: RNA-dependent RNA polymerase 6;(source:Araport11)
• TAIR Accession: locus:2114633
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G49500.1     AT3G49500.2     AT3G49500.3     AT3G49500.4     AT3G49500.5

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Gene Ontology:

• GO:0010267  — acts upstream of or within — ta-siRNA processing
• GO:0051607  — acts upstream of or within — defense response to virus
• GO:0048440  — acts upstream of or within — carpel development
• GO:0005634  — located in — nucleus
• GO:0030422  — involved in — siRNA processing
• GO:0048544  — acts upstream of or within — recognition of pollen
• GO:0030422  — enables — siRNA processing
• GO:0003968  — enables — RNA-dependent RNA polymerase activity
• GO:0031047  — acts upstream of or within — regulatory ncRNA-mediated gene silencing
• GO:0048366  — acts upstream of or within — leaf development
• GO:0030422  — acts upstream of or within — siRNA processing
• GO:0016441  — acts upstream of or within — post-transcriptional gene silencing
• GO:0048467  — acts upstream of or within — gynoecium development
• GO:0009616  — acts upstream of or within — RNAi-mediated antiviral immune response
• GO:0031380  — part of — nuclear RNA-directed RNA polymerase complex

Germplasm Phenotype:

• CS16276  — No visible plant phenotype.
• CS24285  — A proportion of pre-meiotic ovules have two MMCs and have several abnormally enlarged sub-epidermal cells. Post-meiotic ovules showed two independently developing female gametophytes at a frequency of 43.3%
• CS24285  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum; defective in PTGS of sense transgenes.
• CS24286  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum; defective in PTGS of sense transgenes.
• CS24287  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum; defective in PTGS of sense transgenes.
• CS24288  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum; defective in PTGS of sense transgenes.
• CS66111  — Rosette leaves elongated and curled downwards. Early rosette leaves have higher length/width ratios than those of Col-0. Precocious production of abaxial trichomes in early rosette leaves implying accelerated vegetative phase change.
• CS66112  — Rosette leaves elongated and curled downwards. Early rosette leaves have higher length/width ratios than those of Col-0. Precocious production of abaxial trichomes in early rosette leaves implying accelerated vegetative phase change.
• CS66480  — similar to rdr6-15; rosette leaves narrow, highly twisted, curled and irregularly shaped; flowers are sterile, sepals and petals are downwardly curled, narrow and twisted and fail to enclose all organs; stamens are short and lack pollen and the gynoecia are irregularly shaped, swollen and frequently split open at the apical end.
• CS66481  — similar to rdr6-15; rosette leaves narrow, highly twisted, curled and irregularly shaped; flowers are sterile, sepals and petals are downwardly curled, narrow and twisted and fail to enclose all organs; stamens are short and lack pollen and the gynoecia are irregularly shaped, swollen and frequently split open at the apical end.
• CS66485  — similar to rdr6-15; homozygous individuals have elongated, downwardly curled rosette leaves; early rosette leaves have higher length/width ratios than those of Col-0.
• CS67869  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum
• CS67870  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum
• CS67871  — Mutant plants express adult vegetative traits precociously; their vegetative phenotype is most apparent around 10-14 days after germination, when the first two leaves appear more strongly down-rolled than normal; mutant plants display variable seed set under some conditions, and also produce stigmatic tissue at the tip of the septum.
• CS69958  — Exhibits known phenotypes of rdr6-11 (CS24285); precocious transition to adult phase of vegetative development, elongated and downward-curling leaves, stamens that frequently fail to contact the stigma resulting in variable seed sets, split septum producing ectopic stigmatic tissue, and defective posttranscriptional gene silencing of sense transgenes (Peragine et al. 2004).
• CS72500  — GFP fluorescence in nuclei and plasma membrane
• CS72501  — GFP fluorescence in nuclei and plasma membrane
• CS73407  — narrow leaves
• rdr6-5  — Infection with cucumber mosaic virus (CMV) revealed an overaccumulation of CMV RNA compared to wild type.
• rdr6-5  — No obvious leaf developmental defects.
• rdr6-5  — TAS3 but not TAS1 or TAS2 ta-siRNAs were detected.
• rdr6-5 (2a3)  — Reduction in post-transcriptional gene silencing.
• rdr6-6 (2a3)  — Reduction in post-transcriptional gene silencing.
• sgs2-1  — Downward-curled leaf margins.
• sgs2-1  — Enhanced susceptibility to virus, reduction in post-transcriptional gene silencing
• sgs2-1  — Infection with cucumber mosaic virus (CMV) revealed an overaccumulation of CMV RNA compared to wild type.
• sgs2-1  — Reduction in post-transcriptional gene silencing.
• sgs2-1  — TAS1, TAS2, and TAS3 ta-siRNAs were below detectable levels.
• sgs2-10 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-11 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-12 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-13 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-14 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-15 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-16 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-17 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-18  — Infection with cucumber mosaic virus (CMV) revealed an overaccumulation of CMV RNA compared to wild type.
• sgs2-18  — No obvious leaf developmental defects.
• sgs2-18  — TAS1, TAS2, and TAS3 ta-siRNAs were detected.
• sgs2-19 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-2  — Reduction in post-transcriptional gene silencing.
• sgs2-20 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-21 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-22 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-23 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-3  — Reduction in post-transcriptional gene silencing.
• sgs2-4  — Reduction in post-transcriptional gene silencing.
• sgs2-5  — Reduction in post-transcriptional gene silencing.
• sgs2-6 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-7 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-8 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.
• sgs2-9 (L1)  — Restoration of GUS activity of the transgene through inhibition of silencing.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure

Literature:

• An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.   DOI:  10.1016/s0092-8674(00)80864-8 ;  PMID:  10850496
• Arabidopsis mutants impaired in cosuppression.   DOI:  10.1105/tpc.10.10.1747 ;  PMID:  9761800
• SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis.   DOI:  10.1093/emboj/20.8.2069 ;  PMID:  11296239
• Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance.   DOI:  10.1105/tpc.010358 ;  PMID:  11910010
• Analysis of the involvement of an inducible Arabidopsis RNA-dependent RNA polymerase in antiviral defense.   DOI:  10.1094/MPMI.2003.16.3.206 ;  PMID:  12650452
• Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance.   DOI:  10.1016/s0960-9822(03)00293-8 ;  PMID:  12747833
• Genetic and functional diversification of small RNA pathways in plants.   DOI:  10.1371/journal.pbio.0020104 ;  PMID:  15024409
• Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants.   DOI:  10.1111/j.1365-313X.2004.02103.x ;  PMID:  15165191
• Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs.   DOI:  10.1016/j.molcel.2004.09.028 ;  PMID:  15469823
• SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis.   DOI:  10.1101/gad.1231804 ;  PMID:  15466488
• microRNA-directed phasing during trans-acting siRNA biogenesis in plants.   DOI:  10.1016/j.cell.2005.04.004 ;  PMID:  15851028
• The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development.   DOI:  10.1105/tpc.105.033449 ;  PMID:  16006579
• Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs.   DOI:  10.1016/j.cub.2005.07.024 ;  PMID:  16040244
• A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis.   DOI:  10.1101/gad.1352605 ;  PMID:  16131612
• Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis.   DOI:  10.1093/pcp/pcj057 ;  PMID:  16699177
• Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA affects developmental timing and patterning in Arabidopsis.   DOI:  10.1016/j.cub.2006.03.065 ;  PMID:  16682356
• Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway.   DOI:  10.1016/j.cub.2006.03.064 ;  PMID:  16682355
• DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7.   DOI:  10.1016/j.cub.2006.03.035 ;  PMID:  16682354
• Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3.   DOI:  10.1242/dev.02521 ;  PMID:  16914499
• Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing.   DOI:  10.1093/nar/gkl886 ;  PMID:  17090584
• Roles of Arabidopsis cyclin-dependent kinase C complexes in cauliflower mosaic virus infection, plant growth, and development.   DOI:  10.1105/tpc.107.051375 ;  PMID:  17468259
• Genome-wide analysis of the RNA-DEPENDENT RNA POLYMERASE6/DICER-LIKE4 pathway in and tasiRNA-directed targeting.   DOI:  10.1105/tpc.107.050062 ;  PMID:  17400893
• Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis.   DOI:  10.1073/pnas.0706701104 ;  PMID:  17785412
• A novel class of bacteria-induced small RNAs in Arabidopsis.   DOI:  10.1101/gad.1595107 ;  PMID:  18003861
• Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.   DOI:  10.1073/pnas.0805760105 ;  PMID:  18799732
• The ARGONAUTE10 gene modulates shoot apical meristem maintenance and establishment of leaf polarity by repressing miR165/166 in Arabidopsis.   DOI:  10.1111/j.1365-313X.2008.03757.x ;  PMID:  19054365
• The more and smaller cells mutants of Arabidopsis thaliana identify novel roles for SQUAMOSA PROMOTER BINDING PROTEIN-LIKE genes in the control of heteroblasty.   DOI:  10.1242/dev.028613 ;  PMID:  19211679
• Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis.   DOI:  10.1371/journal.pone.0004971 ;  PMID:  19308254
• A pathogen-inducible endogenous siRNA in plant immunity.   DOI:  10.1073/pnas.0608258103 ;  PMID:  17071740
• Structural and genetic requirements for the biogenesis of tobacco rattle virus-derived small interfering RNAs.   DOI:  10.1128/JVI.00272-08 ;  PMID:  18353962
• Auxin regulation of the microRNA390-dependent transacting small interfering RNA pathway in Arabidopsis lateral root development.   DOI:  10.1093/nar/gkp1128 ;  PMID:  19969544
• RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana.   DOI:  10.1073/pnas.0904086107 ;  PMID:  19966292
• Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection.   DOI:  10.1105/tpc.109.073056 ;  PMID:  20190077
• Differential sensitivity of Arabidopsis siRNA biogenesis mutants to genotoxic stress.   DOI:  10.1007/s00299-010-0930-9 ;  PMID:  20953786
• Characterization of the AE7 gene in Arabidopsis suggests that normal cell proliferation is essential for leaf polarity establishment.   DOI:  10.1111/j.1365-313X.2010.04326.x ;  PMID:  21070412
• The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana.   DOI:  10.1105/tpc.110.082305 ;  PMID:  21467580
• Intron splicing suppresses RNA silencing in Arabidopsis.   DOI:  10.1111/j.1365-313X.2011.04676.x ;  PMID:  21689169
• Mutations in the antiviral RNAi defense pathway modify Brome mosaic virus RNA recombinant profiles.   DOI:  10.1094/MPMI-05-11-0137 ;  PMID:  21936664
• Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis.   DOI:  10.1038/emboj.2012.20 ;  PMID:  22327216
• Sequencing of RDR6-dependent double-stranded RNAs reveals novel features of plant siRNA biogenesis.   DOI:  10.1093/nar/gks242 ;  PMID:  22434877
• RDR6-mediated synthesis of complementary RNA is terminated by miRNA stably bound to template RNA.   DOI:  10.1093/nar/gkr760 ;  PMID:  21930511
• The Arabidopsis DCP2 gene is required for proper mRNA turnover and prevents transgene silencing in Arabidopsis.   DOI:  10.1111/j.1365-313X.2012.05066.x ;  PMID:  22639932
• MicroRNA miR396 and RDR6 synergistically regulate leaf development.   DOI:  10.1016/j.mod.2012.07.005 ;  PMID:  22889666
• Roles of dicer-like and argonaute proteins in TAS-derived small interfering RNA-triggered DNA methylation.   DOI:  10.1104/pp.112.200279 ;  PMID:  22846193
• Ago hook and RNA helicase motifs underpin dual roles for SDE3 in antiviral defense and silencing of nonconserved intergenic regions.   DOI:  10.1016/j.molcel.2012.07.028 ;  PMID:  22940249
• Primary and secondary siRNAs in geminivirus-induced gene silencing.   DOI:  10.1371/journal.ppat.1002941 ;  PMID:  23028332
• Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.   DOI:  10.1016/j.cell.2012.10.054 ;  PMID:  23313553
• Protein-coding cis-natural antisense transcripts have high and broad expression in Arabidopsis.   DOI:  10.1104/pp.112.212100 ;  PMID:  23457227
• and effector-triggered immunity through the post-transcriptional control of disease resistance genes.   DOI:  10.1371/journal.ppat.1003883 ;  PMID:  24453975
• Salicylic acid and gentisic acid induce RNA silencing-related genes and plant resistance to RNA pathogens.   DOI:  10.1016/j.plaphy.2014.01.016 ;  PMID:  24531234
• miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.   DOI:  10.1038/nature13069 ;  PMID:  24670663
• DICER-LIKE1 processed trans-acting siRNAs mediate DNA methylation: case study of complex small RNA biogenesis and action pathways in plants.   DOI:  10.4161/psb.22476 ;  PMID:  23104109
• and effector-triggered immunity through the post-transcriptional control of disease resistance genes.   DOI:  10.1371/journal.ppat.1004814 ;  PMID:  25859662
• Post-transcriptional gene silencing triggered by sense transgenes involves uncapped antisense RNA and differs from silencing intentionally triggered by antisense transgenes.   DOI:  10.1093/nar/gkv753 ;  PMID:  26209135
• SKI2 mediates degradation of RISC 5'-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis.   DOI:  10.1093/nar/gkv1014 ;  PMID:  26464441
• Mungbean yellow mosaic Indian virus encoded AC2 protein suppresses RNA silencing by inhibiting Arabidopsis RDR6 and AGO1 activities.   DOI:  10.1016/j.virol.2015.08.015 ;  PMID:  26433748
• Arabidopsis thaliana siRNA biogenesis mutants have the lower frequency of homologous recombination.   DOI:  10.1080/15592324.2016.1151599 ;  PMID:  26901311
• RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases.   DOI:  10.1038/srep23082 ;  PMID:  26979928
• The Slicer Activity of ARGONAUTE1 Is Required Specifically for the Phasing, Not Production, of Trans-Acting Short Interfering RNAs in Arabidopsis.   DOI:  10.1105/tpc.16.00121 ;  PMID:  27354557
• CMV2b-AGO Interaction Is Required for the Suppression of RDR-Dependent Antiviral Silencing in Arabidopsis.   DOI:  10.3389/fmicb.2016.01329 ;  PMID:  27605926
• tasiRNA-ARF pathway moderates floral architecture in Arabidopsis plants subjected to drought stress.   DOI:  10.1155/2014/303451 ;  PMID:  25243128
• Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis.   DOI:  10.1073/pnas.1614204114 ;  PMID:  28123063
• A single miR390 targeting event is sufficient for triggering TAS3-tasiRNA biogenesis in Arabidopsis.   DOI:  10.1093/nar/gkx119 ;  PMID:  28334969
• Arabidopsis ALA1 and ALA2 Mediate RNAi-Based Antiviral Immunity.   DOI:  10.3389/fpls.2017.00422 ;  PMID:  28439275
• Identification of a New Host Factor Required for Antiviral RNAi and Amplification of Viral siRNAs.   DOI:  10.1104/pp.17.01370 ;  PMID:  29184028
• Accumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex.   DOI:  10.1111/tpj.13797 ;  PMID:  29222952
• Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense.   DOI:  10.1016/j.jgg.2017.11.005 ;  PMID:  29396140
• Analysis of RDR1/RDR2/RDR6-independent small RNAs in Arabidopsis thaliana improves MIRNA annotations and reveals unexplained types of short interfering RNA loci.   DOI:  10.1111/tpj.13919 ;  PMID:  29654642
• Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression.   DOI:  10.1016/j.devcel.2018.05.023 ;  PMID:  29920280
• The RNA Export Factor ALY1 Enables Genome-Wide RNA-Directed DNA Methylation.   DOI:  10.1105/tpc.18.00624 ;  PMID:  30814259
• The poly(A) polymerase PAPS1 interacts with the RNA-directed DNA-methylation pathway in sporophyte and pollen development.   DOI:  10.1111/tpj.14348 ;  PMID:  31009115
• Synergy between the anthocyanin and RDR6/SGS3/DCL4 siRNA pathways expose hidden features of Arabidopsis carbon metabolism.   DOI:  10.1038/s41467-020-16289-3 ;  PMID:  32415123
• Developmentally regulated Arabidopsis thaliana susceptibility to tomato spotted wilt virus infection.   DOI:  10.1111/mpp.12944 ;  PMID:  32441865
• A new method for functional analysis of plastid EMBRYO-DEFECTIVE PPR genes by efficiently constructing cosuppression lines in Arabidopsis.   DOI:  10.1186/s13007-020-00696-0 ;  PMID:  33292320
• Global Analysis of RNA-Dependent RNA Polymerase-Dependent Small RNAs Reveals New Substrates and Functions for These Proteins and SGS3 in Arabidopsis.   DOI:  10.3390/ncrna7020028 ;  PMID:  33925339
• A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies.   DOI:  10.15252/embj.2021108050 ;  PMID:  34155657
• Cooperative recruitment of RDR6 by SGS3 and SDE5 during small interfering RNA amplification in Arabidopsis.   DOI:  10.1073/pnas.2102885118 ;  PMID:  34408020
• Arabidopsis CALMODULIN-LIKE 38 Regulates Hypoxia-Induced Autophagy of SUPPRESSOR OF GENE SILENCING 3 Bodies.   DOI:  10.3389/fpls.2021.722940 ;  PMID:  34567037
• Role of the RNA-directed DNA Methylation pathway in the regulation of maternal effects in Arabidopsis thaliana seed germination.   DOI:  10.17912/micropub.biology.000504 ;  PMID:  34901781
• Uridylation and the SKI complex orchestrate the Calvin cycle of photosynthesis through RNA surveillance of TKL1 in Arabidopsis.   DOI:  10.1073/pnas.2205842119 ;  PMID:  36095196
• TYMV and TRV infect Arabidopsis thaliana by expressing weak suppressors of RNA silencing and inducing host RNASE THREE LIKE1.   DOI:  10.1371/journal.ppat.1010482 ;  PMID:  36696453
• Genomic methylation patterns in pre-meiotic gynoecia of wild-type and RdDM mutants of Arabidopsis.   DOI:  10.3389/fpls.2023.1123211 ;  PMID:  36993852
• An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.   DOI:  10.1016/s0092-8674(00)80864-8 ;  PMID:  10850496

Sequences: