Gene Details:

• Gene ID: AT3G48190
• Gene Symbol: ATATM, ATM, ATM-1, PIG1
• Gene Name: ARABIDOPSIS THALIANA ATAXIA-TELANGIECTASIA MUTATED, ataxia-telangiectasia mutated, TAXIA-TELANGIECTASIA MUTATED 1, pcd in male gametogenesis 1
• Description: Serine/Threonine-kinase ATM-like protein;(source:Araport11)
• TAIR Accession: locus:2100459
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G48190.1     AT3G48190.2     AT3G48190.3

Plant Ontology Annotations:

• PO:0000282  — trichome — tricoma (Spanish, exact), 毛茸、糸状体、毛 (Japanese, exact), seta (related), setae (related), capilli (narrow), capillus (narrow), cilia (narrow), cilium (narrow), glochid (narrow), glochidia (narrow), glochidium (narrow), hair (narrow), lepides (narrow), lepis (narrow), non-secretory trichome (narrow), scale (narrow), squama (narrow), squamae (narrow), squamella (narrow), squamellae (narrow), squamule (narrow), barb trichome (broad), bristle (broad)
• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Gene Ontology:

• GO:0007129  — acts upstream of or within — homologous chromosome pairing at meiosis
• GO:0051321  — acts upstream of or within — meiotic cell cycle
• GO:0010332  — acts upstream of or within — response to gamma radiation
• GO:0006281  — involved in — DNA repair
• GO:0009506  — located in — plasmodesma
• GO:0006303  — acts upstream of or within — double-strand break repair via nonhomologous end joining
• GO:0006974  — involved in — DNA damage response
• GO:0010212  — acts upstream of or within — response to ionizing radiation
• GO:0032204  — acts upstream of or within — regulation of telomere maintenance
• GO:0006281  — acts upstream of or within — DNA repair
• GO:0045003  — acts upstream of or within — double-strand break repair via synthesis-dependent strand annealing
• GO:0005515  — enables — protein binding
• GO:0006974  — acts upstream of or within — DNA damage response
• GO:0005634  — located in — nucleus
• GO:0032504  — acts upstream of or within — multicellular organism reproduction
• GO:0043247  — acts upstream of or within — telomere maintenance in response to DNA damage
• GO:0000285  — enables — 1-phosphatidylinositol-3-phosphate 5-kinase activity
• GO:0004674  — enables — protein serine/threonine kinase activity
• GO:0008380  — involved in — RNA splicing
• GO:0033044  — acts upstream of or within — regulation of chromosome organization

Germplasm Phenotype:

• atm / tert  — During five generations of growth, both tert and atm/tert lose about 500 bp of chromosome length per generation. But, whereas tert mutants show no visible growth defects through the G6 generation, atm/tert mutants in G5 show severe growth defects, such as aberrant leaf shape, delayed flowering, a loss of apical dominance, and reduced fertility. atm/tert mutants in G5 have a much higher rate of bridged chromosomes than G5 tert mutants.
• atm / tert  — atm tert mutants undergo Telomere Rapid Deletion (TRD) events, that can lead to the production of a chromosome with a very short telomere. Just one of these structures can prompt end-to-end chromosomal fusion events in the G5 generation. The anaphase bridges apparent in these atm/tert mutants seem to involve only a single chromosome in each distinct mutant line, and seem to occur between sister chromatids. These plants exhibit the same overall level of aneuploidy in the G5 generation as tert mutants do in the G6 generation (~52% of cells showing abnormal centromeric signals in interphase). atm/tert mutants are not as likely to undergo ALT (alternative lengthening of telomeres, a telomerase-independent process) as tert mutants, implicating ATM in this process.
• atm-2 fancd2-1  — Fertility reduced to 0.9 (±1.9; n=317 siliques) seeds per silique.
• atr/atm  — Double mutants are defective in telomere maintainance. Mutants form anaphase bridges.
• fan1-2 atm-2  — Severe chromosome fragmentation and a drastic reduction of fertility (1.9 ± 2.8; n=123 siliques), compared to atm-2 single mutants (6.8 ± 7.2; n=364 siliques; p<0.0001).

Function-related keywords:

• trichome ,  shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  guard cell

Literature:

• Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related.   DOI:  10.1091/mbc.e04-10-0890 ;  PMID:  15772150
• ATR and ATM play both distinct and additive roles in response to ionizing radiation.   DOI:  10.1111/j.1365-313X.2006.02931.x ;  PMID:  17227549
• Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint.   DOI:  10.1105/tpc.106.045047 ;  PMID:  17209125
• NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants.   DOI:  10.1111/j.1365-313X.2007.03220.x ;  PMID:  17672843
• Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage.   DOI:  10.1073/pnas.0810304106 ;  PMID:  19549833
• Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.   DOI:  10.1104/pp.109.140053 ;  PMID:  19571309
• A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana.   DOI:  10.1371/journal.pgen.1000613 ;  PMID:  19696887
• A shared DNA-damage-response pathway for induction of stem-cell death by UVB and by gamma irradiation.   DOI:  10.1016/j.dnarep.2010.06.006 ;  PMID:  20634150
• Arabidopsis homologues of the histone chaperone ASF1 are crucial for chromatin replication and cell proliferation in plant development.   DOI:  10.1111/j.1365-313X.2011.04504.x ;  PMID:  21251110
• Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis.   DOI:  10.1073/pnas.1103584108 ;  PMID:  21613568
• The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage.   DOI:  10.1111/j.1365-313X.2011.04718.x ;  PMID:  21781195
• Breadth by depth: expanding our understanding of the repair of transposon-induced DNA double strand breaks via deep-sequencing.   DOI:  10.1016/j.dnarep.2011.07.011 ;  PMID:  21889425
• Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.   DOI:  10.1105/tpc.111.092387 ;  PMID:  22158468
• The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development.   DOI:  10.1104/pp.113.216796 ;  PMID:  23616603
• Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress.   DOI:  10.1093/pcp/pct051 ;  PMID:  23574700
• The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.   DOI:  10.1105/tpc.113.118943 ;  PMID:  24399300
• ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.   DOI:  10.1038/embor.2013.112 ;  PMID:  23907539
• Evidence for distinct functions of MRE11 in Arabidopsis meiosis.   DOI:  10.1371/journal.pone.0078760 ;  PMID:  24205310
• Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses.   DOI:  10.1371/journal.ppat.1004030 ;  PMID:  24699527
• Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.   DOI:  10.1074/mcp.M114.040352 ;  PMID:  25561503
• Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.   DOI:  10.1111/tpj.12779 ;  PMID:  25641249
• Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation.   DOI:  10.1038/srep15892 ;  PMID:  26516022
• DNA Damage-Induced Transcription of Transposable Elements and Long Non-coding RNAs in Arabidopsis Is Rare and ATM-Dependent.   DOI:  10.1016/j.molp.2016.04.015 ;  PMID:  27150037
• Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.   DOI:  10.1104/pp.17.00031 ;  PMID:  28153919
• Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.   DOI:  10.1105/tpc.17.00745 ;  PMID:  29352063
• Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots.   DOI:  10.1016/j.chemosphere.2018.03.017 ;  PMID:  29533809
• Histone chaperones play crucial roles in maintenance of stem cell niche during plant root development.   DOI:  10.1111/tpj.13933 ;  PMID:  29676825
• Ser-Gln sites of SOG1 are rapidly hyperphosphorylated in response to DNA double-strand breaks.   DOI:  10.1080/15592324.2018.1477904 ;  PMID:  29939818
• The HEM Lines: A New Library of Homozygous Arabidopsis thaliana EMS Mutants and its Potential to Detect Meiotic Phenotypes.   DOI:  10.3389/fpls.2018.01339 ;  PMID:  30283471
• role of SUPPRESSOR OF GAMMA RESPONSE 1: An overview.   DOI:  10.1016/j.mrfmmm.2020.111689 ;  PMID:  32004947
• ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis.   DOI:  10.3389/fpls.2020.00839 ;  PMID:  32670319
• RAB GTPASE HOMOLOG 8D is required for the maintenance of both the root stem cell niche and the meristem.   DOI:  10.1111/tpj.15106 ;  PMID:  33258210
• ATM controls meiotic DNA double-strand break formation and recombination and affects synaptonemal complex organization in plants.   DOI:  10.1093/plcell/koab045 ;  PMID:  33659989
• Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.   DOI:  10.1093/plcell/koab005 ;  PMID:  33793856
• SOG1 transcription factor promotes the onset of endoreduplication under salinity stress in Arabidopsis.   DOI:  10.1038/s41598-021-91293-1 ;  PMID:  34079040
• Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight.   DOI:  10.3390/genes12060938 ;  PMID:  34205326
• Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin.   DOI:  10.1016/j.dnarep.2021.103174 ;  PMID:  34256304
• G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.   DOI:  10.1093/plphys/kiab201 ;  PMID:  34618100
• The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.   DOI:  10.1093/plcell/koab282 ;  PMID:  34791445
• Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.   DOI:  10.1111/jipb.13200 ;  PMID:  34859586
• Ultraviolet-B Radiation Represses Primary Root Elongation by Inhibiting Cell Proliferation in the Meristematic Zone of Arabidopsis Seedlings.   DOI:  10.3389/fpls.2022.829336 ;  PMID:  35401611
• Identification and Characterization of SOG1 (Suppressor of Gamma Response 1) Homologues in Plants Using Data Mining Resources and Gene Expression Profiling.   DOI:  10.3390/genes13040667 ;  PMID:  35456473
• The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development.   DOI:  10.1093/plcell/koac207 ;  PMID:  35861422
• The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions.   DOI:  10.1016/j.cub.2004.02.039 ;  PMID:  15028209
• Cell-specific protein profiling in Arabidopsis thaliana trichomes: identification of trichome-located proteins involved in sulfur metabolism and detoxification.   DOI:  10.1016/j.phytochem.2004.03.026 ;  PMID:  15276459
• NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants.   DOI:  10.1111/j.1365-313X.2007.03220.x ;  PMID:  17672843

Sequences: