Gene Details:
- Gene ID: AT2G42590
- Gene Symbol: GF14 MU, GRF14, GRF9
- Gene Name: general regulatory factor 9
- Description: general regulatory factor 9;(source:Araport11)
- TAIR Accession: locus:2041544
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- PO:0000084 — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)
Gene Ontology:
- GO:0005886 — located in — plasma membrane
- GO:0005737 — located in — cytoplasm
- GO:0005737 — is active in — cytoplasm
- GO:0048528 — acts upstream of or within — post-embryonic root development
- GO:0009570 — located in — chloroplast stroma
- GO:0005829 — located in — cytosol
- GO:0005509 — enables — calcium ion binding
- GO:0005515 — enables — protein binding
- GO:0045309 — enables — protein phosphorylated amino acid binding
- GO:0007165 — involved in — signal transduction
- GO:0005634 — located in — nucleus
Function-related keywords:
- vascular leaf , shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen , plant sperm cell
Literature:
- Interaction of a plant 14-3-3 protein with the signal peptide of a thylakoid-targeted chloroplast precursor protein and the presence of 14-3-3 isoforms in the chloroplast stroma. DOI: 10.1104/pp.122.1.235 ; PMID: 10631267
- Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex. DOI: 10.1105/tpc.11.8.1591 ; PMID: 10449590
- The Arabidopsis 14-3-3 multigene family. DOI: 10.1104/pp.114.4.1421 ; PMID: 9276953
- Evolutionary implications of the family of 14-3-3 brain protein homologs in Arabidopsis thaliana. DOI: 10.1007/BF00163762 ; PMID: 7958937
- The arabidopsis 14-3-3 family of signaling regulators. DOI: 10.1104/pp.126.1.35 ; PMID: 11351068
- High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. DOI: 10.1111/j.1365-313X.2004.02281.x ; PMID: 15610358
- Exposed loop domains of complexed 14-3-3 proteins contribute to structural diversity and functional specificity. DOI: 10.1104/pp.105.073916 ; PMID: 16407442
- Phosphate differentially regulates 14-3-3 family members and GRF9 plays a role in Pi-starvation induced responses. DOI: 10.1007/s00425-007-0569-0 ; PMID: 17598127
- The 14-3-3 Proteins mu and upsilon influence transition to flowering and early phytochrome response. DOI: 10.1104/pp.107.108654 ; PMID: 17951453
- Systems analysis of seed filling in Arabidopsis: using general linear modeling to assess concordance of transcript and protein expression. DOI: 10.1104/pp.109.152413 ; PMID: 20118269
- The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system. DOI: 10.1093/jxb/ers022 ; PMID: 22378945
- The impact of heat stress targeting on the hormonal and transcriptomic response in Arabidopsis. DOI: 10.1016/j.plantsci.2014.11.005 ; PMID: 25575991
- Involvement of 14-3-3 protein GRF9 in root growth and response under polyethylene glycol-induced water stress. DOI: 10.1093/jxb/erv149 ; PMID: 25873671
- Arabidopsis 14-3-3 epsilon members contribute to polarity of PIN auxin carrier and auxin transport-related development. DOI: 10.7554/eLife.24336 ; PMID: 28422008
- Tomato plants ectopically expressing Arabidopsis GRF9 show enhanced resistance to phosphate deficiency and improved fruit production in the field. DOI: 10.1016/j.jplph.2018.04.005 ; PMID: 29698910
- GROWTH-REGULATING FACTOR 9 negatively regulates arabidopsis leaf growth by controlling ORG3 and restricting cell proliferation in leaf primordia. DOI: 10.1371/journal.pgen.1007484 ; PMID: 29985961
- Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization. DOI: 10.1073/pnas.1911892116 ; PMID: 31575745
- The miR396-GRF Regulatory Module Controls the Embryogenic Response in Arabidopsis via an Auxin-Related Pathway. DOI: 10.3390/ijms20205221 ; PMID: 31640280
- Interaction of a plant 14-3-3 protein with the signal peptide of a thylakoid-targeted chloroplast precursor protein and the presence of 14-3-3 isoforms in the chloroplast stroma. DOI: 10.1104/pp.122.1.235 ; PMID: 10631267
- The Arabidopsis 14-3-3 multigene family. DOI: 10.1104/pp.114.4.1421 ; PMID: 9276953
- The arabidopsis 14-3-3 family of signaling regulators. DOI: 10.1104/pp.126.1.35 ; PMID: 11351068
- A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. DOI: 10.1074/mcp.M700099-MCP200 ; PMID: 17644812
- Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling. DOI: 10.1016/j.jprot.2017.06.004 ; PMID: 28627464
- The arabidopsis 14-3-3 family of signaling regulators. DOI: 10.1104/pp.126.1.35 ; PMID: 11351068
- A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. DOI: 10.1074/mcp.M700099-MCP200 ; PMID: 17644812
- The arabidopsis 14-3-3 family of signaling regulators. DOI: 10.1104/pp.126.1.35 ; PMID: 11351068
- A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. DOI: 10.1074/mcp.M700099-MCP200 ; PMID: 17644812
Sequences:
cDNA Sequence
- >AT2G42590.3
GTAGTAATTACCCCGTTTAACCCGCGTTAATTACGCTTGTGTCCCTACGCGCGTCTCAAAGATCTCTCTCTTCTCTGGAGAAAAAATAAAACAAAAGAACAGCGTTCGCCGAGAGATATACATACTCGGATCAGTCGTCAAAAGCTTTGGAATTTGATACTTTTGATTTTTCGAGAATCTTGAAAATCAGTCATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAAAATAAGCCGATTTTGATTCAAGATTTCTTTGCTTATGTTGCAGTGATATGATATGTGTGCACCTGGACAATATGTTTCAAGAACTGAATGTGCGGTGAATAATAGTGAAAAGTAGAGTTTCTCTGTTCCCTATATCATGATTGTCTATGTTACTTGTACTCTGGTTTAGCCCTAAATGTCTCTCTGGTTTGAATGTATTGCATGCCTGTCTCAGGACACTCTTATTTGTAATTCACTACTGTCGTCTTACTATCTATCCTTATGGATCCAATCTTGAAACTTATATTCCTTCATTTCTGAATTGCTGAG - >AT2G42590.1
GTAGTAATTACCCCGTTTAACCCGCGTTAATTACGCTTGTGTCCCTACGCGCGTCTCAAAGATCTCTCTCTTCTCTGGAGAAAAAATAAAACAAAAGAACAGCGTTCGCCGAGAGATATACATACTCGGATCAGTCGTCAAAAGCTTTGGAATTTGATACTTTTGATTTTTCGAGAATCTTGAAAATCAGTCATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAAAATAAGCCGATTTTGATTCAAGATTTCTTTGCTTATGTTGCAGTGATATGATATGTGTGCACCTGGACAATATGTTTCAAGAACTGAATGTGCGGTGAATAATAGTGAAAAGTAGAGTTTCTCTGTTCCCTATATCATGATTGTCTATGTTACTTGTACTCTGGTTTAGCCCTAAATGTCTCTCTGGTTTGAATGTATTGCATGCCTGTCTCAGGACACTCTTATTTGTAATTCACTACTGTCGTCTTACTATCTATCCTTATGGATCCAATCTTGAAACTTATATTCCTTCATTTCTGAATTGCTGAG - >AT2G42590.2
GTAGTAATTACCCCGTTTAACCCGCGTTAATTACGCTTGTGTCCCTACGCGCGTCTCAAAGATCTCTCTCTTCTCTGGAGAAAAAATAAAACAAAAGAACAGCGTTCGCCGAGAGATATACATACTCGGATCAGTCGTCAAAAGCTTTGGAATTTGATACTTTTGATTTTTCGAGAATCTTGAAAATCAGTCATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAAAATAAGCCGATTTTGATTCAAGATTTCTTTGCTTATGTTGCAGTGATATGATATGTGTGCACCTGGACAATATGTTTCAAGAACTGAATGTGCGGTGAATAATAGTGAAAAGTAGAGTTTCTCTGTTCCCTATATCATGATTGTCTATGTTACTTGTACTCTGGTTTAGCCCTAAATGTCTCTCTGGTTTGAATGTATTGCATGCCTGTCTCAGGACACTCTTATTTGTAATTCACTACTGTCGTCTTACTATCTATCCTTATGGATCCAATCTTGAAACTTATATTCCTTCATTTCTGAATTGCTGAG
CDS Sequence
- >AT2G42590.3
ATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAA - >AT2G42590.1
ATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAA - >AT2G42590.2
ATGGGTTCTGGAAAAGAGCGTGACACTTTCGTCTACCTCGCTAAGCTCTCTGAGCAAGCTGAGCGTTATGAAGAAATGGTGGAATCAATGAAAAGTGTTGCGAAATTGAATGTTGATCTGACGGTGGAAGAGAGGAACTTACTCTCTGTGGGTTACAAGAACGTGATTGGTTCAAGGAGAGCTTCGTGGAGGATCTTCTCGTCGATTGAACAAAAGGAAGCAGTGAAAGGGAATGATGTTAATGTAAAGAGGATCAAAGAGTATATGGAGAAGGTTGAGTTAGAGCTTTCTAACATATGCATTGATATTATGTCTGTCTTAGATGAGCATCTCATTCCTTCGGCTTCCGAGGGTGAATCTACTGTCTTCTTCAACAAGATGAAAGGTGACTATTACCGCTATCTTGCTGAGTTCAAATCAGGGAACGAGAGGAAAGAGGCTGCTGATCAGTCTTTGAAAGCCTATGAGATTGCTACTACTGCTGCTGAGGCTAAGCTCCCTCCAACACACCCTATCAGATTGGGTTTGGCTTTGAATTTCTCTGTCTTCTACTACGAGATCATGAACGCACCTGAAAGGGCATGTCACCTTGCTAAGCAGGCGTTCGATGAAGCTATCTCAGAGCTTGACACTCTGAACGAGGAATCCTACAAAGATAGCACCTTAATAATGCAACTCCTTAGGGACAATCTGACCTTGTGGACTTCTGACATCTCAGAAGAAGGAGGAGACGATGCTCATAAGACGAATGGTTCTGCCAAACCTGGTGCTGGTGGAGACGATGCAGAGGTAAGTATAAGAGATTCCTTTACTCGGGGTAAATCAAATTAA
Protein Sequence
- >AT2G42590.3
MGSGKERDTFVYLAKLSEQAERYEEMVESMKSVAKLNVDLTVEERNLLSVGYKNVIGSRRASWRIFSSIEQKEAVKGNDVNVKRIKEYMEKVELELSNICIDIMSVLDEHLIPSASEGESTVFFNKMKGDYYRYLAEFKSGNERKEAADQSLKAYEIATTAAEAKLPPTHPIRLGLALNFSVFYYEIMNAPERACHLAKQAFDEAISELDTLNEESYKDSTLIMQLLRDNLTLWTSDISEEGGDDAHKTNGSAKPGAGGDDAEVSIRDSFTRGKSN - >AT2G42590.1
MGSGKERDTFVYLAKLSEQAERYEEMVESMKSVAKLNVDLTVEERNLLSVGYKNVIGSRRASWRIFSSIEQKEAVKGNDVNVKRIKEYMEKVELELSNICIDIMSVLDEHLIPSASEGESTVFFNKMKGDYYRYLAEFKSGNERKEAADQSLKAYEIATTAAEAKLPPTHPIRLGLALNFSVFYYEIMNAPERACHLAKQAFDEAISELDTLNEESYKDSTLIMQLLRDNLTLWTSDISEEGGDDAHKTNGSAKPGAGGDDAEVSIRDSFTRGKSN - >AT2G42590.2
MGSGKERDTFVYLAKLSEQAERYEEMVESMKSVAKLNVDLTVEERNLLSVGYKNVIGSRRASWRIFSSIEQKEAVKGNDVNVKRIKEYMEKVELELSNICIDIMSVLDEHLIPSASEGESTVFFNKMKGDYYRYLAEFKSGNERKEAADQSLKAYEIATTAAEAKLPPTHPIRLGLALNFSVFYYEIMNAPERACHLAKQAFDEAISELDTLNEESYKDSTLIMQLLRDNLTLWTSDISEEGGDDAHKTNGSAKPGAGGDDAEVSIRDSFTRGKSN