Gene Details:

• Gene ID: AT3G19860
• Gene Symbol: bHLH121, URI
• Gene Name: basic Helix-Loop-Helix 121, r Upstream Regulator of IRT1
• Description: basic helix-loop-helix (bHLH) DNA-binding superfamily protein;(source:Araport11)
• TAIR Accession: locus:2092216
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G19860.1     AT3G19860.2     AT3G19860.3

Plant Ontology Annotations:

• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0003700  — enables — DNA-binding transcription factor activity
• GO:0006879  — acts upstream of or within — intracellular iron ion homeostasis
• GO:0000976  — enables — transcription cis-regulatory region binding
• GO:1990837  — enables — sequence-specific double-stranded DNA binding
• GO:0005634  — located in — nucleus
• GO:0006879  — involved in — intracellular iron ion homeostasis
• GO:0046983  — enables — protein dimerization activity

Germplasm Phenotype:

• SALK_137976C  — Ferric chelate reductase activity is not induced during Fe deficiency; defect in proton release from the roots
• bhlh121&  — 

Function-related keywords:

• pollen

Literature:

• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• The Arabidopsis basic/helix-loop-helix transcription factor family.   DOI:  10.1105/tpc.013839 ;  PMID:  12897250
• Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.   DOI:  10.1105/tpc.151140 ;  PMID:  14600211
• Overexpression of a mutant basic helix-loop-helix protein HFR1, HFR1-deltaN105, activates a branch pathway of light signaling in Arabidopsis.   DOI:  10.1104/pp.103.029751 ;  PMID:  14645731
• Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: and shoot-specific genes.   DOI:  10.1111/j.1365-313X.2004.02051.x ;  PMID:  15078338
• Comparative transcriptome analysis of Arabidopsis thaliana infested by diamond back moth (Plutella xylostella) larvae reveals signatures of stress response, secondary metabolism, and signalling.   DOI:  10.1186/1471-2164-9-154 ;  PMID:  18400103
• The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.   DOI:  10.1105/tpc.110.074096 ;  PMID:  20675571
• Identification and characterization of transcription factors regulating Arabidopsis HAK5.   DOI:  10.1093/pcp/pct094 ;  PMID:  23825216
• Promoter-based integration in plant defense regulation.   DOI:  10.1104/pp.114.248716 ;  PMID:  25352272
• An Arabidopsis gene regulatory network for secondary cell wall synthesis.   DOI:  10.1038/nature14099 ;  PMID:  25533953
• Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.   DOI:  10.1105/tpc.15.00744 ;  PMID:  27650334
• The G-Box Transcriptional Regulatory Code in Arabidopsis.   DOI:  10.1104/pp.17.01086 ;  PMID:  28864470
• Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element.   DOI:  10.3389/fpls.2017.02100 ;  PMID:  29321786
• The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana.   DOI:  10.1007/s10265-018-1068-z ;  PMID:  30417276
• Transcriptional regulation of nitrogen-associated metabolism and growth.   DOI:  10.1038/s41586-018-0656-3 ;  PMID:  30356219
• The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.   DOI:  10.1073/pnas.1916892116 ;  PMID:  31776249
• The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.   DOI:  10.1105/tpc.19.00541 ;  PMID:  31776233
• bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.   DOI:  10.1016/j.molp.2020.01.006 ;  PMID:  31962167
• Further insights into the role of bHLH121 in the regulation of iron homeostasis in Arabidopsis thaliana.   DOI:  10.1080/15592324.2020.1795582 ;  PMID:  32692954
• All together now: regulation of the iron deficiency response.   DOI:  10.1093/jxb/erab003 ;  PMID:  33449088
• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534

Sequences: