Gene Details:

• Gene ID: AT3G09840
• Gene Symbol: ATCDC48, AtCDC48A, CDC48, CDC48A
• Gene Name: cell division cycle 48
• Description: cell division cycle 48;(source:Araport11)
• TAIR Accession: locus:2085064
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G09840.1

Plant Ontology Annotations:

• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0025195  — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)

Gene Ontology:

• GO:0009860  — acts upstream of or within — pollen tube growth
• GO:0031593  — enables — polyubiquitin modification-dependent protein binding
• GO:0030970  — involved in — retrograde protein transport, ER to cytosol
• GO:0071712  — involved in — ER-associated misfolded protein catabolic process
• GO:0005730  — located in — nucleolus
• GO:0009846  — acts upstream of or within — pollen germination
• GO:0097352  — involved in — autophagosome maturation
• GO:0031348  — acts upstream of or within — negative regulation of defense response
• GO:0051228  — involved in — mitotic spindle disassembly
• GO:0034098  — part of — VCP-NPL4-UFD1 AAA ATPase complex
• GO:0005886  — located in — plasma membrane
• GO:0005515  — enables — protein binding
• GO:0005811  — located in — lipid droplet
• GO:0005819  — located in — spindle
• GO:0016310  — has protein modification of type — phosphorylation
• GO:0042802  — enables — identical protein binding
• GO:0030433  — involved in — ubiquitin-dependent ERAD pathway
• GO:0022626  — located in — cytosolic ribosome
• GO:0005737  — located in — cytoplasm
• GO:0005794  — located in — Golgi apparatus
• GO:0016887  — enables — ATP hydrolysis activity
• GO:0009505  — located in — plant-type cell wall
• GO:0031648  — acts upstream of or within — protein destabilization

Germplasm Phenotype:

• CS69995  — Mildly dwarf plants with slightly curled leaves. Partly sterile; produces very small siliques with few seeds. Elevated PR2 gene expression and SNC1 protein level. Significantly enhanced disease resistance to the oomycete pathogen Hyaloperonospora arabidopsidis (H.a.) Noco2.
• cdc48-1  — Heterozygotes have reduced transmission due to defects in pollen tube germination and elongation.
• cdc48-1  — Seedling lethal.Mutants have disorganized roots.
• cdc48A-4  — Mildly dwarf phenotype and slightly curled leaves, suggesting a constitutive immune response, significantly enhanced disease resistance to H.a. Noco2, weak enhanced resistance phenotype, elevated SNC1 protein.

Function-related keywords:

• pollen ,  pollen ,  pollen tube cell ,  pollen

Literature:

• The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1.   DOI:  10.1105/tpc.105.039412 ;  PMID:  16473966
• The Arabidopsis thaliana AAA protein CDC48A interacts in vivo with the somatic embryogenesis receptor-like kinase 1 receptor at the plasma membrane.   DOI:  10.1016/j.jsb.2006.03.004 ;  PMID:  16621602
• In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy.   DOI:  10.1104/pp.107.103986 ;  PMID:  17693538
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis.   DOI:  10.1104/pp.108.132985 ;  PMID:  19176722
• Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis.   DOI:  10.1111/j.1365-313X.2009.03862.x ;  PMID:  19292762
• Systems analysis of seed filling in Arabidopsis: using general linear modeling to assess concordance of transcript and protein expression.   DOI:  10.1104/pp.109.152413 ;  PMID:  20118269
• Proteomic analyses of apoplastic proteins from germinating Arabidopsis thaliana pollen.   DOI:  10.1016/j.bbapap.2011.07.013 ;  PMID:  21798377
• Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds.   DOI:  10.1186/1471-2229-11-113 ;  PMID:  21838868
• Proteomics investigation of endogenous S-nitrosylation in Arabidopsis.   DOI:  10.1016/j.bbrc.2011.11.036 ;  PMID:  22115780
• A proteomics approach identifies novel proteins involved in gravitropic signal transduction.   DOI:  10.3732/ajb.1200339 ;  PMID:  23281391
• The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.   DOI:  10.1073/pnas.1418564111 ;  PMID:  25344531
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• AtCDC48A is involved in the turnover of an NLR immune receptor.   DOI:  10.1111/tpj.13251 ;  PMID:  27340941
• Expression of CLAVATA3 fusions indicates rapid intracellular processing and a role of ERAD.   DOI:  10.1016/j.plantsci.2018.03.020 ;  PMID:  29650159
• PUX10 Is a CDC48A Adaptor Protein That Regulates the Extraction of Ubiquitinated Oleosins from Seed Lipid Droplets in Arabidopsis.   DOI:  10.1105/tpc.18.00275 ;  PMID:  30087208
• Ubiquitin-dependent chloroplast-associated protein degradation in plants.   DOI:  10.1126/science.aav4467 ;  PMID:  30792274
• Arabidopsis OTU1, a linkage-specific deubiquitinase, is required for endoplasmic reticulum-associated protein degradation.   DOI:  10.1111/tpj.14524 ;  PMID:  31491807
• Arabidopsis CALMODULIN-LIKE 38 Regulates Hypoxia-Induced Autophagy of SUPPRESSOR OF GENE SILENCING 3 Bodies.   DOI:  10.3389/fpls.2021.722940 ;  PMID:  34567037
• CDC48B facilitates the intercellular trafficking of SHORT-ROOT during radial patterning in roots.   DOI:  10.1111/jipb.13231 ;  PMID:  35088574
• The CDC48 complex mediates ubiquitin-dependent degradation of intra-chloroplast proteins in plants.   DOI:  10.1016/j.celrep.2022.110664 ;  PMID:  35417702
• GA signaling expands: The plant UBX domain-containing protein 1 is a binding partner for the GA receptor.   DOI:  10.1093/plphys/kiac406 ;  PMID:  36149293
• High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome.   DOI:  10.1007/s11103-005-0699-3 ;  PMID:  15821981
• Proteome mapping of mature pollen of Arabidopsis thaliana.   DOI:  10.1002/pmic.200402011 ;  PMID:  16247729
• A reference map of the Arabidopsis thaliana mature pollen proteome.   DOI:  10.1016/j.bbrc.2005.09.185 ;  PMID:  16242667
• Arabidopsis cell wall proteome defined using multidimensional protein identification technology.   DOI:  10.1002/pmic.200500046 ;  PMID:  16287169
• The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses.   DOI:  10.1002/pmic.200500543 ;  PMID:  16502469
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome.   DOI:  10.1074/mcp.M700099-MCP200 ;  PMID:  17644812
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: