Gene Details:

• Gene ID: AT3G04580
• Gene Symbol: EIN4
• Gene Name: ETHYLENE INSENSITIVE 4
• Description: Signal transduction histidine kinase, hybrid-type, ethylene sensor;(source:Araport11)
• TAIR Accession: locus:2084968
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G04580.1     AT3G04580.2

Gene Ontology:

• GO:0010105  — acts upstream of or within — negative regulation of ethylene-activated signaling pathway
• GO:0000155  — enables — phosphorelay sensor kinase activity
• GO:0005515  — enables — protein binding
• GO:0005783  — is active in — endoplasmic reticulum
• GO:0051740  — enables — ethylene binding
• GO:0004673  — enables — protein histidine kinase activity
• GO:0004674  — enables — protein serine/threonine kinase activity
• GO:0038199  — enables — ethylene receptor activity
• GO:0005783  — located in — endoplasmic reticulum

Germplasm Phenotype:

• CS71770  — Constitutive ethylene response phenotype. Seedlings with compact cotyledons and downwardly-curved morphology.
• CS71771  — Constitutive ethylene response phenotype. Small rosette.
• CS71815  — No visible phenotype.
• CS72383  — mild constitutive ethylene response phenotype; reduced leaf size; short roots with greater density of root hairs
• CS8053  — ethylene insensitive.

Literature:

• Ethylene perception by the ERS1 protein in Arabidopsis.   DOI:  10.1104/pp.123.4.1449 ;  PMID:  10938361
• EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis.   DOI:  10.1105/tpc.10.8.1321 ;  PMID:  9707532
• Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana.   DOI:  10.1016/s0092-8674(00)81425-7 ;  PMID:  9695954
• Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway.   DOI:  10.1093/genetics/139.3.1393 ;  PMID:  7768447
• Ethylene can stimulate Arabidopsis hypocotyl elongation in the light.   DOI:  10.1073/pnas.94.6.2756 ;  PMID:  11038610
• Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission.   DOI:  10.1073/pnas.0237085100 ;  PMID:  12509505
• Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.   DOI:  10.1016/s0092-8674(03)00969-3 ;  PMID:  14675532
• Growth regulators and the control of nucleotide sugar flux.   DOI:  10.1105/tpc.019661 ;  PMID:  14973160
• Requirement of the histidine kinase domain for signal transduction by the ethylene receptor ETR1.   DOI:  10.1104/pp.104.047126 ;  PMID:  15466228
• Arabidopsis seedling growth response and recovery to ethylene. A kinetic analysis.   DOI:  10.1104/pp.104.050369 ;  PMID:  15466220
• [Research progress of ethylene signal transduction in plants].   DOI:  NA ;  PMID:  15643078
• Ethylene-binding activity, gene expression levels, and receptor system output for ethylene receptor family members from Arabidopsis and tomato.   DOI:  10.1111/j.1365-313X.2004.02331.x ;  PMID:  15703053
• Roles of ethylene receptor NTHK1 domains in plant growth, stress response and protein phosphorylation.   DOI:  10.1016/j.febslet.2006.01.037 ;  PMID:  16442528
• A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1.   DOI:  10.1186/1471-2229-7-3 ;  PMID:  17224067
• Ethylene is one of the key elements for cell death and defense response control in the Arabidopsis lesion mimic mutant vad1.   DOI:  10.1104/pp.107.106302 ;  PMID:  17720753
• Subcellular localization and in vivo interactions of the Arabidopsis thaliana ethylene receptor family members.   DOI:  10.1093/mp/ssm015 ;  PMID:  19825542
• Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis.   DOI:  10.1074/jbc.M800641200 ;  PMID:  18577522
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Ethylene mediates response and tolerance to potassium deprivation in Arabidopsis.   DOI:  10.1105/tpc.108.063099 ;  PMID:  19190240
• Ethylene receptors function as components of high-molecular-mass protein complexes in Arabidopsis.   DOI:  10.1371/journal.pone.0008640 ;  PMID:  20062808
• Genetic and transformation studies reveal negative regulation of ERS1 ethylene receptor signaling in Arabidopsis.   DOI:  10.1186/1471-2229-10-60 ;  PMID:  20374664
• Analysis of the functional conservation of ethylene receptors between maize and Arabidopsis.   DOI:  10.1007/s11103-010-9686-4 ;  PMID:  20835883
• Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings.   DOI:  10.1104/pp.110.170621 ;  PMID:  21386032
• Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes.   DOI:  10.1104/pp.111.187757 ;  PMID:  22227969
• Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis.   DOI:  10.1104/pp.112.196790 ;  PMID:  22467798
• A survey of dominant mutations in Arabidopsis thaliana.   DOI:  10.1016/j.tplants.2012.08.006 ;  PMID:  22995285
• The Ethylene Receptors ETHYLENE RESPONSE1 and ETHYLENE RESPONSE2 Have Contrasting Roles in Seed Germination of Arabidopsis during Salt Stress.   DOI:  10.1104/pp.114.241695 ;  PMID:  24820022
• Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis.   DOI:  10.1111/tpj.12799 ;  PMID:  25704455
• Appearance and elaboration of the ethylene receptor family during land plant evolution.   DOI:  10.1007/s11103-015-0296-z ;  PMID:  25682121
• Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana.   DOI:  10.1074/jbc.M115.652503 ;  PMID:  25814663
• Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in Arabidopsis.   DOI:  10.1038/srep12477 ;  PMID:  26207341
• why so much complexity?   DOI:  10.12703/P7-39 ;  PMID:  26171216
• Revisiting the Role of Ethylene and N-End Rule Pathway on Chilling-Induced Dormancy Release in Arabidopsis Seeds.   DOI:  10.3390/ijms19113577 ;  PMID:  30428533
• Molecular Analysis of Protein-Protein Interactions in the Ethylene Pathway in the Different Ethylene Receptor Subfamilies.   DOI:  10.3389/fpls.2019.00726 ;  PMID:  31231408
• EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis.   DOI:  10.1105/tpc.10.8.1321 ;  PMID:  9707532
• Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana.   DOI:  10.1016/s0092-8674(00)81425-7 ;  PMID:  9695954

Sequences: