Gene Details:

• Gene ID: AT3G12280
• Gene Symbol: ATRBR1, RB, RB1, RBR, RBR1
• Gene Name: RETINOBLASTOMA-RELATED PROTEIN 1, RETINOBLASTOMA 1, RETINOBLASTOMA-RELATED, retinoblastoma-related 1
• Description: retinoblastoma-related 1;(source:Araport11)
• TAIR Accession: locus:2082194
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G12280.1     AT3G12280.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000423  — plant zygote — cigoto (Spanish, exact), 植物接合子、接合体 (Japanese, exact), zygote (broad)

Gene Ontology:

• GO:0051726  — involved in — regulation of cell cycle
• GO:0006357  — involved in — regulation of transcription by RNA polymerase II
• GO:0000082  — acts upstream of or within — G1/S transition of mitotic cell cycle
• GO:0005515  — enables — protein binding
• GO:0000082  — involved in — G1/S transition of mitotic cell cycle
• GO:0001558  — acts upstream of or within — regulation of cell growth
• GO:0001558  — involved in — regulation of cell growth
• GO:0009553  — acts upstream of or within — embryo sac development
• GO:0010090  — acts upstream of or within — trichome morphogenesis
• GO:0007129  — involved in — homologous chromosome pairing at meiosis
• GO:0051726  — acts upstream of or within — regulation of cell cycle
• GO:0006349  — acts upstream of or within — regulation of gene expression by genomic imprinting
• GO:0030154  — involved in — cell differentiation
• GO:0051783  — acts upstream of or within — regulation of nuclear division
• GO:0001708  — acts upstream of or within — cell fate specification
• GO:0010377  — involved in — guard cell fate commitment
• GO:0048366  — acts upstream of or within — leaf development
• GO:2000134  — involved in — negative regulation of G1/S transition of mitotic cell cycle
• GO:0008356  — involved in — asymmetric cell division
• GO:0009960  — acts upstream of negative effect — endosperm development
• GO:2000036  — involved in — regulation of stem cell population maintenance
• GO:2000036  — acts upstream of or within — regulation of stem cell population maintenance
• GO:0070176  — located in — DRM complex
• GO:0022619  — acts upstream of or within — generative cell differentiation
• GO:0005634  — located in — nucleus
• GO:0048229  — involved in — gametophyte development
• GO:0001708  — involved in — cell fate specification
• GO:0005667  — part of — transcription regulator complex

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  plant zygote

Literature:

• The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.   DOI:  10.1023/a:1005902226256 ;  PMID:  9620273
• The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.   DOI:  10.1105/tpc.105.033761 ;  PMID:  16055635
• Distinct dynamics of HISTONE3 variants between the two fertilization products in plants.   DOI:  10.1016/j.cub.2007.05.019 ;  PMID:  17555967
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis.   DOI:  10.1371/journal.pbio.0060194 ;  PMID:  18700816
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development.   DOI:  10.1016/j.cub.2008.09.026 ;  PMID:  18976913
• Arabidopsis MSI1 is required for negative regulation of the response to drought stress.   DOI:  10.1093/mp/ssp012 ;  PMID:  19825648
• The E2FD/DEL2 factor is a component of a regulatory network controlling cell proliferation and development in Arabidopsis.   DOI:  10.1007/s11103-009-9577-8 ;  PMID:  19937368
• The Arabidopsis BET bromodomain factor GTE4 regulates the mitotic cell cycle.   DOI:  10.4161/psb.5.6.11571 ;  PMID:  20495359
• Dosage-sensitive function of retinoblastoma related and convergent epigenetic control are required during the Arabidopsis life cycle.   DOI:  10.1371/journal.pgen.1000988 ;  PMID:  20585548
• Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.   DOI:  10.1038/msb.2010.53 ;  PMID:  20706207
• Retinoblastoma protein is essential for early meiotic events in Arabidopsis.   DOI:  10.1038/emboj.2010.344 ;  PMID:  21217641
• The E2F transcription factor family regulates CENH3 expression in Arabidopsis thaliana.   DOI:  10.1111/j.1365-313X.2011.04715.x ;  PMID:  21771121
• Both negative and positive G1 cell cycle regulators undergo proteasome-dependent degradation during sucrose starvation in Arabidopsis.   DOI:  10.4161/psb.6.9.16877 ;  PMID:  22019639
• The Arabidopsis transcription factor AtTCP15 regulates endoreduplication by modulating expression of key cell-cycle genes.   DOI:  10.1093/mp/ssr086 ;  PMID:  21992944
• RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling.   DOI:  10.1105/tpc.113.116632 ;  PMID:  24285791
• Deep functional redundancy between FAMA and FOUR LIPS in stomatal development.   DOI:  10.1111/tpj.12489 ;  PMID:  24571519
• Precise control of plant stem cell activity through parallel regulatory inputs.   DOI:  10.1242/dev.110148 ;  PMID:  25256342
• A mutation of casein kinase 2 α4 subunit affects multiple developmental processes in Arabidopsis.   DOI:  10.1007/s00299-016-1939-5 ;  PMID:  26883224
• Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis.   DOI:  10.1093/jxb/erw288 ;  PMID:  27440937
• Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.   DOI:  10.15252/embj.201694561 ;  PMID:  28320736
• RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis.   DOI:  10.1126/science.aaf6532 ;  PMID:  28450583
• Transcriptional profiling identifies critical steps of cell cycle reprogramming necessary for Plasmodiophora brassicae-driven gall formation in Arabidopsis.   DOI:  10.1111/tpj.14156 ;  PMID:  30431210
• Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators.   DOI:  10.1371/journal.pgen.1007797 ;  PMID:  30500810
• Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase.   DOI:  10.1038/s41477-019-0378-z ;  PMID:  30833711
• ErbB-3 BINDING PROTEIN 1 Regulates Translation and Counteracts RETINOBLASTOMA RELATED to Maintain the Root Meristem.   DOI:  10.1104/pp.19.00805 ;  PMID:  31818906
• DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation.   DOI:  10.1038/s41477-020-0710-7 ;  PMID:  32661276
• The Cyclin CYCA3;4 Is a Postprophase Target of the APC/C(CCS52A2) E3-Ligase Controlling Formative Cell Divisions in Arabidopsis.   DOI:  10.1105/tpc.20.00208 ;  PMID:  32690720
• Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation in Arabidopsis.   DOI:  10.3390/ijms22083862 ;  PMID:  33917959
• The DREAM complex represses growth in response to DNA damage in Arabidopsis.   DOI:  10.26508/lsa.202101141 ;  PMID:  34583930
• Cell cycle checkpoint control in response to DNA damage by environmental stresses.   DOI:  10.1111/tpj.15567 ;  PMID:  34741364
• Histidine kinase inhibitors impair shoot regeneration in Arabidopsis thaliana via cytokinin signaling and SAM patterning determinants.   DOI:  10.3389/fpls.2022.894208 ;  PMID:  36684719
• RETINOBLASTOMA-RELATED interactions with key factors of the RNA-directed DNA methylation (RdDM) pathway and its influence on root development.   DOI:  10.1007/s00425-023-04135-x ;  PMID:  37120771
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519
• Cell type-specific role of the retinoblastoma/E2F pathway during Arabidopsis leaf development.   DOI:  10.1104/pp.105.071027 ;  PMID:  16361519
• BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways.   DOI:  10.1007/s11103-006-9059-1 ;  PMID:  17096212
• The nanovirus-encoded Clink protein affects plant cell cycle regulation through interaction with the retinoblastoma-related protein.   DOI:  10.1128/JVI.02103-06 ;  PMID:  17267511
• Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.   DOI:  10.1021/pr8000173 ;  PMID:  18433157
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis.   DOI:  10.1371/journal.pbio.0060194 ;  PMID:  18700816

Sequences: