Gene Details:

• Gene ID: AT3G21220
• Gene Symbol: ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5
• Gene Name: ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, MAP KINASE KINASE 5, MAP kinase kinase 5
• Description: MAP kinase kinase 5;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G21220.1     AT3G21220.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  pollen tube cell

Literature:

• Molecular cloning and characterization of three cDNAs encoding putative mitogen-activated protein kinase kinases (MAPKKs) in Arabidopsis thaliana.   DOI:  10.1093/dnares/5.6.341 ;  PMID:  10048483
• Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis.   DOI:  10.1006/bbrc.1998.9796 ;  PMID:  9878570
• MAP kinase signalling cascade in Arabidopsis innate immunity.   DOI:  10.1038/415977a ;  PMID:  11875555
• Rapid identification of Arabidopsis insertion mutants by non-radioactive detection of T-DNA tagged genes.   DOI:  10.1046/j.1365-313x.2002.01416.x ;  PMID:  12383089
• Genes involved in biosynthesis and signalisation of ethylene in Brassica oleracea and Arabidopsis thaliana: identification and genome comparative mapping of specific gene homologues.   DOI:  10.1007/s00122-005-0136-7 ;  PMID:  16311726
• MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis.   DOI:  10.1074/jbc.M605319200 ;  PMID:  17023433
• Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis.   DOI:  10.1105/tpc.106.048298 ;  PMID:  17259259
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Regulation of floral organ abscission in Arabidopsis thaliana.   DOI:  10.1073/pnas.0805539105 ;  PMID:  18809915
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis.   DOI:  10.1038/cr.2008.29 ;  PMID:  18268539
• Cell fate transitions during stomatal development.   DOI:  10.1002/bies.200800231 ;  PMID:  19565615
• Suppression of MKK5 reduces ozone-induced signal transmission to both MPK3 and MPK6 and confers increased ozone sensitivity in Arabidopsis thaliana.   DOI:  10.4161/psb.4.8.9298 ;  PMID:  19820329
• Novel and expanded roles for MAPK signaling in Arabidopsis stomatal cell fate revealed by cell type-specific manipulations.   DOI:  10.1105/tpc.109.070110 ;  PMID:  19897669
• Arabidopsis histone methyltransferase SET DOMAIN GROUP8 mediates induction of the jasmonate/ethylene pathway genes in plant defense response to necrotrophic fungi.   DOI:  10.1104/pp.110.161497 ;  PMID:  20810545
• Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system.   DOI:  10.1016/j.phytochem.2011.02.029 ;  PMID:  21477822
• Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana.   DOI:  10.1074/jbc.M112.384453 ;  PMID:  23341468
• MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.   DOI:  10.1093/pcp/pct072 ;  PMID:  23677921
• Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification.   DOI:  10.1074/mcp.M113.029256 ;  PMID:  24019147
• The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1.   DOI:  10.1111/tpj.12381 ;  PMID:  24237140
• EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity.   DOI:  10.1371/journal.pgen.1004389 ;  PMID:  24830651
• Timing is everything: highly specific and transient expression of a MAP kinase determines auxin-induced leaf venation patterns in Arabidopsis.   DOI:  10.1093/mp/ssu080 ;  PMID:  25064848
• Floral organ abscission is regulated by a positive feedback loop.   DOI:  10.1073/pnas.1423595112 ;  PMID:  25730871
• Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.   DOI:  10.1093/jxb/erv305 ;  PMID:  26136265
• Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.   DOI:  10.1111/jpi.12314 ;  PMID:  26927635
• A double-mutant collection targeting MAP kinase related genes in Arabidopsis for studying genetic interactions.   DOI:  10.1111/tpj.13292 ;  PMID:  27490954
• RNA interference of plant MAPK cascades for functional studies.   DOI:  10.1007/978-1-4939-0922-3_8 ;  PMID:  24908122
• AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade.   DOI:  10.1104/pp.16.01386 ;  PMID:  27913741
• Regulation of Stomatal Immunity by Interdependent Functions of a Pathogen-Responsive MPK3/MPK6 Cascade and Abscisic Acid.   DOI:  10.1105/tpc.16.00577 ;  PMID:  28254778
