Gene Details:

• Gene ID: AT3G48430
• Gene Symbol: EIN6, EIN6, JMJ12, REF6
• Gene Name: ETHYLENE INSENSITIVE 6, Jumonji domain-containing protein 12, relative of early flowering 6
• Description: relative of early flowering 6;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G48430.1     AT3G48430.2

Plant Ontology Annotations:

• PO:0000026  — primary root tip — punta de la raíz primaria (Spanish, exact), 一次根端 (Japanese, exact)
• PO:0000027  — lateral root tip — punta de la raíz lateral (Spanish, exact), 側根端 (Japanese, exact)
• PO:0003011  — root vascular system — sistema vascular de la raíz (Spanish, exact), 根維管系 (Japanese, exact), root vein (related)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020148  — shoot apical meristem — SAM (exact), meristema apical del epiblasto (epiblastema) (Spanish, exact), 茎頂分裂組織 (Japanese, exact), primary shoot meristem (related), promeristem (broad)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Germplasm Phenotype:

• SALK_001018C  — ref6-1 mutant seedlings do not have any obvious aberrant phenotypes under light-grown conditions, but they do have a late flowering phenotype. Adult plants have reduced cell elongation, manifested in a ~30% reduction in leaf petiole length as well as shorter leaf blades, but their leaf width is similar to wild-type. The transcript levels of some BR-regulated genes are reduced in ref6-1 mutants. H3K9me3 levels are elevated immediately upstream of the BR-responsive TCH4 gene in ref6-1 mutants.
• SALK_001018C  — ref6-1 mutants flower later than wild-type plants under long- and short-day conditions even though they have the same leaf initiation rate as wild-type plants. FLC mRNA levels are increased in ref6-1 mutants.
• SALK_122006C  — ref6-2 mutants flower later than wild-type plants.
• ref6-3  — ref6-3 mutants flower later than wild-type plants under long- and short-day conditions. Levels of H4 histone acetylation in the the promoter and in the first intron of FLC are reduced in ref6-3 mutants compared to wild-type plants.

Function-related keywords:

• primary root tip ,  lateral root tip ,  root vascular system ,  vascular leaf ,  cotyledon ,  shoot apical meristem ,  guard cell

Literature:

• Genetic analysis of a seedling stress response to ethylene in Arabidopsis.   DOI:  10.1098/rstb.1995.0140 ;  PMID:  8577853
• Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway.   DOI:  10.1093/genetics/139.3.1393 ;  PMID:  7768447
• Mechanically stimulated TCH3 gene expression in Arabidopsis involves protein phosphorylation and EIN6 downstream of calcium.   DOI:  10.1104/pp.010660 ;  PMID:  11950988
• Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.   DOI:  10.1016/s0092-8674(03)00969-3 ;  PMID:  14675532
• Divergent roles of a pair of homologous jumonji/zinc-finger-class transcription factor proteins in the regulation of Arabidopsis flowering time.   DOI:  10.1105/tpc.104.025353 ;  PMID:  15377760
• Conservation of Arabidopsis flowering genes in model legumes.   DOI:  10.1104/pp.104.057018 ;  PMID:  15778459
• Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis.   DOI:  10.1073/pnas.0802254105 ;  PMID:  18467490
• Antagonism between abscisic acid and ethylene in Arabidopsis acts in parallel with the reciprocal regulation of their metabolism and signaling pathways.   DOI:  10.1007/s11103-009-9509-7 ;  PMID:  19513806
• Growth habit determination by the balance of histone methylation activities in Arabidopsis.   DOI:  10.1038/emboj.2010.198 ;  PMID:  20711170
• Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.   DOI:  10.1016/j.cell.2012.10.054 ;  PMID:  23313553
• Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis.   DOI:  10.1038/ncomms5601 ;  PMID:  25105952
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis.   DOI:  10.1038/ng.3555 ;  PMID:  27111034
• Multi-layered Regulation of SPL15 and Cooperation with SOC1 Integrate Endogenous Flowering Pathways at the Arabidopsis Shoot Meristem.   DOI:  10.1016/j.devcel.2016.04.001 ;  PMID:  27134142
• Research progress on the autonomous flowering time pathway in Arabidopsis.   DOI:  10.1007/s12298-017-0458-3 ;  PMID:  28878488
• An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis.   DOI:  10.1038/s41422-019-0145-8 ;  PMID:  30778176
• Floral regulators FLC and SOC1 directly regulate expression of the B3-type transcription factor TARGET OF FLC AND SVP 1 at the Arabidopsis shoot apex via antagonistic chromatin modifications.   DOI:  10.1371/journal.pgen.1008065 ;  PMID:  30946745
• The H3K27me3 demethylase REF6 promotes leaf senescence through directly activating major senescence regulatory and functional genes in Arabidopsis.   DOI:  10.1371/journal.pgen.1008068 ;  PMID:  30969965
• DNA methylation repels targeting of Arabidopsis REF6.   DOI:  10.1038/s41467-019-10026-1 ;  PMID:  31048693
• Epigenetic silencing of a multifunctional plant stress regulator.   DOI:  10.7554/eLife.47835 ;  PMID:  31418686
• Dehydroabietinal promotes flowering time and plant defense in Arabidopsis via the autonomous pathway genes FLOWERING LOCUS D, FVE, and RELATIVE OF EARLY FLOWERING 6.   DOI:  10.1093/jxb/eraa232 ;  PMID:  32392578
• The H3K27me3 Demethylase RELATIVE OF EARLY FLOWERING6 Suppresses Seed Dormancy by Inducing Abscisic Acid Catabolism.   DOI:  10.1104/pp.20.01255 ;  PMID:  33037128
• The histone H3K27 demethylase REF6/JMJ12 promotes thermomorphogenesis in Arabidopsis.   DOI:  10.1093/nsr/nwab213 ;  PMID:  35591912
• The Histone H3K27 Demethylase REF6 Is a Positive Regulator of Light-Initiated Seed Germination in Arabidopsis.   DOI:  10.3390/cells12020295 ;  PMID:  36672228
• Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway.   DOI:  10.1093/genetics/139.3.1393 ;  PMID:  7768447
• Mechanically stimulated TCH3 gene expression in Arabidopsis involves protein phosphorylation and EIN6 downstream of calcium.   DOI:  10.1104/pp.010660 ;  PMID:  11950988
• Sugar and hormone connections.   DOI:  10.1016/S1360-1385(03)00011-6 ;  PMID:  12663220

Sequences: