Gene Details:

• Gene ID: AT3G18290
• Gene Symbol: BTS, EMB2454
• Gene Name: BRUTUS, embryo defective 2454
• Description: zinc finger protein-like protein;(source:Araport11)
• TAIR Accession: locus:2089678
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G18290.1

Plant Ontology Annotations:

• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0010106  — acts upstream of or within — cellular response to iron ion starvation
• GO:0005515  — enables — protein binding
• GO:0010106  — involved in — cellular response to iron ion starvation
• GO:0006511  — involved in — ubiquitin-dependent protein catabolic process
• GO:0009793  — acts upstream of or within — embryo development ending in seed dormancy
• GO:0071456  — acts upstream of or within — cellular response to hypoxia
• GO:0061630  — enables — ubiquitin protein ligase activity
• GO:0060586  — involved in — multicellular organismal-level iron ion homeostasis

Germplasm Phenotype:

• CS16055  — embryo defective; developmental arrest of mutant embryos
• CS16056  — embryo defective; developmental arrest of mutant embryos
• bts-3  — Plants have higher levels of Fe in roots and decreased sensitivity to Fe depravation.

Function-related keywords:

• pollen tube cell ,  pollen

Literature:

• Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome.   DOI:  10.1186/gb-2002-3-4-research0016 ;  PMID:  11983057
• Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.   DOI:  10.1074/jbc.M308435200 ;  PMID:  14576160
• The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis.   DOI:  10.1074/jbc.M313350200 ;  PMID:  14722088
• ABA activates ADPR cyclase and cADPR induces a subset of ABA-responsive genes in Arabidopsis.   DOI:  10.1111/j.1365-313X.2004.02055.x ;  PMID:  15086800
• Identification of genes required for embryo development in Arabidopsis.   DOI:  10.1104/pp.104.045179 ;  PMID:  15266054
• Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis.   DOI:  10.1104/pp.104.052423 ;  PMID:  15644464
• Cis-regulatory element based targeted gene finding: genome-wide identification of and abiotic stress-responsive genes in Arabidopsis thaliana.   DOI:  10.1093/bioinformatics/bti490 ;  PMID:  15890746
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Identification, cloning and characterization of sis7 and sis10 sugar-insensitive mutants of Arabidopsis.   DOI:  10.1186/1471-2229-8-104 ;  PMID:  18854047
• The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.   DOI:  10.1105/tpc.110.074096 ;  PMID:  20675571
• Identification of nuclear genes encoding chloroplast-localized proteins required for embryo development in Arabidopsis.   DOI:  10.1104/pp.110.168120 ;  PMID:  21139083
• The transcriptional response of Arabidopsis leaves to Fe deficiency.   DOI:  10.3389/fpls.2013.00276 ;  PMID:  23888164
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Chromate alters root system architecture and activates expression of genes involved in iron homeostasis and signaling in Arabidopsis thaliana.   DOI:  10.1007/s11103-014-0210-0 ;  PMID:  24928490
• bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana.   DOI:  10.1093/jxb/erx043 ;  PMID:  28369511
• BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana.   DOI:  10.1039/c7mt00152e ;  PMID:  28620661
• Genome-wide analysis of gene expression profiling revealed that COP9 signalosome is essential for correct expression of Fe homeostasis genes in Arabidopsis.   DOI:  10.1007/s10534-017-0036-8 ;  PMID:  28744713
• The E3 ligase BRUTUS facilitates degradation of VOZ1/2 transcription factors.   DOI:  10.1111/pce.13363 ;  PMID:  29878379
• Iron and Phosphate Deficiency Regulators Concertedly Control Coumarin Profiles in Arabidopsis thaliana Roots During Iron, Phosphate, and Combined Deficiencies.   DOI:  10.3389/fpls.2019.00113 ;  PMID:  30804973
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress.   DOI:  10.1105/tpc.19.00463 ;  PMID:  31519798
• The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.   DOI:  10.1073/pnas.1916892116 ;  PMID:  31776249
• The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.   DOI:  10.1105/tpc.19.00541 ;  PMID:  31776233
• Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress.   DOI:  10.1080/15592324.2020.1758455 ;  PMID:  32351167
• Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency.   DOI:  10.1371/journal.pone.0237998 ;  PMID:  32817691
• Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization.   DOI:  10.1093/plcell/koab075 ;  PMID:  33751120
• IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis.   DOI:  10.1073/pnas.2109063118 ;  PMID:  34548401
• Altered metal distribution in the sr45-1 Arabidopsis mutant causes developmental defects.   DOI:  10.1111/tpj.15740 ;  PMID:  35305053
• The Iron Deficiency-Regulated Small Protein Effector FEP3/IRON MAN1 Modulates Interaction of BRUTUS-LIKE1 With bHLH Subgroup IVc and POPEYE Transcription Factors.   DOI:  10.3389/fpls.2022.930049 ;  PMID:  35755670
• ELONGATED HYPOCOTYL 5 regulates BRUTUS and affects iron acquisition and homeostasis in Arabidopsis thaliana.   DOI:  10.1111/tpj.16191 ;  PMID:  36920240
• Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes.   DOI:  10.1371/journal.pone.0203442 ;  PMID:  30169501

Sequences: