Gene Details:
- Gene ID: AT3G15210
- Gene Symbol: ATERF-4, ATERF4, ERF4, RAP2.5
- Gene Name: ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 4, ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 4, ethylene responsive element binding factor 4, RELATED TO AP2 5
- Description: ethylene responsive element binding factor 4;(source:Araport11)
- TAIR Accession: locus:2087065
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009010 — seed — semilla (Spanish, exact), 種子 (Japanese, exact), pyrene (narrow), diaspore (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009047 — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)
- PO:0000084 — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- PO:0025034 — leaf — hoja (Spanish, exact), 葉 (Japanese, exact)
Gene Ontology:
- GO:0005515 — enables — protein binding
- GO:0048359 — involved in — mucilage metabolic process involved in seed coat development
- GO:0005634 — located in — nucleus
- GO:0045892 — acts upstream of or within — negative regulation of DNA-templated transcription
- GO:0071456 — acts upstream of or within — cellular response to hypoxia
- GO:0010105 — acts upstream of or within — negative regulation of ethylene-activated signaling pathway
- GO:0003700 — enables — DNA-binding transcription factor activity
- GO:0000976 — enables — transcription cis-regulatory region binding
- GO:0006355 — acts upstream of or within — regulation of DNA-templated transcription
- GO:0009864 — acts upstream of or within — induced systemic resistance, jasmonic acid mediated signaling pathway
- GO:0010629 — involved in — negative regulation of gene expression
- GO:0009737 — acts upstream of or within — response to abscisic acid
- GO:0016604 — located in — nuclear body
- GO:0000987 — enables — cis-regulatory region sequence-specific DNA binding
- GO:0009723 — acts upstream of or within — response to ethylene
- GO:0003677 — enables — DNA binding
Germplasm Phenotype:
- erf4-1 — Thinner mucilage halo and thickness of the AM was reduced by 30% compared with wild type when the seeds were shaken for 2 h at 200 rpm.
Function-related keywords:
- root , seed , vascular leaf , stem , plant sperm cell , pollen , leaf
Literature:
- Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. DOI: 10.1105/tpc.12.3.393 ; PMID: 10715325
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- Identification of unstable transcripts in Arabidopsis by cDNA microarray and specific clock-controlled genes. DOI: 10.1073/pnas.152204099 ; PMID: 12167669
- Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant. DOI: 10.1242/jcs.00175 ; PMID: 12432076
- A role for the GCC-box in jasmonate-mediated activation of the PDF1.2 gene of Arabidopsis. DOI: 10.1104/pp.102.017814 ; PMID: 12805630
- The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development. DOI: 10.1242/dev.00991 ; PMID: 14973281
- Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. DOI: 10.1074/jbc.M409053200 ; PMID: 15516340
- A two-step strategy for detecting differential gene expression in cDNA microarray data. DOI: 10.1007/s00294-004-0551-3 ; PMID: 15688252
- A guard-cell-specific MYB transcription factor regulates stomatal movements and plant drought tolerance. DOI: 10.1016/j.cub.2005.05.048 ; PMID: 16005291
- Expression profiling reveals COI1 to be a key regulator of genes involved in and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions. DOI: 10.1007/s11103-005-7306-5 ; PMID: 16021335
- Genomewide nonadditive gene regulation in Arabidopsis allotetraploids. DOI: 10.1534/genetics.105.047894 ; PMID: 16172500
- Phylogeny and domain evolution in the APETALA2-like gene family. DOI: 10.1093/molbev/msj014 ; PMID: 16151182
- The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. DOI: 10.1104/pp.105.068171 ; PMID: 16258011
- The Arabidopsis cold-responsive transcriptome and its regulation by ICE1. DOI: 10.1105/tpc.105.035568 ; PMID: 16214899
- Regulation of genes associated with auxin, ethylene and ABA pathways by 2,4-dichlorophenoxyacetic acid in Arabidopsis. DOI: 10.1007/s10142-005-0012-1 ; PMID: 16317577
- AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis. DOI: 10.1007/s11103-005-3880-9 ; PMID: 16429262
- The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis. DOI: 10.1007/s00425-006-0373-2 ; PMID: 16937017
- Expression profiling and mutant analysis reveals complex regulatory networks involved in Arabidopsis response to Botrytis infection. DOI: 10.1111/j.1365-313X.2006.02849.x ; PMID: 16925600
- Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses. DOI: 10.1016/j.cell.2006.05.050 ; PMID: 16901781
- Rapid transcriptome changes induced by cytosolic Ca2+ transients reveal ABRE-related sequences as Ca2+-responsive cis elements in Arabidopsis. DOI: 10.1105/tpc.106.042713 ; PMID: 16980540
- Exploiting the wild crucifer Thlaspi arvense to identify conserved and novel genes expressed during a plant's response to cold stress. DOI: 10.1007/s11103-006-9080-4 ; PMID: 16972165
- Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression. DOI: 10.1186/gb-2007-8-4-r49 ; PMID: 17408486
- Arabidopsis thaliana plants acclimated to low dose rates of ultraviolet B radiation show specific changes in morphology and gene expression in the absence of stress symptoms. DOI: 10.1111/j.1469-8137.2007.02092.x ; PMID: 17587374
- MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis. DOI: 10.1105/tpc.106.048017 ; PMID: 17616737
- Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. DOI: 10.1094/MPMI-20-8-0900 ; PMID: 17722694
- Reduction of plastid-localized carbonic anhydrase activity results in reduced Arabidopsis seedling survivorship. DOI: 10.1104/pp.108.118661 ; PMID: 18434607
- The absence of ALTERNATIVE OXIDASE1a in Arabidopsis results in acute sensitivity to combined light and drought stress. DOI: 10.1104/pp.107.115121 ; PMID: 18424626
- The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense. DOI: 10.1104/pp.108.117523 ; PMID: 18467450
- The Arabidopsis sweetie mutant is affected in carbohydrate metabolism and defective in the control of growth, development and senescence. DOI: 10.1111/j.1365-313X.2008.03541.x ; PMID: 18452589
- Transcriptional profiling of mature Arabidopsis trichomes reveals that NOECK encodes the MIXTA-like transcriptional regulator MYB106. DOI: 10.1104/pp.108.126979 ; PMID: 18805951
- Hypertonic stress increased extracellular ATP levels and the expression of stress-responsive genes in Arabidopsis thaliana seedlings. DOI: 10.1271/bbb.80660 ; PMID: 19502745
- Overexpression of the ethylene-responsive factor gene BrERF4 from Brassica rapa increases tolerance to salt and drought in Arabidopsis plants. DOI: 10.1007/s10059-010-0114-z ; PMID: 20803085
- Characterization of HbEREBP1, a wound-responsive transcription factor gene in laticifers of Hevea brasiliensis Muell. Arg. DOI: 10.1007/s11033-011-1146-y ; PMID: 21761140
- A regulatory cascade involving class II ETHYLENE RESPONSE FACTOR transcriptional repressors operates in the progression of leaf senescence. DOI: 10.1104/pp.113.218115 ; PMID: 23629833
- Arabidopsis BPM proteins function as substrate adaptors to a cullin3-based E3 ligase to affect fatty acid metabolism in plants. DOI: 10.1105/tpc.112.107292 ; PMID: 23792371
- The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation. DOI: 10.1038/srep02866 ; PMID: 24104185
- Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. DOI: 10.1186/1471-2229-13-229 ; PMID: 24377444
- Promoter-based integration in plant defense regulation. DOI: 10.1104/pp.114.248716 ; PMID: 25352272
- An Arabidopsis gene regulatory network for secondary cell wall synthesis. DOI: 10.1038/nature14099 ; PMID: 25533953
- Endogenous Arabidopsis messenger RNAs transported to distant tissues. DOI: 10.1038/nplants.2015.25 ; PMID: 27247031
- A cotton miRNA is involved in regulation of plant response to salt stress. DOI: 10.1038/srep19736 ; PMID: 26813144
- The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling. DOI: 10.1104/pp.16.00154 ; PMID: 27255484
- Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation. DOI: 10.1105/tpc.15.00744 ; PMID: 27650334
- Combinatorial signal integration by APETALA2/Ethylene Response Factor (ERF)-transcription factors and the involvement of AP2-2 in starvation response. DOI: 10.3390/ijms13055933 ; PMID: 22754341
- Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors. DOI: 10.1016/j.devcel.2016.09.031 ; PMID: 27923776
- The ethylene response factor AtERF4 negatively regulates the iron deficiency response in Arabidopsis thaliana. DOI: 10.1371/journal.pone.0186580 ; PMID: 29045490
- Impact of Alternatively Polyadenylated Isoforms of ETHYLENE RESPONSE FACTOR4 with Activator and Repressor Function on Senescence in Arabidopsis thaliana L. DOI: 10.3390/genes10020091 ; PMID: 30696119
- The function of ETHYLENE RESPONSE FACTOR genes in the light-induced anthocyanin production of Arabidopsis thaliana leaves. DOI: 10.5511/plantbiotechnology.18.0122b ; PMID: 31275041
- BYPASS1-LIKE, A DUF793 Family Protein, Participates in Freezing Tolerance via the CBF Pathway in Arabidopsis. DOI: 10.3389/fpls.2019.00807 ; PMID: 31297122
- Transcriptional regulation of nitrogen-associated metabolism and growth. DOI: 10.1038/s41586-018-0656-3 ; PMID: 30356219
- Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. DOI: 10.1105/tpc.19.00463 ; PMID: 31519798
- A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. DOI: 10.1105/tpc.19.00562 ; PMID: 31806676
- ERF4 and MYB52 transcription factors play antagonistic roles in regulating homogalacturonan de-methylesterification in Arabidopsis seed coat mucilage. DOI: 10.1093/plcell/koaa031 ; PMID: 33709105
- 2-Hydroxymelatonin, Rather Than Melatonin, Is Responsible for RBOH-Dependent Reactive Oxygen Species Production Leading to Premature Senescence in Plants. DOI: 10.3390/antiox10111728 ; PMID: 34829600
- ERF4 interacts with and antagonizes TCP15 in regulating endoreduplication and cell growth in Arabidopsis. DOI: 10.1111/jipb.13323 ; PMID: 35775119
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. DOI: 10.1126/science.290.5499.2105 ; PMID: 11118137
- Repression domains of class II ERF transcriptional repressors share an essential motif for active repression. DOI: 10.1105/tpc.010127 ; PMID: 11487705
- Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses. DOI: 10.1007/s11103-005-7294-5 ; PMID: 16021341
- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression. DOI: 10.1104/pp.105.068544 ; PMID: 16183832
- Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. DOI: 10.1093/molbev/msj051 ; PMID: 16280546
- Roles of ethylene receptor NTHK1 domains in plant growth, stress response and protein phosphorylation. DOI: 10.1016/j.febslet.2006.01.037 ; PMID: 16442528
- AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis. DOI: 10.1007/s11103-005-3880-9 ; PMID: 16429262
- Genome-wide analysis of the ERF gene family in Arabidopsis and rice. DOI: 10.1104/pp.105.073783 ; PMID: 16407444
- Modulation of ethylene responses affects plant salt-stress responses. DOI: 10.1104/pp.106.094292 ; PMID: 17189334
- Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. DOI: 10.1094/MPMI-20-8-0900 ; PMID: 17722694
Sequences:
cDNA Sequence
- >AT3G15210.1
GAAGCCGCTAAAACCATTTCAGGCTTTGACTGTTCACAACAAAGCGCCCCAAAAGGAGCGTCGCTTTTACTCTCTCTCCCATCCTATATATAAACAACTCTCTCCTTTCCTCTTCTCCCTTCAATTATCTATCACACCACCACTCTCTCTCTAATCTATCTATCCGAGAATGGCCAAGATGGGCTTGAAACCCGACCCGGCTACTACTAACCAGACCCACAATAATGCCAAGGAGATTCGTTACAGAGGCGTTAGGAAGCGTCCTTGGGGCCGTTATGCCGCCGAGATCCGAGATCCGGGCAAGAAAACCCGCGTCTGGCTTGGCACTTTCGATACGGCTGAAGAGGCGGCGCGTGCTTACGATACGGCGGCGCGTGATTTTCGTGGTGCTAAGGCTAAGACCAATTTCCCAACTTTTCTCGAGCTGAGTGACCAGAAGGTCCCTACCGGTTTCGCGCGTAGCCCTAGCCAGAGCAGCACGCTCGACTGTGCTTCTCCTCCGACGTTAGTTGTGCCTTCAGCGACGGCTGGGAATGTTCCCCCGCAGCTCGAGCTTAGTCTCGGCGGAGGAGGCGGCGGCTCGTGTTATCAGATCCCGATGTCGCGTCCTGTCTACTTTTTGGACCTGATGGGGATCGGTAACGTAGGTCGTGGTCAGCCTCCTCCTGTGACATCGGCGTTTAGATCGCCGGTGGTGCATGTTGCGACGAAGATGGCTTGTGGTGCCCAAAGCGACTCTGATTCGTCATCGGTCGTTGATTTCGAAGGTGGGATGGAGAAGAGATCTCAGCTGTTAGATCTAGATCTTAATTTGCCTCCTCCATCGGAACAGGCCTGAGCTTTTAACGGTGTCGTTTCAATTCGAAGCGCATGCGTTTCTTCTTCTTTTTGAGCTGTGAAAATTCGTTTTCTCATAGTTTTTCCTCTCTCTCTCTCTCAGTCTAAATTTATTACCAGTTTTTAGAAAGAAAAAACAGATTAAATCTGAGAGAGAAAAATATAATTTTAGCTGACATGGATCGTTATGTACATATTATTACATAACCGGAGATCTGAACTTTTGTTGTGTGCTTTTAATTTTTTGCGACTTGGTTTCACCCCATGTTGTTTCTCTATTTTTTTTACTACTTTTTTTTTTTTTGTTCTTCCAAATTTTCAATCAATAATTTGGTAATCTTCAGAATTATCTTGTCCAATCCAATTTCCGAAATTTTGATTATTACTACTTGTGGGTTGTGGCGGCTCCTTCTATTGGCTTTC
CDS Sequence
- >AT3G15210.1
ATGGCCAAGATGGGCTTGAAACCCGACCCGGCTACTACTAACCAGACCCACAATAATGCCAAGGAGATTCGTTACAGAGGCGTTAGGAAGCGTCCTTGGGGCCGTTATGCCGCCGAGATCCGAGATCCGGGCAAGAAAACCCGCGTCTGGCTTGGCACTTTCGATACGGCTGAAGAGGCGGCGCGTGCTTACGATACGGCGGCGCGTGATTTTCGTGGTGCTAAGGCTAAGACCAATTTCCCAACTTTTCTCGAGCTGAGTGACCAGAAGGTCCCTACCGGTTTCGCGCGTAGCCCTAGCCAGAGCAGCACGCTCGACTGTGCTTCTCCTCCGACGTTAGTTGTGCCTTCAGCGACGGCTGGGAATGTTCCCCCGCAGCTCGAGCTTAGTCTCGGCGGAGGAGGCGGCGGCTCGTGTTATCAGATCCCGATGTCGCGTCCTGTCTACTTTTTGGACCTGATGGGGATCGGTAACGTAGGTCGTGGTCAGCCTCCTCCTGTGACATCGGCGTTTAGATCGCCGGTGGTGCATGTTGCGACGAAGATGGCTTGTGGTGCCCAAAGCGACTCTGATTCGTCATCGGTCGTTGATTTCGAAGGTGGGATGGAGAAGAGATCTCAGCTGTTAGATCTAGATCTTAATTTGCCTCCTCCATCGGAACAGGCCTGA
Protein Sequence
- >AT3G15210.1
MAKMGLKPDPATTNQTHNNAKEIRYRGVRKRPWGRYAAEIRDPGKKTRVWLGTFDTAEEAARAYDTAARDFRGAKAKTNFPTFLELSDQKVPTGFARSPSQSSTLDCASPPTLVVPSATAGNVPPQLELSLGGGGGGSCYQIPMSRPVYFLDLMGIGNVGRGQPPPVTSAFRSPVVHVATKMACGAQSDSDSSSVVDFEGGMEKRSQLLDLDLNLPPPSEQA