Gene Details:

• Gene ID: AT3G47520
• Gene Symbol: MDH, pNAD-MDH
• Gene Name: malate dehydrogenase, plastidic NAD-dependent malate dehydrogenase
• Description: malate dehydrogenase;(source:Araport11)
• TAIR Accession: locus:2079177
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G47520.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)

Gene Ontology:

• GO:0006108  — involved in — malate metabolic process
• GO:0005829  — located in — cytosol
• GO:0009706  — located in — chloroplast inner membrane
• GO:0009570  — located in — chloroplast stroma
• GO:0042742  — acts upstream of or within — defense response to bacterium
• GO:0016464  — enables — chloroplast protein-transporting ATPase activity
• GO:0009793  — acts upstream of or within — embryo development ending in seed dormancy
• GO:0005739  — located in — mitochondrion
• GO:0005737  — is active in — cytoplasm
• GO:0030060  — enables — L-malate dehydrogenase activity
• GO:0005515  — enables — protein binding
• GO:0010319  — located in — stromule
• GO:0009409  — acts upstream of or within — response to cold
• GO:0009507  — located in — chloroplast
• GO:0048046  — located in — apoplast
• GO:0009941  — located in — chloroplast envelope
• GO:0009532  — located in — plastid stroma
• GO:0009536  — located in — plastid
• GO:0000325  — located in — plant-type vacuole
• GO:0045037  — acts upstream of or within — protein import into chloroplast stroma
• GO:0008746  — enables — NAD(P)+ transhydrogenase activity
• GO:0009658  — acts upstream of or within — chloroplast organization
• GO:0062091  — part of — Ycf2/FtsHi complex

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  pollen ,  guard cell

Literature:

• Genomic analysis of a nutrient response in Arabidopsis reveals diverse expression patterns and novel metabolic and potential regulatory genes induced by nitrate.   DOI:  10.1105/tpc.12.8.1491 ;  PMID:  10948265
• A novel, non-redox-regulated NAD-dependent malate dehydrogenase from chloroplasts of Arabidopsis thaliana L.   DOI:  10.1074/jbc.273.43.27927 ;  PMID:  9774405
• Evidence for five divergent thioredoxin h sequences in Arabidopsis thaliana.   DOI:  10.1073/pnas.92.12.5620 ;  PMID:  7777559
• Arabidopsis thaliana plants lacking the PSI-D subunit of photosystem I suffer severe photoinhibition, have unstable photosystem I complexes, and altered redox homeostasis in the chloroplast stroma.   DOI:  10.1074/jbc.M305106200 ;  PMID:  12794067
• Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins.   DOI:  10.1105/tpc.016055 ;  PMID:  14671022
• The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show and long-term exposure to low temperature.   DOI:  10.1111/j.1365-313X.2006.02821.x ;  PMID:  16923014
• Deficiency of Arabidopsis thaliana frataxin alters activity of mitochondrial Fe-S proteins and induces oxidative stress.   DOI:  10.1111/j.1365-313X.2006.02923.x ;  PMID:  17092311
• Peroxisomal malate dehydrogenase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release.   DOI:  10.1104/pp.108.122622 ;  PMID:  18685043
• Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis.   DOI:  10.1104/pp.110.171595 ;  PMID:  21311031
• Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.   DOI:  10.1093/jxb/err386 ;  PMID:  22140244
• Serine/threonine protein phosphatase 5 (PP5) interacts with substrate under heat stress conditions and forms protein complex in Arabidopsis.   DOI:  10.4161/psb.19699 ;  PMID:  22516824
• A proteomics approach identifies novel proteins involved in gravitropic signal transduction.   DOI:  10.3732/ajb.1200339 ;  PMID:  23281391
• Proteome and metabolome profiling of cytokinin action in Arabidopsis identifying and up-regulation.   DOI:  10.1093/jxb/ert227 ;  PMID:  24064926
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• 2-Hydroxy Acids in Plant Metabolism.   DOI:  10.1199/tab.0182 ;  PMID:  26380567
• Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by 13C labelling.   DOI:  10.1093/jxb/erw030 ;  PMID:  26889011
• Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana.   DOI:  10.1038/s41422-018-0024-8 ;  PMID:  29540758
• Plastidial NAD-Dependent Malate Dehydrogenase: A Moonlighting Protein Involved in Early Chloroplast Development through Its Interaction with an FtsH12-FtsHi Protease Complex.   DOI:  10.1105/tpc.18.00121 ;  PMID:  29934433
• A Ycf2-FtsHi Heteromeric AAA-ATPase Complex Is Required for Chloroplast Protein Import.   DOI:  10.1105/tpc.18.00357 ;  PMID:  30309901
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis.   DOI:  10.3390/antiox9060515 ;  PMID:  32545358
• Antagonistic Regulation by CPN60A and CLPC1 of TRXL1 that Regulates MDH Activity Leading to Plant Disease Resistance and Thermotolerance.   DOI:  10.1016/j.celrep.2020.108512 ;  PMID:  33326777
• Acetylation of conserved lysines fine-tunes mitochondrial malate dehydrogenase activity in land plants.   DOI:  10.1111/tpj.15556 ;  PMID:  34713507
• A novel, non-redox-regulated NAD-dependent malate dehydrogenase from chloroplasts of Arabidopsis thaliana L.   DOI:  10.1074/jbc.273.43.27927 ;  PMID:  9774405
• Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana.   DOI:  10.1074/mcp.M300030-MCP200 ;  PMID:  12766230
• Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins.   DOI:  10.1105/tpc.016055 ;  PMID:  14671022
• The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions.   DOI:  10.1016/j.cub.2004.02.039 ;  PMID:  15028209
• Proteome mapping of mature pollen of Arabidopsis thaliana.   DOI:  10.1002/pmic.200402011 ;  PMID:  16247729
• The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show and long-term exposure to low temperature.   DOI:  10.1111/j.1365-313X.2006.02821.x ;  PMID:  16923014
• A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture.   DOI:  10.1074/mcp.M600250-MCP200 ;  PMID:  17151019
• Membrane proteomic analysis of Arabidopsis thaliana using alternative solubilization techniques.   DOI:  10.1021/pr060525b ;  PMID:  17432890
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481
• Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study.   DOI:  10.1016/j.phytochem.2008.04.007 ;  PMID:  18538804
• Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis.   DOI:  10.1104/pp.108.124545 ;  PMID:  18633119
• The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts.   DOI:  10.1074/mcp.M500180-MCP200 ;  PMID:  16207701
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: