Information report for AT3G19860
Gene Details
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Functional Descriptions
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- GO:0005515 — enables — protein binding
- GO:0003700 — enables — DNA-binding transcription factor activity
- GO:0006879 — acts upstream of or within — intracellular iron ion homeostasis
- GO:0000976 — enables — transcription cis-regulatory region binding
- GO:1990837 — enables — sequence-specific double-stranded DNA binding
- GO:0005634 — located in — nucleus
- GO:0006879 — involved in — intracellular iron ion homeostasis
- GO:0046983 — enables — protein dimerization activity
- SALK_137976C — Ferric chelate reductase activity is not induced during Fe deficiency; defect in proton release from the roots
- bhlh121& —
Functional Keywords
Literature and News
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. DOI: 10.1093/molbev/msg088 ; PMID: 12679534
- The Arabidopsis basic/helix-loop-helix transcription factor family. DOI: 10.1105/tpc.013839 ; PMID: 12897250
- Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana. DOI: 10.1105/tpc.151140 ; PMID: 14600211
- Overexpression of a mutant basic helix-loop-helix protein HFR1, HFR1-deltaN105, activates a branch pathway of light signaling in Arabidopsis. DOI: 10.1104/pp.103.029751 ; PMID: 14645731
- Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: and shoot-specific genes. DOI: 10.1111/j.1365-313X.2004.02051.x ; PMID: 15078338
- Comparative transcriptome analysis of Arabidopsis thaliana infested by diamond back moth (Plutella xylostella) larvae reveals signatures of stress response, secondary metabolism, and signalling. DOI: 10.1186/1471-2164-9-154 ; PMID: 18400103
- The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. DOI: 10.1105/tpc.110.074096 ; PMID: 20675571
- Identification and characterization of transcription factors regulating Arabidopsis HAK5. DOI: 10.1093/pcp/pct094 ; PMID: 23825216
- Promoter-based integration in plant defense regulation. DOI: 10.1104/pp.114.248716 ; PMID: 25352272
- An Arabidopsis gene regulatory network for secondary cell wall synthesis. DOI: 10.1038/nature14099 ; PMID: 25533953
- Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation. DOI: 10.1105/tpc.15.00744 ; PMID: 27650334
- The G-Box Transcriptional Regulatory Code in Arabidopsis. DOI: 10.1104/pp.17.01086 ; PMID: 28864470
- Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element. DOI: 10.3389/fpls.2017.02100 ; PMID: 29321786
- The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana. DOI: 10.1007/s10265-018-1068-z ; PMID: 30417276
- Transcriptional regulation of nitrogen-associated metabolism and growth. DOI: 10.1038/s41586-018-0656-3 ; PMID: 30356219
- The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI. DOI: 10.1073/pnas.1916892116 ; PMID: 31776249
- The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis. DOI: 10.1105/tpc.19.00541 ; PMID: 31776233
- bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis. DOI: 10.1016/j.molp.2020.01.006 ; PMID: 31962167
- Further insights into the role of bHLH121 in the regulation of iron homeostasis in Arabidopsis thaliana. DOI: 10.1080/15592324.2020.1795582 ; PMID: 32692954
- All together now: regulation of the iron deficiency response. DOI: 10.1093/jxb/erab003 ; PMID: 33449088
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. DOI: 10.1093/molbev/msg088 ; PMID: 12679534
Gene Resources
- UniProt: A0A1I9LN90
- EMBL: CP002686
- AlphaFoldDB: A0A1I9LN90
- EnsemblPlants: AT3G19860.3
- Gramene: AT3G19860.3
- ExpressionAtlas: AT3G19860
- InterPro: IPR011598, IPR036638, IPR044579
- PANTHER: PTHR47001, PTHR47001:SF3
- SUPFAM: SSF47459
- PROSITE: PS50888
- Gene3D: 4.10.280.10
- SWISS-MODEL: A0A1I9LN90
- Conserved Domain Database: cd11446
Homologs
- Brassica napus GSBRNA2T00054328001, GSBRNA2T00074427001
- Brassica oleracea XP_013615996.1, XP_013615991.1
- Brassica rapa XP_009111465.1
- Citrus sinensis orange1.1g022288m
- Raphanus raphanistrum RrC216_p2
- Salvia miltiorrhiza SMil_00007696-RA_Salv
- Sesamum indicum XP_011092862.1
- Ziziphus jujuba XP_015893436.1
Sequences
cDNA Sequence
- >AT3G19860.3
TTTAGGGTTTCGATCACAATCTGGTACTTCTCTTAATCAAAGGAATTTTTATTTTGATTTTGAGGGTTTTATTGGTTTGAACTTAGCTCTCTAGCTCGTGAAAGTGTTGTTAGTTCGTCGTGGAAATCAATTCCTTCCCTGTGTTCTTCTTCAACAACGTTTAGTAATTTTTTCGTAGATGTTTAAATCTCTAACTTGTTGATAGAGATAGATGTTATTATTGCCAAATTAGGTGTACAAAAGAATGTGGAATTTTCTGTTTGAGATTAGCTTCTCTAGTAACCTTCTTTGCAATTCATGATGCCAATTGCTAAGTATGTAACTATGTCTGGTATGTGAGCTGGGATCATATGATACCTGACTATCGACTCAAAGAGAATTATGTTAAGTCAATCAAGGCTTAGTTCTGAGGCTACAGTGTGTGTGGTCGATGTGCTGTTATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGATTCGAAAGAATCTGATGTTGATCATCTCAAGTATCCAAGTATCGTTTCGATGAGTACTGTATATAGTGCGAGTACAAAATGCACTTAGCTGTTTAAAGCAGTGTTTTGATGCACCGTGGCATTCGTTTTCCTCGGATAGTCATTTCTCAGATGATTTTCATCCTTAATAGGTCTGCTTTAGTTCTAAAACTCGGATGATTTGTAATTTCCAGTGTCCAAATCTACTAATTTTATTAATCCTATAAATTAAACAAACTTATATCTTGATTTTTTTTTAAAAATCATAGATTATTTATACTATTGTACAAAAAGAATTACATTTAAA - >AT3G19860.2
TTTAGGGTTTCGATCACAATCTGGTACTTCTCTTAATCAAAGGAATTTTTATTTTGATTTTGAGGGTTTTATTGGTTTGAACTTAGCTCTCTAGCTCGTGAAAGTGTTGTTAGTTCGTCGTGGAAATCAATTCCTTCCCTGTGTTCTTCTTCAACAACGTTTAGTAATTTTTTCGTAGATGTTTAAATCTCTAACTTGTTGATAGAGATAGATGTTATTATTGCCAAATTAGGTGTACAAAAGAATGTGGAATTTTCTGTTTGAGATTAGCTTCTCTAGTAACCTTCTTTGCAATTCATGATGCCAATTGCTAAGTATGTAACTATGTCTGGTATGTGAGCTGGGATCATATGATACCTGACTATCGACTCAAAGAGAATTATGTTAAGTCAATCAAGGCTTAGTTCTGAGGCTACAGTGTGTGTGGTCGATGTGCTGTTATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGATTCGAAAGAATCTGATGTTGATCATCTCAAGTATCCAAGTATCGTTTCGATGAGTACTGTATATAGTGCGAGTACAAAATGCACTTAGCTGTTTAAAGCAGTGTTTTGATGCACCGTGGCATTCGTTTTCCTCGGATAGTCATTTCTCAGATGATTTTCATCCTTAATAGGTCTGCTTTAGTTCTAAAACTCGGATGATTTGTAATTTCCAGTGTCCAAATCTACTAATTTTATTAATCCTATAAATTAAACAAACTTATATCTTGATTTTTTTTTAAAAATCATAGATTATTTATACTATTGTACAAAAAGAATTACATTTAAA - >AT3G19860.1
TTTAGGGTTTCGATCACAATCTGGTACTTCTCTTAATCAAAGGAATTTTTATTTTGATTTTGAGGGTTTTATTGGTTTGAACTTAGCTCTCTAGCTCGTGAAAGTGTTGTTAGTTCGTCGTGGAAATCAATTCCTTCCCTGTGTTCTTCTTCAACAACGTTTAGTAATTTTTTCGTAGATGTTTAAATCTCTAACTTGTTGATAGAGATAGATGTTATTATTGCCAAATTAGGTGTACAAAAGAATGTGGAATTTTCTGTTTGAGATTAGCTTCTCTAGTAACCTTCTTTGCAATTCATGATGCCAATTGCTAAGTATGTAACTATGTCTGGTATGTGAGCTGGGATCATATGATACCTGACTATCGACTCAAAGAGAATTATGTTAAGTCAATCAAGGCTTAGTTCTGAGGCTACAGTGTGTGTGGTCGATGTGCTGTTATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGATTCGAAAGAATCTGATGTTGATCATCTCAAGTATCCAAGTATCGTTTCGATGAGTACTGTATATAGTGCGAGTACAAAATGCACTTAGCTGTTTAAAGCAGTGTTTTGATGCACCGTGGCATTCGTTTTCCTCGGATAGTCATTTCTCAGATGATTTTCATCCTTAATAGGTCTGCTTTAGTTCTAAAACTCGGATGATTTGTAATTTCCAGTGTCCAAATCTACTAATTTTATTAATCCTATAAATTAAACAAACTTATATCTTGATTTTTTTTTAAAAATCATAGATTATTTATACTATTGTACAAAAAGAATTACATTTAAA
CDS Sequence
- >AT3G19860.3
ATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGA - >AT3G19860.2
ATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGA - >AT3G19860.1
ATGGTGGAATTGGATACTAAAATATGTCTAAGAGTGGGACTGCAATATGACCTTCTTAGTTTATTCGATGTTTTGGTTGCAGAAGAGGAGGTCATGGACGTTTCTGCTAGAAAGTCACAAAAAGCTGGGCGCGAAAAGTTGAGGAGGGAAAAACTGAATGAGCATTTTGTTGAACTGGGAAATGTACTCGATCCAGAGAGACCCAAGAATGACAAAGCCACGATTCTGACTGATACTGTTCAGTTGTTGAAAGAGCTCACATCTGAAGTCAACAAACTGAAATCTGAGTACACCGCATTGACAGATGAGTCCCGCGAGTTGACACAGGAGAAAAACGACCTGAGAGAAGAAAAGACATCGCTGAAATCAGATATAGAGAATCTCAATCTTCAATACCAGCAGAGATTAAGGTCAATGTCTCCATGGGGAGCTGCGATGGATCACACAGTCATGATGGCTCCACCACCCTCCTTTCCATACCCTATGCCTATTGCTATGCCTCCCGGGTCAATCCCAATGCATCCATCAATGCCATCTTACACATACTTTGGGAACCAGAACCCTAGCATGATCCCAGCTCCATGTCCTACATACATGCCCTACATGCCTCCTAATACAGTCGTTGAGCAACAATCCGTGCACATTCCACAGAACCCCGGTAACCGTTCTCGGGAACCTAGAGCAAAGGTTTCAAGAGAGAGCAGATCTGAGAAAGCAGAGGACTCCAACGAAGTTGCAACACAACTCGAATTAAAAACCCCTGGATCTACTTCTGATAAGGATACATTGCAAAGGCCAGAGAAGACAAAGAGATGTAAGAGAAACAACAACAACAACTCAATAGAAGAAAGCTCTCATTCTAGCAAGTGTTCATCTTCTCCGAGCGTACGAGACCACAGTTCTTCCAGTAGCGTAGCTGGTGGCCAAAAACCTGATGATGCAAAATGA
Protein Sequence
- >AT3G19860.3
MVELDTKICLRVGLQYDLLSLFDVLVAEEEVMDVSARKSQKAGREKLRREKLNEHFVELGNVLDPERPKNDKATILTDTVQLLKELTSEVNKLKSEYTALTDESRELTQEKNDLREEKTSLKSDIENLNLQYQQRLRSMSPWGAAMDHTVMMAPPPSFPYPMPIAMPPGSIPMHPSMPSYTYFGNQNPSMIPAPCPTYMPYMPPNTVVEQQSVHIPQNPGNRSREPRAKVSRESRSEKAEDSNEVATQLELKTPGSTSDKDTLQRPEKTKRCKRNNNNNSIEESSHSSKCSSSPSVRDHSSSSSVAGGQKPDDAK - >AT3G19860.2
MVELDTKICLRVGLQYDLLSLFDVLVAEEEVMDVSARKSQKAGREKLRREKLNEHFVELGNVLDPERPKNDKATILTDTVQLLKELTSEVNKLKSEYTALTDESRELTQEKNDLREEKTSLKSDIENLNLQYQQRLRSMSPWGAAMDHTVMMAPPPSFPYPMPIAMPPGSIPMHPSMPSYTYFGNQNPSMIPAPCPTYMPYMPPNTVVEQQSVHIPQNPGNRSREPRAKVSRESRSEKAEDSNEVATQLELKTPGSTSDKDTLQRPEKTKRCKRNNNNNSIEESSHSSKCSSSPSVRDHSSSSSVAGGQKPDDAK - >AT3G19860.1
MVELDTKICLRVGLQYDLLSLFDVLVAEEEVMDVSARKSQKAGREKLRREKLNEHFVELGNVLDPERPKNDKATILTDTVQLLKELTSEVNKLKSEYTALTDESRELTQEKNDLREEKTSLKSDIENLNLQYQQRLRSMSPWGAAMDHTVMMAPPPSFPYPMPIAMPPGSIPMHPSMPSYTYFGNQNPSMIPAPCPTYMPYMPPNTVVEQQSVHIPQNPGNRSREPRAKVSRESRSEKAEDSNEVATQLELKTPGSTSDKDTLQRPEKTKRCKRNNNNNSIEESSHSSKCSSSPSVRDHSSSSSVAGGQKPDDAK