Gene Details:

• Gene ID: AT3G17810
• Gene Symbol: PYD1
• Gene Name: pyrimidine 1
• Description: pyrimidine 1;(source:Araport11)
• TAIR Accession: locus:2088570
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G17810.1

Gene Ontology:

• GO:0043562  — acts upstream of or within — cellular response to nitrogen levels
• GO:0019483  — involved in — beta-alanine biosynthetic process
• GO:0006212  — acts upstream of or within — uracil catabolic process
• GO:0005886  — located in — plasma membrane
• GO:0006212  — involved in — uracil catabolic process
• GO:0009570  — located in — chloroplast stroma
• GO:0009536  — located in — plastid
• GO:0002058  — enables — uracil binding
• GO:0009507  — located in — chloroplast
• GO:0052620  — enables — thymine dehydrogenase activity
• GO:0006210  — involved in — thymine catabolic process
• GO:0017113  — enables — dihydropyrimidine dehydrogenase (NADP+) activity
• GO:0050661  — enables — NADP binding

Germplasm Phenotype:

• SALK_083897C  — The pyd1-2 mutant has a wild-type appearance under normal growth conditions. Transcript levels for several genes involved in de novo pyrimidine biosynthesis are up-regulated in pyrd1-1 mutants. Transcripts for salvage pathway enzymes are also altered. Pyrimidine nucleotide and uridine levels are not changed in the mutant, but uracil levels are increased. The mutant has about a 40% decrease in uracil catabolism. These mutants can grow when uracil is provided as a sole nitrogen source.
• pyd1-1  — The mutant has a wild-type appearance under normal growth conditions. Pyrimidine nucleotide and uridine levels are not changed in the mutant, but uracil levels are increased. These mutants can grow when uracil is provided as a sole nitrogen source.
• pyd1-2  — Reduced sensitivity to nitro-oxidative and oxidative stress as determined by seedling root and shoot growth assay in cultured media. Increased sensitivity to drought stress.

Literature:

• Molecular analysis of de novo pyrimidine synthesis in solanaceous species.   DOI:  10.1023/a:1019854531254 ;  PMID:  12369616
• Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.   DOI:  10.1074/jbc.M308435200 ;  PMID:  14576160
• The Arabidopsis thaliana transcriptome in response to Agrobacterium tumefaciens.   DOI:  10.1094/MPMI-19-0665 ;  PMID:  16776300
• The association among gene expression responses to nine abiotic stress treatments in Arabidopsis thaliana.   DOI:  10.1534/genetics.106.061374 ;  PMID:  17028338
• Identification of plant promoter constituents by analysis of local distribution of short sequences.   DOI:  10.1186/1471-2164-8-67 ;  PMID:  17346352
• The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors.   DOI:  10.1093/jxb/ern155 ;  PMID:  18552355
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Drought-induced AtbZIP62 transcription factor regulates drought stress response in Arabidopsis.   DOI:  10.1016/j.plaphy.2020.09.013 ;  PMID:  33007532
• Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA.   DOI:  10.1093/nar/gkad529 ;  PMID:  37334828
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: