Gene Details:
- Gene ID: AT2G32950
- Gene Symbol: ATCOP1, COP1, DET340, EMB168, FUS1
- Gene Name: ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1, CONSTITUTIVE PHOTOMORPHOGENIC 1, DEETIOLATED MUTANT 340, EMBRYO DEFECTIVE 168, FUSCA 1
- Description: Transducin/WD40 repeat-like superfamily protein;(source:Araport11)
- TAIR Accession: locus:2059359
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000037 — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
- PO:0008019 — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0009006 — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
- PO:0009009 — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
- PO:0009025 — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
- PO:0009029 — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
- PO:0009031 — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
- PO:0009046 — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
- PO:0009052 — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
- PO:0020030 — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
- PO:0020038 — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
- PO:0020100 — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
- PO:0020137 — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
- PO:0025022 — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
- PO:0025281 — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
- PO:0025195 — pollen tube cell — célula del tubo polínico (Spanish, exact), 花粉管細胞 (Japanese, exact)
Gene Ontology:
- GO:0006281 — acts upstream of or within — DNA repair
- GO:0005515 — enables — protein binding
- GO:0009640 — acts upstream of or within — photomorphogenesis
- GO:0048573 — acts upstream of or within — photoperiodism, flowering
- GO:0043161 — involved in — proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0061630 — enables — ubiquitin protein ligase activity
- GO:0010119 — acts upstream of or within — regulation of stomatal movement
- GO:0042802 — enables — identical protein binding
- GO:0046283 — acts upstream of or within — anthocyanin-containing compound metabolic process
- GO:0005634 — located in — nucleus
- GO:0080008 — part of — Cul4-RING E3 ubiquitin ligase complex
- GO:0009647 — acts upstream of or within — skotomorphogenesis
- GO:0009641 — acts upstream of or within — shade avoidance
- GO:0004842 — enables — ubiquitin-protein transferase activity
- GO:0016604 — located in — nuclear body
- GO:0000152 — part of — nuclear ubiquitin ligase complex
- GO:0009649 — acts upstream of or within — entrainment of circadian clock
Germplasm Phenotype:
- CS6259 — Blue-light- or dark-grown mutants contain high levels of anthocyanins and are not responsive to cytokinins.
- CS6259 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- CS6259 — accumulation of anthocyanins (purple coloration) in cotyledons of developing embryos; dark-grown seedlings resemble light-grown wild-type seedlings having short hypocotyl, open and enlarged cotyledons, accumulation of anthocyanins, chloroplast-like plastid differentiation; expression of light-induced genes in dark-grown plants; light-grown seedlings are heavily pigmented, with anthocyanin accumulation even in roots, open cotyledons, shoots are small and abnormally shaped, lethal (development arrested soon after initiation of primary leaves).
- CS69040 — Dark-grown cop1-1 seedlings mimic phenotype of light-grown wildtype seedlings. Phenotypes of the dark-grown cop1-1 include the following: short hypocotyls, open and enlarged cotyledons, accumulation of anthocyanins, cell-type differentiation and chloroplast-like plastid differentiation in cotyledons. Light-grown cop1-1 plants have a severe size reduction and greatly reduced seed set than the wildtype.
- CS69041 — Light-grown cop1-6 plants have a severe size reduction and greatly reduced seed set than the wildtype. Dark-grown cop1-6 plants can bolt and flower; dark-grown cop1-6 have enlarged cotyledons compared to dark-grown wildtype.
- cop1-1 — Dark- and light-grown strong mutant seedlings have short hypocotyls of similar length.
- cop1-1 — Dark-grown mutant seedlings are transferred to the light, a significant portion of the seedlings are unable to green and will bleach out and die.
- cop1-1 — Mutant belonging to the strong class. Milder phenotypes than that observed in the mutants of the lethal class. Not adult lethal although mutation causes a severe size reduction of light-grown mature plants and greatly reduce seed set. Dark-grown seedlings homozygous for the mutation exhibit light-grown characteristics, including patterns of cell differentiation and gene expression.
- cop1-1 — The mutant does not show additional hypocotyl elongation under far-red light-enriched conditions, whereas the wild-type seedlings display more than a twofold increase in hypocotyl elongation.
- cop1-1 — Under long-day or continuous light conditions, wild-type plants and the mutant flower after producing approximately seven rosette leaves and growing for 3 to 4 weeks. However, under short-day conditions, wildtype plants produce more than 40 rosette leaves and grow for ~75 days before flowering, whereas the mutant line continues to produce only seven rosette leaves and flower earlier than the wild-type plants.
- cop1-1 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-1 hyh — No suppression of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light. This is in contrast to the phenotype observed in the other two double mutants: cop1-4/hyh and cop1-6/hyh.
- cop1-10 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- cop1-11 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- cop1-3 — Dark- and light-grown strong mutant seedlings have short hypocotyls of similar length.
- cop1-3 — Mutant belonging to the strong class. Milder phenotypes than that observed in the mutants of the lethal class. Not adult lethal although mutation causes a severe size reduction of light-grown mature plants and greatly reduce seed set. Dark-grown seedlings homozygous for the mutation exhibit light-grown characteristics, including patterns of cell differentiation and gene expression.
- cop1-4 — Dark-grown mutant seedlings are transferred to the light, a significant portion of the seedlings are unable to green and will bleach out and die.
- cop1-4 — Dark-grown seedlings homozygous for weak copl mutations have longer hypocotyls than their light-grown siblings and light-grown wild-type seedlings, although they are clearly shorter than etiolated wild-type seedlings.
- cop1-4 — Mutant belonging to the weak class. Milder phenotypes than that observed in the mutants of the strong class. Not adult lethal although mutation causes a severe size reduction of light-grown mature plants and greatly reduce seed set. Dark-grown seedlings homozygous for the mutation exhibit light-grown characteristics, including patterns of cell differentiation and gene expression.
- cop1-4 — The mutant does not show additional hypocotyl elongation under far-red light-enriched conditions, whereas the wild-type seedlings display more than a twofold increase in hypocotyl elongation.
- cop1-4 — Under long-day or continuous light conditions, wild-type plants and the mutant flower after producing approximately seven rosette leaves and growing for 3 to 4 weeks. However, under short-day conditions, wildtype plants produce more than 40 rosette leaves and grow for ~75 days before flowering, whereas the mutant line continues to produce only seven rosette leaves and flower earlier than the wild-type plants.
- cop1-4 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-4 hyh — Suppression in a substantial number of seedlings of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light.
- cop1-6 — Dark-grown mutant seedlings are transferred to the light, a significant portion of the seedlings are unable to green and will bleach out and die.
- cop1-6 — Dark-grown seedlings homozygous for weak copl mutations have longer hypocotyls than their light-grown siblings and light-grown wild-type seedlings, although they are clearly shorter than etiolated wild-type seedlings.
- cop1-6 — Mutant belonging to the weak class. Milder phenotypes than that observed in the mutants of the strong class. Not adult lethal although mutation causes a severe size reduction of light-grown mature plants and greatly reduce seed set. Dark-grown seedlings homozygous for the mutation exhibit light-grown characteristics, including patterns of cell differentiation and gene expression.
- cop1-6 — Roots of the mutant contained ~20-fold the amount of chlorophyll of the wild type.
- cop1-6 — The mutant does not show additional hypocotyl elongation under far-red light-enriched conditions, whereas the wild-type seedlings display more than a twofold increase in hypocotyl elongation.
- cop1-6 — Under long-day or continuous light conditions, wild-type plants and the mutant flower after producing approximately seven rosette leaves and growing for 3 to 4 weeks. However, under short-day conditions, wildtype plants produce more than 40 rosette leaves and grow for ~75 days before flowering, whereas the mutant line continues to produce only seven rosette leaves and flower earlier than the wild-type plants.
- cop1-6 hyh — Indistinguishable from the respective cop1 mutants when grown in darkness.
- cop1-6 hyh — Suppression in a substantial number of seedlings of the light-dependent cop1 phenotype where seedlings bleach and die when transferred from darkness to light.
- cop1-7 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- cop1-8 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- cop1-9 — Both dark- and light-grown homozygous mutant seedlings are severely retarded in their development, with significantly reduced cell elongation in their hypocotyls and reduced cell enlargement in their cotyledons. Both mature seeds and seedlings homozygous for the mutations exhibit dark purple coloration in their hypocotyls and cotyledons due to high levels of anthocyanin accumulation. Most important, homozygous mutants are adult lethal. Occasionally, some mutant individuals will develop up to three pairs of tiny true leaves before senescence. Not a single mutant plant has been able to survive to reproduce.
- csu4-1/cop1-6 — Restores photomorphogenesis.Double mutant restores etiolated phenotype. Dark grown seedlings show normal hypocotyl elongation.
- csu4-3/cop1-6 — Restores photomorphogenesis.Double mutant restores etiolated phenotype. Dark grown seedlings show normal hypocotyl elongation.
Function-related keywords:
- shoot axis apex , leaf lamina base , root , shoot system , plant embryo , vascular leaf , stamen , sepal , flower , inflorescence flower pedicel , cotyledon , petiole , hypocotyl , leaf apex , collective leaf structure , pollen , pollen tube cell
Literature:
- HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain. DOI: 10.1093/emboj/19.18.4997 ; PMID: 10990463
- FIN219, an auxin-regulated gene, defines a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development. DOI: NA ; PMID: 10921909
- Targeted destabilization of HY5 during light-regulated development of Arabidopsis. DOI: 10.1038/35013076 ; PMID: 10839542
- Short communication: the N-terminal fragment of Arabidopsis photomorphogenic repressor COP1 maintains partial function and acts in a concentration-dependent manner. DOI: 10.1046/j.1365-313x.1999.00639.x ; PMID: 10652143
- Light control of Arabidopsis developmental pattern. DOI: NA ; PMID: 10645429
- The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. DOI: 10.1016/s0960-9822(00)80091-3 ; PMID: 10607571
- Structural organization and interactions of COP1, a light-regulated developmental switch. DOI: 10.1023/a:1006324115086 ; PMID: 10579483
- The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. DOI: 10.1074/jbc.274.39.27674 ; PMID: 10488108
- A novel motif mediates the targeting of the Arabidopsis COP1 protein to subnuclear foci. DOI: 10.1074/jbc.274.38.27231 ; PMID: 10480941
- Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. DOI: 10.1016/s0960-9822(99)80314-5 ; PMID: 10395541
- Plastid translation is required for the expression of nuclear photosynthesis genes in the dark and in roots of the pea lip1 mutant. DOI: 10.1105/tpc.11.5.901 ; PMID: 10330474
- The role of COP1 in repression of Arabidopsis photomorphogenic development. DOI: 10.1016/s0962-8924(99)01499-3 ; PMID: 10201077
- Discrete domains mediate the light-responsive nuclear and cytoplasmic localization of Arabidopsis COP1. DOI: 10.1105/tpc.11.3.349 ; PMID: 10072396
- Cloning vectors for the expression of green fluorescent protein fusion proteins in transgenic plants. DOI: 10.1016/s0378-1119(98)00433-8 ; PMID: 9852947
- Multiple photoreceptors mediate the light-induced reduction of GUS-COP1 from Arabidopsis hypocotyl nuclei. DOI: 10.1046/j.1365-313x.1998.00290.x ; PMID: 9839465
- Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. DOI: 10.1105/tpc.10.11.1779 ; PMID: 9811788
- UV-B-induced photomorphogenesis in Arabidopsis thaliana. DOI: 10.1046/j.1365-313x.1998.00246.x ; PMID: 9778848
- Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. DOI: 10.1093/emboj/17.19.5577 ; PMID: 9755158
- Characterization of exon skipping mutants of the COP1 gene from Arabidopsis. DOI: 10.1046/j.1365-313x.1998.00184.x ; PMID: 9744100
- Combinatorial interaction of light-responsive elements plays a critical role in determining the response characteristics of light-regulated promoters in Arabidopsis. DOI: 10.1046/j.1365-313x.1998.00180.x ; PMID: 9744096
- Role of a COP1 interactive protein in mediating light-regulated gene expression in arabidopsis. DOI: 10.1105/tpc.10.7.1083 ; PMID: 9668129
- Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development. DOI: 10.1016/s1097-2765(00)80022-2 ; PMID: 9659918
- The light-regulated Arabidopsis bZIP transcription factor gene ATB2 encodes a protein with an unusually long leucine zipper domain. DOI: 10.1023/a:1005964327725 ; PMID: 9620274
- Etioplast differentiation in arabidopsis: both PORA and PORB restore the prolamellar body and photoactive protochlorophyllide-F655 to the cop1 photomorphogenic mutant. DOI: 10.1105/tpc.10.2.283 ; PMID: 9490750
- COP1b, an isoform of COP1 generated by alternative splicing, has a negative effect on COP1 function in regulating light-dependent seedling development in Arabidopsis. DOI: 10.1007/s004380050662 ; PMID: 9529519
- Molecular cloning and sequencing of the cDNA of cop1 gene from Pisum sativum. DOI: 10.1016/s0167-4781(97)00200-5 ; PMID: 9512668
- Genetic and developmental control of nuclear accumulation of COP1, a repressor of photomorphogenesis in Arabidopsis. DOI: 10.1104/pp.114.3.779 ; PMID: 9232869
- Three knotted1-like homeobox genes in Arabidopsis. DOI: 10.1007/BF00020208 ; PMID: 8980519
- Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis. DOI: 10.1105/tpc.8.11.2047 ; PMID: 8953769
- det1, cop1, and cop9 mutations cause inappropriate expression of several gene sets. DOI: 10.1105/tpc.8.11.1951 ; PMID: 8953766
- Expression of an N-terminal fragment of COP1 confers a dominant-negative effect on light-regulated seedling development in Arabidopsis. DOI: 10.1105/tpc.8.9.1491 ; PMID: 8837504
- The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. DOI: 10.1016/s0092-8674(00)80082-3 ; PMID: 8689678
- Procuste1 mutants identify two distinct genetic pathways controlling hypocotyl and light-grown Arabidopsis seedlings. DOI: 10.1242/dev.122.2.683 ; PMID: 8625819
- Arabidopsis COP1 protein specifically interacts in vitro with a cytoskeleton-associated protein, CIP1. DOI: 10.1073/pnas.92.10.4239 ; PMID: 7753789
- The homeobox gene ATH1 of Arabidopsis is derepressed in the photomorphogenic mutants cop1 and det1. DOI: 10.1105/tpc.7.1.117 ; PMID: 7696878
- Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioning. DOI: 10.1016/0092-8674(94)90034-5 ; PMID: 8001131
- Overexpression of Arabidopsis COP1 results in partial suppression of light-mediated development: evidence for a light-inactivable repressor of photomorphogenesis. DOI: 10.1105/tpc.6.10.1391 ; PMID: 7994173
- Mutational analyses of light-controlled seedling development in Arabidopsis. DOI: 10.1006/scel.1994.1039 ; PMID: 7881072
- The FUSCA genes of Arabidopsis: negative regulators of light responses. DOI: 10.1007/BF00285451 ; PMID: 8058035
- Arabidopsis COP8, COP10, and COP11 genes are involved in repression of photomorphogenic development in darkness. DOI: 10.1105/tpc.6.5.629 ; PMID: 8038603
- Regulatory hierarchy of photomorphogenic loci: allele-specific and light-dependent interaction between the HY5 and COP1 loci. DOI: 10.1105/tpc.6.5.613 ; PMID: 8038602
- Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains. DOI: 10.1105/tpc.6.4.487 ; PMID: 8205001
- Arabidopsis mutants define downstream branches in the phototransduction pathway. DOI: 10.1101/gad.8.3.339 ; PMID: 8314087
- Ring finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain. DOI: S0021-9258(19)36562-7 ; PMID: 8366106
- The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats. DOI: 10.1038/363176a0 ; PMID: 8483503
- Initial characterization of a pea mutant with light-independent photomorphogenesis. DOI: 10.1105/tpc.4.12.1519 ; PMID: 1467651
- COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. DOI: 10.1105/tpc.4.12.1507 ; PMID: 1467650
- COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain. DOI: 10.1016/0092-8674(92)90555-q ; PMID: 1423630
- cop1: a regulatory locus involved in light-controlled development and gene expression in Arabidopsis. DOI: 10.1101/gad.5.7.1172 ; PMID: 2065972
- The pea light-independent photomorphogenesis1 mutant results from partial duplication of COP1 generating an internal promoter and producing two distinct transcripts. DOI: 10.1105/tpc.12.10.1927 ; PMID: 11041887
- Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta. DOI: 10.1104/pp.124.3.979 ; PMID: 11080276
- The roles of photoreceptor systems and the COP1-targeted destabilization of HY5 in light control of Arabidopsis seedling development. DOI: 10.1104/pp.124.4.1520 ; PMID: 11115869
- Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. DOI: 10.1093/emboj/20.1.118 ; PMID: 11226162
- The signaling mechanism of Arabidopsis CRY1 involves direct interaction with COP1. DOI: 10.1105/tpc.010367 ; PMID: 11752373
- Identification of a light-regulated protein kinase activity from seedlings of Arabidopsis thaliana. DOI: 10.1562/0031-8655(2002)075<0178:ioalrp>2.0.co;2 ; PMID: 11883605
- Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. DOI: 10.1101/gad.964602 ; PMID: 11877375
- Isolation and molecular characterization of the COP1 gene homolog from rice, Oryza sativa L. subsp. Indica var. Pusa Basmati 1. DOI: 10.1093/dnares/8.2.73 ; PMID: 11347904
- Phytochrome-mediated control of COP1 gene expression in rice plants. DOI: 10.1007/s004380000396 ; PMID: 11370871
- Cip4, a new COP1 target, is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis. DOI: 10.1105/tpc.13.2.399 ; PMID: 11226193
- Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. DOI: 10.1126/science.1063630 ; PMID: 11509693
- The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis. DOI: 10.1074/jbc.M103140200 ; PMID: 11461903
- Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). DOI: 10.1046/j.1365-313x.2002.01298.x ; PMID: 12028569
- Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. DOI: 10.1101/gad.969702 ; PMID: 12023303
- HFR1, a phytochrome A-signalling component, acts in a separate pathway from HY5, downstream of COP1 in Arabidopsis thaliana. DOI: 10.1046/j.1365-313x.2002.01326.x ; PMID: 12061902
- A role for peroxisomes in photomorphogenesis and development of Arabidopsis. DOI: 10.1126/science.1073633 ; PMID: 12130786
- Chlorophyll Synthesis in a Deetiolated (det340) Mutant of Arabidopsis without NADPH-Protochlorophyllide (PChlide) Oxidoreductase (POR) A and Photoactive PChlide-F655. DOI: 10.1105/tpc.7.12.2081 ; PMID: 12242369
- Light regulated modulation of Z-box containing promoters by photoreceptors and downstream regulatory components, COP1 and HY5, in Arabidopsis. DOI: 10.1046/j.1365-313x.2002.01395.x ; PMID: 12220265
- Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis. DOI: 10.1105/tpc.004416 ; PMID: 12368493
- Epigenetic history of an Arabidopsis trans-silencer locus and a test for relay of trans-silencing activity. DOI: 10.1186/1471-2229-2-11 ; PMID: 12477384
- Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. DOI: 10.1242/dev.00281 ; PMID: 12538522
- The SPA1-like proteins SPA3 and SPA4 repress photomorphogenesis in the light. DOI: 10.1046/j.1365-313x.2003.01813.x ; PMID: 12887588
- Characterization of a novel non-constitutive photomorphogenic cop1 allele. DOI: 10.1104/pp.103.028654 ; PMID: 14605231
- The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. DOI: 10.1101/gad.1122903 ; PMID: 14597662
- Gibberellins repress photomorphogenesis in darkness. DOI: 10.1104/pp.103.035451 ; PMID: 14963246
- Flowering of Arabidopsis cop1 mutants in darkness. DOI: 10.1093/pcp/pch047 ; PMID: 15111714
- The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: mutational analysis by bioluminescence resonance energy transfer. DOI: 10.1073/pnas.0307964101 ; PMID: 15084749
- Constitutive photomorphogenesis 1 and multiple photoreceptors control degradation of phytochrome interacting factor 3, a transcription factor required for light signaling in Arabidopsis. DOI: 10.1105/tpc.021568 ; PMID: 15155879
- Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. DOI: 10.1105/tpc.021949 ; PMID: 15208391
- The SPA quartet: a family of WD-repeat proteins with a central role in suppression of photomorphogenesis in arabidopsis. DOI: 10.1105/tpc.104.024216 ; PMID: 15308756
- Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. DOI: 10.1101/gad.1229504 ; PMID: 15342494
- Light regulates COP1-mediated degradation of HFR1, a transcription factor essential for light signaling in Arabidopsis. DOI: 10.1105/tpc.104.030205 ; PMID: 15705947
- HFR1 is targeted by COP1 E3 ligase for post-translational proteolysis during phytochrome A signaling. DOI: 10.1101/gad.1247205 ; PMID: 15741320
- From The Cover: A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening. DOI: 10.1073/pnas.0501011102 ; PMID: 16093319
- Arabidopsis CONSTANS-LIKE3 is a positive regulator of red light signaling and root growth. DOI: 10.1105/tpc.105.038182 ; PMID: 16339850
- Identification of primary target genes of phytochrome signaling. Early transcriptional control during shade avoidance responses in Arabidopsis. DOI: 10.1104/pp.105.076331 ; PMID: 16565297
- The early dark-response in Arabidopsis thaliana revealed by cDNA microarray analysis. DOI: 10.1007/s11103-005-4211-x ; PMID: 16514558
- Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. DOI: 10.1105/tpc.106.043224 ; PMID: 16844902
- CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis. DOI: 10.1105/tpc.105.040097 ; PMID: 16829591
- The central coiled-coil domain and carboxyl-terminal WD-repeat domain of Arabidopsis SPA1 are responsible for mediating repression of light signaling. DOI: 10.1111/j.1365-313X.2006.02811.x ; PMID: 16813572
- Cryptochrome signaling in plants. DOI: 10.1562/2006-02-28-IR-826 ; PMID: 17002522
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- Post-translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions. DOI: 10.1002/2211-5463.12309 ; PMID: 28979848
- The blue light-induced interaction of cryptochrome 1 with COP1 requires SPA proteins during Arabidopsis light signaling. DOI: 10.1371/journal.pgen.1007044 ; PMID: 28991901
- Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. DOI: 10.1105/tpc.17.00371 ; PMID: 29070509
- COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation. DOI: 10.1073/pnas.1708087114 ; PMID: 29087315
- High Ambient Temperature Represses Anthocyanin Biosynthesis through Degradation of HY5. DOI: 10.3389/fpls.2017.01787 ; PMID: 29104579
- Responses of He-Ne laser on agronomic traits and the crosstalk between UVR8 signaling and phytochrome B signaling pathway in Arabidopsis thaliana subjected to supplementary ultraviolet-B (UV-B) stress. DOI: 10.1007/s00709-017-1184-y ; PMID: 29138939
- FAR-RED INSENSITIVE 219/JAR1 Contributes to Shade Avoidance Responses of Arabidopsis Seedlings by Modulating Key Shade Signaling Components. DOI: 10.3389/fpls.2017.01901 ; PMID: 29163619
- The Transcription Factor COL12 Is a Substrate of the COP1/SPA E3 Ligase and Regulates Flowering Time and Plant Architecture. DOI: 10.1104/pp.17.01207 ; PMID: 29187570
- The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering. DOI: 10.1038/s41467-017-02476-2 ; PMID: 29273730
- The B-Box Domain Protein BBX21 Promotes Photomorphogenesis. DOI: 10.1104/pp.17.01305 ; PMID: 29259103
- The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth. DOI: 10.1371/journal.pgen.1007157 ; PMID: 29357355
- Perception of Sunflecks by the UV-B Photoreceptor UV RESISTANCE LOCUS8. DOI: 10.1104/pp.18.00048 ; PMID: 29530938
- FIN219/JAR1 and cryptochrome1 antagonize each other to modulate photomorphogenesis under blue light in Arabidopsis. DOI: 10.1371/journal.pgen.1007248 ; PMID: 29561841
- Arabidopsis ANGUSTIFOLIA3 (AN3) is associated with the promoter of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) to regulate light-mediated stomatal development. DOI: 10.1111/pce.13212 ; PMID: 29645276
- Regulation of Plant Microprocessor Function in Shaping microRNA Landscape. DOI: 10.3389/fpls.2018.00753 ; PMID: 29922322
- Low Temperature-Enhanced Flavonol Synthesis Requires Light-Associated Regulatory Components in Arabidopsis thaliana. DOI: 10.1093/pcp/pcy132 ; PMID: 30010959
- Long-Day Photoperiod Enhances Jasmonic Acid-Related Plant Defense. DOI: 10.1104/pp.18.00443 ; PMID: 30068539
- Correction: FIN219/JAR1 and cryptochrome1 antagonize each other to modulate photomorphogenesis under blue light in Arabidopsis. DOI: 10.1371/journal.pgen.1007606 ; PMID: 30114209
- B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation. DOI: 10.1105/tpc.18.00226 ; PMID: 30099385
- Dynamic regulation of PIF5 by COP1-SPA complex to optimize photomorphogenesis in Arabidopsis. DOI: 10.1111/tpj.14074 ; PMID: 30144338
- COP1 plays a prominent role in drought stress tolerance in Arabidopsis and Pea. DOI: 10.1016/j.plaphy.2018.08.015 ; PMID: 30139551
- Photoexcited CRYPTOCHROME1 Interacts with Dephosphorylated BES1 to Regulate Brassinosteroid Signaling and Photomorphogenesis in Arabidopsis. DOI: 10.1105/tpc.17.00994 ; PMID: 30131420
- DET1 and COP1 Modulate the Coordination of Growth and Immunity in Response to Key Seasonal Signals in Arabidopsis. DOI: 10.1016/j.celrep.2018.08.096 ; PMID: 30282035
- Ethylene-independent promotion of photomorphogenesis in the dark by cytokinin requires COP1 and the CDD complex. DOI: 10.1093/jxb/ery344 ; PMID: 30272197
- COP1 SUPPRESSOR 4 promotes seedling photomorphogenesis by repressing CCA1 and PIF4 expression in Arabidopsis. DOI: 10.1073/pnas.1813171115 ; PMID: 30352855
- Molecular bases for the constitutive photomorphogenic phenotypes in Arabidopsis. DOI: 10.1242/dev.169870 ; PMID: 30377170
- Two B-Box Domain Proteins, BBX18 and BBX23, Interact with ELF3 and Regulate Thermomorphogenesis in Arabidopsis. DOI: 10.1016/j.celrep.2018.10.060 ; PMID: 30428343
- Hydrogen peroxide facilitates Arabidopsis seedling establishment by interacting with light signalling pathway in the dark. DOI: 10.1111/pce.13482 ; PMID: 30474863
- Light-dependent suppression of COP1 multimeric complex formation is determined by the blue-light receptor FKF1 in Arabidopsis. DOI: 10.1016/j.bbrc.2018.11.032 ; PMID: 30471853
- TOR and RPS6 transmit light signals to enhance protein translation in deetiolating Arabidopsis seedlings. DOI: 10.1073/pnas.1809526115 ; PMID: 30482859
- Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance. DOI: 10.1104/pp.19.00070 ; PMID: 30760637
- Two E3 ligases antagonistically regulate the UV-B response in Arabidopsis. DOI: 10.1073/pnas.1816268116 ; PMID: 30787186
- Impact of UV-B radiation on the photosystem II activity, pro-/antioxidant balance and expression of light-activated genes in Arabidopsis thaliana hy4 mutants grown under light of different spectral composition. DOI: 10.1016/j.jphotobiol.2019.02.003 ; PMID: 30897399
- Different irradiances of UV and PAR in the same ratios alter the flavonoid profiles of Arabidopsis thaliana wild types and UV-signalling pathway mutants. DOI: 10.1039/c8pp00496j ; PMID: 31166333
- Regulation of Arabidopsis gene expression by low fluence rate UV-B independently of UVR8 and stress signaling. DOI: 10.1039/c9pp00151d ; PMID: 31218318
- A phyB-PIF1-SPA1 kinase regulatory complex promotes photomorphogenesis in Arabidopsis. DOI: 10.1038/s41467-019-12110-y ; PMID: 31527679
- STO and GA negatively regulate UV-B-induced Arabidopsis root growth inhibition. DOI: 10.1080/15592324.2019.1675471 ; PMID: 31595819
- PHYTOCHROME INTERACTING FACTOR8 Inhibits Phytochrome A-Mediated Far-Red Light Responses in Arabidopsis. DOI: 10.1105/tpc.19.00515 ; PMID: 31732705
- Cryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesis. DOI: 10.1073/pnas.1909181116 ; PMID: 31822614
- HY5 Contributes to Light-Regulated Root System Architecture Under a Root-Covered Culture System. DOI: 10.3389/fpls.2019.01490 ; PMID: 31850011
- PCH1 and PCHL Directly Interact with PIF1, Promote Its Degradation, and Inhibit Its Transcriptional Function during Photomorphogenesis. DOI: 10.1016/j.molp.2020.02.003 ; PMID: 32061894
- Chimeric Activators and Repressors Define HY5 Activity and Reveal a Light-Regulated Feedback Mechanism. DOI: 10.1105/tpc.19.00772 ; PMID: 32086365
- Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH. DOI: 10.1111/tpj.14736 ; PMID: 32142184
- Genomic evidence reveals SPA-regulated developmental and metabolic pathways in dark-grown Arabidopsis seedlings. DOI: 10.1111/ppl.13095 ; PMID: 32187694
- A dynamic model of UVR8 photoreceptor signalling in UV-B-acclimated Arabidopsis. DOI: 10.1111/nph.16581 ; PMID: 32255498
- Molecular mechanisms suppressing COP1/SPA E3 ubiquitin ligase activity in blue light. DOI: 10.1111/ppl.13103 ; PMID: 32248530
- COP1 destabilizes DELLA proteins in Arabidopsis. DOI: 10.1073/pnas.1907969117 ; PMID: 32471952
- The C-terminal 17 amino acids of the photoreceptor UVR8 is involved in the fine-tuning of UV-B signaling. DOI: 10.1111/jipb.12977 ; PMID: 32492260
- A COP1-PIF-HEC regulatory module fine-tunes photomorphogenesis in Arabidopsis. DOI: 10.1111/tpj.14908 ; PMID: 32652745
- COP1 regulates the stability of CAM7 to promote photomorphogenic growth. DOI: 10.1002/pld3.144 ; PMID: 31245782
- COLD-REGULATED GENE27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis. DOI: 10.1105/tpc.20.00192 ; PMID: 32732313
- COR27 and COR28 Are Novel Regulators of the COP1-HY5 Regulatory Hub and Photomorphogenesis in Arabidopsis. DOI: 10.1105/tpc.20.00195 ; PMID: 32769132
- Regulation of COP1 Function by Brassinosteroid Signaling. DOI: 10.3389/fpls.2020.01151 ; PMID: 32849709
- A HY5-COL3-COL13 regulatory chain for controlling hypocotyl elongation in Arabidopsis. DOI: 10.1111/pce.13899 ; PMID: 33011994
- Molecular pathways regulating elongation of aerial plant organs: a focus on light, the circadian clock, and temperature. DOI: 10.1111/tpj.14996 ; PMID: 32986276
- Phytochrome A inhibits shade avoidance responses under strong shade through repressing the brassinosteroid pathway in Arabidopsis. DOI: 10.1111/tpj.15018 ; PMID: 33037720
- COP1 promotes ABA-induced stomatal closure by modulating the abundance of ABI/HAB and AHG3 phosphatases. DOI: 10.1111/nph.17001 ; PMID: 33048351
- The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution. DOI: 10.1016/j.xplc.2020.100044 ; PMID: 33367240
- Coordinated Shoot and Root Responses to Light Signaling in Arabidopsis. DOI: 10.1016/j.xplc.2020.100026 ; PMID: 33367230
- Expression of Tomato UVR8 in Arabidopsis reveals conserved photoreceptor function. DOI: 10.1016/j.plantsci.2020.110766 ; PMID: 33487351
- COP1 mediates light-dependent regulation of flavonol biosynthesis through HY5 in Arabidopsis. DOI: 10.1016/j.plantsci.2020.110760 ; PMID: 33487344
- DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis. DOI: 10.1016/j.molp.2021.03.009 ; PMID: 33711490
- Direct phosphorylation of HY5 by SPA kinases to regulate photomorphogenesis in Arabidopsis. DOI: 10.1111/nph.17332 ; PMID: 33686674
- Arabidopsis cryptochrome 1 controls photomorphogenesis through regulation of H2A.Z deposition. DOI: 10.1093/plcell/koab091 ; PMID: 33768238
- Light-induced degradation of SPA2 via its N-terminal kinase domain is required for photomorphogenesis. DOI: 10.1093/plphys/kiab156 ; PMID: 33822236
- Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis. DOI: 10.3389/fpls.2021.662793 ; PMID: 33841486
- Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis. DOI: 10.1111/jipb.13111 ; PMID: 33982818
- Long-term abscisic acid promotes golden2-like1 degradation through constitutive photomorphogenic 1 in a light intensity-dependent manner to suppress chloroplast development. DOI: 10.1111/pce.14130 ; PMID: 34129248
- Functional comparison of the WD-repeat domains of SPA1 and COP1 in suppression of photomorphogenesis. DOI: 10.1111/pce.14148 ; PMID: 34251043
- New Insights on the Regulation of Glucosinolate Biosynthesis via COP1 and DELLA Proteins in Arabidopsis Thaliana. DOI: 10.3389/fpls.2021.680255 ; PMID: 34276733
- Calmodulin7: recent insights into emerging roles in plant development and stress. DOI: 10.1007/s11103-021-01177-1 ; PMID: 34398355
- UV RESISTANCE LOCUS8 mediates ultraviolet-B-induced stomatal closure in an ethylene-dependent manner. DOI: 10.1016/j.plantsci.2020.110679 ; PMID: 33218642
- The hydrogen sulfide signal enhances seed germination tolerance to high temperatures by retaining nuclear COP1 for HY5 degradation. DOI: 10.1016/j.plantsci.2019.04.024 ; PMID: 31203892
- Arabidopsis cryptochrome 1 undergoes COP1 and LRBs-dependent degradation in response to high blue light. DOI: 10.1111/nph.17695 ; PMID: 34449898
- Constitutive Photomorphogenic 1 Enhances ER Stress Tolerance in Arabidopsis. DOI: 10.3390/ijms221910772 ; PMID: 34639112
- Mutual upregulation of HY5 and TZP in mediating phytochrome A signaling. DOI: 10.1093/plcell/koab254 ; PMID: 34741605
- Integration of Light and Brassinosteroid Signaling during Seedling Establishment. DOI: 10.3390/ijms222312971 ; PMID: 34884771
- A missense mutation in WRKY32 converts its function from a positive regulator to a repressor of photomorphogenesis. DOI: 10.1111/nph.17932 ; PMID: 34935148
- BBX17 Interacts with CO and Negatively Regulates Flowering Time in Arabidopsis thaliana. DOI: 10.1093/pcp/pcac005 ; PMID: 35016218
- CONSTITUTIVE PHOTOMORPHOGENIC 1 promotes seed germination by destabilizing RGA-LIKE 2 in Arabidopsis. DOI: 10.1093/plphys/kiac060 ; PMID: 35166830
- Abscisic acid-induced cytoplasmic translocation of constitutive photomorphogenic 1 enhances reactive oxygen species accumulation through the HY5-ABI5 pathway to modulate seed germination. DOI: 10.1111/pce.14298 ; PMID: 35199338
- COP1 positively regulates ABA signaling during Arabidopsis seedling growth in darkness by mediating ABA-induced ABI5 accumulation. DOI: 10.1093/plcell/koac073 ; PMID: 35263433
- Signaling Mechanisms by Arabidopsis Cryptochromes. DOI: 10.3389/fpls.2022.844714 ; PMID: 35295637
- Dark secrets of phytomelatonin. DOI: 10.1093/jxb/erac168 ; PMID: 35522068
- Arabidopsis B-box transcription factors BBX20-22 promote UVR8 photoreceptor-mediated UV-B responses. DOI: 10.1111/tpj.15806 ; PMID: 35555928
- ELONGATED HYPOCOTYL 5-mediated suppression of melatonin biosynthesis is alleviated by darkness and promotes cotyledon opening. DOI: 10.1093/jxb/erac176 ; PMID: 35580847
- Genetic Dissection of Light-Regulated Adventitious Root Induction in Arabidopsis thaliana Hypocotyls. DOI: 10.3390/ijms23105301 ; PMID: 35628112
- Cysteines have a role in conformation of the UVR8 photoreceptor. DOI: 10.1111/tpj.15841 ; PMID: 35608127
- Arabidopsis SPA2 represses seedling de-etiolation under multiple light conditions. DOI: 10.1002/pld3.403 ; PMID: 35662851
- UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth. DOI: 10.1016/j.cub.2022.05.046 ; PMID: 35700731
- COP1 controls salt stress tolerance by modulating sucrose content. DOI: 10.1080/15592324.2022.2096784 ; PMID: 35833514
- and PIF4-mediated signaling. DOI: 10.1111/jipb.13329 ; PMID: 35848532
- Organ-specific COP1 control of BES1 stability adjusts plant growth patterns under shade or warmth. DOI: 10.1016/j.devcel.2022.07.003 ; PMID: 35901789
- Blue light-induced phosphorylation of Arabidopsis cryptochrome 1 is essential for its photosensitivity. DOI: 10.1111/jipb.13331 ; PMID: 35894630
- The RNA helicase UAP56 and the E3 ubiquitin ligase COP1 coordinately regulate alternative splicing to repress photomorphogenesis in Arabidopsis. DOI: 10.1093/plcell/koac235 ; PMID: 35920787
- COP1 dynamics integrate conflicting seasonal light and thermal cues in the control of Arabidopsis elongation. DOI: 10.1126/sciadv.abp8412 ; PMID: 35984876
- RUP2 facilitates UVR8 redimerization via two interfaces. DOI: 10.1016/j.xplc.2022.100428 ; PMID: 36065466
- Mechanisms of UV-B light-induced photoreceptor UVR8 nuclear localization dynamics. DOI: 10.1111/nph.18468 ; PMID: 36089828
- The involvement of the N-terminal PHR domain of Arabidopsis cryptochromes in mediating light signaling. DOI: 10.1007/s42994-021-00044-3 ; PMID: 36304752
- A hidden mutation in the seventh WD40-repeat of COP1 determines the early flowering trait in a set of Arabidopsis myc mutants. DOI: 10.1093/plcell/koac319 ; PMID: 36331342
- Arabidopsis phytochromes A and B synergistically repress SPA1 under blue light. DOI: 10.1111/jipb.13412 ; PMID: 36394421
- Stable ARMADILLO REPEAT KINESIN 2 in light inhibits hypocotyl elongation and facilitates light-induced cortical microtubule reorientation in Arabidopsis. DOI: 10.1093/jxb/erac473 ; PMID: 36453983
- COP1 Mediates Dark-Induced Stomatal Closure by Suppressing FT, TSF and SOC1 Expression to Promote NO Accumulation in Arabidopsis Guard Cells. DOI: 10.3390/ijms232315037 ; PMID: 36499365
- Dissecting the functions of COP1 in the UVR8 pathway with a COP1 variant in Arabidopsis. DOI: 10.1111/tpj.16059 ; PMID: 36495441
- MYB30 integrates light signals with antioxidant biosynthesis to regulate plant responses during postsubmergence recovery. DOI: 10.1111/nph.18674 ; PMID: 36513604
- Shade avoidance in the context of climate change. DOI: 10.1093/plphys/kiad004 ; PMID: 36617439
- HSP90s are required for hypocotyl elongation during skotomorphogenesis and thermomorphogenesis via the COP1-ELF3-PIF4 pathway in Arabidopsis. DOI: 10.1111/nph.18776 ; PMID: 36707919
- Co-action of COP1, SPA and cryptochrome in light signal transduction and photomorphogenesis of the moss Physcomitrium patens. DOI: 10.1111/tpj.16128 ; PMID: 36710658
- HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis. DOI: 10.1016/j.xplc.2023.100570 ; PMID: 36864727
- Integration of light and ABA signaling pathways to combat drought stress in plants. DOI: 10.1007/s00299-023-02999-7 ; PMID: 36906730
- Arabidopsis FIN219/JAR1 interacts with phytochrome A under far-red light and jasmonates in regulating hypocotyl elongation via a functional demand manner. DOI: 10.1371/journal.pgen.1010779 ; PMID: 37216398
- A novel motif mediates the targeting of the Arabidopsis COP1 protein to subnuclear foci. DOI: 10.1074/jbc.274.38.27231 ; PMID: 10480941
- The role of COP1 in repression of Arabidopsis photomorphogenic development. DOI: 10.1016/s0962-8924(99)01499-3 ; PMID: 10201077
- Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta. DOI: 10.1104/pp.124.3.979 ; PMID: 11080276
- Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. DOI: 10.1105/tpc.107.055418 ; PMID: 18223036
- The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. DOI: 10.1242/dev.020743 ; PMID: 18434413
- Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. DOI: 10.1105/tpc.108.058891 ; PMID: 18552200
- Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes. DOI: 10.1371/journal.pone.0203442 ; PMID: 30169501
Sequences:
cDNA Sequence
- >AT2G32950.1
ACCACACCTCAGCCTCACTCCTCCTTCATCTCCGACGTCATACCCAAACCACTCTTTTCTCACAATTCCGATTTTCTCAAAAACCAAAATCACAATCGAAGAAATCTTTTGAAAGCAAAATGGAAGAGATTTCGACGGATCCGGTTGTTCCAGCGGTGAAACCTGACCCGAGAACATCTTCAGTTGGTGAAGGTGCTAATCGTCATGAAAATGACGACGGAGGAAGCGGCGGTTCTGAGATTGGAGCACCGGATCTGGATAAAGACTTGCTTTGTCCGATTTGTATGCAGATTATTAAAGATGCTTTCCTCACGGCTTGTGGTCATAGTTTCTGCTATATGTGTATCATCACACATCTTAGGAACAAGAGTGATTGTCCCTGTTGTAGCCAACACCTCACCAATAATCAGCTTTACCCTAATTTCTTGCTCGATAAGCTATTGAAGAAAACTTCAGCTCGGCATGTGTCAAAAACTGCATCGCCCTTGGATCAGTTTCGGGAAGCACTACAAAGGGGTTGTGATGTGTCAATTAAGGAGGTTGATAATCTTCTGACACTTCTTGCGGAAAGGAAGAGAAAAATGGAACAGGAAGAAGCTGAGAGGAACATGCAGATACTTTTGGACTTTTTGCATTGTCTAAGGAAGCAAAAAGTTGATGAACTAAATGAGGTGCAAACTGATCTCCAGTATATTAAAGAAGATATAAATGCCGTTGAGAGACATAGAATAGATTTATACCGAGCTAGGGACAGATATTCTGTAAAGTTGCGGATGCTCGGAGATGATCCAAGCACAAGAAATGCATGGCCACATGAGAAGAACCAGATTGGTTTCAACTCCAATTCTCTCAGCATAAGAGGAGGAAATTTTGTAGGCAATTATCAAAACAAAAAGGTAGAGGGGAAGGCACAAGGAAGCTCTCATGGGCTACCAAAGAAGGATGCGCTGAGTGGGTCAGATTCGCAAAGTTTGAATCAGTCAACTGTCTCAATGGCTAGAAAGAAACGGATTCATGCTCAGTTCAATGATTTACAAGAATGTTACCTCCAAAAGCGGCGTCAGTTGGCAGACCAACCAAATAGTAAACAAGAAAATGATAAGAGTGTAGTACGGAGGGAAGGCTATAGCAACGGCCTTGCAGATTTTCAATCTGTGTTGACTACCTTCACTCGCTACAGTCGTCTAAGAGTTATAGCAGAAATCCGGCATGGGGATATATTTCATTCAGCCAACATTGTATCAAGCATAGAGTTTGATCGTGATGATGAGCTGTTTGCCACTGCTGGTGTTTCTAGATGTATAAAGGTTTTTGACTTCTCTTCGGTTGTAAATGAACCAGCAGATATGCAGTGTCCGATTGTGGAGATGTCAACTCGGTCTAAACTTAGTTGCTTGAGTTGGAATAAGCATGAAAAAAATCACATAGCAAGCAGTGATTATGAAGGAATAGTAACAGTGTGGGATGTAACTACTAGGCAGAGTCTTATGGAGTATGAAGAGCACGAAAAACGTGCCTGGAGTGTTGACTTTTCACGAACAGAACCATCAATGCTTGTATCTGGTAGTGACGACTGCAAGGTTAAAGTTTGGTGCACGAGGCAGGAAGCAAGTGTGATTAATATTGATATGAAAGCAAACATATGTTGTGTCAAGTACAATCCTGGCTCAAGCAACTACATTGCGGTCGGATCAGCTGATCATCACATCCATTATTACGATCTAAGAAACATAAGCCAACCACTTCATGTCTTCAGTGGACACAAGAAAGCAGTTTCCTATGTTAAATTTTTGTCCAACAACGAGCTCGCTTCTGCGTCCACAGATAGCACACTACGCTTATGGGATGTCAAAGACAACTTGCCAGTTCGAACATTCAGAGGACATACTAACGAGAAGAACTTTGTGGGTCTCACAGTGAACAGCGAGTATCTCGCCTGTGGAAGCGAGACAAACGAAGTATATGTATATCACAAGGAAATCACGAGACCCGTGACATCGCACAGATTTGGATCGCCAGACATGGACGATGCAGAGGAAGAGGCAGGTTCCTACTTTATTAGTGCGGTTTGCTGGAAGAGTGATAGTCCCACGATGTTGACTGCGAATAGTCAAGGAACCATCAAAGTTCTGGTACTCGCTGCGTGATTCTAGTAGACATTACAAAAGATCTTATAGCTTCGTGAATCAATAAAAACAAATTTGCCGTCTATGTTCTTTAGTGGGAGTTACATATAGAGAGAGAACAATTTATTAAAAGTAGGGTTCATCATTTGGAAAGCAACTTTGTATTATTATGCTTGCCTTGGAACACTCCTCAAGAAGAATTTGTATCAGTGATGTAGATATGTCTTACGGTTTCTTAGCTTCTACTTTATATAATTAAATGTTAGAATCAAAATGCGGTGATGTGAATCGGTCATGAAAAGTCAAACCTTGGCTTATACAAAAGGTCCGACCCATGCAATAAGTCAT - >AT2G32950.2
ACCACACCTCAGCCTCACTCCTCCTTCATCTCCGACGTCATACCCAAACCACTCTTTTCTCACAATTCCGATTTTCTCAAAAACCAAAATCACAATCGAAGAAATCTTTTGAAAGCAAAATGGAAGAGATTTCGACGGATCCGGTTGTTCCAGCGGTGAAACCTGACCCGAGAACATCTTCAGTTGGTGAAGGTGCTAATCGTCATGAAAATGACGACGGAGGAAGCGGCGGTTCTGAGATTGGAGCACCGGATCTGGATAAAGACTTGCTTTGTCCGATTTGTATGCAGATTATTAAAGATGCTTTCCTCACGGCTTGTGGTCATAGTTTCTGCTATATGTGTATCATCACACATCTTAGGAACAAGAGTGATTGTCCCTGTTGTAGCCAACACCTCACCAATAATCAGCTTTACCCTAATTTCTTGCTCGATAAGCTATTGAAGAAAACTTCAGCTCGGCATGTGTCAAAAACTGCATCGCCCTTGGATCAGTTTCGGGAAGCACTACAAAGGGGTTGTGATGTGTCAATTAAGGAGGTTGATAATCTTCTGACACTTCTTGCGGAAAGGAAGAGAAAAATGGAACAGGAAGAAGCTGAGAGGAACATGCAGATACTTTTGGACTTTTTGCATTGTCTAAGGAAGCAAAAAGTTGATGAACTAAATGAGGTGCAAACTGATCTCCAGTATATTAAAGAAGATATAAATGCCGTTGAGAGACATAGAATAGATTTATACCGAGCTAGGGACAGATATTCTGTAAAGTTGCGGATGCTCGGAGATGATCCAAGCACAAGAAATGCATGGCCACATGAGAAGAACCAGATTGGTTTCAACTCCAATTCTCTCAGCATAAGAGGAGGAAATTTTGTAGGCAATTATCAAAACAAAAAGGTAGAGGGGAAGGCACAAGGAAGCTCTCATGGGCTACCAAAGAAGGATGCGCTGAGTGGGTCAGATTCGCAAAGTTTGAATCAGTCAACTGTCTCAATGGCTAGAAAGAAACGGATTCATGCTCAGTTCAATGATTTACAAGAATGTTACCTCCAAAAGCGGCGTCAGTTGGCAGACCAACCAAATAGTAAACAAGAAAATGATAAGAGTGTAGTACGGAGGGAAGGCTATAGCAACGGCCTTGCAGATTTTCAATCTGTGTTGACTACCTTCACTCGCTACAGTCGTCTAAGAGTTATAGCAGAAATCCGGCATGGGGATATATTTCATTCAGCCAACATTGTATCAAGCATAGAGTTTGATCGTGATGATGAGCTGTTTGCCACTGCTGGTGTTTCTAGATGTATAAAGGTTTTTGACTTCTCTTCGGTTGTAAATGAACCAGCAGATATGCAGTGTCCGATTGTGGAGATGTCAACTCGGTCTAAACTTAGTTGCTTGAGTTGGAATAAGCATGAAAAAAATCACATAGCAAGCAGTGATTATGAAGGAATAGTAACAGTGTGGGATGTAACTACTAGGCAGAGTCTTATGGAGTATGAAGAGCACGAAAAACGTGCCTGGAGTGTTGACTTTTCACGAACAGAACCATCAATGCTTGTATCTGGTAGTGACGACTGCAAGGTTAAAGTTTGGTGCACGAGGCAGGAAGCAAGTGTGATTAATATTGATATGAAAGCAAACATATGTTGTGTCAAGTACAATCCTGGCTCAAGCAACTACATTGCGGTCGGATCAGCTGATCATCACATCCATTATTACGATCTAAGAAACATAAGCCAACCACTTCATGTCTTCAGTGGACACAAGAAAGCAGTTTCCTATGTTAAATTTTTGTCCAACAACGAGCTCGCTTCTGCGTCCACAGATAGCACACTACGCTTATGGGATGTCAAAGACAACTTGCCAGTTCGAACATTCAGAGGACATACTAACGAGAAGAACTTTGTGGGTCTCACAGTGAACAGCGAGTATCTCGCCTGTGGAAGCGAGACAAACGAAGTATATGTATATCACAAGGAAATCACGAGACCCGTGACATCGCACAGATTTGGATCGCCAGACATGGACGATGCAGAGGAAGAGGCAGGTTCCTACTTTATTAGTGCGGTTTGCTGGAAGAGTGATAGTCCCACGATGTTGACTGCGAATAGTCAAGGAACCATCAAAGTTCTGGTACTCGCTGCGTGATTCTAGTAGACATTACAAAAGATCTTATAGCTTCGTGAATCAATAAAAACAAATTTGCCGTCTATGTTCTTTAGTGGGAGTTACATATAGAGAGAGAACAATTTATTAAAAGTAGGGTTCATCATTTGGAAAGCAACTTTGTATTATTATGCTTGCCTTGGAACACTCCTCAAGAAGAATTTGTATCAGTGATGTAGATATGTCTTACGGTTTCTTAGCTTCTACTTTATATAATTAAATGTTAGAATCAAAATGCGGTGATGTGAATCGGTCATGAAAAGTCAAACCTTGGCTTATACAAAAGGTCCGACCCATGCAATAAGTCAT
CDS Sequence
- >AT2G32950.1
ATGGAAGAGATTTCGACGGATCCGGTTGTTCCAGCGGTGAAACCTGACCCGAGAACATCTTCAGTTGGTGAAGGTGCTAATCGTCATGAAAATGACGACGGAGGAAGCGGCGGTTCTGAGATTGGAGCACCGGATCTGGATAAAGACTTGCTTTGTCCGATTTGTATGCAGATTATTAAAGATGCTTTCCTCACGGCTTGTGGTCATAGTTTCTGCTATATGTGTATCATCACACATCTTAGGAACAAGAGTGATTGTCCCTGTTGTAGCCAACACCTCACCAATAATCAGCTTTACCCTAATTTCTTGCTCGATAAGCTATTGAAGAAAACTTCAGCTCGGCATGTGTCAAAAACTGCATCGCCCTTGGATCAGTTTCGGGAAGCACTACAAAGGGGTTGTGATGTGTCAATTAAGGAGGTTGATAATCTTCTGACACTTCTTGCGGAAAGGAAGAGAAAAATGGAACAGGAAGAAGCTGAGAGGAACATGCAGATACTTTTGGACTTTTTGCATTGTCTAAGGAAGCAAAAAGTTGATGAACTAAATGAGGTGCAAACTGATCTCCAGTATATTAAAGAAGATATAAATGCCGTTGAGAGACATAGAATAGATTTATACCGAGCTAGGGACAGATATTCTGTAAAGTTGCGGATGCTCGGAGATGATCCAAGCACAAGAAATGCATGGCCACATGAGAAGAACCAGATTGGTTTCAACTCCAATTCTCTCAGCATAAGAGGAGGAAATTTTGTAGGCAATTATCAAAACAAAAAGGTAGAGGGGAAGGCACAAGGAAGCTCTCATGGGCTACCAAAGAAGGATGCGCTGAGTGGGTCAGATTCGCAAAGTTTGAATCAGTCAACTGTCTCAATGGCTAGAAAGAAACGGATTCATGCTCAGTTCAATGATTTACAAGAATGTTACCTCCAAAAGCGGCGTCAGTTGGCAGACCAACCAAATAGTAAACAAGAAAATGATAAGAGTGTAGTACGGAGGGAAGGCTATAGCAACGGCCTTGCAGATTTTCAATCTGTGTTGACTACCTTCACTCGCTACAGTCGTCTAAGAGTTATAGCAGAAATCCGGCATGGGGATATATTTCATTCAGCCAACATTGTATCAAGCATAGAGTTTGATCGTGATGATGAGCTGTTTGCCACTGCTGGTGTTTCTAGATGTATAAAGGTTTTTGACTTCTCTTCGGTTGTAAATGAACCAGCAGATATGCAGTGTCCGATTGTGGAGATGTCAACTCGGTCTAAACTTAGTTGCTTGAGTTGGAATAAGCATGAAAAAAATCACATAGCAAGCAGTGATTATGAAGGAATAGTAACAGTGTGGGATGTAACTACTAGGCAGAGTCTTATGGAGTATGAAGAGCACGAAAAACGTGCCTGGAGTGTTGACTTTTCACGAACAGAACCATCAATGCTTGTATCTGGTAGTGACGACTGCAAGGTTAAAGTTTGGTGCACGAGGCAGGAAGCAAGTGTGATTAATATTGATATGAAAGCAAACATATGTTGTGTCAAGTACAATCCTGGCTCAAGCAACTACATTGCGGTCGGATCAGCTGATCATCACATCCATTATTACGATCTAAGAAACATAAGCCAACCACTTCATGTCTTCAGTGGACACAAGAAAGCAGTTTCCTATGTTAAATTTTTGTCCAACAACGAGCTCGCTTCTGCGTCCACAGATAGCACACTACGCTTATGGGATGTCAAAGACAACTTGCCAGTTCGAACATTCAGAGGACATACTAACGAGAAGAACTTTGTGGGTCTCACAGTGAACAGCGAGTATCTCGCCTGTGGAAGCGAGACAAACGAAGTATATGTATATCACAAGGAAATCACGAGACCCGTGACATCGCACAGATTTGGATCGCCAGACATGGACGATGCAGAGGAAGAGGCAGGTTCCTACTTTATTAGTGCGGTTTGCTGGAAGAGTGATAGTCCCACGATGTTGACTGCGAATAGTCAAGGAACCATCAAAGTTCTGGTACTCGCTGCGTGA - >AT2G32950.2
ATGGAAGAGATTTCGACGGATCCGGTTGTTCCAGCGGTGAAACCTGACCCGAGAACATCTTCAGTTGGTGAAGGTGCTAATCGTCATGAAAATGACGACGGAGGAAGCGGCGGTTCTGAGATTGGAGCACCGGATCTGGATAAAGACTTGCTTTGTCCGATTTGTATGCAGATTATTAAAGATGCTTTCCTCACGGCTTGTGGTCATAGTTTCTGCTATATGTGTATCATCACACATCTTAGGAACAAGAGTGATTGTCCCTGTTGTAGCCAACACCTCACCAATAATCAGCTTTACCCTAATTTCTTGCTCGATAAGCTATTGAAGAAAACTTCAGCTCGGCATGTGTCAAAAACTGCATCGCCCTTGGATCAGTTTCGGGAAGCACTACAAAGGGGTTGTGATGTGTCAATTAAGGAGGTTGATAATCTTCTGACACTTCTTGCGGAAAGGAAGAGAAAAATGGAACAGGAAGAAGCTGAGAGGAACATGCAGATACTTTTGGACTTTTTGCATTGTCTAAGGAAGCAAAAAGTTGATGAACTAAATGAGGTGCAAACTGATCTCCAGTATATTAAAGAAGATATAAATGCCGTTGAGAGACATAGAATAGATTTATACCGAGCTAGGGACAGATATTCTGTAAAGTTGCGGATGCTCGGAGATGATCCAAGCACAAGAAATGCATGGCCACATGAGAAGAACCAGATTGGTTTCAACTCCAATTCTCTCAGCATAAGAGGAGGAAATTTTGTAGGCAATTATCAAAACAAAAAGGTAGAGGGGAAGGCACAAGGAAGCTCTCATGGGCTACCAAAGAAGGATGCGCTGAGTGGGTCAGATTCGCAAAGTTTGAATCAGTCAACTGTCTCAATGGCTAGAAAGAAACGGATTCATGCTCAGTTCAATGATTTACAAGAATGTTACCTCCAAAAGCGGCGTCAGTTGGCAGACCAACCAAATAGTAAACAAGAAAATGATAAGAGTGTAGTACGGAGGGAAGGCTATAGCAACGGCCTTGCAGATTTTCAATCTGTGTTGACTACCTTCACTCGCTACAGTCGTCTAAGAGTTATAGCAGAAATCCGGCATGGGGATATATTTCATTCAGCCAACATTGTATCAAGCATAGAGTTTGATCGTGATGATGAGCTGTTTGCCACTGCTGGTGTTTCTAGATGTATAAAGGTTTTTGACTTCTCTTCGGTTGTAAATGAACCAGCAGATATGCAGTGTCCGATTGTGGAGATGTCAACTCGGTCTAAACTTAGTTGCTTGAGTTGGAATAAGCATGAAAAAAATCACATAGCAAGCAGTGATTATGAAGGAATAGTAACAGTGTGGGATGTAACTACTAGGCAGAGTCTTATGGAGTATGAAGAGCACGAAAAACGTGCCTGGAGTGTTGACTTTTCACGAACAGAACCATCAATGCTTGTATCTGGTAGTGACGACTGCAAGGTTAAAGTTTGGTGCACGAGGCAGGAAGCAAGTGTGATTAATATTGATATGAAAGCAAACATATGTTGTGTCAAGTACAATCCTGGCTCAAGCAACTACATTGCGGTCGGATCAGCTGATCATCACATCCATTATTACGATCTAAGAAACATAAGCCAACCACTTCATGTCTTCAGTGGACACAAGAAAGCAGTTTCCTATGTTAAATTTTTGTCCAACAACGAGCTCGCTTCTGCGTCCACAGATAGCACACTACGCTTATGGGATGTCAAAGACAACTTGCCAGTTCGAACATTCAGAGGACATACTAACGAGAAGAACTTTGTGGGTCTCACAGTGAACAGCGAGTATCTCGCCTGTGGAAGCGAGACAAACGAAGTATATGTATATCACAAGGAAATCACGAGACCCGTGACATCGCACAGATTTGGATCGCCAGACATGGACGATGCAGAGGAAGAGGCAGGTTCCTACTTTATTAGTGCGGTTTGCTGGAAGAGTGATAGTCCCACGATGTTGACTGCGAATAGTCAAGGAACCATCAAAGTTCTGGTACTCGCTGCGTGA
Protein Sequence
- >AT2G32950.1
MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA - >AT2G32950.2
MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA