Information report for AT3G15730
Gene Details
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Functional Descriptions
- GO:0009395 — involved in — phospholipid catabolic process
- GO:0009789 — acts upstream of or within — positive regulation of abscisic acid-activated signaling pathway
- GO:0009845 — acts upstream of or within — seed germination
- GO:0005096 — enables — GTPase activator activity
- GO:0005515 — enables — protein binding
- GO:0005546 — enables — phosphatidylinositol-4,5-bisphosphate binding
- GO:0006631 — acts upstream of or within — fatty acid metabolic process
- GO:0030136 — located in — clathrin-coated vesicle
- GO:0009737 — acts upstream of or within — response to abscisic acid
- GO:0005509 — enables — calcium ion binding
- GO:0005634 — located in — nucleus
- GO:0009738 — acts upstream of or within — abscisic acid-activated signaling pathway
- GO:0010358 — acts upstream of or within — leaf shaping
- GO:0005829 — located in — cytosol
- GO:0046470 — involved in — phosphatidylcholine metabolic process
- GO:0005739 — located in — mitochondrion
- GO:0010119 — acts upstream of or within — regulation of stomatal movement
- GO:0004630 — enables — phospholipase D activity
- GO:0016020 — located in — membrane
- GO:0070290 — enables — N-acylphosphatidylethanolamine-specific phospholipase D activity
- GO:0009507 — located in — chloroplast
- GO:0004620 — enables — phospholipase activity
- GO:0005886 — located in — plasma membrane
- GO:0009506 — located in — plasmodesma
- GO:0005886 — is active in — plasma membrane
Functional Keywords
Literature and News
- Distinct Ca2+ binding properties of novel C2 domains of plant phospholipase dalpha and beta. DOI: 10.1074/jbc.M001945200 ; PMID: 10777500
- Subcellular distribution and tissue expression of phospholipase Dalpha, Dbeta, and Dgamma in Arabidopsis. DOI: 10.1104/pp.119.4.1371 ; PMID: 10198096
- Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDgamma and regulation of plant PLDgamma, -beta, and -alpha by polyphosphoinositides and calcium. DOI: 10.1074/jbc.272.45.28267 ; PMID: 9353280
- Molecular cloning and functional analysis of polyphosphoinositide-dependent phospholipase D, PLDbeta, from Arabidopsis. DOI: 10.1074/jbc.272.11.7055 ; PMID: 9054397
- Involvement of phospholipase D in wound-induced accumulation of jasmonic acid in arabidopsis. DOI: 10.1105/tpc.12.11.2237 ; PMID: 11090221
- The Arabidopsis phospholipase D family. Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains. DOI: 10.1104/pp.010928 ; PMID: 11891260
- Characterization of five tomato phospholipase D cDNAs: rapid and specific expression of LePLDbeta1 on elicitation with xylanase. DOI: 10.1046/j.1365-313x.2001.01023.x ; PMID: 11446372
- Differential expression of genes encoding Arabidopsis phospholipases after challenge with virulent or avirulent Pseudomonas isolates. DOI: 10.1094/MPMI.2002.15.8.808 ; PMID: 12182338
- Regulation of plant water loss by manipulating the expression of phospholipase Dalpha. DOI: 10.1046/j.1365-313x.2001.01138.x ; PMID: 11722757
- The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. DOI: 10.1104/pp.105.068171 ; PMID: 16258011
- A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. DOI: 10.1126/science.1123769 ; PMID: 16614222
- Suppression of phospholipase Dalpha1 induces freezing tolerance in Arabidopsis: response of cold-responsive genes and osmolyte accumulation. DOI: 10.1016/j.jplph.2005.08.006 ; PMID: 16949955
- Early PLDalpha-mediated events in response to progressive drought stress in Arabidopsis: a transcriptome analysis. DOI: 10.1093/jxb/erl262 ; PMID: 17261695
- Arabidopsis PLDzeta2 regulates vesicle trafficking and is required for auxin response. DOI: 10.1105/tpc.106.041426 ; PMID: 17259265
- F-box protein DOR functions as a novel inhibitory factor for abscisic acid-induced stomatal closure under drought stress in Arabidopsis, DOI: 10.1104/pp.108.126912 ; PMID: 18835996
- Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth. DOI: 10.1111/j.1365-313X.2009.03788.x ; PMID: 19143999
- Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. DOI: 10.1105/tpc.108.062992 ; PMID: 19690149
- Depletion of the membrane-associated acyl-coenzyme A-binding protein ACBP1 enhances the ability of cold acclimation in Arabidopsis. DOI: 10.1104/pp.109.147066 ; PMID: 20107029
- Systems analysis of seed filling in Arabidopsis: using general linear modeling to assess concordance of transcript and protein expression. DOI: 10.1104/pp.109.152413 ; PMID: 20118269
- Phosphatidic acid mediates salt stress response by regulation of MPK6 in Arabidopsis thaliana. DOI: 10.1111/j.1469-8137.2010.03422.x ; PMID: 20796215
- and 1,3-diacylglycerophosphocholines by phospholipases. DOI: 10.1016/j.chemphyslip.2010.12.009 ; PMID: 21195068
- A proteomic analysis of Arabidopsis thaliana seedling responses to 3-oxo-octanoyl-homoserine lactone, a bacterial quorum-sensing signal. DOI: 10.1016/j.bbrc.2012.09.044 ; PMID: 22995300
- Phosphatidic acid regulates microtubule organization by interacting with MAP65-1 in response to salt stress in Arabidopsis. DOI: 10.1105/tpc.112.104182 ; PMID: 23150630
- Arabidopsis acyl-CoA-binding protein ACBP1 participates in the regulation of seed germination and seedling development. DOI: 10.1111/tpj.12121 ; PMID: 23448237
- Acyl-lipid metabolism. DOI: 10.1199/tab.0161 ; PMID: 23505340
- Phosphatidic acid (PA) binds PP2AA1 to regulate PP2A activity and PIN1 polar localization. DOI: 10.1093/mp/sst076 ; PMID: 23686948
- Overexpression of a phospholipase Dα gene from Ammopiptanthus nanus enhances salt tolerance of phospholipase Dα1-deficient Arabidopsis mutant. DOI: 10.1007/s00425-015-2390-5 ; PMID: 26318308
- Endogenous Arabidopsis messenger RNAs transported to distant tissues. DOI: 10.1038/nplants.2015.25 ; PMID: 27247031
- Heterotrimeric G-protein regulatory circuits in plants: Conserved and novel mechanisms. DOI: 10.1080/15592324.2017.1325983 ; PMID: 28532301
- Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors. DOI: 10.1111/nph.14965 ; PMID: 29288621
- Hydrogen Sulfide Increases Production of NADPH Oxidase-Dependent Hydrogen Peroxide and Phospholipase D-Derived Phosphatidic Acid in Guard Cell Signaling. DOI: 10.1104/pp.17.01636 ; PMID: 29438048
- and SA-independent basal resistance against adapted powdery mildew. DOI: 10.1093/jxb/ery146 ; PMID: 29912376
- Phosphatidic Acid Directly Regulates PINOID-Dependent Phosphorylation and Activation of the PIN-FORMED2 Auxin Efflux Transporter in Response to Salt Stress. DOI: 10.1105/tpc.18.00528 ; PMID: 30464035
- Shot-Gun Proteomic Analysis on Roots of Arabidopsis pldα1 Mutants Suggesting the Involvement of PLDα1 in Mitochondrial Protein Import, Vesicular Trafficking and Glucosinolate Biosynthesis. DOI: 10.3390/ijms20010082 ; PMID: 30587782
- CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDα1. DOI: 10.1104/pp.19.00560 ; PMID: 31118265
- Halotropism requires phospholipase Dζ1-mediated modulation of cellular polarity of auxin transport carriers. DOI: 10.1111/pce.13646 ; PMID: 31430837
- Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress. DOI: 10.1016/j.plantsci.2019.110190 ; PMID: 31481213
- Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity. DOI: 10.1105/tpc.19.00534 ; PMID: 31597687
- CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis. DOI: 10.1105/tpc.19.00525 ; PMID: 32034035
- [Phospholipase Dα1 and hydrogen sulfide were involved in the allelopathy of oridonin to Arabidopsis thaliana]. DOI: 10.13287/j.1001-9332.202003.035 ; PMID: 32537993
- Phospholipase Dα1 mediates the high-Mg(2)(+) stress response partially through regulation of K(+) homeostasis. DOI: 10.1111/pce.13831 ; PMID: 32583878
- FORGETTER2 protein phosphatase and phospholipase D modulate heat stress memory in Arabidopsis. DOI: 10.1111/tpj.14927 ; PMID: 32654320
- Arabidopsis NRT1.2 interacts with the PHOSPHOLIPASE Dα1 (PLDα1) to positively regulate seed germination and seedling development in response to ABA treatment. DOI: 10.1016/j.bbrc.2020.08.025 ; PMID: 32933749
- and MPK6-mediated hypoxia signaling in Arabidopsis. DOI: 10.1093/plcell/koab289 ; PMID: 34850198
- Phospholipase Dδ and H(2)S increase the production of NADPH oxidase-dependent H(2)O(2) to respond to osmotic stress-induced stomatal closure in Arabidopsis thaliana. DOI: 10.1016/j.jplph.2022.153617 ; PMID: 35042010
- Mechanical stress effects on transcriptional regulation of genes encoding and actin-associated proteins. DOI: 10.1007/s12298-021-01123-x ; PMID: 35210715
- The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. DOI: 10.1016/j.cub.2004.02.039 ; PMID: 15028209
- The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. DOI: 10.1002/pmic.200500543 ; PMID: 16502469
- Membrane proteomic analysis of Arabidopsis thaliana using alternative solubilization techniques. DOI: 10.1021/pr060525b ; PMID: 17432890
- Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. DOI: 10.1371/journal.pone.0001994 ; PMID: 18431481
- Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling. DOI: 10.1016/j.jprot.2017.06.004 ; PMID: 28627464
Gene Resources
- UniProt: A0A178VKX2
- EMBL: CACRSJ010000106, CACSHJ010000089, LUHQ01000003
- AlphaFoldDB: A0A178VKX2
- EnsemblPlants: AT3G15730.1
- Gramene: AT3G15730.1
- KEGG: ath:AT3G15730
- Orthologous matrix: PNWGRGI
- ExpressionAtlas: AT3G15730
- InterPro: IPR000008, IPR001736, IPR011402
- PANTHER: PTHR18896, PTHR18896:SF115
- SUPFAM: SSF49562, SSF56024
- PROSITE: PS50004, PS50035
- Gene3D: 2.60.40.150, 3.30.870.10
- OrthoDB: A0A178VKX2
- SWISS-MODEL: A0A178VKX2
- Conserved Domain Database: cd04015, cd09197, cd09199
Homologs
- Brassica napus GSBRNA2T00154795001
- Cucumis sativus CsPLDα
- Fragaria vesca FvH4_5g01271
- Glycine max GmPLDγ
- Oryza sativa OsPLDalpha1, OsPLDalpha4, OsPLDalpha5, OsPLDbeta1
- Prunus avium Pav_sc0000595.1_g140.1.br
- Zea mays GRMZM2G015037_P01
Sequences
cDNA Sequence
- >AT3G15730.1
GTAGGGCTGAAACTAATAACAATTCGTACGTTGGGTCACTATTAAATCATCAAAGATCTGTAGAAAATAATGAAAAAGTGGCCCCACACGCTCCAATTAAATTACAGCAGCTCCACAAAGTAGCTCTTAAAGAGCTTCCATCACGGACCAGATCCCGAATTCTTCTTCTGACCACCGAACGATTGAGTTTCTCCGATCAGATCTCAGTTTCTGGGAATAATTCGAAGTGAAAAAATGGCGCAGCATCTGTTGCACGGGACTTTACATGCTACCATCTATGAAGTTGATGCCCTCCATGGTGGTGGTGTTAGGCAAGGCTTCCTTGGCAAGATTCTGGCAAATGTAGAAGAGACGATTGGTGTTGGTAAAGGAGAAACACAGTTGTATGCGACGATTGATCTGCAAAAAGCTAGAGTTGGGAGAACCAGGAAGATCAAAAATGAACCTAAGAACCCAAAGTGGTATGAGTCGTTTCATATTTACTGTGCTCACTTGGCTTCTGATATCATCTTCACTGTTAAAGATGATAATCCCATTGGAGCTACCCTTATCGGAAGAGCTTACATTCCTGTTGATCAAGTCATTAACGGCGAGGAAGTGGATCAGTGGGTTGAGATCTTGGATAATGACAGAAACCCTATTCAGGGAGGATCAAAGATTCATGTCAAGCTTCAATATTTCCATGTTGAGGAGGATCGTAACTGGAACATGGGTATCAAAAGTGCCAAGTTCCCTGGAGTGCCATACACATTCTTCTCGCAGAGACAAGGCTGCAAAGTTTCTCTGTACCAAGATGCTCATATTCCAGACAACTTTGTCCCTAGAATTCCTCTCGCTGGAGGGAAGAACTATGAGCCTCAAAGATGTTGGGAGGATATTTTTGATGCTATTAGCAATGCAAAACACTTGATCTACATTACTGGTTGGTCTGTTTACGCTGAGATTGCTTTAGTGAGGGACTCGAGGAGGCCTAAGCCTGGAGGTGATGTGACCATTGGTGAGCTACTCAAGAAGAAGGCTAGTGAAGGTGTCAGGGTTCTTTTGCTTGTTTGGGATGACAGAACTTCTGTTGATGTGCTGAAGAAAGATGGGCTCATGGCTACTCATGATGAAGAGACCGAGAATTTCTTCAGGGGAAGTGATGTCCATTGTATTCTGTGCCCTCGTAACCCGGATGACGGTGGTAGCATAGTCCAAAGTTTGCAGATCTCTACTATGTTCACGCATCATCAGAAAATCGTTGTTGTGGACAGCGAGATGCCAAGCAGAGGAGGATCAGAAATGAGGAGAATTGTGAGTTTTGTTGGCGGTATTGATCTTTGTGATGGAAGATACGACACTCCGTTCCACTCCTTGTTCAGGACATTGGACACAGTCCACCATGATGACTTCCATCAACCTAACTTCACTGGTGCTGCTATCACTAAAGGTGGTCCAAGGGAGCCTTGGCATGACATTCACTCCCGTCTTGAAGGTCCAATTGCTTGGGATGTCATGTACAACTTCGAGCAGAGATGGAGCAAGCAGGGTGGTAAAGACATTCTGGTTAAGTTGAGAGATCTTAGTGATATTATTATCACCCCTTCTCCTGTTATGTTCCAAGAGGACCACGATGTGTGGAATGTCCAATTGTTTAGGTCCATTGATGGAGGAGCTGCTGCTGGGTTTCCCGAGTCGCCTGAAGCTGCTGCGGAAGCCGGGCTTGTAAGTGGGAAAGATAACATCATTGATAGGAGTATCCAAGATGCTTACATTCATGCAATCAGACGTGCTAAGGATTTCATCTACGTTGAAAACCAGTACTTCCTTGGGAGTTCTTTTGCTTGGGCAGCCGATGGTATTACTCCTGAGGACATCAATGCCCTGCACTTAATCCCAAAAGAGTTGTCGCTGAAGATAGTTAGCAAGATTGAGAAAGGAGAGAAGTTCAGGGTCTATGTTGTGGTTCCAATGTGGCCAGAAGGTCTCCCAGAGAGTGGATCAGTGCAAGCTATATTAGACTGGCAGAGGAGGACCATGGAGATGATGTACAAGGATGTGATTCAGGCTCTCAGGGCCCAGGGTCTTGAGGAAGATCCAAGAAACTATCTGACATTCTTCTGTCTTGGAAACCGTGAGGTCAAGAAAGATGGAGAGTATGAGCCTGCTGAGAAACCAGACCCCGACACTGATTACATGAGGGCGCAAGAAGCACGCCGTTTCATGATTTACGTCCACACCAAAATGATGATCGTTGACGATGAATACATTATCATTGGGTCTGCTAACATCAACCAGAGGTCAATGGACGGTGCAAGAGACTCTGAGATAGCAATGGGAGGTTATCAACCACATCACTTGTCCCATAGACAACCAGCTCGTGGCCAGATCCATGGGTTTCGTATGTCACTCTGGTACGAACACCTGGGAATGCTCGATGAAACCTTCCTCGATCCATCAAGCTTGGAATGCATTGAGAAAGTTAACCGCATTTCTGACAAGTATTGGGACTTTTACTCAAGTGAGTCACTCGAACATGACCTTCCTGGTCACTTGCTCCGCTACCCGATCGGTGTAGCCAGCGAAGGCGACATCACTGAGCTTCCAGGATTTGAATTCTTCCCGGACACAAAGGCCCGTATCCTCGGCACCAAATCAGACTACCTGCCTCCAATCCTTACAACCTAATCTCACTAAGCATGTCAAGTAATGATCTCTCTCTCCCTCTCTGCTTTGCTGCTGTTGTAGCTTTGAATAAAACTTGAGTGTCTACCTTTAGAATTAAGAAGTCAAATGGTTGTTATGATGATGCACTTCTTTACCCCTTTGGTTTTTATATTCGTACAATGACGTGGTGAGAGAATGTAGCTTTGTGATCTTGTTTTGTTGTTGTTATGTACCTTTGGACTTATGAATCTTATATCTGATCCTTTTCTTTTTATTTAGTGTGTTTCACATC
CDS Sequence
- >AT3G15730.1
ATGGCGCAGCATCTGTTGCACGGGACTTTACATGCTACCATCTATGAAGTTGATGCCCTCCATGGTGGTGGTGTTAGGCAAGGCTTCCTTGGCAAGATTCTGGCAAATGTAGAAGAGACGATTGGTGTTGGTAAAGGAGAAACACAGTTGTATGCGACGATTGATCTGCAAAAAGCTAGAGTTGGGAGAACCAGGAAGATCAAAAATGAACCTAAGAACCCAAAGTGGTATGAGTCGTTTCATATTTACTGTGCTCACTTGGCTTCTGATATCATCTTCACTGTTAAAGATGATAATCCCATTGGAGCTACCCTTATCGGAAGAGCTTACATTCCTGTTGATCAAGTCATTAACGGCGAGGAAGTGGATCAGTGGGTTGAGATCTTGGATAATGACAGAAACCCTATTCAGGGAGGATCAAAGATTCATGTCAAGCTTCAATATTTCCATGTTGAGGAGGATCGTAACTGGAACATGGGTATCAAAAGTGCCAAGTTCCCTGGAGTGCCATACACATTCTTCTCGCAGAGACAAGGCTGCAAAGTTTCTCTGTACCAAGATGCTCATATTCCAGACAACTTTGTCCCTAGAATTCCTCTCGCTGGAGGGAAGAACTATGAGCCTCAAAGATGTTGGGAGGATATTTTTGATGCTATTAGCAATGCAAAACACTTGATCTACATTACTGGTTGGTCTGTTTACGCTGAGATTGCTTTAGTGAGGGACTCGAGGAGGCCTAAGCCTGGAGGTGATGTGACCATTGGTGAGCTACTCAAGAAGAAGGCTAGTGAAGGTGTCAGGGTTCTTTTGCTTGTTTGGGATGACAGAACTTCTGTTGATGTGCTGAAGAAAGATGGGCTCATGGCTACTCATGATGAAGAGACCGAGAATTTCTTCAGGGGAAGTGATGTCCATTGTATTCTGTGCCCTCGTAACCCGGATGACGGTGGTAGCATAGTCCAAAGTTTGCAGATCTCTACTATGTTCACGCATCATCAGAAAATCGTTGTTGTGGACAGCGAGATGCCAAGCAGAGGAGGATCAGAAATGAGGAGAATTGTGAGTTTTGTTGGCGGTATTGATCTTTGTGATGGAAGATACGACACTCCGTTCCACTCCTTGTTCAGGACATTGGACACAGTCCACCATGATGACTTCCATCAACCTAACTTCACTGGTGCTGCTATCACTAAAGGTGGTCCAAGGGAGCCTTGGCATGACATTCACTCCCGTCTTGAAGGTCCAATTGCTTGGGATGTCATGTACAACTTCGAGCAGAGATGGAGCAAGCAGGGTGGTAAAGACATTCTGGTTAAGTTGAGAGATCTTAGTGATATTATTATCACCCCTTCTCCTGTTATGTTCCAAGAGGACCACGATGTGTGGAATGTCCAATTGTTTAGGTCCATTGATGGAGGAGCTGCTGCTGGGTTTCCCGAGTCGCCTGAAGCTGCTGCGGAAGCCGGGCTTGTAAGTGGGAAAGATAACATCATTGATAGGAGTATCCAAGATGCTTACATTCATGCAATCAGACGTGCTAAGGATTTCATCTACGTTGAAAACCAGTACTTCCTTGGGAGTTCTTTTGCTTGGGCAGCCGATGGTATTACTCCTGAGGACATCAATGCCCTGCACTTAATCCCAAAAGAGTTGTCGCTGAAGATAGTTAGCAAGATTGAGAAAGGAGAGAAGTTCAGGGTCTATGTTGTGGTTCCAATGTGGCCAGAAGGTCTCCCAGAGAGTGGATCAGTGCAAGCTATATTAGACTGGCAGAGGAGGACCATGGAGATGATGTACAAGGATGTGATTCAGGCTCTCAGGGCCCAGGGTCTTGAGGAAGATCCAAGAAACTATCTGACATTCTTCTGTCTTGGAAACCGTGAGGTCAAGAAAGATGGAGAGTATGAGCCTGCTGAGAAACCAGACCCCGACACTGATTACATGAGGGCGCAAGAAGCACGCCGTTTCATGATTTACGTCCACACCAAAATGATGATCGTTGACGATGAATACATTATCATTGGGTCTGCTAACATCAACCAGAGGTCAATGGACGGTGCAAGAGACTCTGAGATAGCAATGGGAGGTTATCAACCACATCACTTGTCCCATAGACAACCAGCTCGTGGCCAGATCCATGGGTTTCGTATGTCACTCTGGTACGAACACCTGGGAATGCTCGATGAAACCTTCCTCGATCCATCAAGCTTGGAATGCATTGAGAAAGTTAACCGCATTTCTGACAAGTATTGGGACTTTTACTCAAGTGAGTCACTCGAACATGACCTTCCTGGTCACTTGCTCCGCTACCCGATCGGTGTAGCCAGCGAAGGCGACATCACTGAGCTTCCAGGATTTGAATTCTTCCCGGACACAAAGGCCCGTATCCTCGGCACCAAATCAGACTACCTGCCTCCAATCCTTACAACCTAA
Protein Sequence
- >AT3G15730.1
MAQHLLHGTLHATIYEVDALHGGGVRQGFLGKILANVEETIGVGKGETQLYATIDLQKARVGRTRKIKNEPKNPKWYESFHIYCAHLASDIIFTVKDDNPIGATLIGRAYIPVDQVINGEEVDQWVEILDNDRNPIQGGSKIHVKLQYFHVEEDRNWNMGIKSAKFPGVPYTFFSQRQGCKVSLYQDAHIPDNFVPRIPLAGGKNYEPQRCWEDIFDAISNAKHLIYITGWSVYAEIALVRDSRRPKPGGDVTIGELLKKKASEGVRVLLLVWDDRTSVDVLKKDGLMATHDEETENFFRGSDVHCILCPRNPDDGGSIVQSLQISTMFTHHQKIVVVDSEMPSRGGSEMRRIVSFVGGIDLCDGRYDTPFHSLFRTLDTVHHDDFHQPNFTGAAITKGGPREPWHDIHSRLEGPIAWDVMYNFEQRWSKQGGKDILVKLRDLSDIIITPSPVMFQEDHDVWNVQLFRSIDGGAAAGFPESPEAAAEAGLVSGKDNIIDRSIQDAYIHAIRRAKDFIYVENQYFLGSSFAWAADGITPEDINALHLIPKELSLKIVSKIEKGEKFRVYVVVPMWPEGLPESGSVQAILDWQRRTMEMMYKDVIQALRAQGLEEDPRNYLTFFCLGNREVKKDGEYEPAEKPDPDTDYMRAQEARRFMIYVHTKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGGYQPHHLSHRQPARGQIHGFRMSLWYEHLGMLDETFLDPSSLECIEKVNRISDKYWDFYSSESLEHDLPGHLLRYPIGVASEGDITELPGFEFFPDTKARILGTKSDYLPPILTT