Gene Details:
- Gene ID: AT3G23590
- Gene Symbol: MED33A, MED5A, RFR1
- Gene Name: REF4-related 1
- Description: REF4-related 1;(source:Araport11)
- TAIR Accession:
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
Function-related keywords:
- shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen
Literature:
- Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. DOI: 10.1016/j.molcel.2007.05.007 ; PMID: 17560376
- The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis. DOI: 10.1105/tpc.109.066910 ; PMID: 19671879
- Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. DOI: 10.1016/j.diff.2010.02.003 ; PMID: 20219281
- The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. DOI: 10.1104/pp.111.188300 ; PMID: 22021418
- REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis. DOI: 10.1074/jbc.M111.312298 ; PMID: 22167189
- The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes. DOI: 10.1105/tpc.113.117796 ; PMID: 24415770
- The Mediator Complex Subunits MED14, MED15, and MED16 Are Involved in Defense Signaling Crosstalk in Arabidopsis. DOI: 10.3389/fpls.2016.01947 ; PMID: 28066497
- Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis. DOI: 10.1105/tpc.17.00282 ; PMID: 29203634
- Transcriptome Analysis of Four Arabidopsis thaliana Mediator Tail Mutants Reveals Overlapping and Unique Functions in Gene Regulation. DOI: 10.1534/g3.118.200573 ; PMID: 30049745
- Global profiling of plant nuclear membrane proteome in Arabidopsis. DOI: 10.1038/s41477-020-0700-9 ; PMID: 32601417
- The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. DOI: 10.1111/jipb.13052 ; PMID: 33325122
- Transcript and metabolite network perturbations in lignin biosynthetic mutants of Arabidopsis. DOI: 10.1093/plphys/kiac344 ; PMID: 35880844
- Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling. DOI: 10.1016/j.jprot.2017.06.004 ; PMID: 28627464
Sequences:
cDNA Sequence
- >AT3G23590.1
CATAAACAGTGGAGAGATTTGTGAAATGTGAACTCTTTTGACGTCTTTCTCATATTTCGTCTCGGGACAATTCACACGCACTGAATCATCTCTCTCACGAGGACTATTCAGCCATTTGCAAACGCACACACAAACGCACACGCGTTTATTTTTTTTTCGCCAAATCAAATCTGAAGAGTTCCTGTATCTTTTAACCGCTCTTCTTCTTCTTCAGAGAGCTTCGTTGATTGAACGGAAAAAATGGTGGTTCCTGGACGGAGAACCGTCTGGGATTGTGTGATTGAGCTGACAAAGATGGCTCAAGAGAACTGTGTCGATCCTCGTCTTTGGGCTTCTCAGTTATCATCGAATTTGAAATTCTTCGCCGTGGAGTTACCGTCGACGGAGCTTGCGGAGGTTATTGTTTCGTACATTTGTTGGGATAATAACGTTCCTATTGTTTGGAAGTTTCTTGAAAGAGCTATGGCTTTGAAGCTTGTTTCTCCTCTCGTTGTTCTTGCTCTTCTCGCTGACAGAGTTGTTCCAACCCGGTCTACGCAACAAGCAGCTTATAGAATTTACTTGGAGCTGCTCAAGAGAAATATGTTCACCATTAAAGATCATATTAGTGGACCTCACTACCAGAAGGTCATGATTTCAGTATCCAATATTCTTCGTCTTTCAGAGTTATTTGATCTGGACACAAGCAAACCTGGTGTGCTTTTAGTAGAGTTTGTTTTTAAGATGGTGTCACAATTGCTAGATGCAGCGTTAAGTGATGAAGGTTTGCTAGAGCTAAGCCAAGACTCGAGCTCCCAGTGGCTAGTTAAGTCTCAAGATATGGAAATTGATGCTCCTGAGAGATATAATGAAAAGACTGGATCACTAGAGAAGTTACAGAGTTTGAATACCATCATGGCTATTGAGTTGATAGCGGAATTCCTCAGAAATACAGTGATTGCGAGATTGCTATACTTGGTATCTTCCAACAGGGCTTCGAAGTGGCATGAATTTGTCCAGAAAGTGCAGCTTCTTGGAGAAAATTCATCGGCTTTAAAACACTCAAAGGTTCTAAATTCTGGGGATCTATTACAATTGATTTCGAATAGACGATTTGGGTATTCTTATGATAGCAAAGTAACTTCAGCACGGAAATCCAATGCAATTGTGGATTTTGGATCTCTCTCTTCCTATGCTGGCTTATGCCATGGAGCAAGTCTCTCTTCACTTTGGCTTCCTCTTGATCTAGTATTTGAAGATGCAATGGATGGATATCAAGTAAACCCAACTAGTGCGATTGAAATCATTACCGGTCTAGCTAAAACACTTAAAGAAATTAATGGGAGCACTTGGCATGACACTTTCTTGGGGCTTTGGATAGCAGCTCTCCGACTTGTTCAAAGGGAAAGGGATCCTATTGAGGGACCTATTCCTCGACTGGACACAAGGCTGTGCATGTCATTATGTATTGTGCCTCTTGTGGTCGCAAACCTTATTGAAGAGGGGAAATACGAATCTGTCATGGAAAAGCTGCGAGATGACCTTGTTACAAGTTTGCAGGTCCTCGGTGATTTCCCTGGATTGCTGGCTCCTCCCAAATGCGTTGTTTCTGCTGCCAACAAGGCTGCCACAAAGGCAATCTTGTTTTTGTCTGGTGGCAATGTTGGAAAGTCATGTTTTGATGTCATAAACATGAAGGACATGCCTGTCAACTGCTCTGGAAACATGCGCCACCTGATAGTCGAGGCTTGTATTGCAAGAAACATACTGGATATGTCGGCTTATTCGTGGCCTGGCTATGTTAATGGCCGAATCAACCAAATACCTCAGAGTCTGCCGAATGAAGTACCCTGCTGGTCATCATTTGTGAAAGGGGCTCCACTAAATGCCGCAATGGTGAATACATTAGTTTCAGTTCCTGCTTCAAGCTTAGCAGAGCTCGAGAAACTATTTGAGGTTGCAGTCAAAGGATCGGATGACGAGAAGATATCTGCTGCTACAGTTCTTTGCGGGGCATCTCTCACACGGGGTTGGAACATACAGGAACACACTGTTGAATATCTTACAAGATTACTATCCCCACCCGTTCCAGCAGATTATTCCAGGGCTGAAAATCATTTGATTGGTTATGCCTGCATGTTGAATGTTGTTATTGTTGGGATAGGATCTGTTGACAGCATTCAAATTTTCTCTTTACATGGCATGGTTCCGCAACTTGCTTGCTCACTAATGCCAATTTGTGAAGAGTTTGGATCTTACACCCCGAGTGTATCATGGACTCTTCCTTCTGGAGAAGCAATATCAGCATATTCTGTTTTCTCAAATGCATTCACTCTTCTTTTAAAGCTATGGAGATTCAATCATCCTCCTATTGAGCATGGTGTGGGAGATGTTCCCACAGTTGGCTCCCAACTCACTCCTGAACATCTTCTTTCAGTGCGTAATTCTTATCTTGTTTCGTCGGAGATCCTTGATAGAGACCGAAACAGAAAGAGACTTTCAGAAGTTGCAAGGGCAGCATCTTGCCAGCCCGTGTTTGTGGACTCGTTCCCCAAGCTGAAAGTCTGGTATAGGCAGCACCAAAGATGCATAGCAGCCACATTATCTGGACTTACACATGGATCTCCCGTTCATCAGACAGTTGAAGCACTTCTCAACATGACGTTCGGAAAGGTCAGAGGCAGTCAGACTTTAAATCCAGTAAATTCGGGCACAAGCAGTTCATCAGGAGCTGCAAGTGAAGATAGCAATATTAGACCTGAGTTTCCTGCTTGGGATATCCTCAAAGCCGTTCCATATGTTGTCGATGCTGCTTTAACCGCTTGTACTCATGGAAGGCTTTCGCCTCGTCAGTTAGCTACAGGGCTGAAAGACTTAGCAGATTTTCTCCCGGCATCATTAGCAACGATAGTAAGCTATTTCTCAGCTGAGGTGAGTAGAGGTGTTTGGAAGCCAGTATTCATGAACGGCGTGGATTGGCCAAGTCCAGCTACAAATCTATCCACTGTTGAGGAATATATAACGAAAATTCTTGCAACAACAGGCGTCGATATCCCTAGCCTTGCTCCAGGAGGGAGTTCTCCGGCAACGCTTCCTTTACCTCTAGCCGCATTTGTTAGTCTAACCATTACTTACAAAATTGACAAAGCCTCAGAGCGGTTTCTCAACCTGGCTGGCCCAGCTCTGGAGTGCTTGGCTGCAGGCTGCCCTTGGCCTTGCATGCCCATTGTAGCTTCATTATGGACCCAAAAGGCGAAACGTTGGTTTGACTTCCTTGTTTTCTCTGCCTCTCGCACCGTCTTCCTTCACAACCAAGACGCTGTGATTCAGCTCCTCAGAAACTGCTTCAGTGCCACTCTGGGTTTGAATGCTGCCCCCATGTCAAATGATGGTGGCGTTGGAGCTCTTCTTGGCCATGGATTCGGCTCTCATTTCTATGGAGGGATCTCTCCTGTAGCACCAGGGATTCTTTATCTCCGTATGTATCGTGCTCTCAGAGATACTGTCTCCGTATCGGAAGAGATTCTCTCTCTGCTGATACATTCGGTGGAGGATATAGCCCAGAACAGGCTCTCAAAGGAGAAGCTGGAAAAGCTGAAGACAGTGAAGAACGGATCAAGATACGGCCAAAGTTCTCTAGCAACAGCAATGACTCAAGTGAAGCTTGCTGCTTCGCTGAGTGCCTCGTTGGTATGGCTAACCGGTGGCTTAGGTGTGGTCCACGTTCTCATCAAAGAAACGATCCCATCTTGGTTTCTATCAACTGACAAATCAGACCGAGAACAAGGACCATCGGATCTAGTTGCAGAGCTAAGAGGTCATGCCCTTGCCTACTTTGTGGTCCTATGTGGAGCACTTACTTGGGGCGTGGATTCAAGATCATCTGCATCCAAACGCCGCCGCCAAGCAATCTTGGGAAGCCACTTGGAGTTCATCGCGAGTGCCTTAGATGGGAAAATATCAGTGGGATGTGAAACAGCAACTTGGCGAACATATATTTCCGGTTTGGTGAGTCTAATGGTGAGCTGTTTGCCGCTCTGGGTGACAGAGATCGATACAGAAGTGTTAAAGAGTCTAAGCAATGGACTAAGAAAATGGGGAAAAGACGAGCTAGCGATTGTATTACTCTCCTTGGGAGGTCTCAAAACAATGGATTACGCAGCTGATTTCATCATTCATTTGCGTTCATAGCTTCTTAAAAAGTTTTGATCTTCTCCAGATTTCAGATAGTTGTTTGATAGATGTTTTTCTTCTAGTGTTTGCTTCCTTGTTGTGACTTGTGTTCTCTAGCTCCAGTGTTGTGTGATGAAATCAATCACGCATATGTATAGAGAGAAACAGAAAAAAAA
CDS Sequence
- >AT3G23590.1
ATGGTGGTTCCTGGACGGAGAACCGTCTGGGATTGTGTGATTGAGCTGACAAAGATGGCTCAAGAGAACTGTGTCGATCCTCGTCTTTGGGCTTCTCAGTTATCATCGAATTTGAAATTCTTCGCCGTGGAGTTACCGTCGACGGAGCTTGCGGAGGTTATTGTTTCGTACATTTGTTGGGATAATAACGTTCCTATTGTTTGGAAGTTTCTTGAAAGAGCTATGGCTTTGAAGCTTGTTTCTCCTCTCGTTGTTCTTGCTCTTCTCGCTGACAGAGTTGTTCCAACCCGGTCTACGCAACAAGCAGCTTATAGAATTTACTTGGAGCTGCTCAAGAGAAATATGTTCACCATTAAAGATCATATTAGTGGACCTCACTACCAGAAGGTCATGATTTCAGTATCCAATATTCTTCGTCTTTCAGAGTTATTTGATCTGGACACAAGCAAACCTGGTGTGCTTTTAGTAGAGTTTGTTTTTAAGATGGTGTCACAATTGCTAGATGCAGCGTTAAGTGATGAAGGTTTGCTAGAGCTAAGCCAAGACTCGAGCTCCCAGTGGCTAGTTAAGTCTCAAGATATGGAAATTGATGCTCCTGAGAGATATAATGAAAAGACTGGATCACTAGAGAAGTTACAGAGTTTGAATACCATCATGGCTATTGAGTTGATAGCGGAATTCCTCAGAAATACAGTGATTGCGAGATTGCTATACTTGGTATCTTCCAACAGGGCTTCGAAGTGGCATGAATTTGTCCAGAAAGTGCAGCTTCTTGGAGAAAATTCATCGGCTTTAAAACACTCAAAGGTTCTAAATTCTGGGGATCTATTACAATTGATTTCGAATAGACGATTTGGGTATTCTTATGATAGCAAAGTAACTTCAGCACGGAAATCCAATGCAATTGTGGATTTTGGATCTCTCTCTTCCTATGCTGGCTTATGCCATGGAGCAAGTCTCTCTTCACTTTGGCTTCCTCTTGATCTAGTATTTGAAGATGCAATGGATGGATATCAAGTAAACCCAACTAGTGCGATTGAAATCATTACCGGTCTAGCTAAAACACTTAAAGAAATTAATGGGAGCACTTGGCATGACACTTTCTTGGGGCTTTGGATAGCAGCTCTCCGACTTGTTCAAAGGGAAAGGGATCCTATTGAGGGACCTATTCCTCGACTGGACACAAGGCTGTGCATGTCATTATGTATTGTGCCTCTTGTGGTCGCAAACCTTATTGAAGAGGGGAAATACGAATCTGTCATGGAAAAGCTGCGAGATGACCTTGTTACAAGTTTGCAGGTCCTCGGTGATTTCCCTGGATTGCTGGCTCCTCCCAAATGCGTTGTTTCTGCTGCCAACAAGGCTGCCACAAAGGCAATCTTGTTTTTGTCTGGTGGCAATGTTGGAAAGTCATGTTTTGATGTCATAAACATGAAGGACATGCCTGTCAACTGCTCTGGAAACATGCGCCACCTGATAGTCGAGGCTTGTATTGCAAGAAACATACTGGATATGTCGGCTTATTCGTGGCCTGGCTATGTTAATGGCCGAATCAACCAAATACCTCAGAGTCTGCCGAATGAAGTACCCTGCTGGTCATCATTTGTGAAAGGGGCTCCACTAAATGCCGCAATGGTGAATACATTAGTTTCAGTTCCTGCTTCAAGCTTAGCAGAGCTCGAGAAACTATTTGAGGTTGCAGTCAAAGGATCGGATGACGAGAAGATATCTGCTGCTACAGTTCTTTGCGGGGCATCTCTCACACGGGGTTGGAACATACAGGAACACACTGTTGAATATCTTACAAGATTACTATCCCCACCCGTTCCAGCAGATTATTCCAGGGCTGAAAATCATTTGATTGGTTATGCCTGCATGTTGAATGTTGTTATTGTTGGGATAGGATCTGTTGACAGCATTCAAATTTTCTCTTTACATGGCATGGTTCCGCAACTTGCTTGCTCACTAATGCCAATTTGTGAAGAGTTTGGATCTTACACCCCGAGTGTATCATGGACTCTTCCTTCTGGAGAAGCAATATCAGCATATTCTGTTTTCTCAAATGCATTCACTCTTCTTTTAAAGCTATGGAGATTCAATCATCCTCCTATTGAGCATGGTGTGGGAGATGTTCCCACAGTTGGCTCCCAACTCACTCCTGAACATCTTCTTTCAGTGCGTAATTCTTATCTTGTTTCGTCGGAGATCCTTGATAGAGACCGAAACAGAAAGAGACTTTCAGAAGTTGCAAGGGCAGCATCTTGCCAGCCCGTGTTTGTGGACTCGTTCCCCAAGCTGAAAGTCTGGTATAGGCAGCACCAAAGATGCATAGCAGCCACATTATCTGGACTTACACATGGATCTCCCGTTCATCAGACAGTTGAAGCACTTCTCAACATGACGTTCGGAAAGGTCAGAGGCAGTCAGACTTTAAATCCAGTAAATTCGGGCACAAGCAGTTCATCAGGAGCTGCAAGTGAAGATAGCAATATTAGACCTGAGTTTCCTGCTTGGGATATCCTCAAAGCCGTTCCATATGTTGTCGATGCTGCTTTAACCGCTTGTACTCATGGAAGGCTTTCGCCTCGTCAGTTAGCTACAGGGCTGAAAGACTTAGCAGATTTTCTCCCGGCATCATTAGCAACGATAGTAAGCTATTTCTCAGCTGAGGTGAGTAGAGGTGTTTGGAAGCCAGTATTCATGAACGGCGTGGATTGGCCAAGTCCAGCTACAAATCTATCCACTGTTGAGGAATATATAACGAAAATTCTTGCAACAACAGGCGTCGATATCCCTAGCCTTGCTCCAGGAGGGAGTTCTCCGGCAACGCTTCCTTTACCTCTAGCCGCATTTGTTAGTCTAACCATTACTTACAAAATTGACAAAGCCTCAGAGCGGTTTCTCAACCTGGCTGGCCCAGCTCTGGAGTGCTTGGCTGCAGGCTGCCCTTGGCCTTGCATGCCCATTGTAGCTTCATTATGGACCCAAAAGGCGAAACGTTGGTTTGACTTCCTTGTTTTCTCTGCCTCTCGCACCGTCTTCCTTCACAACCAAGACGCTGTGATTCAGCTCCTCAGAAACTGCTTCAGTGCCACTCTGGGTTTGAATGCTGCCCCCATGTCAAATGATGGTGGCGTTGGAGCTCTTCTTGGCCATGGATTCGGCTCTCATTTCTATGGAGGGATCTCTCCTGTAGCACCAGGGATTCTTTATCTCCGTATGTATCGTGCTCTCAGAGATACTGTCTCCGTATCGGAAGAGATTCTCTCTCTGCTGATACATTCGGTGGAGGATATAGCCCAGAACAGGCTCTCAAAGGAGAAGCTGGAAAAGCTGAAGACAGTGAAGAACGGATCAAGATACGGCCAAAGTTCTCTAGCAACAGCAATGACTCAAGTGAAGCTTGCTGCTTCGCTGAGTGCCTCGTTGGTATGGCTAACCGGTGGCTTAGGTGTGGTCCACGTTCTCATCAAAGAAACGATCCCATCTTGGTTTCTATCAACTGACAAATCAGACCGAGAACAAGGACCATCGGATCTAGTTGCAGAGCTAAGAGGTCATGCCCTTGCCTACTTTGTGGTCCTATGTGGAGCACTTACTTGGGGCGTGGATTCAAGATCATCTGCATCCAAACGCCGCCGCCAAGCAATCTTGGGAAGCCACTTGGAGTTCATCGCGAGTGCCTTAGATGGGAAAATATCAGTGGGATGTGAAACAGCAACTTGGCGAACATATATTTCCGGTTTGGTGAGTCTAATGGTGAGCTGTTTGCCGCTCTGGGTGACAGAGATCGATACAGAAGTGTTAAAGAGTCTAAGCAATGGACTAAGAAAATGGGGAAAAGACGAGCTAGCGATTGTATTACTCTCCTTGGGAGGTCTCAAAACAATGGATTACGCAGCTGATTTCATCATTCATTTGCGTTCATAG
Protein Sequence
- >AT3G23590.1
MVVPGRRTVWDCVIELTKMAQENCVDPRLWASQLSSNLKFFAVELPSTELAEVIVSYICWDNNVPIVWKFLERAMALKLVSPLVVLALLADRVVPTRSTQQAAYRIYLELLKRNMFTIKDHISGPHYQKVMISVSNILRLSELFDLDTSKPGVLLVEFVFKMVSQLLDAALSDEGLLELSQDSSSQWLVKSQDMEIDAPERYNEKTGSLEKLQSLNTIMAIELIAEFLRNTVIARLLYLVSSNRASKWHEFVQKVQLLGENSSALKHSKVLNSGDLLQLISNRRFGYSYDSKVTSARKSNAIVDFGSLSSYAGLCHGASLSSLWLPLDLVFEDAMDGYQVNPTSAIEIITGLAKTLKEINGSTWHDTFLGLWIAALRLVQRERDPIEGPIPRLDTRLCMSLCIVPLVVANLIEEGKYESVMEKLRDDLVTSLQVLGDFPGLLAPPKCVVSAANKAATKAILFLSGGNVGKSCFDVINMKDMPVNCSGNMRHLIVEACIARNILDMSAYSWPGYVNGRINQIPQSLPNEVPCWSSFVKGAPLNAAMVNTLVSVPASSLAELEKLFEVAVKGSDDEKISAATVLCGASLTRGWNIQEHTVEYLTRLLSPPVPADYSRAENHLIGYACMLNVVIVGIGSVDSIQIFSLHGMVPQLACSLMPICEEFGSYTPSVSWTLPSGEAISAYSVFSNAFTLLLKLWRFNHPPIEHGVGDVPTVGSQLTPEHLLSVRNSYLVSSEILDRDRNRKRLSEVARAASCQPVFVDSFPKLKVWYRQHQRCIAATLSGLTHGSPVHQTVEALLNMTFGKVRGSQTLNPVNSGTSSSSGAASEDSNIRPEFPAWDILKAVPYVVDAALTACTHGRLSPRQLATGLKDLADFLPASLATIVSYFSAEVSRGVWKPVFMNGVDWPSPATNLSTVEEYITKILATTGVDIPSLAPGGSSPATLPLPLAAFVSLTITYKIDKASERFLNLAGPALECLAAGCPWPCMPIVASLWTQKAKRWFDFLVFSASRTVFLHNQDAVIQLLRNCFSATLGLNAAPMSNDGGVGALLGHGFGSHFYGGISPVAPGILYLRMYRALRDTVSVSEEILSLLIHSVEDIAQNRLSKEKLEKLKTVKNGSRYGQSSLATAMTQVKLAASLSASLVWLTGGLGVVHVLIKETIPSWFLSTDKSDREQGPSDLVAELRGHALAYFVVLCGALTWGVDSRSSASKRRRQAILGSHLEFIASALDGKISVGCETATWRTYISGLVSLMVSCLPLWVTEIDTEVLKSLSNGLRKWGKDELAIVLLSLGGLKTMDYAADFIIHLRS