Gene Details:
- Gene ID: AT2G43790
- Gene Symbol: ATMAPK6, ATMPK6, MAPK6, MPK6
- Gene Name: MAP kinase 6, MAP kinase 6, MAP kinase 6, MAP kinase 6
- Description: MAP kinase 6;(source:Araport11)
- TAIR Accession: locus:2043904
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- PO:0000084 — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)
- PO:0025195 — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
Gene Ontology:
- GO:0010150 — involved in — leaf senescence
- GO:2000037 — acts upstream of or within — regulation of stomatal complex patterning
- GO:0005515 — enables — protein binding
- GO:0010120 — acts upstream of or within — camalexin biosynthetic process
- GO:0009737 — acts upstream of or within — response to abscisic acid
- GO:0051510 — involved in — regulation of unidimensional cell growth
- GO:0050826 — acts upstream of or within — response to freezing
- GO:0005938 — located in — cell cortex
- GO:0010229 — acts upstream of or within — inflorescence development
- GO:0009864 — acts upstream of or within — induced systemic resistance, jasmonic acid mediated signaling pathway
- GO:0048481 — acts upstream of or within — plant ovule development
- GO:0009738 — involved in — abscisic acid-activated signaling pathway
- GO:0010183 — acts upstream of or within — pollen tube guidance
- GO:0009409 — acts upstream of or within — response to cold
- GO:0004674 — enables — protein serine/threonine kinase activity
- GO:0051301 — acts upstream of or within — cell division
- GO:0005829 — located in — cytosol
- GO:0005737 — is active in — cytoplasm
- GO:0009524 — located in — phragmoplast
- GO:0009723 — acts upstream of or within — response to ethylene
- GO:0000302 — acts upstream of or within — response to reactive oxygen species
- GO:0006468 — acts upstream of or within — protein phosphorylation
- GO:0009574 — located in — preprophase band
- GO:0009651 — acts upstream of or within — response to salt stress
- GO:0080136 — acts upstream of or within — priming of cellular response to stress
- GO:0009620 — involved in — response to fungus
- GO:0005802 — located in — trans-Golgi network
- GO:0042542 — acts upstream of or within — response to hydrogen peroxide
- GO:0005634 — located in — nucleus
- GO:0016310 — has protein modification of type — phosphorylation
- GO:1902065 — acts upstream of or within — response to L-glutamate
- GO:0042742 — acts upstream of or within — defense response to bacterium
- GO:0019902 — enables — phosphatase binding
- GO:0004707 — enables — MAP kinase activity
- GO:0048364 — acts upstream of or within — root development
- GO:0009555 — acts upstream of or within — pollen development
- GO:0004672 — enables — protein kinase activity
- GO:0006979 — acts upstream of or within — response to oxidative stress
- GO:0005634 — is active in — nucleus
- GO:0010224 — acts upstream of or within — response to UV-B
- GO:0010082 — involved in — regulation of root meristem growth
- GO:0035556 — involved in — intracellular signal transduction
- GO:0006970 — acts upstream of or within — response to osmotic stress
- GO:0051301 — involved in — cell division
- GO:2000038 — acts upstream of or within — regulation of stomatal complex development
- GO:0090333 — involved in — regulation of stomatal closure
- GO:0007165 — acts upstream of or within — signal transduction
Germplasm Phenotype:
- CS31099 — No visible mutant phenotype.
- CS71691 — No visible phenotype
- SALK_062471C — Reduced fertility; silique length is shorter than the wild type; embryo was found to be protruding out of the dried seed coat; approximately 10% of the seed produced display this protruding embryo phenotype.
- mpk6-1 — Defects in root development. Short roots and sometimes even no roots.Ectopic cell divisions in the roots and disorganized cells and cell files.
- mpk6-2 — Defects in root development. Short roots and sometimes even no roots.Ectopic cell divisions in the roots and disorganized cells and cell files.
- mpk6-2 — Less sensitive to l-Glu treatments, displayed longer primary roots when treated with l-Glu as compared to wt.l-Glu slightly decreases the number of mitotic cells, minor effect on starch grain production, as well as on the overall structure of the root cap.
- mpk6-3 — Defects in root development. Short roots and sometimes even no roots.Ectopic cell divisions in the roots and disorganized cells and cell files.
- mpk6-3/mpk3-1 — Female sterile. Integuments undergo early cell division arrest, as a result, the embryo sac becomes constricted and protrudes from the micropyle.
Function-related keywords:
- shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen , plant sperm cell , pollen tube cell , pollen
Literature:
- Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. DOI: 10.1073/pnas.97.6.2940 ; PMID: 10717008
- Microbial elicitors induce activation and dual phosphorylation of the Arabidopsis thaliana MAPK 6. DOI: 10.1074/jbc.275.11.7521 ; PMID: 10713056
- Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6. DOI: 10.1046/j.1365-313x.2000.00913.x ; PMID: 11123804
- MAP kinase signalling cascade in Arabidopsis innate immunity. DOI: 10.1038/415977a ; PMID: 11875555
- Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. DOI: 10.1093/pcp/pce123 ; PMID: 11577197
- Mapping out the roles of MAP kinases in plant defense. DOI: 10.1016/s1360-1385(01)02058-1 ; PMID: 11544109
- Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6. DOI: 10.1104/pp.126.4.1579 ; PMID: 11500556
- Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6. DOI: 10.1016/s0014-5793(02)03162-9 ; PMID: 12220631
- NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. DOI: 10.1073/pnas.252641899 ; PMID: 12506203
- Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1. DOI: 10.1093/emboj/cdf646 ; PMID: 12456655
- Mitogen-activated protein kinase cascades in plants: a new nomenclature. DOI: 10.1016/s1360-1385(02)02302-6 ; PMID: 12119167
- A MAPK pathway mediates ethylene signaling in plants. DOI: 10.1093/emboj/cdg131 ; PMID: 12628921
- OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis. DOI: 10.1038/nature02353 ; PMID: 14985766
- Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis. DOI: 10.1105/tpc.015552 ; PMID: 15020743
- The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. DOI: 10.1016/j.molcel.2004.06.023 ; PMID: 15225555
- Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana. DOI: 10.1074/jbc.M405259200 ; PMID: 15292193
- Involvement of MPK4 in osmotic stress response pathways in cell suspensions and plantlets of Arabidopsis thaliana: activation by hypoosmolarity and negative role in hyperosmolarity tolerance. DOI: 10.1016/j.febslet.2004.08.001 ; PMID: 15358537
- High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression. DOI: 10.1111/j.1365-313X.2004.02180.x ; PMID: 15341634
- Stress hormone-independent activation and nuclear translocation of mitogen-activated protein kinases in Arabidopsis thaliana during ozone exposure. DOI: 10.1111/j.1365-313X.2004.02229.x ; PMID: 15500467
- Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. DOI: 10.1105/tpc.104.026609 ; PMID: 15539472
- RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3. DOI: 10.1016/j.envpol.2005.04.017 ; PMID: 15964670
- High throughput identification of potential Arabidopsis mitogen-activated protein kinases substrates. DOI: 10.1074/mcp.M500007-MCP200 ; PMID: 16009969
- Involvement of PPS3 phosphorylated by elicitor-responsive mitogen-activated protein kinases in the regulation of plant cell death. DOI: 10.1104/pp.105.066795 ; PMID: 16306147
- The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. DOI: 10.1111/j.1365-313X.2006.02888.x ; PMID: 17059410
- A Mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis. DOI: 10.1074/jbc.M605293200 ; PMID: 17043356
- MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis. DOI: 10.1074/jbc.M605319200 ; PMID: 17023433
- MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants. DOI: 10.1104/pp.106.091389 ; PMID: 17142480
- Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis. DOI: 10.1105/tpc.106.048298 ; PMID: 17259259
- The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis. DOI: 10.1105/tpc.106.046581 ; PMID: 17369371
- Mutational evidence that the Arabidopsis MAP kinase MPK6 is involved in anther, inflorescence, and embryo development. DOI: 10.1093/jxb/erm092 ; PMID: 17519351
- The MAP kinase kinase MKK2 affects disease resistance in Arabidopsis. DOI: 10.1094/MPMI-20-5-0589 ; PMID: 17506336
- Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs. DOI: 10.1074/jbc.M701888200 ; PMID: 17586809
- The PP2C-type phosphatase AP2C1, which negatively regulates MPK4 and MPK6, modulates innate immunity, jasmonic acid, and ethylene levels in Arabidopsis. DOI: 10.1105/tpc.106.049585 ; PMID: 17630279
- The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling. DOI: 10.1105/tpc.106.050039 ; PMID: 17933903
- MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway. DOI: 10.1111/j.1365-313X.2008.03404.x ; PMID: 18182027
- Signaling pathways mediating the suppression of Arabidopsis thaliana Ku gene expression by abscisic acid. DOI: 10.1016/j.bbagrm.2007.12.005 ; PMID: 18179780
- An Arabidopsis protein phosphorylated in response to microbial elicitation, AtPHOS32, is a substrate of MAP kinases 3 and 6. DOI: 10.1074/jbc.M800735200 ; PMID: 18285339
- AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis. DOI: 10.1111/j.1365-313X.2008.03433.x ; PMID: 18248592
- Haplo-insufficiency of MPK3 in MPK6 mutant background uncovers a novel function of these two MAPKs in Arabidopsis ovule development. DOI: 10.1105/tpc.108.058032 ; PMID: 18364464
- The wheat mitogen-activated protein kinases TaMPK3 and TaMPK6 are differentially regulated at multiple levels during compatible disease interactions with Mycosphaerella graminicola. DOI: 10.1104/pp.108.119511 ; PMID: 18441220
- A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis. DOI: 10.1073/pnas.0711301105 ; PMID: 18378893
- Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. DOI: 10.1104/pp.108.121038 ; PMID: 18650403
- Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis. DOI: 10.1074/jbc.M801392200 ; PMID: 18693252
- Regulation of floral organ abscission in Arabidopsis thaliana. DOI: 10.1073/pnas.0805539105 ; PMID: 18809915
- Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. DOI: 10.1104/pp.108.126375 ; PMID: 18775970
- Arabidopsis stomatal initiation is controlled by MAPK-mediated regulation of the bHLH SPEECHLESS. DOI: 10.1126/science.1162263 ; PMID: 19008449
- Mitogen-activated protein kinase cascades and ethylene: signaling, biosynthesis, or both? DOI: 10.1104/pp.108.132241 ; PMID: 19109412
- Mitogen-activated protein kinases 3 and 6 are required for full priming of stress responses in Arabidopsis thaliana. DOI: 10.1105/tpc.108.062158 ; PMID: 19318610
- An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence. DOI: 10.1104/pp.108.133439 ; PMID: 19251906
- A cell wall extract from the endophytic fungus Piriformospora indica promotes growth of Arabidopsis seedlings and induces intracellular calcium elevation in roots. DOI: 10.1111/j.1365-313X.2009.03867.x ; PMID: 19392691
- Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling. DOI: 10.1073/pnas.0810206106 ; PMID: 19416906
- A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. DOI: 10.1016/j.chom.2007.03.006 ; PMID: 18005697
- Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. DOI: 10.1038/nature06543 ; PMID: 18273012
- Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis. DOI: 10.1038/cr.2008.29 ; PMID: 18268539
- AtMKK1 and AtMPK6 are involved in abscisic acid and sugar signaling in Arabidopsis seed germination. DOI: 10.1007/s11103-009-9503-0 ; PMID: 19484493
- Cell fate transitions during stomatal development. DOI: 10.1002/bies.200800231 ; PMID: 19565615
- The Arabidopsis MAP kinase kinase 7: A crosstalk point between auxin signaling and defense responses? DOI: 10.4161/psb.3.4.5230 ; PMID: 19704652
- A Novel MAPKK Involved in Cell Death and Defense Signaling. DOI: 10.4161/psb.2.5.4267 ; PMID: 19704612
- Arabidopsis MPK6 is involved in cell division plane control during early root development, and localizes to the pre-prophase band, phragmoplast, trans-Golgi network and plasma membrane. DOI: 10.1111/j.1365-313X.2009.04046.x ; PMID: 19832943
- Suppression of MKK5 reduces ozone-induced signal transmission to both MPK3 and MPK6 and confers increased ozone sensitivity in Arabidopsis thaliana. DOI: 10.4161/psb.4.8.9298 ; PMID: 19820329
- Sometimes new results raise new questions: the question marks between mitogen-activated protein kinase and ethylene signaling. DOI: 10.1073/pnas.0810206106 ; PMID: 19820303
- Quantitative proteomics identifies oxidant-induced, AtMPK6-dependent changes in Arabidopsis thaliana protein profiles. DOI: 10.4161/psb.4.6.8538 ; PMID: 19816138
- The missing link?: Arabidopsis SPCH is a MAPK specificity factor that controls entry into the stomatal lineage. DOI: 10.4161/psb.4.5.8296 ; PMID: 19816100
- MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis. DOI: 10.1105/tpc.109.067678 ; PMID: 19789277
- Regulation of Arabidopsis early anther development by the mitogen-activated protein kinases, MPK3 and MPK6, and the ERECTA and related receptor-like kinases. DOI: 10.1093/mp/ssn029 ; PMID: 19825569
- Cadmium activates Arabidopsis MPK3 and MPK6 via accumulation of reactive oxygen species. DOI: 10.1016/j.phytochem.2010.01.005 ; PMID: 20116811
- A mitogen-activated protein kinase, AhMPK6 from peanut localizes to the nucleus and also induces defense responses upon transient expression in tobacco. DOI: 10.1016/j.plaphy.2010.03.010 ; PMID: 20409725
- The Ca(2+) -dependent protein kinase CPK3 is required for MAPK-independent salt-stress acclimation in Arabidopsis. DOI: 10.1111/j.1365-313X.2010.04257.x ; PMID: 20497378
- Activation of a mitogen-activated protein kinase pathway in Arabidopsis by chitin. DOI: 10.1111/j.1364-3703.2004.00215.x ; PMID: 20565589
- Mitogen-activated protein kinase 3 and 6 regulate Botrytis cinerea-induced ethylene production in Arabidopsis. DOI: 10.1111/j.1365-313X.2010.04318.x ; PMID: 20659280
- MAPK phosphatase MKP2 mediates disease responses in Arabidopsis and functionally interacts with MPK3 and MPK6. DOI: 10.1111/j.1365-313X.2010.04297.x ; PMID: 20626661
- Phosphatidic acid mediates salt stress response by regulation of MPK6 in Arabidopsis thaliana. DOI: 10.1111/j.1469-8137.2010.03422.x ; PMID: 20796215
- Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis. DOI: 10.1105/tpc.109.072959 ; PMID: 20870959
- Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2. DOI: 10.4161/psb.5.11.13645 ; PMID: 21057191
- MAMP-responsive MAPK cascades regulate phytoalexin biosynthesis. DOI: 10.4161/psb.5.12.13982 ; PMID: 21150304
- MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. DOI: 10.1371/journal.pone.0015357 ; PMID: 21203456
- The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases. DOI: 10.1111/j.1742-4658.2011.08033.x ; PMID: 21276203
- Arabidopsis MAP Kinase Phosphatase 1 (AtMKP1) negatively regulates MPK6-mediated PAMP responses and resistance against bacteria. DOI: 10.1111/j.1365-313X.2011.04588.x ; PMID: 21447069
- Arabidopsis MAP kinase phosphatase 1 is phosphorylated and activated by its substrate AtMPK6. DOI: 10.1007/s00299-011-1064-4 ; PMID: 21455789
- Phosphorylation of a WRKY transcription factor by two pathogen-responsive MAPKs drives phytoalexin biosynthesis in Arabidopsis. DOI: 10.1105/tpc.111.084996 ; PMID: 21498677
- Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. DOI: 10.1016/j.phytochem.2011.02.029 ; PMID: 21477822
- Phosphorylation by MPK6: a conserved transcriptional modification mediates nitrate reductase activation and NO production? DOI: 10.4161/psb.6.6.15308 ; PMID: 21593598
- Lipase activity in insect oral secretions mediates defense responses in Arabidopsis. DOI: 10.1104/pp.111.173567 ; PMID: 21546453
- MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. DOI: 10.1111/j.1469-8137.2011.03727.x ; PMID: 21534970
- Arabidopsis MAP kinase phosphatase 1 and its target MAP kinases 3 and 6 antagonistically determine UV-B stress tolerance, independent of the UVR8 photoreceptor pathway. DOI: 10.1111/j.1365-313X.2011.04725.x ; PMID: 21790814
- Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia. DOI: 10.1007/s11033-011-1232-1 ; PMID: 21947882
- N-acyl-homoserine lactone confers resistance toward biotrophic and hemibiotrophic pathogens via altered activation of AtMPK6. DOI: 10.1104/pp.111.180604 ; PMID: 21940998
- Arabidopsis MKKK20 is involved in osmotic stress response via regulation of MPK6 activity. DOI: 10.1007/s00299-011-1157-0 ; PMID: 21969089
- Transient MPK6 activation in response to oxygen deprivation and reoxygenation is mediated by mitochondria and aids seedling survival in Arabidopsis. DOI: 10.1007/s11103-011-9850-5 ; PMID: 22086331
- Alkamides activate jasmonic acid biosynthesis and signaling pathways and confer resistance to Botrytis cinerea in Arabidopsis thaliana. DOI: 10.1371/journal.pone.0027251 ; PMID: 22076141
- Activation of the Arabidopsis thaliana mitogen-activated protein kinase MPK11 by the flagellin-derived elicitor peptide, flg22. DOI: 10.1094/MPMI-11-11-0281 ; PMID: 22204645
- A dominant allele of Arabidopsis pectin-binding wall-associated kinase induces a stress response suppressed by MPK6 but not MPK3 mutations. DOI: 10.1093/mp/ssr096 ; PMID: 22155845
- Identification of a C2H2-type zinc finger transcription factor (ZAT10) from Arabidopsis as a substrate of MAP kinase. DOI: 10.1007/s00299-011-1192-x ; PMID: 22134874
- or flagellin-induced resistance against Botrytis cinerea. DOI: 10.1104/pp.111.174003 ; PMID: 21803860
- Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling. DOI: 10.1111/j.1469-8137.2011.04017.x ; PMID: 22236066
- A MAP kinase kinase interacts with SymRK and regulates nodule organogenesis in Lotus japonicus. DOI: 10.1105/tpc.112.095984 ; PMID: 22353370
- Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation. DOI: 10.1038/emboj.2012.56 ; PMID: 22407295
- Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. DOI: 10.4161/psb.6.10.16981 ; PMID: 21921699
- MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis. DOI: 10.1111/j.1469-8137.2012.04131.x ; PMID: 22497243
- Determination of primary sequence specificity of Arabidopsis MAPKs MPK3 and MPK6 leads to identification of new substrates. DOI: 10.1042/BJ20111809 ; PMID: 22631074
- Nitric oxide promotes MPK6-mediated caspase-3-like activation in cadmium-induced Arabidopsis thaliana programmed cell death. DOI: 10.1111/j.1365-3040.2012.02543.x ; PMID: 22621159
- Phosphorylation by AtMPK6 is required for the biological function of AtMYB41 in Arabidopsis. DOI: 10.1016/j.bbrc.2012.04.137 ; PMID: 22575450
- Over-expression of Arabidopsis Bax inhibitor-1 delays methyl jasmonate-induced leaf senescence by suppressing the activation of MAP kinase 6. DOI: 10.1093/jxb/ers122 ; PMID: 22563118
- Phosphorylation of the transcriptional regulator MYB44 by mitogen activated protein kinase regulates Arabidopsis seed germination. DOI: 10.1016/j.bbrc.2012.06.019 ; PMID: 22704933
- MAP Kinase Cascades in Arabidopsis Innate Immunity. DOI: 10.3389/fpls.2012.00169 ; PMID: 22837762
- Rice mitogen-activated protein kinase interactome analysis using the yeast two-hybrid system. DOI: 10.1104/pp.112.200071 ; PMID: 22786887
- Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in Arabidopsis. DOI: 10.1371/journal.pgen.1002767 ; PMID: 22761583
- Sorting out the role of nitric oxide in cadmium-induced Arabidopsis thaliana programmed cell death. DOI: 10.4161/psb.21893 ; PMID: 22918505
- MPK11-a fourth elicitor-responsive mitogen-activated protein kinase in Arabidopsis thaliana. DOI: 10.4161/psb.21323 ; PMID: 22899057
- Drought-induced activation and rehydration-induced inactivation of MPK6 in Arabidopsis. DOI: 10.1016/j.bbrc.2012.08.141 ; PMID: 22975351
- Roles of Arabidopsis bax inhibitor-1 in delaying methyl jasmonate-induced leaf senescence. DOI: 10.4161/psb.21776 ; PMID: 22960756
- Phosphorylation and stabilization of Arabidopsis MAP kinase phosphatase 1 in response to UV-B stress. DOI: 10.1074/jbc.M112.434654 ; PMID: 23188831
- Phosphorylation of the zinc finger transcriptional regulator ZAT6 by MPK6 regulates Arabidopsis seed germination under salt and osmotic stress. DOI: 10.1016/j.bbrc.2012.12.039 ; PMID: 23257164
- ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis. DOI: 10.1111/tpj.12095 ; PMID: 23237049
- The MPK6-ERF6-ROS-responsive cis-acting Element7/GCC box complex modulates oxidative gene transcription and the oxidative response in Arabidopsis. DOI: 10.1104/pp.112.210724 ; PMID: 23300166
- Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana. DOI: 10.1074/jbc.M112.384453 ; PMID: 23341468
- Acyl-lipid metabolism. DOI: 10.1199/tab.0161 ; PMID: 23505340
- An abscisic acid-independent oxylipin pathway controls stomatal closure and immune defense in Arabidopsis. DOI: 10.1371/journal.pbio.1001513 ; PMID: 23526882
- Phosphorylation of an ERF transcription factor by Arabidopsis MPK3/MPK6 regulates plant defense gene induction and fungal resistance. DOI: 10.1105/tpc.112.109074 ; PMID: 23524660
- Knockout of AtMKK1 enhances salt tolerance and modifies metabolic activities in Arabidopsis. DOI: 10.4161/psb.24206 ; PMID: 23511202
- Pattern-triggered immunity suppresses programmed cell death triggered by fumonisin b1. DOI: 10.1371/journal.pone.0060769 ; PMID: 23560104
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- AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity. DOI: 10.1111/pce.14002 ; PMID: 33464564
- Ethylene-induced stomatal closure is mediated via MKK1/3-MPK3/6 cascade to EIN2 and EIN3. DOI: 10.1111/jipb.13083 ; PMID: 33605510
- SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants. DOI: 10.1073/pnas.2021351118 ; PMID: 33649235
- A C-terminal fragment of Arabidopsis OXIDATIVE STRESS 2 can play a positive role in salt tolerance. DOI: 10.1016/j.bbrc.2021.03.127 ; PMID: 33836344
- Mitogen-activated protein kinase 6 negatively regulates secondary wall biosynthesis by modulating MYB46 protein stability in Arabidopsis thaliana. DOI: 10.1371/journal.pgen.1009510 ; PMID: 33826618
- Cross Inhibition of MPK10 and WRKY10 Participating in the Growth of Endosperm in Arabidopsis thaliana. DOI: 10.3389/fpls.2021.640346 ; PMID: 33897728
- A dual-specificity phosphatase, MAP kinase phosphatase 1, positively regulates blue light-mediated seedling development in Arabidopsis. DOI: 10.1007/s00425-021-03649-6 ; PMID: 34057637
- Modulation of polyamine metabolism in Arabidopsis thaliana by salicylic acid. DOI: 10.1111/ppl.13478 ; PMID: 34109645
- Naringenin Induces Pathogen Resistance Against Pseudomonas syringae Through the Activation of NPR1 in Arabidopsis. DOI: 10.3389/fpls.2021.672552 ; PMID: 34093630
- MPK6 Kinase Regulates Plasma Membrane H(+)-ATPase Activity in Cold Acclimation. DOI: 10.3390/ijms22126338 ; PMID: 34199294
- Multiple phosphorylation events of the mitochondrial membrane protein TTM1 regulate cell death during senescence. DOI: 10.1111/tpj.15470 ; PMID: 34409658
- MPK3/6-induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis. DOI: 10.15252/embr.202152457 ; PMID: 34402578
- A New Approach for Wounding Research: MYC2 Gene Expression and Protein Stability in Wounded Arabidopsis Protoplasts. DOI: 10.3390/plants10081518 ; PMID: 34451563
- MPK3/MPK6-mediated phosphorylation of ERF72 positively regulates resistance to Botrytis cinerea through directly and indirectly activating the transcription of camalexin biosynthesis enzymes. DOI: 10.1093/jxb/erab415 ; PMID: 34499162
- The kinase CIPK14 functions as a negative regulator of plant immune responses to Pseudomonas syringae in Arabidopsis. DOI: 10.1016/j.plantsci.2021.111017 ; PMID: 34620426
- Lectin receptor-like kinase LecRK-VIII.2 is a missing link in MAPK signaling-mediated yield control. DOI: 10.1093/plphys/kiab241 ; PMID: 34618128
- MKK4/5-MPK3/6 Cascade Regulates Agrobacterium-Mediated Transformation by Modulating Plant Immunity in Arabidopsis. DOI: 10.3389/fpls.2021.731690 ; PMID: 34659297
- Inhibition of Arabidopsis stomatal development by plastoquinone oxidation. DOI: 10.1016/j.cub.2021.10.018 ; PMID: 34727522
- and MPK6-mediated VLN3 phosphorylation regulates actin dynamics during stomatal immunity in Arabidopsis. DOI: 10.1038/s41467-021-26827-2 ; PMID: 34753953
- and MPK6-mediated hypoxia signaling in Arabidopsis. DOI: 10.1093/plcell/koab289 ; PMID: 34850198
- AtPFA-DSP5 interacts with MPK3/MPK6 and negatively regulates plant salt responses. DOI: 10.1080/15592324.2021.2000808 ; PMID: 34839796
- Two phylogenetically unrelated peptide-receptor modules jointly regulate lateral root initiation via a partially shared signaling pathway in Arabidopsis thaliana. DOI: 10.1111/nph.17919 ; PMID: 34913488
- MPK3 and MPK6 control salicylic acid signaling by up-regulating NLR receptors and effector-triggered immunity. DOI: 10.1093/jxb/erab544 ; PMID: 35032388
- Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis. DOI: 10.1093/jxb/erac018 ; PMID: 35088853
- S-Nitrosation of Arabidopsis thaliana Protein Tyrosine Phosphatase 1 Prevents Its Irreversible Oxidation by Hydrogen Peroxide. DOI: 10.3389/fpls.2022.807249 ; PMID: 35222471
- Regulation of Arabidopsis Matrix Metalloproteinases by Mitogen-Activated Protein Kinases and Their Function in Leaf Senescence. DOI: 10.3389/fpls.2022.864986 ; PMID: 35463412
- Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination. DOI: 10.1038/s41467-022-30254-2 ; PMID: 35508457
- Phytocytokine signalling reopens stomata in plant immunity and water loss. DOI: 10.1038/s41586-022-04684-3 ; PMID: 35508659
- Phosphorylation of an ethylene response factor by MPK3/MPK6 mediates negative feedback regulation of pathogen-induced ethylene biosynthesis in Arabidopsis. DOI: 10.1016/j.jgg.2022.04.012 ; PMID: 35562093
- Multilayered synergistic regulation of phytoalexin biosynthesis by ethylene, jasmonate, and MAPK signaling pathways in Arabidopsis. DOI: 10.1093/plcell/koac139 ; PMID: 35543483
- Overlapping functions of YDA and MAPKKK3/MAPKKK5 upstream of MPK3/MPK6 in plant immunity and growth/development. DOI: 10.1111/jipb.13309 ; PMID: 35652263
- Bacterial cyclodipeptides elicit Arabidopsis thaliana immune responses reducing the pathogenic effects of Pseudomonas aeruginosa PAO1 strains on plant development. DOI: 10.1016/j.jplph.2022.153738 ; PMID: 35690030
- CYSTEINE-RICH RECEPTOR-LIKE KINASE5 (CRK5) and CRK22 regulate the response to Verticillium dahliae toxins. DOI: 10.1093/plphys/kiac277 ; PMID: 35674361
- Bacillus amyloliquefaciens PMB05 Increases Resistance to Bacterial Wilt by Activating Mitogen-Activated Protein Kinase and Reactive Oxygen Species Pathway Crosstalk in Arabidopsis thaliana. DOI: 10.1094/PHYTO-04-22-0134-R ; PMID: 35793151
- Mucilaginibacter sp. K Improves Growth and Induces Salt Tolerance in Nonhost Plants via Multilevel Mechanisms. DOI: 10.3389/fpls.2022.938697 ; PMID: 35832221
- Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases. DOI: 10.3724/abbs.2022089 ; PMID: 35866601
- Phosphorylation of the auxin signaling transcriptional repressor IAA15 by MPKs is required for the suppression of root development under drought stress in Arabidopsis. DOI: 10.1093/nar/gkac798 ; PMID: 36161329
- Arabidopsis MPK3 and MPK6 regulates D-glucose signaling and interacts with G-protein, RGS1. DOI: 10.1016/j.plantsci.2022.111484 ; PMID: 36195119
- Cellular messengers involved in the inhibition of the Arabidopsis primary root growth by bacterial quorum-sensing signal N-decanoyl-L-homoserine lactone. DOI: 10.1186/s12870-022-03865-6 ; PMID: 36229795
- BPL3 binds the long non-coding RNA nalncFL7 to suppress FORKED-LIKE7 and modulate HAI1-mediated MPK3/6 dephosphorylation in plant immunity. DOI: 10.1093/plcell/koac311 ; PMID: 36269178
- Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity. DOI: 10.1111/jipb.13391 ; PMID: 36250681
- ROOT MERISTEM GROWTH FACTOR1 (RGF1)-RGF1 INSENSITIVE 1 peptide-receptor pair inhibits lateral root development via the MPK6-PUCHI module in Arabidopsis. DOI: 10.1093/jxb/erac495 ; PMID: 36516421
- RAV1 family members function as transcriptional regulators and play a positive role in plant disease resistance. DOI: 10.1111/tpj.16114 ; PMID: 36703574
- Phosphorylation of the LCB1 subunit of Arabidopsis serine palmitoyltransferase stimulates its activity and modulates sphingolipid biosynthesis. DOI: 10.1111/jipb.13461 ; PMID: 36738228
- An EPFL peptide signaling pathway promotes stamen elongation via enhancing filament cell proliferation to ensure successful self-pollination in Arabidopsis thaliana. DOI: 10.1111/nph.18806 ; PMID: 36772858
- Sphingolipid Long-Chain Base Signaling in Compatible and Non-Compatible Plant-Pathogen Interactions in Arabidopsis. DOI: 10.3390/ijms24054384 ; PMID: 36901815
- Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module. DOI: 10.1016/j.molp.2023.04.004 ; PMID: 37041748
- A prospective study of short-term apoplastic responses to ammonium treatment. DOI: 10.1016/j.jplph.2023.154008 ; PMID: 37245458
- Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells. DOI: 10.1111/jipb.13536 ; PMID: 37226855
- MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis. DOI: 10.1016/j.xplc.2023.100628 ; PMID: 37221824
- Mitogen-activated protein kinase cascades in plants: a new nomenclature. DOI: 10.1016/s1360-1385(02)02302-6 ; PMID: 12119167
- Ancient signals: comparative genomics of plant MAPK and MAPKK gene families. DOI: 10.1016/j.tplants.2006.02.007 ; PMID: 16537113
- Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis. DOI: 10.1105/tpc.106.048298 ; PMID: 17259259
- Comparative Analysis of CDPK Family in Maize, Arabidopsis, Rice, and Sorghum Revealed Potential Targets for Drought Tolerance Improvement. DOI: 10.3389/fchem.2017.00115 ; PMID: 29312925
Sequences:
cDNA Sequence
- >AT2G43790.1
TGAAGACCCAAAAAAAAATAAAAAAATTAATAGATCCGTACGCACATGACTTTCACTTCTTGTCTCTCAGATCTGTTTTGACCCCAAAACCAACGAATATCAATTTCTCCAATTTCATTCATAATTCACTCACCCCAAAATTACAAAAAAAAAAAAAAAAAAAGATTTTCCATTTCCCTCTTCTCGATCCACCACCACCACCAACCTCAAAAGCTTTCATCTTTACCGGTCATGGACGGTGGTTCAGGTCAACCGGCGGCTGATACAGAGATGACAGAAGCTCCTGGAGGTTTTCCCGCGGCGGCTCCATCGCCTCAGATGCCTGGGATTGAGAATATTCCGGCGACTCTTAGCCATGGTGGTAGGTTTATTCAGTATAACATATTTGGAAACATCTTCGAGGTCACCGCTAAGTATAAGCCTCCGATCATGCCTATTGGCAAGGGTGCTTATGGCATCGTTTGTTCGGCTATGAATTCTGAAACTAACGAGAGCGTTGCGATTAAGAAAATTGCTAACGCTTTTGACAATAAGATTGATGCTAAGAGGACTCTCCGTGAGATCAAGCTGCTTCGTCACATGGATCATGAAAATATTGTTGCAATCAGAGATATTATCCCGCCACCATTAAGAAACGCTTTCAACGATGTTTACATCGCGTATGAGTTAATGGACACTGATCTCCATCAAATCATTCGGTCAAATCAAGCATTATCCGAAGAACATTGCCAGTATTTTCTTTACCAGATCCTCCGTGGATTGAAATACATTCACTCTGCAAATGTGCTTCACAGGGATTTGAAACCAAGTAATCTCCTCCTGAACGCAAACTGCGACCTAAAAATCTGCGATTTTGGGCTAGCTCGAGTCACTTCTGAGAGTGATTTCATGACTGAATATGTTGTCACGAGATGGTACCGTGCACCAGAGCTTCTCTTAAACTCTTCTGATTATACTGCAGCTATCGATGTTTGGTCTGTAGGCTGTATTTTCATGGAGTTAATGGACCGTAAGCCACTCTTCCCTGGACGAGATCATGTCCATCAGCTTCGCTTGCTCATGGAGCTCATAGGAACTCCATCAGAAGAAGAGCTCGAGTTCTTGAACGAAAACGCAAAGCGATACATAAGACAGCTTCCACCTTATCCTCGCCAATCCATCACTGATAAGTTCCCGACAGTGCATCCTTTAGCTATAGACCTTATCGAGAAGATGTTAACATTTGATCCTAGACGGAGAATCACAGTTTTAGACGCATTGGCCCATCCATACCTGAACTCGTTGCACGACATAAGCGATGAGCCAGAGTGTACAATACCTTTCAACTTTGATTTTGAAAACCATGCACTCTCAGAGGAGCAGATGAAGGAACTAATCTACCGCGAGGCGCTTGCTTTCAATCCAGAATATCAGCAATAGTTTGAAGAACAGCATTTGGGAGATGAAGATGAGATAAGGGTTTGGCGTTATTTGGTTTGGACAACATTCTTAAAAGGAGGAAAGATCATTGTTTGTCTTTTGTGTATACTTGTGAGAGATGTTGAAGGGGATGGGTCTCAAACTTTATATTTCAGTCTTTTGGATAATTTGTTCTCTCTGTTTTTTTTTTTCCTATTCGTATTTGTAATTTGCCCTCATTTTGTTGTTGCAGTTATTTAAGACTTAAATTGTCTCAGAAATAGTTATGTTATGATAGCCCACCTTCAATTCCTCT
CDS Sequence
- >AT2G43790.1
ATGGACGGTGGTTCAGGTCAACCGGCGGCTGATACAGAGATGACAGAAGCTCCTGGAGGTTTTCCCGCGGCGGCTCCATCGCCTCAGATGCCTGGGATTGAGAATATTCCGGCGACTCTTAGCCATGGTGGTAGGTTTATTCAGTATAACATATTTGGAAACATCTTCGAGGTCACCGCTAAGTATAAGCCTCCGATCATGCCTATTGGCAAGGGTGCTTATGGCATCGTTTGTTCGGCTATGAATTCTGAAACTAACGAGAGCGTTGCGATTAAGAAAATTGCTAACGCTTTTGACAATAAGATTGATGCTAAGAGGACTCTCCGTGAGATCAAGCTGCTTCGTCACATGGATCATGAAAATATTGTTGCAATCAGAGATATTATCCCGCCACCATTAAGAAACGCTTTCAACGATGTTTACATCGCGTATGAGTTAATGGACACTGATCTCCATCAAATCATTCGGTCAAATCAAGCATTATCCGAAGAACATTGCCAGTATTTTCTTTACCAGATCCTCCGTGGATTGAAATACATTCACTCTGCAAATGTGCTTCACAGGGATTTGAAACCAAGTAATCTCCTCCTGAACGCAAACTGCGACCTAAAAATCTGCGATTTTGGGCTAGCTCGAGTCACTTCTGAGAGTGATTTCATGACTGAATATGTTGTCACGAGATGGTACCGTGCACCAGAGCTTCTCTTAAACTCTTCTGATTATACTGCAGCTATCGATGTTTGGTCTGTAGGCTGTATTTTCATGGAGTTAATGGACCGTAAGCCACTCTTCCCTGGACGAGATCATGTCCATCAGCTTCGCTTGCTCATGGAGCTCATAGGAACTCCATCAGAAGAAGAGCTCGAGTTCTTGAACGAAAACGCAAAGCGATACATAAGACAGCTTCCACCTTATCCTCGCCAATCCATCACTGATAAGTTCCCGACAGTGCATCCTTTAGCTATAGACCTTATCGAGAAGATGTTAACATTTGATCCTAGACGGAGAATCACAGTTTTAGACGCATTGGCCCATCCATACCTGAACTCGTTGCACGACATAAGCGATGAGCCAGAGTGTACAATACCTTTCAACTTTGATTTTGAAAACCATGCACTCTCAGAGGAGCAGATGAAGGAACTAATCTACCGCGAGGCGCTTGCTTTCAATCCAGAATATCAGCAATAG
Protein Sequence
- >AT2G43790.1
MDGGSGQPAADTEMTEAPGGFPAAAPSPQMPGIENIPATLSHGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQQ