Gene Details:

• Gene ID: AT2G41560
• Gene Symbol: ACA4
• Gene Name: autoinhibited Ca(2+)-ATPase, isoform 4
• Description: autoinhibited Ca(2+)-ATPase, isoform 4;(source:Araport11)
• TAIR Accession: locus:2062673
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G41560.1     AT2G41560.3     AT2G41560.4     AT2G41560.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0042742  — acts upstream of or within — defense response to bacterium
• GO:0005634  — located in — nucleus
• GO:0009705  — located in — plant-type vacuole membrane
• GO:0005773  — located in — vacuole
• GO:0005516  — enables — calmodulin binding
• GO:0009651  — acts upstream of or within — response to salt stress
• GO:0000325  — located in — plant-type vacuole
• GO:0055081  — acts upstream of or within — monoatomic anion homeostasis
• GO:0005774  — located in — vacuolar membrane
• GO:0009507  — located in — chloroplast
• GO:0009624  — acts upstream of or within — response to nematode
• GO:0005388  — enables — P-type calcium transporter activity
• GO:0005829  — located in — cytosol
• GO:0070588  — involved in — calcium ion transmembrane transport
• GO:0006970  — acts upstream of or within — response to osmotic stress
• GO:0043069  — acts upstream of or within — negative regulation of programmed cell death
• GO:0051480  — involved in — regulation of cytosolic calcium ion concentration
• GO:0016887  — enables — ATP hydrolysis activity
• GO:0043231  — is active in — intracellular membrane-bounded organelle

Germplasm Phenotype:

• CS86277  — Small and dark-green rosettes; epinastic leaves (leaf margins curled down) giving the appearance of narrow leaves; early flowering (bolting occurs 20 days after planting); short internodes; short siliques; short plants; average height = 21 cm.
• CS93631  — Segregating for very small and yellow-green rosettes that eventually die (30%); survived plants are short, short internodes; short siliques; average height = 20 cm.
• CS93727  — Slow growth; short internodes; short pedicels; short siliques; somewhat short plants; average height = 22 cm.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  root

Literature:

• The ACA4 gene of Arabidopsis encodes a vacuolar membrane calcium pump that improves salt tolerance in yeast.   DOI:  10.1104/pp.124.4.1814 ;  PMID:  11115896
• Genes encoding calmodulin-binding proteins in the Arabidopsis genome.   DOI:  10.1074/jbc.M111626200 ;  PMID:  11782485
• Inventory of the superfamily of P-type ion pumps in Arabidopsis.   DOI:  10.1104/pp.126.2.696 ;  PMID:  11402198
• Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress.   DOI:  10.1104/pp.008532 ;  PMID:  12481097
• Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice.   DOI:  10.1104/pp.103.021923 ;  PMID:  12805592
• The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins.   DOI:  10.1105/tpc.104.027078 ;  PMID:  15539469
• Nematode-induced changes of transporter gene expression in Arabidopsis roots.   DOI:  10.1094/MPMI-18-1247 ;  PMID:  16478044
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• Identification of a vacuolar sucrose transporter in barley and Arabidopsis mesophyll cells by a tonoplast proteomic approach.   DOI:  10.1104/pp.106.079533 ;  PMID:  16581873
• Comparison between a coffee single copy chromosomal region and Arabidopsis duplicated counterparts evidenced high level synteny between the coffee genome and the ancestral Arabidopsis genome.   DOI:  10.1007/s11103-007-9191-6 ;  PMID:  17551672
• Identification of a calmodulin-regulated autoinhibited Ca2+-ATPase (ACA11) that is localized to vacuole membranes in Arabidopsis.   DOI:  10.1016/j.febslet.2007.07.023 ;  PMID:  17662727
• Novel tonoplast transporters identified using a proteomic approach with vacuoles isolated from cauliflower buds.   DOI:  10.1104/pp.107.096917 ;  PMID:  17660356
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Identification, cloning and characterization of sis7 and sis10 sugar-insensitive mutants of Arabidopsis.   DOI:  10.1186/1471-2229-8-104 ;  PMID:  18854047
• Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway.   DOI:  10.1104/pp.110.159038 ;  PMID:  20837703
• Cell-specific vacuolar calcium storage mediated by CAX1 regulates apoplastic calcium concentration, gas exchange, and plant productivity in Arabidopsis.   DOI:  10.1105/tpc.109.072769 ;  PMID:  21258004
• Jasmonate controls polypeptide patterning in undamaged tissue in wounded Arabidopsis leaves.   DOI:  10.1104/pp.111.181008 ;  PMID:  21693672
• Tonoplast-localized Ca(2+) pumps regulate Ca(2+) signals during pattern-triggered immunity in Arabidopsis thaliana.   DOI:  10.1073/pnas.2004183117 ;  PMID:  32690691
• Arabidopsis Ca2+-ATPases 1, 2, and 7 in the endoplasmic reticulum contribute to growth and pollen fitness.   DOI:  10.1093/plphys/kiab021 ;  PMID:  33575795
• Resting cytosol Ca2+ level maintained by Ca2+ pumps affects environmental responses in Arabidopsis.   DOI:  10.1093/plphys/kiad047 ;  PMID:  36715402
• Genes encoding calmodulin-binding proteins in the Arabidopsis genome.   DOI:  10.1074/jbc.M111626200 ;  PMID:  11782485
• Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice.   DOI:  10.1104/pp.103.021923 ;  PMID:  12805592
• The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins.   DOI:  10.1105/tpc.104.027078 ;  PMID:  15539469
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture.   DOI:  10.1074/mcp.M600250-MCP200 ;  PMID:  17151019
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481

Sequences: