Gene Details:

• Gene ID: AT3G43920
• Gene Symbol: ATDCL3, DCL3
• Gene Name: DICER-LIKE 3, dicer-like 3
• Description: dicer-like 3;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G43920.1     AT3G43920.2     AT3G43920.3     AT3G43920.4     AT3G43920.6     AT3G43920.5

Plant Ontology Annotations:

• PO:0009049  — inflorescence — inflorescencia (Spanish, exact), 花序 (Japanese, exact), Triticeae spike (narrow)
• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Germplasm Phenotype:

• CS16390  — No visible phenotype.
• CS16391  — Subtle elongation of leaves resulting in less rounded tips at early stages of development.
• CS16393  — No visible phenotype.
• CS66484  — similar to rdr6-15 phenotype: homozygous individuals have elongated, downwardly curled rosette leaves; early rosette leaves have higher length/width ratios than those of Col-0.
• CS69179  — No visible phenotype.
• CS9606  — impaired in siRNA production and some aspects of gene silencing

Function-related keywords:

• inflorescence ,  shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure

Literature:

• Genetic and functional diversification of small RNA pathways in plants.   DOI:  10.1371/journal.pbio.0020104 ;  PMID:  15024409
• Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs.   DOI:  10.1016/j.molcel.2004.09.028 ;  PMID:  15469823
• microRNA-directed phasing during trans-acting siRNA biogenesis in plants.   DOI:  10.1016/j.cell.2005.04.004 ;  PMID:  15851028
• RNA polymerase IV directs silencing of endogenous DNA.   DOI:  10.1126/science.1106910 ;  PMID:  15692015
• Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs.   DOI:  10.1016/j.cub.2005.07.024 ;  PMID:  16040244
• It's a small RNA world, after all.   DOI:  10.1126/science.1117805 ;  PMID:  16141062
• Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana.   DOI:  10.1007/s11103-004-6853-5 ;  PMID:  15821876
• Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning.   DOI:  10.1038/ng1804 ;  PMID:  16699516
• The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center.   DOI:  10.1016/j.cell.2006.05.031 ;  PMID:  16839878
• An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs.   DOI:  10.1038/sj.emboj.7601217 ;  PMID:  16810317
• Two-step recruitment of RNA-directed DNA methylation to tandem repeats.   DOI:  10.1371/journal.pbio.0040363 ;  PMID:  17105345
• Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing.   DOI:  10.1093/nar/gkl886 ;  PMID:  17090584
• RNA silencing of host transcripts by cauliflower mosaic virus requires coordinated action of the four Arabidopsis Dicer-like proteins.   DOI:  10.1073/pnas.0604627103 ;  PMID:  17164336
• Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC.   DOI:  10.1073/pnas.0611459104 ;  PMID:  17360694
• Role of RNA polymerase IV in plant small RNA metabolism.   DOI:  10.1073/pnas.0611456104 ;  PMID:  17360559
• Cell biology of the Arabidopsis nuclear siRNA pathway for RNA-directed chromatin modification.   DOI:  10.1101/sqb.2006.71.046 ;  PMID:  17381329
• An SNF2 protein associated with nuclear RNA silencing and the spread of a silencing signal between cells in Arabidopsis.   DOI:  10.1105/tpc.107.051540 ;  PMID:  17526749
• Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs.   DOI:  10.1105/tpc.106.047449 ;  PMID:  17586651
• and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways.   DOI:  10.1038/ng2081 ;  PMID:  17558406
• Transcript profiling of the hypomethylated hog1 mutant of Arabidopsis.   DOI:  10.1007/s11103-007-9221-4 ;  PMID:  17786563
• Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis.   DOI:  10.1073/pnas.0706701104 ;  PMID:  17785412
• ARGONAUTE4 is required for resistance to Pseudomonas syringae in Arabidopsis.   DOI:  10.1105/tpc.107.054494 ;  PMID:  17993621
• The roles of plant dsRNA-binding proteins in RNAi-like pathways.   DOI:  10.1016/j.febslet.2008.07.004 ;  PMID:  18625233
• Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.   DOI:  10.1073/pnas.0805760105 ;  PMID:  18799732
• Evolution of Arabidopsis MIR genes generates novel microRNA classes.   DOI:  10.1093/nar/gkn670 ;  PMID:  18842626
• Dicer-like (DCL) proteins in plants.   DOI:  10.1007/s10142-009-0111-5 ;  PMID:  19221817
• Structural and genetic requirements for the biogenesis of tobacco rattle virus-derived small interfering RNAs.   DOI:  10.1128/JVI.00272-08 ;  PMID:  18353962
• Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins.   DOI:  10.1016/j.molcel.2008.11.009 ;  PMID:  19061642
• Computational and analytical framework for small RNA profiling by high-throughput sequencing.   DOI:  10.1261/rna.1473809 ;  PMID:  19307293
• RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independently of the 24-nt siRNA-directed DNA methylation pathway.   DOI:  10.1093/mp/ssp006 ;  PMID:  19825650
• Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.   DOI:  10.1101/gad.1908710 ;  PMID:  20439431
• siRNAs from miRNA sites mediate DNA methylation of target genes.   DOI:  10.1093/nar/gkq590 ;  PMID:  20621980
• Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome.   DOI:  10.1073/pnas.1012891107 ;  PMID:  20870966
• A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA.   DOI:  10.1371/journal.pgen.1000690 ;  PMID:  19834541
• Differential sensitivity of Arabidopsis siRNA biogenesis mutants to genotoxic stress.   DOI:  10.1007/s00299-010-0930-9 ;  PMID:  20953786
• Transcriptional silencing induced by Arabidopsis T-DNA mutants is associated with 35S promoter siRNAs and requires genes involved in siRNA-mediated chromatin silencing.   DOI:  10.1111/j.1365-313X.2010.04358.x ;  PMID:  21070421
• An siRNA pathway prevents transgenerational retrotransposition in plants subjected to stress.   DOI:  10.1038/nature09861 ;  PMID:  21399627
• Mutations in the antiviral RNAi defense pathway modify Brome mosaic virus RNA recombinant profiles.   DOI:  10.1094/MPMI-05-11-0137 ;  PMID:  21936664
• The splicing factor SR45 affects the RNA-directed DNA methylation pathway in Arabidopsis.   DOI:  10.4161/epi.7.1.18782 ;  PMID:  22274613
• Herbivory in the previous generation primes plants for enhanced insect resistance.   DOI:  10.1104/pp.111.187831 ;  PMID:  22209873
• Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function.   DOI:  10.1186/gb-2012-13-3-r20 ;  PMID:  22439910
• Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.   DOI:  10.1016/j.cell.2012.10.054 ;  PMID:  23313553
• Protein-coding cis-natural antisense transcripts have high and broad expression in Arabidopsis.   DOI:  10.1104/pp.112.212100 ;  PMID:  23457227
• Arabidopsis double-stranded RNA binding protein DRB3 participates in methylation-mediated defense against geminiviruses.   DOI:  10.1128/JVI.02305-13 ;  PMID:  24352449
• Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants.   DOI:  10.1093/jxb/eru447 ;  PMID:  25385769
• The rolB gene activates the expression of genes encoding microRNA processing machinery.   DOI:  10.1007/s10529-014-1743-7 ;  PMID:  25491479
• PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis.   DOI:  10.1371/journal.pgen.1004841 ;  PMID:  25474114
• DICER-LIKE1 processed trans-acting siRNAs mediate DNA methylation: case study of complex small RNA biogenesis and action pathways in plants.   DOI:  10.4161/psb.22476 ;  PMID:  23104109
• CMA33/XCT Regulates Small RNA Production through Modulating the Transcription of Dicer-Like Genes in Arabidopsis.   DOI:  10.1016/j.molp.2015.03.002 ;  PMID:  25770820
• Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing.   DOI:  10.1105/tpc.15.00264 ;  PMID:  26023161
• Retraction for Moissiard and Voinnet, RNA silencing of host transcripts by cauliflower mosaic virus requires coordinated action of the four Arabidopsis Dicer-like proteins.   DOI:  10.1073/pnas.1513620112 ;  PMID:  26216957
• Dicer-independent RNA-directed DNA methylation in Arabidopsis.   DOI:  10.1038/cr.2015.145 ;  PMID:  26642813
• A Dicer-Independent Route for Biogenesis of siRNAs that Direct DNA Methylation in Arabidopsis.   DOI:  10.1016/j.molcel.2015.11.015 ;  PMID:  26711010
• Arabidopsis thaliana siRNA biogenesis mutants have the lower frequency of homologous recombination.   DOI:  10.1080/15592324.2016.1151599 ;  PMID:  26901311
• Antiviral Defense Involves AGO4 in an Arabidopsis-Potexvirus Interaction.   DOI:  10.1094/MPMI-09-16-0188-R ;  PMID:  27762650
• A complex of Arabidopsis DRB proteins can impair dsRNA processing.   DOI:  10.1261/rna.059519.116 ;  PMID:  28232389
• DAWDLE Interacts with DICER-LIKE Proteins to Mediate Small RNA Biogenesis.   DOI:  10.1104/pp.18.00354 ;  PMID:  29784765
• APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.   DOI:  10.1105/tpc.18.00287 ;  PMID:  30135084
• Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation.   DOI:  10.1038/s41467-018-07010-6 ;  PMID:  30385760
• Analysis of siRNA Precursors Generated by RNA Polymerase IV and RNA-Dependent RNA Polymerase 2 in Arabidopsis.   DOI:  10.1007/978-1-4939-9045-0_2 ;  PMID:  30945177
• Chemical enhancers of posttranscriptional gene silencing in Arabidopsis.   DOI:  10.1261/rna.068627.118 ;  PMID:  31164480
• Crosstalk between epigenetic silencing and infection by tobacco rattle virus in Arabidopsis.   DOI:  10.1111/mpp.12850 ;  PMID:  31274236
• Post-transcriptional gene silencing triggers dispensable DNA methylation in gene body in Arabidopsis.   DOI:  10.1093/nar/gkz636 ;  PMID:  31372641
• Developmentally regulated Arabidopsis thaliana susceptibility to tomato spotted wilt virus infection.   DOI:  10.1111/mpp.12944 ;  PMID:  32441865
• Role of the RNA-directed DNA Methylation pathway in the regulation of maternal effects in Arabidopsis thaliana seed germination.   DOI:  10.17912/micropub.biology.000504 ;  PMID:  34901781
• The RNA-binding protein RBP45D of Arabidopsis promotes transgene silencing and flowering time.   DOI:  10.1111/tpj.15637 ;  PMID:  34919766
• Arabidopsis Trithorax histone methyltransferases are redundant in regulating development and DNA methylation.   DOI:  10.1111/jipb.13406 ;  PMID:  36354145
• RETINOBLASTOMA-RELATED interactions with key factors of the RNA-directed DNA methylation (RdDM) pathway and its influence on root development.   DOI:  10.1007/s00425-023-04135-x ;  PMID:  37120771

Sequences: