Gene Details:

• Gene ID: AT3G19260
• Gene Symbol: LAG1 HOMOLOG 2, LOH2
• Gene Name: LONGEVITY ASSURANCE GENE1 HOMOLOG 2, LAG1 homologue 2
• Description: LAG1 homologue 2;(source:Araport11)
• TAIR Accession: locus:2094133
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G19260.1

Plant Ontology Annotations:

• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0006665  — involved in — sphingolipid metabolic process
• GO:0046513  — involved in — ceramide biosynthetic process
• GO:0002238  — acts upstream of or within — response to molecule of fungal origin
• GO:0050291  — enables — sphingosine N-acyltransferase activity
• GO:0042759  — acts upstream of or within — long-chain fatty acid biosynthetic process
• GO:0005783  — located in — endoplasmic reticulum
• GO:0005886  — located in — plasma membrane
• GO:0010256  — involved in — endomembrane system organization
• GO:0005783  — is active in — endoplasmic reticulum
• GO:0005634  — located in — nucleus
• GO:0005794  — located in — Golgi apparatus

Germplasm Phenotype:

• CS66114  — Hypersensitive to Fumonisin B1

Function-related keywords:

• plant sperm cell ,  pollen tube cell ,  pollen

Literature:

• A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana.   DOI:  10.1093/aob/mch071 ;  PMID:  15037448
• Mining the Arabidopsis thaliana genome for highly-divergent seven transmembrane receptors.   DOI:  10.1186/gb-2006-7-10-r96 ;  PMID:  17064408
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings.   DOI:  10.1111/j.1365-313X.2008.03596.x ;  PMID:  18643979
• Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.   DOI:  10.1016/j.bbrc.2008.08.056 ;  PMID:  18725200
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis.   DOI:  10.1105/tpc.110.080473 ;  PMID:  21666002
• Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana.   DOI:  10.1111/j.1469-8137.2011.03852.x ;  PMID:  21883234
• Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes.   DOI:  10.1016/j.plaphy.2012.05.024 ;  PMID:  22710144
• Acyl-lipid metabolism.   DOI:  10.1199/tab.0161 ;  PMID:  23505340
• Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis.   DOI:  10.1371/journal.pgen.1005143 ;  PMID:  25822663
• Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling.   DOI:  10.1016/j.phytochem.2015.02.019 ;  PMID:  25794895
• Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance.   DOI:  10.1104/pp.15.00987 ;  PMID:  26276842
• Sphingolipid-Induced Programmed Cell Death is a Salicylic Acid and EDS1-Dependent Phenotype in Arabidopsis Fatty Acid Hydroxylase (Fah1, Fah2) and Ceramide Synthase (Loh2) Triple Mutants.   DOI:  10.1093/pcp/pcab174 ;  PMID:  34910213
• The Two Classes of Ceramide Synthases Play Different Roles in Plant Immunity and Cell Death.   DOI:  10.3389/fpls.2022.824585 ;  PMID:  35463421
• Overexpression of a ceramide synthase gene,GhCS1, inhibits fiber cell initiation and elongation by promoting the synthesis of ceramides containing dihydroxy LCB and VLCFA.   DOI:  10.3389/fpls.2022.1000348 ;  PMID:  36119591
• Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.   DOI:  10.1074/mcp.T300006-MCP200 ;  PMID:  14506206
• Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings.   DOI:  10.1111/j.1365-313X.2008.03596.x ;  PMID:  18643979
• Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.   DOI:  10.1016/j.bbrc.2008.08.056 ;  PMID:  18725200

Sequences: