Gene Details:

• Gene ID: AT2G39200
• Gene Symbol: ATMLO12, MLO12
• Gene Name: MILDEW RESISTANCE LOCUS O 12, MILDEW RESISTANCE LOCUS O 12
• Description: Seven transmembrane MLO family protein;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G39200.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0000025  — root tip — punta de la raíz (Spanish, exact), 根端 (Japanese, exact)
• PO:0000035  — cotyledon vascular system — sistema vascular del cotiledón (Spanish, exact), 子葉維管系 (Japanese, exact)
• PO:0003011  — root vascular system — sistema vascular de la raíz (Spanish, exact), 根維管系 (Japanese, exact), root vein (related)
• PO:0006503  — fruit abscission zone — zona de absición del fruto (Spanish, exact), 落果実 (fruit shedding zone) (Japanese, exact)
• PO:0009047  — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)
• PO:0009049  — inflorescence — inflorescencia (Spanish, exact), 花序 (Japanese, exact), Triticeae spike (narrow)
• PO:0009066  — anther — antera (Spanish, exact), 半葯,花粉のう (Japanese, exact), Poaceae anther (narrow), Zea anther (narrow)
• PO:0009073  — stigma — estigma (Spanish, exact), stigmas (exact, plural), stigmata (exact, plural), 柱頭 (Japanese, exact), Poaceae stigma (narrow), Zea stigma (narrow)

Germplasm Phenotype:

• CS66549  — broad spectrum powdery mildew resistance
• CS66550  — No visible phenotype.
• CS66551  — No visible phenotype.
• CS66552  — No visible phenotype.
• CS66564  — No visible phenotype.
• CS66568  — Broad-spectrum powdery mildew resistance
• CS66569  — Broad-spectrum powdery mildew resistance
• CS9712  — none
• CS9713  — broad-spectrum powdery mildew resistance
• CS9715  — broad-spectrum powdery mildew resistance

Function-related keywords:

• root ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  cotyledon ,  collective leaf structure ,  root tip ,  cotyledon vascular system ,  root vascular system ,  fruit abscission zone ,  root ,  vascular leaf ,  stem ,  inflorescence ,  anther ,  stigma

Literature:

• Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family.   DOI:  10.1007/s00239-002-2382-5 ;  PMID:  12569425
• Expression profiling of the host response to bacterial infection: the transition from basal to induced defence responses in RPM1-mediated resistance.   DOI:  10.1046/j.1365-313x.2003.01653.x ;  PMID:  12609040
• The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis.   DOI:  10.1104/pp.103.036749 ;  PMID:  15181213
• Leucine-rich repeat receptor-like kinase1 is a key membrane-bound regulator of abscisic acid early signaling in Arabidopsis.   DOI:  10.1105/tpc.104.027474 ;  PMID:  15772289
• Detoxification and transcriptome response in Arabidopsis seedlings exposed to the allelochemical benzoxazolin-2(3H)-one.   DOI:  10.1074/jbc.M500694200 ;  PMID:  15824099
• Expression analysis of the AtMLO gene family encoding plant-specific seven-transmembrane domain proteins.   DOI:  10.1007/s11103-005-5082-x ;  PMID:  16525893
• Conserved requirement for a plant host cell protein in powdery mildew pathogenesis.   DOI:  10.1038/ng1806 ;  PMID:  16732289
• Phytotoxicity and innate immune responses induced by Nep1-like proteins.   DOI:  10.1105/tpc.106.044180 ;  PMID:  17194768
• Dual regulation role of GH3.5 in salicylic acid and auxin signaling during Arabidopsis-Pseudomonas syringae interaction.   DOI:  10.1104/pp.107.106021 ;  PMID:  17704230
• The Arabidopsis SDG4 contributes to the regulation of pollen tube growth by methylation of histone H3 lysines 4 and 36 in mature pollen.   DOI:  10.1016/j.ydbio.2007.12.016 ;  PMID:  18252252
• General detoxification and stress responses are mediated by oxidized lipids through TGA transcription factors in Arabidopsis.   DOI:  10.1105/tpc.107.054809 ;  PMID:  18334669
• Microarray expression profiling of Arabidopsis thaliana L. in response to allelochemicals identified in buckwheat.   DOI:  10.1093/jxb/ern168 ;  PMID:  18603616
• Tryptophan-derived metabolites are required for antifungal defense in the Arabidopsis mlo2 mutant.   DOI:  10.1104/pp.109.147660 ;  PMID:  20023151
• Host cell entry of powdery mildew is correlated with endosomal transport of antagonistically acting VvPEN1 and VvMLO to the papilla.   DOI:  10.1094/MPMI-04-13-0091-R ;  PMID:  23819806
• Loss-of-Function Mutations in CsMLO1 Confer Durable Powdery Mildew Resistance in Cucumber (Cucumis sativus L.).   DOI:  10.3389/fpls.2015.01155 ;  PMID:  26734050
• Key Components of Different Plant Defense Pathways Are Dispensable for Powdery Mildew Resistance of the Arabidopsis mlo2 mlo6 mlo12 Triple Mutant.   DOI:  10.3389/fpls.2017.01006 ;  PMID:  28674541
• The powdery mildew-resistant Arabidopsis mlo2 mlo6 mlo12 triple mutant displays altered infection phenotypes with diverse types of phytopathogens.   DOI:  10.1038/s41598-017-07188-7 ;  PMID:  28839137
• Arabidopsis MLO2 is a negative regulator of sensitivity to extracellular reactive oxygen species.   DOI:  10.1111/pce.13144 ;  PMID:  29333607
• EMR, a cytosolic-abundant ring finger E3 ligase, mediates ER-associated protein degradation in Arabidopsis.   DOI:  10.1111/nph.15279 ;  PMID:  29932218
• Arabidopsis mlo3 mutant plants exhibit spontaneous callose deposition and signs of early leaf senescence.   DOI:  10.1007/s11103-019-00877-z ;  PMID:  31049793
• Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.   DOI:  10.1074/mcp.M600429-MCP200 ;  PMID:  17317660
• General detoxification and stress responses are mediated by oxidized lipids through TGA transcription factors in Arabidopsis.   DOI:  10.1105/tpc.107.054809 ;  PMID:  18334669

Sequences: