Gene Details:

• Gene ID: AT3G26744
• Gene Symbol: ATICE1, ICE1, SCREAM, SCRM
• Gene Name: A. THALIANA INDUCER OF CBP EXPRESSION 1, INDUCER OF CBF EXPRESSION 1, , SCREAM
• Description: basic helix-loop-helix (bHLH) DNA-binding superfamily protein;(source:Araport11)
• TAIR Accession: locus:2090847
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G26744.1     AT3G26744.4     AT3G26744.2     AT3G26744.5     AT3G26744.6

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0002000  — stomatal complex — complejo estomático (Spanish, exact), stomatal apparatus (exact), stomate (exact), 気孔装置 (Japanese, exact), stoma (broad), stomata (broad)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
• PO:0000293  — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)
• PO:0000263  — non-hair root epidermal cell — atrichoblast (exact), atricoblasto (Spanish, exact), 非毛根形成細胞、アトリコブラスト (Japanese, exact), non-hair cell (broad)

Gene Ontology:

• GO:0010162  — acts upstream of or within — seed dormancy process
• GO:0045892  — acts upstream of or within — negative regulation of DNA-templated transcription
• GO:0005634  — located in — nucleus
• GO:0048317  — acts upstream of or within — seed morphogenesis
• GO:0000976  — enables — transcription cis-regulatory region binding
• GO:0009738  — acts upstream of or within — abscisic acid-activated signaling pathway
• GO:0010115  — acts upstream of or within — regulation of abscisic acid biosynthetic process
• GO:0009409  — acts upstream of or within — response to cold
• GO:0005515  — enables — protein binding
• GO:0046983  — enables — protein dimerization activity
• GO:0001046  — enables — core promoter sequence-specific DNA binding
• GO:0009960  — acts upstream of or within — endosperm development
• GO:0003677  — enables — DNA binding
• GO:0006355  — involved in — regulation of DNA-templated transcription
• GO:0045893  — acts upstream of or within — positive regulation of DNA-templated transcription
• GO:0003700  — enables — DNA-binding transcription factor activity
• GO:0010440  — acts upstream of or within — stomatal lineage progression
• GO:0050826  — acts upstream of or within — response to freezing
• GO:0000987  — enables — cis-regulatory region sequence-specific DNA binding
• GO:0005634  — is active in — nucleus
• GO:0043565  — enables — sequence-specific DNA binding

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  stomatal complex ,  pollen tube cell ,  guard cell ,  non-hair root epidermal cell

Literature:

• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis.   DOI:  10.1101/gad.1077503 ;  PMID:  12672693
• The Arabidopsis cold-responsive transcriptome and its regulation by ICE1.   DOI:  10.1105/tpc.105.035568 ;  PMID:  16214899
• The negative regulator of plant cold responses, HOS1, is a RING E3 ligase that mediates the ubiquitination and degradation of ICE1.   DOI:  10.1073/pnas.0602874103 ;  PMID:  16702557
• Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.   DOI:  10.1111/j.1365-313X.2006.02994.x ;  PMID:  17316173
• SCREAM/ICE1 and SCREAM2 specify three cell-state transitional steps leading to arabidopsis stomatal differentiation.   DOI:  10.1105/tpc.108.060848 ;  PMID:  18641265
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Identification of ICE2, a gene involved in cold acclimation which determines freezing tolerance in Arabidopsis thaliana.   DOI:  10.1016/j.gene.2008.10.016 ;  PMID:  19026725
• Cell fate transitions during stomatal development.   DOI:  10.1002/bies.200800231 ;  PMID:  19565615
• HHP1, a novel signalling component in the cross-talk between the cold and osmotic signalling pathways in Arabidopsis.   DOI:  10.1093/jxb/erq162 ;  PMID:  20566565
• Dwarf apple MbDREB1 enhances plant tolerance to low temperature, drought, and salt stress via both ABA-dependent and ABA-independent pathways.   DOI:  10.1007/s00425-010-1279-6 ;  PMID:  20967459
• ICE1 Ser403 is necessary for protein stabilization and regulation of cold signaling and tolerance.   DOI:  10.1111/j.1365-313X.2011.04589.x ;  PMID:  21447070
• A gene regulatory network for root epidermis cell differentiation in Arabidopsis.   DOI:  10.1371/journal.pgen.1002446 ;  PMID:  22253603
• A survey of dominant mutations in Arabidopsis thaliana.   DOI:  10.1016/j.tplants.2012.08.006 ;  PMID:  22995285
• Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase.   DOI:  10.3389/fpls.2013.00001 ;  PMID:  23346092
• Jasmonate regulates the inducer of cbf expression-C-repeat binding factor/DRE binding factor1 cascade and freezing tolerance in Arabidopsis.   DOI:  10.1105/tpc.113.112631 ;  PMID:  23933884
• HOS1-mediated activation of FLC via chromatin remodeling under cold stress.   DOI:  10.4161/psb.27342 ;  PMID:  24390058
• Endosperm breakdown in Arabidopsis requires heterodimers of the basic helix-loop-helix proteins ZHOUPI and INDUCER OF CBP EXPRESSION 1.   DOI:  10.1242/dev.103531 ;  PMID:  24553285
• FAMA is an essential component for the differentiation of two distinct cell types, myrosin cells and guard cells, in Arabidopsis.   DOI:  10.1105/tpc.114.129874 ;  PMID:  25304202
• OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis.   DOI:  10.1016/j.devcel.2014.12.023 ;  PMID:  25669882
• Isolation of a WRKY30 gene from Muscadinia rotundifolia (Michx) and validation of its function under biotic and abiotic stresses.   DOI:  10.1007/s00709-015-0769-6 ;  PMID:  25643917
• The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis.   DOI:  10.1111/tpj.12866 ;  PMID:  25912720
• Identification of ICE1 as a negative regulator of ABA-dependent pathways in seeds and seedlings of Arabidopsis.   DOI:  10.1007/s11103-015-0335-9 ;  PMID:  26048037
• The unified ICE-CBF pathway provides a transcriptional feedback control of freezing tolerance during cold acclimation in Arabidopsis.   DOI:  10.1007/s11103-015-0365-3 ;  PMID:  26311645
• INDUCER OF CBF EXPRESSION 1 integrates cold signals into FLOWERING LOCUS C-mediated flowering pathways in Arabidopsis.   DOI:  10.1111/tpj.12956 ;  PMID:  26248809
• Delayed germination of Arabidopsis seeds under chilling stress by overexpressing an abiotic stress inducible GhTPS11.   DOI:  10.1016/j.gene.2015.08.056 ;  PMID:  26325072
• Burkholderia phytofirmans PsJN reduces impact of freezing temperatures on photosynthesis in Arabidopsis thaliana.   DOI:  10.3389/fpls.2015.00810 ;  PMID:  26483823
• Integration of photoperiod and cold temperature signals into flowering genetic pathways in Arabidopsis.   DOI:  10.1080/15592324.2015.1089373 ;  PMID:  26430754
• LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls.   DOI:  10.1105/tpc.15.00783 ;  PMID:  26917680
• NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.   DOI:  10.1242/dev.129098 ;  PMID:  26989174
• Molecular Framework of a Regulatory Circuit Initiating Two-Dimensional Spatial Patterning of Stomatal Lineage.   DOI:  10.1371/journal.pgen.1005374 ;  PMID:  26203655
• Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors.   DOI:  10.1016/j.devcel.2016.09.031 ;  PMID:  27923776
• Phosphorylation of the transcriptional repressor MYB15 by mitogen-activated protein kinase 6 is required for freezing tolerance in Arabidopsis.   DOI:  10.1093/nar/gkx417 ;  PMID:  28510716
• TransDetect Identifies a New Regulatory Module Controlling Phosphate Accumulation.   DOI:  10.1104/pp.17.00568 ;  PMID:  28827455
• and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis.   DOI:  10.1016/j.devcel.2017.09.025 ;  PMID:  29056553
• Role of carbon ion beams irradiation in mitigating cold stress in Arabidopsis thaliana.   DOI:  10.1016/j.ecoenv.2018.07.013 ;  PMID:  30005407
• MYC-type transcription factors, MYC67 and MYC70, interact with ICE1 and negatively regulate cold tolerance in Arabidopsis.   DOI:  10.1038/s41598-018-29722-x ;  PMID:  30072714
• bHLH093/NFL and bHLH061 are required for apical meristem function in Arabidopsis thaliana.   DOI:  10.1080/15592324.2018.1486146 ;  PMID:  30160638
• Variation in ICE1 Methylation Primarily Determines Phenotypic Variation in Freezing Tolerance in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcy197 ;  PMID:  30295898
• ICE1 and ZOU determine the depth of primary seed dormancy in Arabidopsis independently of their role in endosperm development.   DOI:  10.1111/tpj.14211 ;  PMID:  30570804
• The Transcription Factor INDUCER OF CBF EXPRESSION1 Interacts with ABSCISIC ACID INSENSITIVE5 and DELLA Proteins to Fine-Tune Abscisic Acid Signaling during Seed Germination in Arabidopsis.   DOI:  10.1105/tpc.18.00825 ;  PMID:  31123050
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• BRASSINOSTEROID-INSENSITIVE2 Negatively Regulates the Stability of Transcription Factor ICE1 in Response to Cold Stress in Arabidopsis.   DOI:  10.1105/tpc.19.00058 ;  PMID:  31409630
• The SWI/SNF ATP-Dependent Chromatin Remodeling Complex in Arabidopsis Responds to Environmental Changes in Temperature-Dependent Manner.   DOI:  10.3390/ijms21030762 ;  PMID:  31979421
• DREB1A/CBF3 Is Repressed by Transgene-Induced DNA Methylation in the Arabidopsis ice1 -1 Mutant.   DOI:  10.1105/tpc.19.00532 ;  PMID:  32034036
• The MAPK substrate MASS proteins regulate stomatal development in Arabidopsis.   DOI:  10.1371/journal.pgen.1008706 ;  PMID:  32240168
• DNA demethylase ROS1 prevents inheritable DREB1A/CBF3 repression by transgene-induced promoter methylation in the Arabidopsis ice1-1 mutant.   DOI:  10.1007/s11103-020-01061-4 ;  PMID:  33000386
• FOUR LIPS plays a role in meristemoid-to-GMC fate transition during stomatal development in Arabidopsis.   DOI:  10.1111/tpj.16146 ;  PMID:  36786686
• Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells.   DOI:  10.1111/jipb.13536 ;  PMID:  37226855
• PUB25 and PUB26 dynamically modulate ICE1 stability via differential ubiquitination during cold stress in Arabidopsis.   DOI:  10.1093/plcell/koad159 ;  PMID:  37279565
• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534

Sequences: