Gene Details:
- Gene ID: AT3G21640
- Gene Symbol: ATFKBP42, FKBP42, TWD1, UCU2
- Gene Name: FK506-BINDING PROTEIN 42, TWISTED DWARF 1, ULTRACURVATA 2
- Description: FKBP-type peptidyl-prolyl cis-trans isomerase family protein;(source:Araport11)
- TAIR Accession:
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
Germplasm Phenotype:
- ucu2 — Rolled leaves
Function-related keywords:
- shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen
Literature:
- TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. DOI: 10.1091/mbc.e02-10-0698 ; PMID: 14517332
- The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling. DOI: 10.1104/pp.103.032524 ; PMID: 14730066
- Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. DOI: 10.1091/mbc.e03-11-0831 ; PMID: 15133126
- Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins. DOI: 10.1074/jbc.M604604200 ; PMID: 16887800
- Modulation of P-glycoproteins by auxin transport inhibitors is mediated by interaction with immunophilins. DOI: 10.1074/jbc.M709655200 ; PMID: 18499676
- AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis. DOI: 10.1093/jxb/erp209 ; PMID: 19567478
- Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. DOI: 10.1016/j.cub.2010.01.051 ; PMID: 20226671
- In silico identification of carboxylate clamp type tetratricopeptide repeat proteins in Arabidopsis and rice as putative co-chaperones of Hsp90/Hsp70. DOI: 10.1371/journal.pone.0012761 ; PMID: 20856808
- The ER-localized TWD1 immunophilin is necessary for localization of multidrug resistance-like proteins required for polar auxin transport in Arabidopsis roots. DOI: 10.1105/tpc.110.078360 ; PMID: 20971896
- Species specific amino acid sequence-protein local structure relationships: An analysis in the light of a structural alphabet. DOI: 10.1016/j.jtbi.2011.01.047 ; PMID: 21333657
- Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants. DOI: 10.1074/jbc.M111.300749 ; PMID: 22134914
- Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane. DOI: 10.1105/tpc.112.105999 ; PMID: 23321285
- Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter. DOI: 10.1111/tpj.12103 ; PMID: 23279701
- Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation. DOI: 10.1038/emboj.2012.120 ; PMID: 22549467
- Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in Arabidopsis. DOI: 10.1016/j.molp.2016.01.008 ; PMID: 26808213
- Geometric constraints and the anatomical interpretation of twisted plant organ phenotypes. DOI: 10.3389/fpls.2011.00062 ; PMID: 22645544
- Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase. DOI: 10.1074/jbc.RA120.014104 ; PMID: 32699109
- Non-steroidal Anti-inflammatory Drugs Target TWISTED DWARF1-Regulated Actin Dynamics and Auxin Transport-Mediated Plant Development. DOI: 10.1016/j.celrep.2020.108463 ; PMID: 33264621
- Arabidopsis TWISTED DWARF1 regulates stamen elongation by differential activation of ABCB1,19-mediated auxin transport. DOI: 10.1093/jxb/erac185 ; PMID: 35512423
- Loss of Multiple ABCB Auxin Transporters Recapitulates the Major twisted dwarf 1 Phenotypes in Arabidopsis thaliana. DOI: 10.3389/fpls.2022.840260 ; PMID: 35528937
Sequences:
cDNA Sequence
- >AT3G21640.1
AAAAGTCGAAGGGTCTCTTTATATTTTCAGAATCAAAATCTGAAATTTATCTCTCGGTCGATCCAGTCTTCGTGAGTGACTTCGACGACGACGACGAGTCACACTACTCTTGAGCTTCTCATACTTCACCCAGGTTGATTTGGGAAATAATGGATGAATCTCTGGAGCATCAAACTCAAACACATGACCAAGAGAGCGAAATAGTTACTGAAGGAAGTGCCGTTGTGCATAGTGAGCCATCTCAAGAGGGTAATGTTCCTCCTAAAGTTGATAGTGAAGCTGAGGTCTTGGATGAGAAAGTCAGTAAGCAGATTATAAAGGAAGGTCACGGTTCCAAACCATCCAAGTACTCTACATGCTTTTTGCACTACAGGGCATGGACCAAAAACTCGCAGCACAAATTTGAGGATACATGGCATGAGCAGCAACCTATTGAATTGGTTCTTGGAAAAGAGAAAAAAGAACTAGCCGGTTTAGCCATCGGTGTTGCTAGCATGAAGTCTGGTGAACGTGCGCTTGTGCATGTTGGCTGGGAATTAGCTTATGGGAAAGAAGGAAACTTTTCTTTTCCGAATGTTCCACCTATGGCAGACTTGTTATATGAGGTGGAAGTTATTGGGTTTGATGAAACAAAGGAGGGAAAAGCTCGCAGTGATATGACTGTAGAGGAAAGGATTGGTGCAGCAGACAGAAGAAAAATGGATGGGAATTCTCTTTTTAAGGAGGAGAAACTGGAGGAAGCCATGCAACAGTATGAAATGGCCATAGCATACATGGGGGACGATTTTATGTTTCAGCTGTATGGGAAGTACCAGGATATGGCTTTAGCAGTTAAAAACCCATGCCATCTTAACATAGCAGCTTGCCTCATCAAACTAAAACGATACGATGAAGCAATTGGTCACTGCAACATTGTGTTGACAGAAGAAGAGAAAAACCCAAAAGCACTGTTCAGAAGAGGGAAAGCAAAGGCAGAGCTAGGACAGATGGACTCAGCACGTGATGATTTCCGAAAGGCACAAAAGTATGCTCCTGACGACAAGGCGATTAGAAGAGAGCTACGAGCACTTGCAGAGCAAGAGAAAGCCTTGTACCAAAAGCAGAAAGAAATGTACAAAGGAATATTCAAAGGGAAAGATGAAGGTGGTGCTAAGTCAAAGAGCCTTTTTTGGTTGATAGTGTTATGGCAATGGTTTGTTTCCCTTTTCTCCCGTATCTTTCGACGCCACAGAGTTAAAGCAGATTAATGTATGAAGAAGGGTAACAATTCAACTCTAAAAGACCAACGTGAAAGATCTACCCCCATTTCTTATTAGTGAGAATTTTGAAAAATATTTTATATAAGAAAAAAAAATAGTCTCTATTGTTTTCGATTATAAAGTAACTTTATATTTTGATCCAAAAAAATAAATTTTTAACAA
CDS Sequence
- >AT3G21640.1
ATGGATGAATCTCTGGAGCATCAAACTCAAACACATGACCAAGAGAGCGAAATAGTTACTGAAGGAAGTGCCGTTGTGCATAGTGAGCCATCTCAAGAGGGTAATGTTCCTCCTAAAGTTGATAGTGAAGCTGAGGTCTTGGATGAGAAAGTCAGTAAGCAGATTATAAAGGAAGGTCACGGTTCCAAACCATCCAAGTACTCTACATGCTTTTTGCACTACAGGGCATGGACCAAAAACTCGCAGCACAAATTTGAGGATACATGGCATGAGCAGCAACCTATTGAATTGGTTCTTGGAAAAGAGAAAAAAGAACTAGCCGGTTTAGCCATCGGTGTTGCTAGCATGAAGTCTGGTGAACGTGCGCTTGTGCATGTTGGCTGGGAATTAGCTTATGGGAAAGAAGGAAACTTTTCTTTTCCGAATGTTCCACCTATGGCAGACTTGTTATATGAGGTGGAAGTTATTGGGTTTGATGAAACAAAGGAGGGAAAAGCTCGCAGTGATATGACTGTAGAGGAAAGGATTGGTGCAGCAGACAGAAGAAAAATGGATGGGAATTCTCTTTTTAAGGAGGAGAAACTGGAGGAAGCCATGCAACAGTATGAAATGGCCATAGCATACATGGGGGACGATTTTATGTTTCAGCTGTATGGGAAGTACCAGGATATGGCTTTAGCAGTTAAAAACCCATGCCATCTTAACATAGCAGCTTGCCTCATCAAACTAAAACGATACGATGAAGCAATTGGTCACTGCAACATTGTGTTGACAGAAGAAGAGAAAAACCCAAAAGCACTGTTCAGAAGAGGGAAAGCAAAGGCAGAGCTAGGACAGATGGACTCAGCACGTGATGATTTCCGAAAGGCACAAAAGTATGCTCCTGACGACAAGGCGATTAGAAGAGAGCTACGAGCACTTGCAGAGCAAGAGAAAGCCTTGTACCAAAAGCAGAAAGAAATGTACAAAGGAATATTCAAAGGGAAAGATGAAGGTGGTGCTAAGTCAAAGAGCCTTTTTTGGTTGATAGTGTTATGGCAATGGTTTGTTTCCCTTTTCTCCCGTATCTTTCGACGCCACAGAGTTAAAGCAGATTAA
Protein Sequence
- >AT3G21640.1
MDESLEHQTQTHDQESEIVTEGSAVVHSEPSQEGNVPPKVDSEAEVLDEKVSKQIIKEGHGSKPSKYSTCFLHYRAWTKNSQHKFEDTWHEQQPIELVLGKEKKELAGLAIGVASMKSGERALVHVGWELAYGKEGNFSFPNVPPMADLLYEVEVIGFDETKEGKARSDMTVEERIGAADRRKMDGNSLFKEEKLEEAMQQYEMAIAYMGDDFMFQLYGKYQDMALAVKNPCHLNIAACLIKLKRYDEAIGHCNIVLTEEEKNPKALFRRGKAKAELGQMDSARDDFRKAQKYAPDDKAIRRELRALAEQEKALYQKQKEMYKGIFKGKDEGGAKSKSLFWLIVLWQWFVSLFSRIFRRHRVKAD