• Mitogen-activated protein kinases and calcium-dependent protein kinases are involved in wounding-induced ethylene biosynthesis in Arabidopsis thaliana.   DOI:  10.1111/pce.12984 ;  PMID:  28543054
• Maternal control of embryogenesis by MPK6 and its upstream MKK4/MKK5 in Arabidopsis.   DOI:  10.1111/tpj.13737 ;  PMID:  29024034
• BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.   DOI:  10.1104/pp.17.01757 ;  PMID:  29440595
• Dissection of MAPK signaling specificity through protein engineering in a developmental context.   DOI:  10.1186/s12870-018-1274-9 ;  PMID:  29636017
• Antagonistic interactions between two MAP kinase cascades in plant development and immune signaling.   DOI:  10.15252/embr.201745324 ;  PMID:  29789386
• PFLP-Intensified Disease Resistance Against Bacterial Soft Rot Through the MAPK Pathway in PAMP-Triggered Immunity.   DOI:  10.1094/PHYTO-03-18-0100-R ;  PMID:  29975159
• Regulation of pollen lipid body biogenesis by MAP kinases and downstream WRKY transcription factors in Arabidopsis.   DOI:  10.1371/journal.pgen.1007880 ;  PMID:  30586356
• Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling.   DOI:  10.1111/tpj.14232 ;  PMID:  30659683
• Protein and metabolite composition of Arabidopsis stress granules.   DOI:  10.1111/nph.15690 ;  PMID:  30664249
• SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis.   DOI:  10.1016/j.molp.2019.04.011 ;  PMID:  31059824
• A PAMP-triggered MAPK cascade inhibits phosphatidylinositol 4,5-bisphosphate production by PIP5K6 in Arabidopsis thaliana.   DOI:  10.1111/nph.16069 ;  PMID:  31318449
• Arabidopsis MAPKKK δ-1 is required for full immunity against bacterial and fungal infection.   DOI:  10.1093/jxb/erz556 ;  PMID:  31844896
• MKK4/MKK5-MPK1/MPK2 cascade mediates SA-activated leaf senescence via phosphorylation of NPR1 in Arabidopsis.   DOI:  10.1007/s11103-019-00958-z ;  PMID:  31916083
• Wounding and Insect Feeding Trigger Two Independent MAPK Pathways with Distinct Regulation and Kinetics.   DOI:  10.1105/tpc.19.00917 ;  PMID:  32265268
• Induction of γ-aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae.   DOI:  10.1111/jipb.12974 ;  PMID:  32458527
• Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.   DOI:  10.1111/jipb.13007 ;  PMID:  32877006
• The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem.   DOI:  10.1016/j.molp.2020.09.004 ;  PMID:  32916336
• RGF1-RGI1, a Peptide-Receptor Complex, Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade.   DOI:  10.1016/j.molp.2020.09.005 ;  PMID:  32916335
• MKK4/5-MPK3/6 Cascade Regulates Agrobacterium-Mediated Transformation by Modulating Plant Immunity in Arabidopsis.   DOI:  10.3389/fpls.2021.731690 ;  PMID:  34659297
• Regulation of Arabidopsis Matrix Metalloproteinases by Mitogen-Activated Protein Kinases and Their Function in Leaf Senescence.   DOI:  10.3389/fpls.2022.864986 ;  PMID:  35463412
• Overlapping functions of YDA and MAPKKK3/MAPKKK5 upstream of MPK3/MPK6 in plant immunity and growth/development.   DOI:  10.1111/jipb.13309 ;  PMID:  35652263
• Bacillus amyloliquefaciens PMB05 Increases Resistance to Bacterial Wilt by Activating Mitogen-Activated Protein Kinase and Reactive Oxygen Species Pathway Crosstalk in Arabidopsis thaliana.   DOI:  10.1094/PHYTO-04-22-0134-R ;  PMID:  35793151
• Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases.   DOI:  10.3724/abbs.2022089 ;  PMID:  35866601
• Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.   DOI:  10.1111/jipb.13391 ;  PMID:  36250681
• An EPFL peptide signaling pathway promotes stamen elongation via enhancing filament cell proliferation to ensure successful self-pollination in Arabidopsis thaliana.   DOI:  10.1111/nph.18806 ;  PMID:  36772858
• The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.   DOI:  10.1093/plcell/koad029 ;  PMID:  36762404
• Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells.   DOI:  10.1111/jipb.13536 ;  PMID:  37226855
• Ancient signals: comparative genomics of plant MAPK and MAPKK gene families.   DOI:  10.1016/j.tplants.2006.02.007 ;  PMID:  16537113
• Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis.   DOI:  10.1105/tpc.106.048298 ;  PMID:  17259259

Sequences: