Gene Details:

• Gene ID: AT3G47450
• Gene Symbol: ATNOA1, ATNOS1, NOA1, NOS1, RIF1, SVR10
• Gene Name: NO ASSOCIATED 1, NITRIC OXIDE SYNTHASE 1, RESISTANT TO INHIBITION WITH FOSMIDOMYCIN 1, SUPPRESSOR OF VARIEGATION 10
• Description: P-loop containing nucleoside triphosphate hydrolases superfamily protein;(source:Araport11)
• TAIR Accession: locus:2099520
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G47450.1     AT3G47450.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Gene Ontology:

• GO:0005739  — located in — mitochondrion
• GO:0009507  — located in — chloroplast
• GO:0010322  — acts upstream of or within — regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
• GO:0006979  — acts upstream of or within — response to oxidative stress
• GO:0048366  — acts upstream of or within — leaf development
• GO:0009657  — acts upstream of or within — plastid organization
• GO:0006809  — acts upstream of or within — nitric oxide biosynthetic process
• GO:0009651  — involved in — response to salt stress
• GO:0051246  — acts upstream of or within — regulation of protein metabolic process
• GO:0010027  — acts upstream of or within — thylakoid membrane organization
• GO:0010193  — acts upstream of or within — response to ozone
• GO:0003924  — enables — GTPase activity

Germplasm Phenotype:

• CS25735  — rif1-3 mutants are pale green with delayed leaf development. They are resistant to fosmidomycin, an inhibitor of the isoprenoid biosynthetic enzyme DXP
• CS6511  — Not impaired in NO biosynthesis in response to exogenous H2O2 compared to wild-type.
• CS6511  — Reduced nitric oxide synthase (NOS) production in leaves and root tips; impaired organ growth: yellowish first true leaves, reduced root and inflorescence growth, reduced fertility; defective abscisic acid- induced stomatal movements; kanamycin resistant
• CS6511  — Significantly impaired in NO biosynthesis in response to ABA compared to wild-type.
• CS6511  — Stomatal aperture not affected by treatment with sodium nitroprusside (SNP).
• CS6511  — rif1-2 mutants are pale green with delayed leaf development. They are resistant to fosmidomycin, an inhibitor of the isoprenoid biosynthetic enzyme DXR
• CS6511  — sensitive to ozone (O3)
• rif1-1  — rif1-1 mutants are pale green with delayed leaf development. They have a strong resistance to fosmidomycin (FSM), an inhibitor of the isoprenoid biosynthetic enzyme DXR. The reduced rate of degradation of DXS and DXR in rif1-1 mutants leads to a higher accumulation of these two MEP biosynthetic enzymes. Though RIF1 was originally believed to be an NO-synthase, treatment with an NO donor, does not rescue the DXR over-accumulation phenotype, implying that this is not an NO-dependent phenotype. There is a reduction in the level of the large subunit of Rubisco, and two other plastid-encoded proteins in the rif1-1 mutant, however, levels of the plastid-encoded ClpP1 protease are elevated in rif1-1 mutants, compared to wild type seedlings. A plastid-targeted YqeH-GFP construct can rescue the growth, pigmentation, and FSM-resistance phenotypes of rif1-1. YqeH is a GTPase implicated in ribosomal biogenesis in bacteria.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure

Literature:

• ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis.   DOI:  10.1111/j.1365-313X.2005.02615.x ;  PMID:  16367958
• A mutant impaired in the production of plastome-encoded proteins uncovers a mechanism for the homeostasis of isoprenoid biosynthetic enzymes in Arabidopsis plastids.   DOI:  10.1105/tpc.108.058768 ;  PMID:  18469163
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Nitric oxide modulates ozone-induced cell death, hormone biosynthesis and gene expression in Arabidopsis thaliana.   DOI:  10.1111/j.1365-313X.2008.03756.x ;  PMID:  19054359
• A signaling pathway linking nitric oxide production to heterotrimeric G protein and hydrogen peroxide regulates extracellular calmodulin induction of stomatal closure in Arabidopsis.   DOI:  10.1104/pp.109.137067 ;  PMID:  19321706
• Verticillium dahliae toxins-induced nitric oxide production in Arabidopsis is major dependent on nitrate reductase.   DOI:  10.5483/bmbrep.2008.41.1.079 ;  PMID:  18304455
• Nitric oxide functions as a positive regulator of root hair development.   DOI:  10.4161/psb.1.1.2398 ;  PMID:  19521473
• Nitric reductase-dependent nitric oxide production is involved in cold acclimation and freezing tolerance in Arabidopsis.   DOI:  10.1104/pp.109.140996 ;  PMID:  19710235
• Targeting of pollen tubes to ovules is dependent on nitric oxide (NO) signaling.   DOI:  10.1093/mp/ssn034 ;  PMID:  19825574
• Enhanced abscisic acid-mediated responses in nia1nia2noa1-2 triple mutant and AtNOA1-dependent nitric oxide biosynthesis in Arabidopsis.   DOI:  10.1104/pp.109.148023 ;  PMID:  20007448
• Nitric oxide acts downstream of auxin to trigger root ferric-chelate reductase activity in response to iron deficiency in Arabidopsis.   DOI:  10.1104/pp.110.161109 ;  PMID:  20699398
• Nitric oxide is involved in alkamide-induced lateral root development in Arabidopsis.   DOI:  10.1093/pcp/pcq117 ;  PMID:  20685967
• Identification of nuclear genes encoding chloroplast-localized proteins required for embryo development in Arabidopsis.   DOI:  10.1104/pp.110.168120 ;  PMID:  21139083
• Oleic acid-dependent modulation of NITRIC OXIDE ASSOCIATED1 protein levels regulates nitric oxide-mediated defense signaling in Arabidopsis.   DOI:  10.1105/tpc.112.096768 ;  PMID:  22492810
• Roles of NIA/NR/NOA1-dependent nitric oxide production and HY1 expression in the modulation of Arabidopsis salt tolerance.   DOI:  10.1093/jxb/ert149 ;  PMID:  23744476
• Hydrogen peroxide acts upstream of nitric oxide in the heat shock pathway in Arabidopsis seedlings.   DOI:  10.1104/pp.113.229369 ;  PMID:  24510762
• Nitric oxide and hydrogen peroxide are important signals mediating the allelopathic response of Arabidopsis to p-hydroxybenzoic acid.   DOI:  10.1111/ppl.12164 ;  PMID:  24502504
• Nitric oxide plays a role in stem cell niche homeostasis through its interaction with auxin.   DOI:  10.1104/pp.114.247445 ;  PMID:  25315603
• NITRIC OXIDE-ASSOCIATED PROTEIN1 (AtNOA1) is essential for salicylic acid-induced root waving in Arabidopsis thaliana.   DOI:  10.1111/nph.13327 ;  PMID:  25690466
• Mutations in circularly permuted GTPase family genes AtNOA1/RIF1/SVR10 and BPG2 suppress var2-mediated leaf variegation in Arabidopsis thaliana.   DOI:  10.1007/s11120-015-0195-9 ;  PMID:  26435530
• Elevated CO2-induced production of nitric oxide (NO) by NO synthase differentially affects nitrate reductase activity in Arabidopsis plants under different nitrate supplies.   DOI:  10.1093/jxb/erv506 ;  PMID:  26608644
• Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.   DOI:  10.3389/fpls.2016.00112 ;  PMID:  27014280
• Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.   DOI:  10.1016/j.plantsci.2016.08.005 ;  PMID:  27717464
• Nitric oxide participates in plant flowering repression by ascorbate.   DOI:  10.1038/srep35246 ;  PMID:  27731387
• Nitric Oxide Controls Constitutive Freezing Tolerance in Arabidopsis by Attenuating the Levels of Osmoprotectants, Stress-Related Hormones and Anthocyanins.   DOI:  10.1038/s41598-018-27668-8 ;  PMID:  29915353
• Atnoa1 and Atnia1nia2noa1-2 produce nitric oxide in MS growth medium and on uranium exposure.   DOI:  10.1016/j.plaphy.2019.04.042 ;  PMID:  31078053
• Cyclic nucleotide-gated ion channel 6 mediates thermotolerance in Arabidopsis seedlings by regulating nitric oxide production via cytosolic calcium ions.   DOI:  10.1186/s12870-019-1974-9 ;  PMID:  31429706
• Multi-Walled Carbon Nanotubes Can Promote Brassica napus L. and Arabidopsis thaliana L. Root Hair Development through Nitric Oxide and Ethylene Pathways.   DOI:  10.3390/ijms21239109 ;  PMID:  33266061
• Nitric Oxide Alters the Pattern of Auxin Maxima and PIN-FORMED1 During Shoot Development.   DOI:  10.3389/fpls.2021.630792 ;  PMID:  34122465
• Salicylic acid activates nitric oxide synthesis in Arabidopsis.   DOI:  10.1093/jxb/erm001 ;  PMID:  17317674
• Exogenous auxin-induced NO synthesis is nitrate reductase-associated in Arabidopsis thaliana root primordia.   DOI:  10.1016/j.jplph.2007.07.019 ;  PMID:  17936409
• Zeatin-induced nitric oxide (NO) biosynthesis in Arabidopsis thaliana mutants of NO biosynthesis and of two-component signaling genes.   DOI:  10.1111/j.1469-8137.2008.02383.x ;  PMID:  18298431
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481
• A mutant impaired in the production of plastome-encoded proteins uncovers a mechanism for the homeostasis of isoprenoid biosynthetic enzymes in Arabidopsis plastids.   DOI:  10.1105/tpc.108.058768 ;  PMID:  18469163

Sequences: