Gene Details:
- Gene ID: AT3G17609
- Gene Symbol: HYH
- Gene Name: HY5-homolog
- Description: HY5-homolog;(source:Araport11)
- TAIR Accession: locus:1005716533
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Gene Ontology:
- GO:0000976 — enables — transcription cis-regulatory region binding
- GO:0005515 — enables — protein binding
- GO:0045944 — involved in — positive regulation of transcription by RNA polymerase II
- GO:0010017 — involved in — red or far-red light signaling pathway
- GO:0000981 — enables — DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0005634 — located in — nucleus
- GO:0005634 — is active in — nucleus
- GO:0010099 — involved in — regulation of photomorphogenesis
- GO:0010114 — involved in — response to red light
- GO:0003700 — enables — DNA-binding transcription factor activity
- GO:0010218 — involved in — response to far red light
- GO:0010224 — acts upstream of or within — response to UV-B
Germplasm Phenotype:
- cop1-1 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-1 hyh — No suppression of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light. This is in contrast to the phenotype observed in the other two double mutants: cop1-4/hyh and cop1-6/hyh.
- cop1-4 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-4 hyh — Suppression in a substantial number of seedlings of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light.
- cop1-6 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-6 hyh — Suppression in a substantial number of seedlings of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light.
- hy5-KS50 hyh — Blue-light-grown double-mutant seedlings have a longer hypocotyl than seedlings carrying the hyh or hy5 mutation alone.
- hy5-KS50 hyh — Mutant produces significantly reduced levels of anthocyanins and is not responsive to cytokinins at all.
- hy5-KS50 hyh — The double-mutant seedlings contains &
- hyh — White-light-grown mutant seedlings are slightly paler than wild-type seedlings. No significant difference in chlorophyll content was observed, but hyh seedlings accumulate slightly reduced levels of anthocyanin.
Literature:
- bZIP transcription factors in Arabidopsis. DOI: 10.1016/s1360-1385(01)02223-3 ; PMID: 11906833
- Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. DOI: 10.1101/gad.969702 ; PMID: 12023303
- HY5 is a point of convergence between cryptochrome and cytokinin signalling pathways in Arabidopsis thaliana. DOI: 10.1111/j.1365-313X.2006.02973.x ; PMID: 17217468
- Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis. DOI: 10.1111/j.1365-313X.2008.03435.x ; PMID: 18266923
- The common function of a novel subfamily of B-Box zinc finger proteins with reference to circadian-associated events in Arabidopsis thaliana. DOI: 10.1271/bbb.80041 ; PMID: 18540109
- Synergism of red and blue light in the control of Arabidopsis gene expression and development. DOI: 10.1016/j.cub.2009.05.062 ; PMID: 19559617
- The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1. DOI: 10.1016/j.jplph.2009.05.010 ; PMID: 19540016
- Light control of peroxisome proliferation during Arabidopsis photomorphogenesis. DOI: 10.4161/psb.3.10.5876 ; PMID: 19704562
- Dynamics of peroxisome abundance: a tale of division and proliferation. DOI: 10.1016/j.pbi.2009.08.001 ; PMID: 19734083
- Dynamic landscapes of four histone modifications during deetiolation in Arabidopsis. DOI: 10.1105/tpc.109.066845 ; PMID: 20008096
- Karrikins enhance light responses during germination and seedling development in Arabidopsis thaliana. DOI: 10.1073/pnas.0911635107 ; PMID: 20351290
- Peroxisome division and proliferation in plants. DOI: 10.1042/BST0380817 ; PMID: 20491669
- det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression. DOI: 10.1111/j.1365-313X.2010.04249.x ; PMID: 20487384
- Unique status of NIA2 in nitrate assimilation: NIA2 expression is promoted by HY5/HYH and inhibited by PIF4. DOI: 10.4161/psb.4.11.9795 ; PMID: 20009559
- Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana. DOI: 10.1111/j.1365-313X.2011.04573.x ; PMID: 21395889
- Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation. DOI: 10.1093/mp/ssr049 ; PMID: 21715650
- Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner. DOI: 10.4161/psb.6.5.14343 ; PMID: 21636970
- UV-B signaling pathways and fluence rate dependent transcriptional regulation of ARIADNE12. DOI: 10.1111/j.1399-3054.2011.01561.x ; PMID: 22188380
- Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana. DOI: 10.1074/jbc.M111.333906 ; PMID: 22692212
- Induction of ARI12 upon broad band UV-B radiation is suppressed by UVR8 and cryptochromes. DOI: 10.4161/psb.22052 ; PMID: 22990446
- Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis. DOI: 10.1105/tpc.112.104869 ; PMID: 23645630
- Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development. DOI: 10.4161/psb.25208 ; PMID: 23733077
- The UVR8 UV-B Photoreceptor: Perception, Signaling and Response. DOI: 10.1199/tab.0164 ; PMID: 23864838
- Dynamics of the shade-avoidance response in Arabidopsis. DOI: 10.1104/pp.113.221549 ; PMID: 23893169
- Three transcription factors, HFR1, LAF1 and HY5, regulate largely independent signaling pathways downstream of phytochrome A. DOI: 10.1093/pcp/pct042 ; PMID: 23503597
- Ultraviolet-B-induced stomatal closure in Arabidopsis is regulated by the UV RESISTANCE LOCUS8 photoreceptor in a nitric oxide-dependent mechanism. DOI: 10.1104/pp.113.231753 ; PMID: 24586043
- HUA ENHANCER1 is involved in posttranscriptional regulation of positive and negative regulators in Arabidopsis photomorphogenesis. DOI: 10.1105/tpc.114.126722 ; PMID: 25052717
- In silico analysis of the structure and interaction of COP1 protein of Arabidopsis thaliana. DOI: NA ; PMID: 25630103
- Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development. DOI: 10.1111/tpj.12899 ; PMID: 26047210
- Exploring potential new floral organ morphogenesis genes of Arabidopsis thaliana using systems biology approach. DOI: 10.3389/fpls.2015.00829 ; PMID: 26528302
- Light affects salt stress-induced transcriptional memory of P5CS1 in Arabidopsis. DOI: 10.1073/pnas.1610670114 ; PMID: 27930298
- The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis. DOI: 10.1242/jcs.203927 ; PMID: 28720596
- Genome-wide regulation of light-controlled seedling morphogenesis by three families of transcription factors. DOI: 10.1073/pnas.1803861115 ; PMID: 29844157
- RSM1, an Arabidopsis MYB protein, interacts with HY5/HYH to modulate seed germination and seedling development in response to abscisic acid and salinity. DOI: 10.1371/journal.pgen.1007839 ; PMID: 30566447
- Impact of UV-B radiation on the photosystem II activity, pro-/antioxidant balance and expression of light-activated genes in Arabidopsis thaliana hy4 mutants grown under light of different spectral composition. DOI: 10.1016/j.jphotobiol.2019.02.003 ; PMID: 30897399
- Different irradiances of UV and PAR in the same ratios alter the flavonoid profiles of Arabidopsis thaliana wild types and UV-signalling pathway mutants. DOI: 10.1039/c8pp00496j ; PMID: 31166333
- Regulation of Arabidopsis gene expression by low fluence rate UV-B independently of UVR8 and stress signaling. DOI: 10.1039/c9pp00151d ; PMID: 31218318
- Transcriptional regulation of nitrogen-associated metabolism and growth. DOI: 10.1038/s41586-018-0656-3 ; PMID: 30356219
- Degradation of the transcription factors PIF4 and PIF5 under UV-B promotes UVR8-mediated inhibition of hypocotyl growth in Arabidopsis. DOI: 10.1111/tpj.14556 ; PMID: 31571300
- phyB and HY5 are Involved in the Blue Light-Mediated Alleviation of Dormancy of Arabidopsis Seeds Possibly via the Modulation of Expression of Genes Related to Light, GA, and ABA. DOI: 10.3390/ijms20235882 ; PMID: 31771191
- A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. DOI: 10.1105/tpc.19.00562 ; PMID: 31806676
- MYC2 regulates ARR16, a component of cytokinin signaling pathways, in Arabidopsis seedling development. DOI: 10.1002/pld3.177 ; PMID: 31788657
- Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH. DOI: 10.1111/tpj.14736 ; PMID: 32142184
- Time-Course Transcriptome Study Reveals Mode of bZIP Transcription Factors on Light Exposure in Arabidopsis. DOI: 10.3390/ijms21061993 ; PMID: 32183354
- Nucleo-plastidic PAP8/pTAC6 couples chloroplast formation with photomorphogenesis. DOI: 10.15252/embj.2020104941 ; PMID: 33001465
- Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis. DOI: 10.1111/jipb.13111 ; PMID: 33982818
- UV-B Irradiation Results in Inhibition of Hypocotyl Elongation, Cell Cycle Arrest, and Decreased Endoreduplication Mediated by miR5642. DOI: 10.1111/php.13574 ; PMID: 34882800
- In silico analysis of cis-elements and identification of transcription factors putatively involved in the regulation of the OAS cluster genes SDI1 and SDI2. DOI: 10.1111/tpj.15735 ; PMID: 35315155
- ELONGATED HYPOCOTYL5 (HY5) and HY5 HOMOLOGUE (HYH) maintain shade avoidance suppression in UV-B. DOI: 10.1111/tpj.16328 ; PMID: 37243898
- bZIP transcription factors in Arabidopsis. DOI: 10.1016/s1360-1385(01)02223-3 ; PMID: 11906833
- HY5 is a point of convergence between cryptochrome and cytokinin signalling pathways in Arabidopsis thaliana. DOI: 10.1111/j.1365-313X.2006.02973.x ; PMID: 17217468
- Genome-wide gene expression analysis reveals a critical role for CRYPTOCHROME1 in the response of Arabidopsis to high irradiance. DOI: 10.1104/pp.107.098293 ; PMID: 17478635
- HY5 and HYH are positive regulators of nitrate reductase in seedlings and rosette stage plants. DOI: 10.1007/s00425-007-0638-4 ; PMID: 17929051
- UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH. DOI: 10.1104/pp.107.108456 ; PMID: 18055587
- Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de-etiolation in darkness. DOI: 10.1111/j.1365-313X.2007.03346.x ; PMID: 18053005
- Light induces peroxisome proliferation in Arabidopsis seedlings through the photoreceptor phytochrome A, the transcription factor HY5 HOMOLOG, and the peroxisomal protein PEROXIN11b. DOI: 10.1104/pp.107.113555 ; PMID: 18203870
Sequences:
cDNA Sequence
- >AT3G17609.2
GTTGCAGACTTTGAGTGGCCCCAAAGAAGAAAGAAAAGATGCAATTTCCTTTGGTTTGATATTCTCTTCAACCTCTTACCTCTCTATTCTCGTCTTTAGCAAAATCTCAAAAGACAAAAAGATATTGATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAAATATTTACCCTTTAATCCATTGTTCAGTGTTGTATGATTATCTTTCTTTCTTTTTTGGTTTTGGTTTGTATACACTTTTTGTTCGAATAACATTCACTTTGAGCATCATTGTCATTCAGATTTGC - >AT3G17609.3
GTTGCAGACTTTGAGTGGCCCCAAAGAAGAAAGAAAAGATGCAATTTCCTTTGGTTTGATATTCTCTTCAACCTCTTACCTCTCTATTCTCGTCTTTAGCAAAATCTCAAAAGACAAAAAGATATTGATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAAATATTTACCCTTTAATCCATTGTTCAGTGTTGTATGATTATCTTTCTTTCTTTTTTGGTTTTGGTTTGTATACACTTTTTGTTCGAATAACATTCACTTTGAGCATCATTGTCATTCAGATTTGC - >AT3G17609.1
GTTGCAGACTTTGAGTGGCCCCAAAGAAGAAAGAAAAGATGCAATTTCCTTTGGTTTGATATTCTCTTCAACCTCTTACCTCTCTATTCTCGTCTTTAGCAAAATCTCAAAAGACAAAAAGATATTGATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAAATATTTACCCTTTAATCCATTGTTCAGTGTTGTATGATTATCTTTCTTTCTTTTTTGGTTTTGGTTTGTATACACTTTTTGTTCGAATAACATTCACTTTGAGCATCATTGTCATTCAGATTTGC - >AT3G17609.4
GTTGCAGACTTTGAGTGGCCCCAAAGAAGAAAGAAAAGATGCAATTTCCTTTGGTTTGATATTCTCTTCAACCTCTTACCTCTCTATTCTCGTCTTTAGCAAAATCTCAAAAGACAAAAAGATATTGATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAAATATTTACCCTTTAATCCATTGTTCAGTGTTGTATGATTATCTTTCTTTCTTTTTTGGTTTTGGTTTGTATACACTTTTTGTTCGAATAACATTCACTTTGAGCATCATTGTCATTCAGATTTGC
CDS Sequence
- >AT3G17609.2
ATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAA - >AT3G17609.3
ATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAA - >AT3G17609.1
ATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAA - >AT3G17609.4
ATGTCTCTCCAACGACCCAATGGGAACTCGAGTTCGTCTTCTTCCCACAAGAAGCACAAAACTGAGGAAAGTGATGAGGAGTTGTTGATGGTTCCTGACATGGAAGCAGCTGGATCAACATGTGTTCTAAGCAGCAGCGCCGACGATGGAGTCAACAATCCGGAGCTTGACCAGACTCAAAATGGAGTCTCTACAGCTAAACGCCGCCGTGGAAGAAACCCTGTTGATAAAGAATATAGAAGCCTCAAGAGATTATTGAGGAACAGAGTATCAGCGCAACAAGCAAGAGAGAGGAAGAAAGTGTATGTGAGTGATTTGGAATCAAGAGCTAATGAGTTACAGAACAACAATGACCAGCTCGAAGAGAAGATTTCTACTTTGACGAACGAGAACACAATGCTTCGTAAAATGCTTATTAACACAAGGCCTAAAACTGATGACAATCACTAA
Protein Sequence
- >AT3G17609.2
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH - >AT3G17609.3
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH - >AT3G17609.1
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH - >AT3G17609.4
MSLQRPNGNSSSSSSHKKHKTEESDEELLMVPDMEAAGSTCVLSSSADDGVNNPELDQTQNGVSTAKRRRGRNPVDKEYRSLKRLLRNRVSAQQARERKKVYVSDLESRANELQNNNDQLEEKISTLTNENTMLRKMLINTRPKTDDNH