Gene Details:

• Gene ID: AT2G45280
• Gene Symbol: ATRAD51C, RAD51C
• Gene Name: RAS associated with diabetes protein 51C, RAS associated with diabetes protein 51C
• Description: RAS associated with diabetes protein 51C;(source:Araport11)
• TAIR Accession: locus:2050852
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G45280.1     AT2G45280.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Gene Ontology:

• GO:0007140  — acts upstream of or within — male meiotic nuclear division
• GO:0000707  — involved in — meiotic DNA recombinase assembly
• GO:0007143  — acts upstream of or within — female meiotic nuclear division
• GO:0007131  — involved in — reciprocal meiotic recombination
• GO:0005524  — enables — ATP binding
• GO:0033065  — part of — Rad51C-XRCC3 complex
• GO:0000150  — enables — DNA strand exchange activity
• GO:0000724  — acts upstream of or within — double-strand break repair via homologous recombination
• GO:0003697  — enables — single-stranded DNA binding
• GO:0008821  — contributes to — crossover junction DNA endonuclease activity
• GO:0005657  — is active in — replication fork
• GO:0051321  — acts upstream of or within — meiotic cell cycle
• GO:0000400  — contributes to — four-way junction DNA binding
• GO:0007131  — acts upstream of or within — reciprocal meiotic recombination
• GO:0016444  — acts upstream of or within — somatic cell DNA recombination
• GO:0033063  — part of — Rad51B-Rad51C-Rad51D-XRCC2 complex
• GO:0045003  — acts upstream of or within — double-strand break repair via synthesis-dependent strand annealing
• GO:0003677  — enables — DNA binding
• GO:0005515  — enables — protein binding
• GO:0005634  — located in — nucleus

Germplasm Phenotype:

• SALK_021960  — Male and female sterile. Defects in meiosis beginning in metaphase I. Hypersensitivity to a crosslinking reagent, cisplatin, and to gamma-irradiation. Somatic homologous recombination is reduced twofold below wild-type frequency.
• atradc-1  — Homozygotes are sterile. Pollen is not viable and female gametophyte development is blocked after meiosis.

Function-related keywords:

• root ,  flower ,  shoot axis apex ,  root ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  hypocotyl ,  collective leaf structure

Literature:

• Molecular cloning and characterization of RAD51-like genes from Arabidopsis thaliana.   DOI:  10.1023/a:1016047231597 ;  PMID:  12139010
• Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.   DOI:  10.1016/s0092-8674(03)00969-3 ;  PMID:  14675532
• The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis.   DOI:  10.1038/sj.emboj.7600055 ;  PMID:  14726957
• CENTRIN2 modulates homologous recombination and nucleotide excision repair in Arabidopsis.   DOI:  10.1105/tpc.021378 ;  PMID:  15155891
• Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair.   DOI:  10.1111/j.1365-313X.2004.02318.x ;  PMID:  15686518
• The AtRAD51C gene is required for normal meiotic chromosome synapsis and double-stranded break repair in Arabidopsis.   DOI:  10.1104/pp.104.058347 ;  PMID:  15923332
• Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis.   DOI:  10.1104/pp.105.065243 ;  PMID:  16169964
• The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants.   DOI:  10.1105/tpc.106.045088 ;  PMID:  16980538
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells.   DOI:  10.1007/s11103-005-2187-1 ;  PMID:  15952068
• RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.   DOI:  10.1105/tpc.110.078568 ;  PMID:  20971895
• Silencing of meiosis-critical genes for engineering male sterility in plants.   DOI:  10.1007/s00299-011-1193-9 ;  PMID:  22120011
• Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.   DOI:  10.1371/journal.pgen.1002636 ;  PMID:  22532804
• Systematic identification of functional plant modules through the integration of complementary data sources.   DOI:  10.1104/pp.112.196725 ;  PMID:  22589469
• The requirement for recombination factors differs considerably between different pathways of homologous double-strand break repair in somatic plant cells.   DOI:  10.1111/j.1365-313X.2012.05119.x ;  PMID:  22860689
• Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination.   DOI:  10.1371/journal.pgen.1006827 ;  PMID:  28562599
• The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.   DOI:  10.1104/pp.18.00123 ;  PMID:  29463775
• COMET Functions as a PCH2 Cofactor in Regulating the HORMA Domain Protein ASY1.   DOI:  10.1016/j.cub.2020.07.089 ;  PMID:  32857973

Sequences: