Gene Details:
- Gene ID: AT3G21160
- Gene Symbol: MANIA, MNS2
- Gene Name: ALPHA-MANNOSIDASE IA, alpha-mannosidase 2
- Description: alpha-mannosidase 2;(source:Araport11)
- TAIR Accession:
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- PO:0025195 — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
Function-related keywords:
- shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen , pollen tube cell , pollen
Literature:
- The age of the Arabidopsis thaliana genome duplication. DOI: 10.1023/a:1023001130337 ; PMID: 12777046
- The Arabidopsis Rab GTPase RabA4b localizes to the tips of growing root hair cells. DOI: 10.1105/tpc.021634 ; PMID: 15155878
- Mapping the Arabidopsis organelle proteome. DOI: 10.1073/pnas.0506958103 ; PMID: 16618929
- Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. DOI: 10.1104/pp.108.126375 ; PMID: 18775970
- Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation. DOI: 10.1093/glycob/cwp170 ; PMID: 19914916
- Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana. DOI: 10.1105/tpc.109.072363 ; PMID: 20023195
- Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. DOI: 10.1016/j.molp.2018.01.006 ; PMID: 29409894
- Processing of the Terminal Alpha-1,2-Linked Mannose Residues From Oligomannosidic N-Glycans Is Critical for Proper Root Growth. DOI: 10.3389/fpls.2018.01807 ; PMID: 30574158
- Comparative Label-Free Quantitative Proteomics Analysis Reveals the Essential Roles of N-Glycans in Salt Tolerance by Modulating Protein Abundance in Arabidopsis. DOI: 10.3389/fpls.2021.646425 ; PMID: 34276718
- MNSs-mediated N-glycan processing is essential for auxin homeostasis in Arabidopsis roots during alkaline response. DOI: 10.1016/j.isci.2022.104298 ; PMID: 35602943
- Stop-and-go movements of plant Golgi stacks are mediated by the acto-myosin system. DOI: 10.1104/pp.121.4.1127 ; PMID: 10594100
- Mapping the Arabidopsis organelle proteome. DOI: 10.1073/pnas.0506958103 ; PMID: 16618929
Sequences:
cDNA Sequence
- >AT3G21160.1
AAACCAACTGATTTAAACCGGATCATTCCCTCTCTTTACTCTGATCCGATCTCTTCCTCTCTTTTTAATTCATGGTTTCAATTTCTTCTTCTTCTCCTTTTTCAAAAATTTGTCACCTCCGAGATCAGATCTGATCGTCGGAATTGAGATGGCGAGGAATAAACTTGTAAGTGGTAGTCATGGGATATGGAAATATTTCAACCCAGCGTTTTATCTCCGAAGACCAAGACGTCTTGCTTTGCTCATCATCCTCTTCGTCTCTGTTTCAATGGTTGTTTGGGATCGTCAATCTCTTTCCCGAGACTACCAGTTTGAAGTTTCCAAGTTAAATGAAGAAGTTTTGCGGTTGCAGCAGATGTTGGAAGAGATAAAGAGCGTCACTGAGGATGTGTCTGTCAATAGTTTGAAGGATGTTCAGGAAGATCCAGTTGATGCTCAGCGAATGCAGAGAGTTAAAGAGGCAATGGTTCATGCTTGGAGTTCATATGAAAAGTATGCCTGGGGACAAGATGAGCTTCAGCCCCAGACAAAGGATGGTGTTGACAGCTTTGGTGGCCTGGGTGCAACTATGATAGATGCATTAGACACACTATATATAATGGGTCTAGATGAGCAGTTTCAGAAAGCCAGAGAGTGGGTAGCAAGCTCATTAGATTTCGACAAGGATTATGCTGCCAGTATGTTTGAGACAACCATAAGAGTGGTAGGAGGGCTTCTCAGTGCGTATGATCTTTCTGGGGATAAAATTTTCCTTGAAAAGGCTATGGATATTGCAGACAGATTATTGCCTGCATGGGACACTCAATCGGGTATACCATATAATATTATCAACTTGAAGCATGGAAATGCTCACAATCCTACATGGGCGGGGGGAGACAGTATTCTTGCAGATTCTGGTACTGAGCAGCTTGAATTTATTGCCCTTTCCCAGAGGACAGGGGACCCAAAATATCAGCAAAAGGTAGAAAAGGTTATTTCAGTGCTAAATAAGAACTTCCCTGCTGATGGTTTACTTCCGATATATATAAATCCCGATACAGCTAATCCATCGCAGTCTACAATAACATTTGGTGCCATGGGAGACAGCTTTTACGAATATTTGCTCAAAGTTTGGGTGTTTGGGAACAAAACTTCAGCAGTGAAACACTATAGAGATATGTGGGAGAAGTCAATGAATGGTCTGCTAAGCTTGGTTAAGAAATCAACACCTTTGTCGTTTACATATATCTGTGAGAAGAGTGGAAATTCTTTGATCGATAAGATGGATGAATTGGCATGCTTTGCTCCTGGAATGTTGGCTTTAGGAGCATCTGGGTATAGTGATCCTGCTGAAGGAAAGAAGTTTCTCACACTCGCTGAAGAGCTTGCGTGGACATGTTATAACTTTTACCAATCAACTCCAACAAAACTGGCTGGGGAGAATTATTTCTTCAACTCTGGGAGTGACATGAGTGTTGGAACGTCGTGGAACATCTTGAGACCAGAAACTGTCGAATCACTGTTTTACCTCTGGCGGTTAACTGGAAACAAGACATATCAAGAGTGGGGATGGAATATATTTGAAGCATTTGAGAAGAACTCGCGCATAGAGTCTGGATATGTTGGTTTGAAGGATGTTAATACAGGCGTTAAGGACAACAAGATGCAAAGTTTCTTCCTTGCAGAGACACTCAAGTATCTCTATCTACTCTTCTCGCCGACAACAGTCATTCCTTTAGACGAGTGGGTATTCAACACCGAAGCTCATCCACTTAAGATTAAGTCTCGAAACGATCAGGTAAATCTCAAACAATCCAACAAAGTACTGCTACGAAAACCGGCATTTAGAATACGCCAGAGGCATTATGGTCGGATAACAAAGAAGTAAAACTCCCTGGAGAGGTCACAGTGTGATTCGTAGGAGGGGCTCTATGGATATATCTTAACAGAGCAATTGGATTTAGCTTGGCTATTCAAAGACCCTTTTATTTAAGAAACCATTTTTGGAAAGATTTCAAGATATAGACTATTGTTGTACTAGTTGGGATCAGAACCCAAACAGGTTCACCACAGTTTACACCTTGTGTTTTGTATCCTTACTCCTTAGATTATAAATTAAGAGTATTATCTTCTGTTTTGTATTCGACAAAAGATCAATGTATAAAAGTTTATATAAAAGACTGCAACAATGCAGAAGAAATGTAATGGAAGCAACCAAGAAAAGAAGAAGAAGCAATTTGC - >AT3G21160.2
AAACCAACTGATTTAAACCGGATCATTCCCTCTCTTTACTCTGATCCGATCTCTTCCTCTCTTTTTAATTCATGGTTTCAATTTCTTCTTCTTCTCCTTTTTCAAAAATTTGTCACCTCCGAGATCAGATCTGATCGTCGGAATTGAGATGGCGAGGAATAAACTTGTAAGTGGTAGTCATGGGATATGGAAATATTTCAACCCAGCGTTTTATCTCCGAAGACCAAGACGTCTTGCTTTGCTCATCATCCTCTTCGTCTCTGTTTCAATGGTTGTTTGGGATCGTCAATCTCTTTCCCGAGACTACCAGTTTGAAGTTTCCAAGTTAAATGAAGAAGTTTTGCGGTTGCAGCAGATGTTGGAAGAGATAAAGAGCGTCACTGAGGATGTGTCTGTCAATAGTTTGAAGGATGTTCAGGAAGATCCAGTTGATGCTCAGCGAATGCAGAGAGTTAAAGAGGCAATGGTTCATGCTTGGAGTTCATATGAAAAGTATGCCTGGGGACAAGATGAGCTTCAGCCCCAGACAAAGGATGGTGTTGACAGCTTTGGTGGCCTGGGTGCAACTATGATAGATGCATTAGACACACTATATATAATGGGTCTAGATGAGCAGTTTCAGAAAGCCAGAGAGTGGGTAGCAAGCTCATTAGATTTCGACAAGGATTATGCTGCCAGTATGTTTGAGACAACCATAAGAGTGGTAGGAGGGCTTCTCAGTGCGTATGATCTTTCTGGGGATAAAATTTTCCTTGAAAAGGCTATGGATATTGCAGACAGATTATTGCCTGCATGGGACACTCAATCGGGTATACCATATAATATTATCAACTTGAAGCATGGAAATGCTCACAATCCTACATGGGCGGGGGGAGACAGTATTCTTGCAGATTCTGGTACTGAGCAGCTTGAATTTATTGCCCTTTCCCAGAGGACAGGGGACCCAAAATATCAGCAAAAGGTAGAAAAGGTTATTTCAGTGCTAAATAAGAACTTCCCTGCTGATGGTTTACTTCCGATATATATAAATCCCGATACAGCTAATCCATCGCAGTCTACAATAACATTTGGTGCCATGGGAGACAGCTTTTACGAATATTTGCTCAAAGTTTGGGTGTTTGGGAACAAAACTTCAGCAGTGAAACACTATAGAGATATGTGGGAGAAGTCAATGAATGGTCTGCTAAGCTTGGTTAAGAAATCAACACCTTTGTCGTTTACATATATCTGTGAGAAGAGTGGAAATTCTTTGATCGATAAGATGGATGAATTGGCATGCTTTGCTCCTGGAATGTTGGCTTTAGGAGCATCTGGGTATAGTGATCCTGCTGAAGGAAAGAAGTTTCTCACACTCGCTGAAGAGCTTGCGTGGACATGTTATAACTTTTACCAATCAACTCCAACAAAACTGGCTGGGGAGAATTATTTCTTCAACTCTGGGAGTGACATGAGTGTTGGAACGTCGTGGAACATCTTGAGACCAGAAACTGTCGAATCACTGTTTTACCTCTGGCGGTTAACTGGAAACAAGACATATCAAGAGTGGGGATGGAATATATTTGAAGCATTTGAGAAGAACTCGCGCATAGAGTCTGGATATGTTGGTTTGAAGGATGTTAATACAGGCGTTAAGGACAACAAGATGCAAAGTTTCTTCCTTGCAGAGACACTCAAGTATCTCTATCTACTCTTCTCGCCGACAACAGTCATTCCTTTAGACGAGTGGGTATTCAACACCGAAGCTCATCCACTTAAGATTAAGTCTCGAAACGATCAGGTAAATCTCAAACAATCCAACAAAGTACTGCTACGAAAACCGGCATTTAGAATACGCCAGAGGCATTATGGTCGGATAACAAAGAAGTAAAACTCCCTGGAGAGGTCACAGTGTGATTCGTAGGAGGGGCTCTATGGATATATCTTAACAGAGCAATTGGATTTAGCTTGGCTATTCAAAGACCCTTTTATTTAAGAAACCATTTTTGGAAAGATTTCAAGATATAGACTATTGTTGTACTAGTTGGGATCAGAACCCAAACAGGTTCACCACAGTTTACACCTTGTGTTTTGTATCCTTACTCCTTAGATTATAAATTAAGAGTATTATCTTCTGTTTTGTATTCGACAAAAGATCAATGTATAAAAGTTTATATAAAAGACTGCAACAATGCAGAAGAAATGTAATGGAAGCAACCAAGAAAAGAAGAAGAAGCAATTTGC
CDS Sequence
- >AT3G21160.1
ATGGCGAGGAATAAACTTGTAAGTGGTAGTCATGGGATATGGAAATATTTCAACCCAGCGTTTTATCTCCGAAGACCAAGACGTCTTGCTTTGCTCATCATCCTCTTCGTCTCTGTTTCAATGGTTGTTTGGGATCGTCAATCTCTTTCCCGAGACTACCAGTTTGAAGTTTCCAAGTTAAATGAAGAAGTTTTGCGGTTGCAGCAGATGTTGGAAGAGATAAAGAGCGTCACTGAGGATGTGTCTGTCAATAGTTTGAAGGATGTTCAGGAAGATCCAGTTGATGCTCAGCGAATGCAGAGAGTTAAAGAGGCAATGGTTCATGCTTGGAGTTCATATGAAAAGTATGCCTGGGGACAAGATGAGCTTCAGCCCCAGACAAAGGATGGTGTTGACAGCTTTGGTGGCCTGGGTGCAACTATGATAGATGCATTAGACACACTATATATAATGGGTCTAGATGAGCAGTTTCAGAAAGCCAGAGAGTGGGTAGCAAGCTCATTAGATTTCGACAAGGATTATGCTGCCAGTATGTTTGAGACAACCATAAGAGTGGTAGGAGGGCTTCTCAGTGCGTATGATCTTTCTGGGGATAAAATTTTCCTTGAAAAGGCTATGGATATTGCAGACAGATTATTGCCTGCATGGGACACTCAATCGGGTATACCATATAATATTATCAACTTGAAGCATGGAAATGCTCACAATCCTACATGGGCGGGGGGAGACAGTATTCTTGCAGATTCTGGTACTGAGCAGCTTGAATTTATTGCCCTTTCCCAGAGGACAGGGGACCCAAAATATCAGCAAAAGGTAGAAAAGGTTATTTCAGTGCTAAATAAGAACTTCCCTGCTGATGGTTTACTTCCGATATATATAAATCCCGATACAGCTAATCCATCGCAGTCTACAATAACATTTGGTGCCATGGGAGACAGCTTTTACGAATATTTGCTCAAAGTTTGGGTGTTTGGGAACAAAACTTCAGCAGTGAAACACTATAGAGATATGTGGGAGAAGTCAATGAATGGTCTGCTAAGCTTGGTTAAGAAATCAACACCTTTGTCGTTTACATATATCTGTGAGAAGAGTGGAAATTCTTTGATCGATAAGATGGATGAATTGGCATGCTTTGCTCCTGGAATGTTGGCTTTAGGAGCATCTGGGTATAGTGATCCTGCTGAAGGAAAGAAGTTTCTCACACTCGCTGAAGAGCTTGCGTGGACATGTTATAACTTTTACCAATCAACTCCAACAAAACTGGCTGGGGAGAATTATTTCTTCAACTCTGGGAGTGACATGAGTGTTGGAACGTCGTGGAACATCTTGAGACCAGAAACTGTCGAATCACTGTTTTACCTCTGGCGGTTAACTGGAAACAAGACATATCAAGAGTGGGGATGGAATATATTTGAAGCATTTGAGAAGAACTCGCGCATAGAGTCTGGATATGTTGGTTTGAAGGATGTTAATACAGGCGTTAAGGACAACAAGATGCAAAGTTTCTTCCTTGCAGAGACACTCAAGTATCTCTATCTACTCTTCTCGCCGACAACAGTCATTCCTTTAGACGAGTGGGTATTCAACACCGAAGCTCATCCACTTAAGATTAAGTCTCGAAACGATCAGGTAAATCTCAAACAATCCAACAAAGTACTGCTACGAAAACCGGCATTTAGAATACGCCAGAGGCATTATGGTCGGATAACAAAGAAGTAA - >AT3G21160.2
ATGGCGAGGAATAAACTTGTAAGTGGTAGTCATGGGATATGGAAATATTTCAACCCAGCGTTTTATCTCCGAAGACCAAGACGTCTTGCTTTGCTCATCATCCTCTTCGTCTCTGTTTCAATGGTTGTTTGGGATCGTCAATCTCTTTCCCGAGACTACCAGTTTGAAGTTTCCAAGTTAAATGAAGAAGTTTTGCGGTTGCAGCAGATGTTGGAAGAGATAAAGAGCGTCACTGAGGATGTGTCTGTCAATAGTTTGAAGGATGTTCAGGAAGATCCAGTTGATGCTCAGCGAATGCAGAGAGTTAAAGAGGCAATGGTTCATGCTTGGAGTTCATATGAAAAGTATGCCTGGGGACAAGATGAGCTTCAGCCCCAGACAAAGGATGGTGTTGACAGCTTTGGTGGCCTGGGTGCAACTATGATAGATGCATTAGACACACTATATATAATGGGTCTAGATGAGCAGTTTCAGAAAGCCAGAGAGTGGGTAGCAAGCTCATTAGATTTCGACAAGGATTATGCTGCCAGTATGTTTGAGACAACCATAAGAGTGGTAGGAGGGCTTCTCAGTGCGTATGATCTTTCTGGGGATAAAATTTTCCTTGAAAAGGCTATGGATATTGCAGACAGATTATTGCCTGCATGGGACACTCAATCGGGTATACCATATAATATTATCAACTTGAAGCATGGAAATGCTCACAATCCTACATGGGCGGGGGGAGACAGTATTCTTGCAGATTCTGGTACTGAGCAGCTTGAATTTATTGCCCTTTCCCAGAGGACAGGGGACCCAAAATATCAGCAAAAGGTAGAAAAGGTTATTTCAGTGCTAAATAAGAACTTCCCTGCTGATGGTTTACTTCCGATATATATAAATCCCGATACAGCTAATCCATCGCAGTCTACAATAACATTTGGTGCCATGGGAGACAGCTTTTACGAATATTTGCTCAAAGTTTGGGTGTTTGGGAACAAAACTTCAGCAGTGAAACACTATAGAGATATGTGGGAGAAGTCAATGAATGGTCTGCTAAGCTTGGTTAAGAAATCAACACCTTTGTCGTTTACATATATCTGTGAGAAGAGTGGAAATTCTTTGATCGATAAGATGGATGAATTGGCATGCTTTGCTCCTGGAATGTTGGCTTTAGGAGCATCTGGGTATAGTGATCCTGCTGAAGGAAAGAAGTTTCTCACACTCGCTGAAGAGCTTGCGTGGACATGTTATAACTTTTACCAATCAACTCCAACAAAACTGGCTGGGGAGAATTATTTCTTCAACTCTGGGAGTGACATGAGTGTTGGAACGTCGTGGAACATCTTGAGACCAGAAACTGTCGAATCACTGTTTTACCTCTGGCGGTTAACTGGAAACAAGACATATCAAGAGTGGGGATGGAATATATTTGAAGCATTTGAGAAGAACTCGCGCATAGAGTCTGGATATGTTGGTTTGAAGGATGTTAATACAGGCGTTAAGGACAACAAGATGCAAAGTTTCTTCCTTGCAGAGACACTCAAGTATCTCTATCTACTCTTCTCGCCGACAACAGTCATTCCTTTAGACGAGTGGGTATTCAACACCGAAGCTCATCCACTTAAGATTAAGTCTCGAAACGATCAGGTAAATCTCAAACAATCCAACAAAGTACTGCTACGAAAACCGGCATTTAGAATACGCCAGAGGCATTATGGTCGGATAACAAAGAAGTAA
Protein Sequence
- >AT3G21160.1
MARNKLVSGSHGIWKYFNPAFYLRRPRRLALLIILFVSVSMVVWDRQSLSRDYQFEVSKLNEEVLRLQQMLEEIKSVTEDVSVNSLKDVQEDPVDAQRMQRVKEAMVHAWSSYEKYAWGQDELQPQTKDGVDSFGGLGATMIDALDTLYIMGLDEQFQKAREWVASSLDFDKDYAASMFETTIRVVGGLLSAYDLSGDKIFLEKAMDIADRLLPAWDTQSGIPYNIINLKHGNAHNPTWAGGDSILADSGTEQLEFIALSQRTGDPKYQQKVEKVISVLNKNFPADGLLPIYINPDTANPSQSTITFGAMGDSFYEYLLKVWVFGNKTSAVKHYRDMWEKSMNGLLSLVKKSTPLSFTYICEKSGNSLIDKMDELACFAPGMLALGASGYSDPAEGKKFLTLAEELAWTCYNFYQSTPTKLAGENYFFNSGSDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFEAFEKNSRIESGYVGLKDVNTGVKDNKMQSFFLAETLKYLYLLFSPTTVIPLDEWVFNTEAHPLKIKSRNDQVNLKQSNKVLLRKPAFRIRQRHYGRITKK - >AT3G21160.2
MARNKLVSGSHGIWKYFNPAFYLRRPRRLALLIILFVSVSMVVWDRQSLSRDYQFEVSKLNEEVLRLQQMLEEIKSVTEDVSVNSLKDVQEDPVDAQRMQRVKEAMVHAWSSYEKYAWGQDELQPQTKDGVDSFGGLGATMIDALDTLYIMGLDEQFQKAREWVASSLDFDKDYAASMFETTIRVVGGLLSAYDLSGDKIFLEKAMDIADRLLPAWDTQSGIPYNIINLKHGNAHNPTWAGGDSILADSGTEQLEFIALSQRTGDPKYQQKVEKVISVLNKNFPADGLLPIYINPDTANPSQSTITFGAMGDSFYEYLLKVWVFGNKTSAVKHYRDMWEKSMNGLLSLVKKSTPLSFTYICEKSGNSLIDKMDELACFAPGMLALGASGYSDPAEGKKFLTLAEELAWTCYNFYQSTPTKLAGENYFFNSGSDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFEAFEKNSRIESGYVGLKDVNTGVKDNKMQSFFLAETLKYLYLLFSPTTVIPLDEWVFNTEAHPLKIKSRNDQVNLKQSNKVLLRKPAFRIRQRHYGRITKK