Gene Details:

• Gene ID: AT3G04460
• Gene Symbol: APM4, ATPEX12, PEX12
• Gene Name: ABERRANT PEROXISOME MORPHOLOGY 4, PEROXIN-12, peroxin-12
• Description: peroxin-12;(source:Araport11)
• TAIR Accession: locus:2100890
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G04460.1     AT3G04460.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009010  — seed — semilla (Spanish, exact), 種子 (Japanese, exact), pyrene (narrow), diaspore (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009049  — inflorescence — inflorescencia (Spanish, exact), 花序 (Japanese, exact), Triticeae spike (narrow)
• PO:0009072  — plant ovary — ovario vegetal (Spanish, exact), 子房 (Japanese, exact), Poaceae ovary (narrow), Zea ovary (narrow)

Gene Ontology:

• GO:0048598  — acts upstream of or within — embryonic morphogenesis
• GO:1990429  — part of — peroxisomal importomer complex
• GO:0004842  — enables — ubiquitin-protein transferase activity
• GO:0016558  — involved in — protein import into peroxisome matrix
• GO:0016558  — acts upstream of or within — protein import into peroxisome matrix
• GO:0006635  — acts upstream of or within — fatty acid beta-oxidation
• GO:0005777  — located in — peroxisome
• GO:0008270  — enables — zinc ion binding
• GO:0005778  — located in — peroxisomal membrane
• GO:0007031  — acts upstream of or within — peroxisome organization

Germplasm Phenotype:

• SALK_013612  — Embryonic lethal in homozygotes. In heterozygous plants immature siliques had approximately 22% white seeds, which became purplish and shriveled as the siliques matured. Knockout embryos showed retarded growth and in most cases were able to develop to the heart stage, but failed to grow further into torpedo and mature embryos. Null embryos lacked peroxisomes, contained small and underdeveloped plastids, and were missing characteristic lipid body structures.
• apm4  — apm4 mutants showed decreased efficiency of PTS1- and PTS2- (peroxisome targeting signal)-dependent protein transport into peroxisome. apm4 mutation also represses plant growth.

Function-related keywords:

• root ,  seed ,  vascular leaf ,  flower ,  inflorescence ,  plant ovary

Literature:

• How are peroxisomes formed? The role of the endoplasmic reticulum and peroxins.   DOI:  10.1016/s1360-1385(01)01951-3 ;  PMID:  11378467
• Functional differentiation of peroxisomes revealed by expression profiles of peroxisomal genes in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcg173 ;  PMID:  14701923
• The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development.   DOI:  10.1104/pp.105.066811 ;  PMID:  16113209
• and PTS2-dependent protein transport to peroxisomes.   DOI:  10.1111/j.1365-313X.2006.02809.x ;  PMID:  16813573
• Comparative mapping of Brassica juncea and Arabidopsis thaliana using Intron Polymorphism (IP) markers: homoeologous relationships, diversification and evolution of the A, B and C Brassica genomes.   DOI:  10.1186/1471-2164-9-113 ;  PMID:  18315867
• Molecular components required for the targeting of PEX7 to peroxisomes in Arabidopsis thaliana.   DOI:  10.1111/j.1365-313X.2009.03970.x ;  PMID:  19594707
• Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import.   DOI:  10.1073/pnas.1009174107 ;  PMID:  20679226
• Arabidopsis RING peroxins are E3 ubiquitin ligases that interact with two homologous ubiquitin receptor proteins(F).   DOI:  10.1111/jipb.12014 ;  PMID:  23336935
• Peroxisomal ubiquitin-protein ligases peroxin2 and peroxin10 have distinct but synergistic roles in matrix protein import and peroxin5 retrotranslocation in Arabidopsis.   DOI:  10.1104/pp.114.247148 ;  PMID:  25214533
• Genetic Interactions between PEROXIN12 and Other Peroxisome-Associated Ubiquitination Components.   DOI:  10.1104/pp.16.01211 ;  PMID:  27650450
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• Functional classification of Arabidopsis peroxisome biogenesis factors proposed from analyses of knockdown mutants.   DOI:  10.1093/pcp/pcm053 ;  PMID:  17478547

Sequences: