Gene Details:

• Gene ID: AT3G08040
• Gene Symbol: ATFRD3, FRD3, MAN1
• Gene Name: FERRIC REDUCTASE DEFECTIVE 3, MANGANESE ACCUMULATOR 1
• Description: MATE efflux family protein;(source:Araport11)
• TAIR Accession: locus:2077477
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G08040.1     AT3G08040.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0006203  — pericycle — periciclo (Spanish, exact), portion of pericycle tissue (exact), portion of pericyclic tissue (exact), 内鞘 (Japanese, exact)
• PO:0020124  — root stele — estela de la raíz (Spanish, exact), 根中心柱 (Japanese, exact), root vascular cylinder (related)

Gene Ontology:

• GO:0016036  — acts upstream of or within — cellular response to phosphate starvation
• GO:0009737  — involved in — response to abscisic acid
• GO:0030001  — involved in — metal ion transport
• GO:0006879  — involved in — intracellular iron ion homeostasis
• GO:0015297  — enables — antiporter activity
• GO:0005381  — enables — iron ion transmembrane transporter activity
• GO:0060586  — acts upstream of or within — multicellular organismal-level iron ion homeostasis
• GO:0015137  — enables — citrate transmembrane transporter activity
• GO:0042910  — enables — xenobiotic transmembrane transporter activity
• GO:0046873  — enables — metal ion transmembrane transporter activity
• GO:0006879  — acts upstream of or within — intracellular iron ion homeostasis
• GO:0005886  — located in — plasma membrane

Germplasm Phenotype:

• CS6584  — defective in iron translocation; chlorotic plants; expression of iron deficiency responses under conditions of iron sufficiency; overaccumulation of iron and other metals (plants accumulate approximately two-fold excess iron, four-fold excess manganesse and two-fold excess zinc in their shoots); detached roots are capable of repressing iron uptake responses when cultured under iron-sufficient conditions; when shoots are appropriately supplied with iron, they regreen and the plants are capable of correctly regulating root iron uptake responses; isolated protoplasts have lower iron levels than those from wild type plants; plants accumulate abnormal levels of ferric iron in their root vasculature, FRD3 is expressed in the pericycle and other vascular cylinder cells in the mature portion of the root; lacks trichomes on stems and leaves.
• CS6585  — defective in iron translocation; chlorotic plants; expression of iron deficiency responses under conditions of iron sufficiency; overaccumulation of iron and other metals (plants accumulate approximately two-fold excess iron, four-fold excess manganesse and two-fold excess zinc in their shoots); detached roots are capable of repressing iron uptake responses when cultured under iron-sufficient conditions; when shoots are appropriately supplied with iron, they regreen and the plants are capable of correctly regulating root iron uptake responses; isolated protoplasts have lower iron levels than those from wild type plants; plants accumulate abnormal levels of ferric iron in their root vasculature, FRD3 is expressed in the pericycle and other vascular cylinder cells in the mature portion of the root; lacks trichomes on stems and leaves.
• CS8506  — small pale green seedlings under fluorescent light on agar; can become dark green under some conditions; reduced plant size; has high metal conc. in leaves; flowers later than wild type; has constitutive ferric-chelate reductase activity in roots.
• frd3-1  — constitutive ferric chelate reductase activity, chlorotic

Function-related keywords:

• root ,  pericycle ,  root stele

Literature:

• FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.   DOI:  10.1105/tpc.001495 ;  PMID:  12172022
• Transgenic proteoid roots of white lupin: a vehicle for characterizing and silencing root genes involved in adaptation to P stress.   DOI:  10.1111/j.1365-313X.2005.02573.x ;  PMID:  16297074
• Zinc-dependent global transcriptional control, transcriptional deregulation, and higher gene copy number for genes in metal homeostasis of the hyperaccumulator Arabidopsis halleri.   DOI:  10.1104/pp.105.076232 ;  PMID:  16844841
• Quantitative trait locus mapping for seed mineral concentrations in two Arabidopsis thaliana recombinant inbred populations.   DOI:  10.1111/j.1469-8137.2008.02544.x ;  PMID:  18631293
• Ethylene and nitric oxide involvement in the up-regulation of key genes related to iron acquisition and homeostasis in Arabidopsis.   DOI:  10.1093/jxb/erq203 ;  PMID:  20627899
• Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis.   DOI:  10.1105/tpc.111.095042 ;  PMID:  22374397
• Abscisic acid alleviates iron deficiency by promoting root iron reutilization and transport from root to shoot in Arabidopsis.   DOI:  10.1111/pce.12203 ;  PMID:  24111973
• GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.   DOI:  10.1104/pp.15.00397 ;  PMID:  26002909
• Comparative expression profiling reveals a role of the root apoplast in local phosphate response.   DOI:  10.1186/s12870-016-0790-8 ;  PMID:  27121119
• Genome-wide analysis of gene expression profiling revealed that COP9 signalosome is essential for correct expression of Fe homeostasis genes in Arabidopsis.   DOI:  10.1007/s10534-017-0036-8 ;  PMID:  28744713
• Sulphur availability modulates Arabidopsis thaliana responses to iron deficiency.   DOI:  10.1371/journal.pone.0237998 ;  PMID:  32817691
• Altered metal distribution in the sr45-1 Arabidopsis mutant causes developmental defects.   DOI:  10.1111/tpj.15740 ;  PMID:  35305053
• MNB1 gene is involved in regulating the iron-deficiency stress response in Arabidopsis thaliana.   DOI:  10.1186/s12870-022-03553-5 ;  PMID:  35346040
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660

Sequences: